Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00458 (966 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9GZT4|SRR_HUMAN Serine racemase 167 4e-41 sp|Q9QZX7|SRR_MOUSE Serine racemase 165 2e-40 sp|P36007|YKV8_YEAST Hypothetical 34.9 kDa protein in COS9-... 153 8e-37 sp|O59791|YCNE_SCHPO Hypothetical protein C320.14 in chromo... 147 6e-35 sp|O42615|THDH_ARXAD Threonine dehydratase, mitochondrial p... 123 9e-28 sp|P11954|THD2_SALTY Threonine dehydratase catabolic (Threo... 115 2e-25 sp|P00927|THDH_YEAST Threonine dehydratase, mitochondrial p... 113 7e-25 sp|P05792|THD2_ECOLI Threonine dehydratase catabolic (Threo... 112 1e-24 sp|P46493|THD1_HAEIN Threonine dehydratase biosynthetic (Th... 109 1e-23 sp|P55664|Y4TJ_RHISN Putative threonine dehydratase (Threon... 103 9e-22
>sp|Q9GZT4|SRR_HUMAN Serine racemase Length = 340 Score = 167 bits (423), Expect = 4e-41 Identities = 102/275 (37%), Positives = 152/275 (55%), Gaps = 3/275 (1%) Frame = +1 Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLE-- 183 ++ A I + IH TPV+ S+++N L RN+FFKCE QKTGSFK+RGA N + + Sbjct: 12 VEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDA 71 Query: 184 -KQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360 ++ VVTHSSGNHGQA YAAKL IPA IVVP++ P K AI YGA IV+ E + Sbjct: 72 LERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131 Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540 +SRE + ++ +E GQGT+ +E L Q+P +DA+++ + Sbjct: 132 DESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLA 191 Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTF 720 K L P ++VY EP + + +L +T+A+G+K G T+ Sbjct: 192 GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP-PETIADGVK-SSIGLNTW 249 Query: 721 PILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825 PI+ DL + +IF+VT E+ ++ + +K +IE Sbjct: 250 PIIRDLVD-DIFTVTEDEIKCATQLVWERMKLLIE 283
>sp|Q9QZX7|SRR_MOUSE Serine racemase Length = 339 Score = 165 bits (417), Expect = 2e-40 Identities = 103/279 (36%), Positives = 155/279 (55%), Gaps = 7/279 (2%) Frame = +1 Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNI---LCKL 180 ++ A I + IH TPV+ S+++N + RN+FFKCE QKTGSFK+RGA N I + Sbjct: 12 VEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDT 71 Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360 ++ VVTHSSGNHGQA YAAKL IPA IVVP++ P K AI YGA IV+ + + Sbjct: 72 PEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPS 131 Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540 +SRE++ ++ +E GQGT+ +E L Q+P +DA+++ + Sbjct: 132 DESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVA 191 Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE----QKCLDTVAEGLKVHHPG 708 K L P ++VY EP ++ +S KGE +T+A+G+K G Sbjct: 192 GIAITIKALKPSVKVYAAEP--SNADDCYQS---KLKGELTPNLHPPETIADGVK-SSIG 245 Query: 709 QLTFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825 T+PI+ DL + ++F+VT E+ ++ +K +IE Sbjct: 246 LNTWPIIRDLVD-DVFTVTEDEIKYATQLVWGRMKLLIE 283
