Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_I24
(774 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Au... 113 5e-25
sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19... 111 2e-24
sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinas... 111 2e-24
sp|P27636|CDC15_YEAST Cell division control protein 15 110 4e-24
sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinas... 109 7e-24
sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Au... 108 2e-23
sp|Q10407|MKH1_SCHPO MAP kinase kinase kinase mkh1 108 2e-23
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 108 2e-23
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 108 2e-23
sp|O59790|ARK1_SCHPO Serine/threonine-protein kinase ark1 (... 106 8e-23
>sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Aurora kinase)
Length = 358
Score = 113 bits (283), Expect = 5e-25
Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Frame = +1
Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKETN--------LEH 303
F+ G KL + K+Y + +SG FIC +K + NL+K+ ++H
Sbjct: 100 FEVGRKLGKGKFGKVYCVRHKKSG--FICALKAIEKNEILQFNLLKQLKREVDIQLGMDH 157
Query: 304 KNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEGLAFLH 483
NI+K Y + + Y +E+ L+K +++ P + + HY Q+ + L ++H
Sbjct: 158 PNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGP--FNDVLASHYIYQIADALHYMH 215
Query: 484 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 663
++IHRD+KP +LI DN+VK+ G S + + T CGT +Y++PE+I
Sbjct: 216 KKRIIHRDVKPENVLIGFDNVVKLADFGWS------ILNPEGSKRKTLCGTIDYLSPEMI 269
Query: 664 NDEDYWYPVDIWSVGPTITEMVTGLPPY 747
+Y VD+W++G E+V G+PP+
Sbjct: 270 TpreYDEQVDVWALGVLAYELVVGVPPF 297
>sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19)
Length = 1895
Score = 111 bits (278), Expect = 2e-24
Identities = 74/212 (34%), Positives = 113/212 (53%), Gaps = 12/212 (5%)
Frame = +1
Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE--------TNLEH 303
+QKG+ L +Y+ S G F K LD+ I++ + L+H
Sbjct: 1626 WQKGQLLGRGSLGSVYE-GISADGDFFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQH 1684
Query: 304 KNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEGLAFLH 483
+NIV+Y GTT+ ++ Y FLE V +L K + N L + V+ YT+Q+L+GL +LH
Sbjct: 1685 QNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQR---NQLGDSVVSLYTRQILDGLKYLH 1741
Query: 484 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 663
IHR+IK + +L+ + VK+ G+++V+ +L R +N+MAPEVI
Sbjct: 1742 DKGFIHRNIKCANVLVDANGTVKLADFGLAKVM-----------SLWRTPYWNWMAPEVI 1790
Query: 664 -NDED---YWYPVDIWSVGPTITEMVTGLPPY 747
N +D Y P DIWS+G T+ EM+TG PY
Sbjct: 1791 LNPKDYDGYGTPADIWSLGCTVLEMLTGQIPY 1822
>sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4)
Length = 1597
Score = 111 bits (278), Expect = 2e-24
Identities = 75/222 (33%), Positives = 109/222 (49%), Gaps = 17/222 (7%)
Frame = +1
Query: 142 FTFQKGEKLETTQTSKIYKCQESQSGRIFICK-----------VKEFLDEKKYVENLIKE 288
F +Q+G K+ Q K+Y C +G + K +KE DE K E +
Sbjct: 1330 FKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--- 1386
Query: 289 TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEG 468
+H N+V+Y+G + + Y F+EY + TL +V LQE VI YTKQ+
Sbjct: 1387 ---KHPNLVRYFGVELHREEMYIFMEYCDEGTLE----EVSRLGLQEHVIRLYTKQITVA 1439
Query: 469 LAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMT---DNLTRCGTY 639
+ LH + ++HRDIK + I ++ ++K+ G S L NA T + + GT
Sbjct: 1440 INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS----VKLKNNAQTMPGEVNSTLGTA 1495
Query: 640 NYMAPEVI---NDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756
YMAPEVI E + DIWS+G + EMVTG P+H Y
Sbjct: 1496 AYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1537
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 110 bits (275), Expect = 4e-24
Identities = 63/160 (39%), Positives = 86/160 (53%)
Frame = +1
Query: 292 NLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEGL 471
NL H NIVKY+G + Y LEY +L +++ L E Y Q L GL
Sbjct: 76 NLNHNNIVKYHGFIRKSYELYILLEYCANGSL-RRLISRSSTGLSENESKTYVTQTLLGL 134
Query: 472 AFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMA 651
+LH VIHRDIK + IL+S DN VK+ G+S +V+++ LT GT N+MA
Sbjct: 135 KYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSA--------LTLAGTLNWMA 186
Query: 652 PEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGYTQTKL 771
PE++ + DIWS+G T+ EM+T PPYH T +
Sbjct: 187 PEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANI 226
>sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1)
Length = 1607
Score = 109 bits (273), Expect = 7e-24
Identities = 74/222 (33%), Positives = 109/222 (49%), Gaps = 17/222 (7%)
Frame = +1
Query: 142 FTFQKGEKLETTQTSKIYKCQESQSGRIFICK-----------VKEFLDEKKYVENLIKE 288
F +Q+G K+ Q K+Y C +G + K +KE DE K E +
Sbjct: 1340 FKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--- 1396
Query: 289 TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEG 468
+H N+V+Y+G + + Y F+EY + TL +V LQE VI Y+KQ+
Sbjct: 1397 ---KHPNLVRYFGVELHREEMYIFMEYCDEGTLE----EVSRLGLQEHVIRLYSKQITIA 1449
Query: 469 LAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMT---DNLTRCGTY 639
+ LH + ++HRDIK + I ++ ++K+ G S L NA T + + GT
Sbjct: 1450 INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS----VKLKNNAQTMPGEVNSTLGTA 1505
Query: 640 NYMAPEVI---NDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756
YMAPEVI E + DIWS+G + EMVTG P+H Y
