Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_A02
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9GZT4|SRR_HUMAN Serine racemase 172 1e-42
sp|Q9QZX7|SRR_MOUSE Serine racemase 170 5e-42
sp|P36007|YKV8_YEAST Hypothetical 34.9 kDa protein in COS9-... 154 4e-37
sp|O59791|YCNE_SCHPO Hypothetical protein C320.14 in chromo... 147 5e-35
sp|O42615|THDH_ARXAD Threonine dehydratase, mitochondrial p... 122 1e-27
sp|P11954|THD2_SALTY Threonine dehydratase catabolic (Threo... 118 2e-26
sp|P05792|THD2_ECOLI Threonine dehydratase catabolic (Threo... 115 2e-25
sp|P00927|THDH_YEAST Threonine dehydratase, mitochondrial p... 114 3e-25
sp|P46493|THD1_HAEIN Threonine dehydratase biosynthetic (Th... 106 9e-23
sp|P55664|Y4TJ_RHISN Putative threonine dehydratase (Threon... 105 2e-22
>sp|Q9GZT4|SRR_HUMAN Serine racemase
Length = 340
Score = 172 bits (435), Expect = 1e-42
Identities = 105/282 (37%), Positives = 155/282 (54%), Gaps = 3/282 (1%)
Frame = +1
Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLE-- 183
++ A I + IH TPV+ S+++N L RN+FFKCE QKTGSFK+RGA N + +
Sbjct: 12 VEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGALNAVRSLVPDA 71
Query: 184 -KQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360
++ VVTHSSGNHGQA YAAKL IPA IVVP++ P K AI YGA IV+ E +
Sbjct: 72 LERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQAYGASIVYCEPS 131
Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540
+SRE + ++ +E GQGT+ +E L Q+P +DA+++ +
Sbjct: 132 DESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMLA 191
Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTF 720
K L P ++VY EP + + +L +T+A+G+K G T+
Sbjct: 192 GIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYP-PETIADGVK-SSIGLNTW 249
Query: 721 PILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGAAV 846
PI+ DL + +IF+VT E+ ++ + +K +IE AG V
Sbjct: 250 PIIRDLVD-DIFTVTEDEIKCATQLVWERMKLLIEPTAGVGV 290
>sp|Q9QZX7|SRR_MOUSE Serine racemase
Length = 339
Score = 170 bits (430), Expect = 5e-42
Identities = 106/286 (37%), Positives = 159/286 (55%), Gaps = 7/286 (2%)
Frame = +1
Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNI---LCKL 180
++ A I + IH TPV+ S+++N + RN+FFKCE QKTGSFK+RGA N I +
Sbjct: 12 VEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDT 71
Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360
++ VVTHSSGNHGQA YAAKL IPA IVVP++ P K AI YGA IV+ + +
Sbjct: 72 PEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPS 131
Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540
+SRE++ ++ +E GQGT+ +E L Q+P +DA+++ +
Sbjct: 132 DESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVA 191
Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE----QKCLDTVAEGLKVHHPG 708
K L P ++VY EP ++ +S KGE +T+A+G+K G
Sbjct: 192 GIAITIKALKPSVKVYAAEP--SNADDCYQS---KLKGELTPNLHPPETIADGVK-SSIG 245
Query: 709 QLTFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGAAV 846
T+PI+ DL + ++F+VT E+ ++ +K +IE AG A+
Sbjct: 246 LNTWPIIRDLVD-DVFTVTEDEIKYATQLVWGRMKLLIEPTAGVAL 290