>sp|P36007|YKV8_YEAST Hypothetical 34.9 kDa protein in COS9-JEN1 intergenic region Length = 326 Score = 153 bits (386), Expect = 8e-37 Identities = 86/271 (31%), Positives = 150/271 (55%), Gaps = 1/271 (0%) Frame = +1 Query: 16 DAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNI 195 DA RI ++++TPV+ S ++N + ++FK E+ Q+ G+FK RGA N + +++ Sbjct: 11 DASNRIKEYVNKTPVLTSRMLNDRLGAQIYFKGENFQRVGAFKFRGAMNAVSKLSDEKRS 70 Query: 196 NGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQSRE 375 GV+ SSGNH QA A +AKLLN+PA IV+P+ P +K A YGA I+ + RE Sbjct: 71 KGVIAFSSGNHAQAIALSAKLLNVPATIVMPEDAPALKVAATAGYGAHIIRYNRYTEDRE 130 Query: 376 ELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXXXXXX 555 ++ ++A E+ GQGT E L+++ LDA+ + + Sbjct: 131 QIGRQLAAEHGFALIPPYDHPDVIAGQGTSAKELLEEVGQLDALFVPLGGGGLLSGSALA 190 Query: 556 XKNLNPKIRVYCVEP-FGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILC 732 ++L+P +++ VEP G + ++S RSGS + K T+A+G + H G+ TF I+ Sbjct: 191 ARSLSPGCKIFGVEPEAGNDGQQSFRSGSIVHINTPK---TIADGAQTQHLGEYTFAIIR 247 Query: 733 DLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825 + + +I +V++ E+++ + + +K V+E Sbjct: 248 ENVD-DILTVSDQELVKCMHFLAERMKVVVE 277
>sp|O59791|YCNE_SCHPO Hypothetical protein C320.14 in chromosome III Length = 323 Score = 147 bits (370), Expect = 6e-35 Identities = 88/273 (32%), Positives = 141/273 (51%), Gaps = 1/273 (0%) Frame = +1 Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQ 189 + A +RI F ++TPV+ S+ +N VFFKCE+ QK G+FK RGA N + E Q Sbjct: 13 VASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQLNEAQ 72 Query: 190 NINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQS 369 GV+T SSGNH QA A +AK+L IPA I++P P+ K A YG +++ + Sbjct: 73 RKAGVLTFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIMYDRYKDD 132 Query: 370 REELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXXXX 549 RE++ ++++ GQGT E +++ LDA+ + + Sbjct: 133 REKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDALFVCLGGGGLLSGSA 192 Query: 550 XXXKNLNPKIRVYCVEP-FGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPI 726 ++ P VY VEP G + ++S R GS + K T+A+G + H G TF I Sbjct: 193 LAARHFAPNCEVYGVEPEAGNDGQQSFRKGSIVHIDTPK---TIADGAQTQHLGNYTFSI 249 Query: 727 LCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825 + + + +I +V++ E+I+ +K +K V+E Sbjct: 250 IKEKVD-DILTVSDEELIDCLKFYAARMKIVVE 281
>sp|O42615|THDH_ARXAD Threonine dehydratase, mitochondrial precursor (Threonine deaminase) Length = 550 Score = 123 bits (308), Expect = 9e-28 Identities = 84/287 (29%), Positives = 140/287 (48%), Gaps = 3/287 (1%) Frame = +1 Query: 28 RISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNINGVV 207 ++ + +ETPV + +++ + N+F K E LQ SFKLRGA N + ++ GV+ Sbjct: 48 KVYDVCNETPVTPAVNLSSKLGANIFLKREDLQPVFSFKLRGAYNMMAHLPQETRWKGVI 107 Query: 208 THSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQSREELCS 387 S+GNH Q AY+AK LNIPA IV+P TP IK + + GAK+V + + + C+ Sbjct: 108 ACSAGNHAQGVAYSAKHLNIPATIVMPVVTPAIKYKNVDRLGAKVVLHGNDFDAAKAECN 167 Query: 388 KMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQI--PNLDAVLISISXXXXXXXXXXXXK 561 ++++++ GQGT+G+E L+QI +L A+ + I K Sbjct: 168 RLSEKHGLTNIPLFDNPYVIAGQGTIGVELLRQIDVESLKAIFVCIGGGGLIAGVGAYIK 227 Query: 562 NLNPKIRVYCVEPF-GKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILCDL 738 + P++++ VE + + +SL+ G R+ E + A+G V G+ TF LC Sbjct: 228 RIAPQVKIIGVETYDANAMRQSLQKGERITLSE---VGLFADGAAVKILGEETFR-LCQQ 283 Query: 739 AERNIFSVTNSEMIEGVKMSMKYLKQVIEHXXXXXXXXLFKYNKDIP 879 I V+ E+ +K + ++E L KY + P Sbjct: 284 VVDEIVLVSTDEICAAIKDVFTETRSIVEPAGALSVAGLVKYVESHP 330