Sbjct: 1506 AYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1547
>sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Aurora kinase)
(Increase-in-ploidy protein 1)
Length = 367
Score = 108 bits (270), Expect = 2e-23
Identities = 68/219 (31%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Frame = +1
Query: 115 KFCATSLADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE-- 288
KF + SL DF + G+KL + K+Y + +G I KV E + KY NL K+
Sbjct: 95 KFKSLSLDDF--ELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKY--NLQKQFR 150
Query: 289 ------TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYT 450
T+L H N+ K YG + + Y +EY+ ++K +R P + + Y
Sbjct: 151 REVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGP--FNDILASDYI 208
Query: 451 KQVLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRC 630
Q+ L ++H +IHRDIKP ILI +N++K+ G S + T C
Sbjct: 209 YQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSII------NPPENRRKTVC 262
Query: 631 GTYNYMAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPY 747
GT +Y++PE++ +Y + +D W++G E++TG PP+
Sbjct: 263 GTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPF 301
>sp|Q10407|MKH1_SCHPO MAP kinase kinase kinase mkh1
Length = 1116
Score = 108 bits (270), Expect = 2e-23
Identities = 68/219 (31%), Positives = 114/219 (52%), Gaps = 15/219 (6%)
Frame = +1
Query: 136 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLD---------EKKYVENLIKE 288
A F + KGE + K++ +G + K E K V+++ E
Sbjct: 821 ATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAE 880
Query: 289 ----TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQ 456
+L+H NIV+Y G + + FLEYV+G ++ + +R+ P +E+++ ++Q
Sbjct: 881 ISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGP--FEEQLVRFVSRQ 938
Query: 457 VLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGT 636
VL GL++LH +IHRD+K +LI D + KI G+S+ D +A NL+ G+
Sbjct: 939 VLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDA---NLSMQGS 995
Query: 637 YNYMAPEVINDEDYWY--PVDIWSVGPTITEMVTGLPPY 747
+MAPEVI+++ Y VD+WS+G + EM+ G P+
Sbjct: 996 IFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPW 1034
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 108 bits (269), Expect = 2e-23
Identities = 70/217 (32%), Positives = 113/217 (52%), Gaps = 10/217 (4%)
Frame = +1
Query: 136 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 291
A +++G+ L ++Y C + +GR K +F + K V L E
Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417
Query: 292 NLEHKNIVKYYGTTEIQNKDYF--FLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLE 465
NL+H+ IV+YYG + + F+EY+ G ++ +++ L E V YT+Q+LE
Sbjct: 418 NLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475
Query: 466 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNY 645
G+++LH N ++HRDIK + IL VK+ G S+ + T ++T GT +
Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVT--GTPYW 533
Query: 646 MAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756
M+PEVI+ E Y D+WS+G T+ EM+T PP+ Y
Sbjct: 534 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 108 bits (269), Expect = 2e-23
Identities = 72/218 (33%), Positives = 115/218 (52%), Gaps = 11/218 (5%)
Frame = +1
Query: 136 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 291
A +++G+ L ++Y C + +GR K +F + K V L E
Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417
Query: 292 NLEHKNIVKYYGTTEIQNKDYF--FLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLE 465
NL+H+ IV+YYG + + F+EY+ G ++ +++ L E V YT+Q+LE
Sbjct: 418 NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475
Query: 466 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDT-TLSGNAMTDNLTRCGTYN 642
G+++LH N ++HRDIK + IL VK+ G S+ + T +SG M + GT
Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMR---SVTGTPY 532
Query: 643 YMAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756
+M+PEVI+ E Y D+WS+G T+ EM+T PP+ Y
Sbjct: 533 WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEY 570
>sp|O59790|ARK1_SCHPO Serine/threonine-protein kinase ark1 (Aurora-related kinase 1)
Length = 355
Score = 106 bits (264), Expect = 8e-23
Identities = 65/206 (31%), Positives = 105/206 (50%), Gaps = 6/206 (2%)
Frame = +1
Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICKV--KEFLDEKKYVENLIKE----TNLEHKN 309
F+ G+ L + ++Y +E ++G I K K L + K + + +E +NL HKN
Sbjct: 89 FEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN 148
Query: 310 IVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDVKPNCLQEKVILHYTKQVLEGLAFLHHN 489
I++ YG + + Y LE+ L++ +R K E+V Y Q+ L++LH
Sbjct: 149 ILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKR--FSEEVASKYIFQMANALSYLHKK 206
Query: 490 KVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVIND 669
VIHRDIKP IL+ +D +K+ G S N T T CGT +Y+ PE++
Sbjct: 207 HVIHRDIKPENILLGIDGEIKLSDFGWS----VHAPSNRRT---TLCGTLDYLPPEMVEG 259
Query: 670 EDYWYPVDIWSVGPTITEMVTGLPPY 747
+++ VD+WS+G E + G PP+
Sbjct: 260 KEHTEKVDLWSLGVLTYEFLVGAPPF 285
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,306,416
Number of Sequences: 369166
Number of extensions: 2062163
Number of successful extensions: 8887
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6582
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6916
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7212136400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)