>sp|P36007|YKV8_YEAST Hypothetical 34.9 kDa protein in COS9-JEN1 intergenic region
Length = 326
Score = 154 bits (388), Expect = 4e-37
Identities = 87/274 (31%), Positives = 151/274 (55%), Gaps = 1/274 (0%)
Frame = +1
Query: 16 DAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNI 195
DA RI ++++TPV+ S ++N + ++FK E+ Q+ G+FK RGA N + +++
Sbjct: 11 DASNRIKEYVNKTPVLTSRMLNDRLGAQIYFKGENFQRVGAFKFRGAMNAVSKLSDEKRS 70
Query: 196 NGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQSRE 375
GV+ SSGNH QA A +AKLLN+PA IV+P+ P +K A YGA I+ + RE
Sbjct: 71 KGVIAFSSGNHAQAIALSAKLLNVPATIVMPEDAPALKVAATAGYGAHIIRYNRYTEDRE 130
Query: 376 ELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXXXXXX 555
++ ++A E+ GQGT E L+++ LDA+ + +
Sbjct: 131 QIGRQLAAEHGFALIPPYDHPDVIAGQGTSAKELLEEVGQLDALFVPLGGGGLLSGSALA 190
Query: 556 XKNLNPKIRVYCVEP-FGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILC 732
++L+P +++ VEP G + ++S RSGS + K T+A+G + H G+ TF I+
Sbjct: 191 ARSLSPGCKIFGVEPEAGNDGQQSFRSGSIVHINTPK---TIADGAQTQHLGEYTFAIIR 247
Query: 733 DLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAA 834
+ + +I +V++ E+++ + + +K V+E A
Sbjct: 248 ENVD-DILTVSDQELVKCMHFLAERMKVVVEPTA 280
>sp|O59791|YCNE_SCHPO Hypothetical protein C320.14 in chromosome III
Length = 323
Score = 147 bits (370), Expect = 5e-35
Identities = 88/273 (32%), Positives = 141/273 (51%), Gaps = 1/273 (0%)
Frame = +1
Query: 10 IDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQ 189
+ A +RI F ++TPV+ S+ +N VFFKCE+ QK G+FK RGA N + E Q
Sbjct: 13 VASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMGAFKFRGALNALSQLNEAQ 72
Query: 190 NINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQS 369
GV+T SSGNH QA A +AK+L IPA I++P P+ K A YG +++ +
Sbjct: 73 RKAGVLTFSSGNHAQAIALSAKILGIPAKIIMPLDAPEAKVAATKGYGGQVIMYDRYKDD 132
Query: 370 REELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXXXX 549
RE++ ++++ GQGT E +++ LDA+ + +
Sbjct: 133 REKMAKEISEREGLTIIPPYDHPHVLAGQGTAAKELFEEVGPLDALFVCLGGGGLLSGSA 192
Query: 550 XXXKNLNPKIRVYCVEP-FGKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPI 726
++ P VY VEP G + ++S R GS + K T+A+G + H G TF I
Sbjct: 193 LAARHFAPNCEVYGVEPEAGNDGQQSFRKGSIVHIDTPK---TIADGAQTQHLGNYTFSI 249
Query: 727 LCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825
+ + + +I +V++ E+I+ +K +K V+E
Sbjct: 250 IKEKVD-DILTVSDEELIDCLKFYAARMKIVVE 281
>sp|O42615|THDH_ARXAD Threonine dehydratase, mitochondrial precursor (Threonine
deaminase)
Length = 550
Score = 122 bits (307), Expect = 1e-27
Identities = 82/276 (29%), Positives = 138/276 (50%), Gaps = 3/276 (1%)
Frame = +1
Query: 28 RISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNINGVV 207
++ + +ETPV + +++ + N+F K E LQ SFKLRGA N + ++ GV+
Sbjct: 48 KVYDVCNETPVTPAVNLSSKLGANIFLKREDLQPVFSFKLRGAYNMMAHLPQETRWKGVI 107
Query: 208 THSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTPQSREELCS 387
S+GNH Q AY+AK LNIPA IV+P TP IK + + GAK+V + + + C+
Sbjct: 108 ACSAGNHAQGVAYSAKHLNIPATIVMPVVTPAIKYKNVDRLGAKVVLHGNDFDAAKAECN 167