>sp|P11954|THD2_SALTY Threonine dehydratase catabolic (Threonine deaminase) Length = 329 Score = 115 bits (288), Expect = 2e-25 Identities = 74/262 (28%), Positives = 127/262 (48%), Gaps = 3/262 (1%) Frame = +1 Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180 + I +A KR++ I++T + +SN + +F K E++Q+TGSFK+RGA N + Sbjct: 11 IEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLT 70 Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360 E + GVV S+GNH Q + + +L I +V+PK P+ K A Y A++V D Sbjct: 71 EAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDN 130 Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540 S++ + GQGT+G+E ++ + ++D V++ I Sbjct: 131 FNDTIAKVSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGGGGLIA 190 Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE---QKCLDTVAEGLKVHHPGQ 711 K++NP I+V G + E + + GE + T+A+G V PG Sbjct: 191 GIAIAIKSINPTIKV-----IGVQAENVHGMAASYYTGEITTHRTTGTLADGCDVSRPGN 245 Query: 712 LTFPILCDLAERNIFSVTNSEM 777 LT+ I+ +L + +I V+ E+ Sbjct: 246 LTYEIVRELVD-DIVLVSEDEI 266
>sp|P00927|THDH_YEAST Threonine dehydratase, mitochondrial precursor (Threonine deaminase) Length = 576 Score = 113 bits (283), Expect = 7e-25 Identities = 83/283 (29%), Positives = 134/283 (47%), Gaps = 5/283 (1%) Frame = +1 Query: 31 ISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNINGVVT 210 + + I+E+P+ Q +++ +N NV K E L SFKLRGA N I + Q GV+ Sbjct: 72 VYDVINESPISQGVGLSSRLNTNVILKREDLLPVFSFKLRGAYNMIAKLDDSQRNQGVIA 131 Query: 211 HSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIV-FSEDTPQSREELCS 387 S+GNH Q A+AAK L IPA IV+P TP IK + ++ G+++V + D +++ E C+ Sbjct: 132 CSAGNHAQGVAFAAKHLKIPATIVMPVCTPSIKYQNVSRLGSQVVLYGNDFDEAKAE-CA 190 Query: 388 KMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQI---PNLDAVLISISXXXXXXXXXXXX 558 K+A+E GQGT+ ME L+Q+ + AV + + Sbjct: 191 KLAEERGLTNIPPFDHPYVIAGQGTVAMEILRQVRTANKIGAVFVPVGGGGLIAGIGAYL 250 Query: 559 KNLNPKIRVYCVEPF-GKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILCD 735 K + P I++ VE + L SL+ R + T A+G V G+ TF + Sbjct: 251 KRVAPHIKIIGVETYDAATLHNSLQRNQRT---PLPVVGTFADGTSVRMIGEETFRVAQQ 307 Query: 736 LAERNIFSVTNSEMIEGVKMSMKYLKQVIEHXXXXXXXXLFKY 864 + + + V E+ VK + + ++E + KY Sbjct: 308 VVD-EVVLVNTDEICAAVKDIFEDTRSIVEPSGALSVAGMKKY 349
>sp|P05792|THD2_ECOLI Threonine dehydratase catabolic (Threonine deaminase) Length = 329 Score = 112 bits (281), Expect = 1e-24 Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 3/262 (1%) Frame = +1 Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180 + I +A +R++ I++T + +SN + +F K E++Q+TGSFK+RGA N + Sbjct: 11 IDDIIEAKQRLAGRIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLT 70 Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360 + + GVV S+GNH Q + + +L I +V+PK P+ K A Y A++V D Sbjct: 71 DAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDN 130 Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540 S++ + GQGT+G+E ++ + ++D V++ I Sbjct: 131 FNDTIAKVSEIVEMEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGGGGLIA 190 Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE---QKCLDTVAEGLKVHHPGQ 711 K++NP IRV G + E + GE + T+A+G V PG Sbjct: 191 GIAVAIKSINPTIRV-----IGVQSENVHGMAASFHSGEITTHRTTGTLADGCDVSRPGN 245 Query: 712 LTFPILCDLAERNIFSVTNSEM 777 LT+ I+ +L + +I V+ E+ Sbjct: 246 LTYEIVRELVD-DIVLVSEDEI 266