Query: 388 KMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQI--PNLDAVLISISXXXXXXXXXXXXK 561
++++++ GQGT+G+E L+QI +L A+ + I K
Sbjct: 168 RLSEKHGLTNIPLFDNPYVIAGQGTIGVELLRQIDVESLKAIFVCIGGGGLIAGVGAYIK 227
Query: 562 NLNPKIRVYCVEPF-GKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILCDL 738
+ P++++ VE + + +SL+ G R+ E + A+G V G+ TF LC
Sbjct: 228 RIAPQVKIIGVETYDANAMRQSLQKGERITLSE---VGLFADGAAVKILGEETFR-LCQQ 283
Query: 739 AERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGAAV 846
I V+ E+ +K + ++E A +V
Sbjct: 284 VVDEIVLVSTDEICAAIKDVFTETRSIVEPAGALSV 319
>sp|P11954|THD2_SALTY Threonine dehydratase catabolic (Threonine deaminase)
Length = 329
Score = 118 bits (296), Expect = 2e-26
Identities = 80/283 (28%), Positives = 136/283 (48%), Gaps = 3/283 (1%)
Frame = +1
Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180
+ I +A KR++ I++T + +SN + +F K E++Q+TGSFK+RGA N +
Sbjct: 11 IEDILEAKKRLAGKIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLT 70
Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360
E + GVV S+GNH Q + + +L I +V+PK P+ K A Y A++V D
Sbjct: 71 EAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDN 130
Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540
S++ + GQGT+G+E ++ + ++D V++ I
Sbjct: 131 FNDTIAKVSEIVETEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGGGGLIA 190
Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE---QKCLDTVAEGLKVHHPGQ 711
K++NP I+V G + E + + GE + T+A+G V PG
Sbjct: 191 GIAIAIKSINPTIKV-----IGVQAENVHGMAASYYTGEITTHRTTGTLADGCDVSRPGN 245
Query: 712 LTFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGA 840
LT+ I+ +L + +I V+ E I +++ +VI AGA
Sbjct: 246 LTYEIVRELVD-DIVLVSEDE-IRNSMIALIQRNKVITEGAGA 286
>sp|P05792|THD2_ECOLI Threonine dehydratase catabolic (Threonine deaminase)
Length = 329
Score = 115 bits (288), Expect = 2e-25
Identities = 78/283 (27%), Positives = 135/283 (47%), Gaps = 3/283 (1%)
Frame = +1
Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180
+ I +A +R++ I++T + +SN + +F K E++Q+TGSFK+RGA N +
Sbjct: 11 IDDIIEAKQRLAGRIYKTGMPRSNYFSERCKGEIFLKFENMQRTGSFKIRGAFNKLSSLT 70
Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360
+ + GVV S+GNH Q + + +L I +V+PK P+ K A Y A++V D
Sbjct: 71 DAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDN 130
Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540
S++ + GQGT+G+E ++ + ++D V++ I
Sbjct: 131 FNDTIAKVSEIVEMEGRIFIPPYDDPKVIAGQGTIGLEIMEDLYDVDNVIVPIGGGGLIA 190
Query: 541 XXXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGE---QKCLDTVAEGLKVHHPGQ 711
K++NP IRV G + E + GE + T+A+G V PG
Sbjct: 191 GIAVAIKSINPTIRV-----IGVQSENVHGMAASFHSGEITTHRTTGTLADGCDVSRPGN 245
Query: 712 LTFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGA 840
LT+ I+ +L + +I V+ E I +++ +V+ AGA
Sbjct: 246 LTYEIVRELVD-DIVLVSEDE-IRNSMIALIQRNKVVTEGAGA 286
>sp|P00927|THDH_YEAST Threonine dehydratase, mitochondrial precursor (Threonine
deaminase)
Length = 576
Score = 114 bits (285), Expect = 3e-25