>sp|P46493|THD1_HAEIN Threonine dehydratase biosynthetic (Threonine deaminase) Length = 513 Score = 109 bits (273), Expect = 1e-23 Identities = 82/299 (27%), Positives = 139/299 (46%), Gaps = 7/299 (2%) Frame = +1 Query: 16 DAVKRISNFIHE----TPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLE 183 +A+ ++ + ++E TP+ + ++ ++ N++ K E Q SFKLRGA I Sbjct: 17 NAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVNSFKLRGAYAMISSLSA 76 Query: 184 KQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTP 363 +Q GV+ S+GNH Q A +AK L + A+IV+P++TP IK +A+ +G +++ Sbjct: 77 EQKAAGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVDAVRGFGGEVLLHGANF 136 Query: 364 QSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXX 543 + +++KE GQGTL ME L+Q+ +LD V + + Sbjct: 137 DEAKAKAIELSKEKNMTFIPPFDHPLVIAGQGTLAMEMLQQVADLDYVFVQVGGGGLAAG 196 Query: 544 XXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGEQKCLDTV---AEGLKVHHPGQL 714 K P+I++ G E ++S + L KGE L + A+G+ V G Sbjct: 197 VAILLKQFMPEIKI-----IGVESKDSACLKAALDKGEPTDLTHIGLFADGVAVKRIGDE 251 Query: 715 TFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHXXXXXXXXLFKYNKDIPLECK 891 TF LC ++ V + E+ +K + ++ V E L KY K +E K Sbjct: 252 TFR-LCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAEPSGALGLAGLKKYVKQNHIEGK 309
>sp|P55664|Y4TJ_RHISN Putative threonine dehydratase (Threonine deaminase) Length = 332 Score = 103 bits (256), Expect = 9e-22 Identities = 75/277 (27%), Positives = 125/277 (45%), Gaps = 2/277 (0%) Frame = +1 Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180 L I+ A +RI + TP+ S + L V K EH Q+TGSFKLRGA N IL Sbjct: 9 LESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGATNAILQLS 68 Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360 GV+ S+GNHG+A +YAAK + A I + P+ K I GA + + Sbjct: 69 PSDRARGVIAASTGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGATVRIVGSS 128 Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540 + ++ E GQ T+G+E ++ +P++ VL+ +S Sbjct: 129 QDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQRTVGLEIVEAMPDVAMVLLPLSGGGLAA 188 Query: 541 XXXXXXKNLNPKIRVYCVE-PFGKELEESLRSGSRLWKGEQKCL-DTVAEGLKVHHPGQL 714 K L P R+ V G ++ S+ +G + E + L D++ G+ + Sbjct: 189 GVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGIGM--ANAW 246 Query: 715 TFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825 TF +C ++ V E+ G++ + ++ +Q++E Sbjct: 247 TFQ-MCRALLDDVVLVNEGEIAAGIRHAYEHERQILE 282
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 101,317,346 Number of Sequences: 369166 Number of extensions: 1938752 Number of successful extensions: 4931 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4777 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4901 length of database: 68,354,980 effective HSP length: 111 effective length of database: 47,849,395 effective search space used: 10048372950 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)