Identities = 82/277 (29%), Positives = 134/277 (48%), Gaps = 5/277 (1%)
Frame = +1
Query: 31 ISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLEKQNINGVVT 210
+ + I+E+P+ Q +++ +N NV K E L SFKLRGA N I + Q GV+
Sbjct: 72 VYDVINESPISQGVGLSSRLNTNVILKREDLLPVFSFKLRGAYNMIAKLDDSQRNQGVIA 131
Query: 211 HSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIV-FSEDTPQSREELCS 387
S+GNH Q A+AAK L IPA IV+P TP IK + ++ G+++V + D +++ E C+
Sbjct: 132 CSAGNHAQGVAFAAKHLKIPATIVMPVCTPSIKYQNVSRLGSQVVLYGNDFDEAKAE-CA 190
Query: 388 KMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQI---PNLDAVLISISXXXXXXXXXXXX 558
K+A+E GQGT+ ME L+Q+ + AV + +
Sbjct: 191 KLAEERGLTNIPPFDHPYVIAGQGTVAMEILRQVRTANKIGAVFVPVGGGGLIAGIGAYL 250
Query: 559 KNLNPKIRVYCVEPF-GKELEESLRSGSRLWKGEQKCLDTVAEGLKVHHPGQLTFPILCD 735
K + P I++ VE + L SL+ R + T A+G V G+ TF +
Sbjct: 251 KRVAPHIKIIGVETYDAATLHNSLQRNQRT---PLPVVGTFADGTSVRMIGEETFRVAQQ 307
Query: 736 LAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGAAV 846
+ + + V E+ VK + + ++E + +V
Sbjct: 308 VVD-EVVLVNTDEICAAVKDIFEDTRSIVEPSGALSV 343
>sp|P46493|THD1_HAEIN Threonine dehydratase biosynthetic (Threonine deaminase)
Length = 513
Score = 106 bits (264), Expect = 9e-23
Identities = 76/277 (27%), Positives = 132/277 (47%), Gaps = 7/277 (2%)
Frame = +1
Query: 16 DAVKRISNFIHE----TPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKLE 183
+A+ ++ + ++E TP+ + ++ ++ N++ K E Q SFKLRGA I
Sbjct: 17 NAIVKLGSRVYEAAQVTPLQKMGKLSERLHNNIWIKREDRQPVNSFKLRGAYAMISSLSA 76
Query: 184 KQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDTP 363
+Q GV+ S+GNH Q A +AK L + A+IV+P++TP IK +A+ +G +++
Sbjct: 77 EQKAAGVIAASAGNHAQGVALSAKQLGLKALIVMPQNTPSIKVDAVRGFGGEVLLHGANF 136
Query: 364 QSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXXX 543
+ +++KE GQGTL ME L+Q+ +LD V + +
Sbjct: 137 DEAKAKAIELSKEKNMTFIPPFDHPLVIAGQGTLAMEMLQQVADLDYVFVQVGGGGLAAG 196
Query: 544 XXXXXKNLNPKIRVYCVEPFGKELEESLRSGSRLWKGEQKCLDTV---AEGLKVHHPGQL 714
K P+I++ G E ++S + L KGE L + A+G+ V G
Sbjct: 197 VAILLKQFMPEIKI-----IGVESKDSACLKAALDKGEPTDLTHIGLFADGVAVKRIGDE 251
Query: 715 TFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIE 825
TF LC ++ V + E+ +K + ++ V E
Sbjct: 252 TFR-LCQQYLDDMVLVDSDEVCAAMKDLFENVRAVAE 287
>sp|P55664|Y4TJ_RHISN Putative threonine dehydratase (Threonine deaminase)
Length = 332
Score = 105 bits (261), Expect = 2e-22
Identities = 76/284 (26%), Positives = 127/284 (44%), Gaps = 2/284 (0%)
Frame = +1
Query: 1 LSHIDDAVKRISNFIHETPVMQSNVINTLVNRNVFFKCEHLQKTGSFKLRGAANNILCKL 180
L I+ A +RI + TP+ S + L V K EH Q+TGSFKLRGA N IL
Sbjct: 9 LESIERARERIEEHVFRTPLTTSRSLTELTGTQVSLKLEHYQRTGSFKLRGATNAILQLS 68
Query: 181 EKQNINGVVTHSSGNHGQATAYAAKLLNIPAIIVVPKSTPQIKCEAITFYGAKIVFSEDT 360
GV+ S+GNHG+A +YAAK + A I + P+ K I GA + +
Sbjct: 69 PSDRARGVIAASTGNHGRALSYAAKAVGSRATICMSDLVPENKVSEIRKLGATVRIVGSS 128
Query: 361 PQSREELCSKMAKENXXXXXXXXXXXXXXNGQGTLGMEFLKQIPNLDAVLISISXXXXXX 540
+ ++ E GQ T+G+E ++ +P++ VL+ +S
Sbjct: 129 QDDAQVEVERLVAEEGLSMIPPFDHPHIIAGQRTVGLEIVEAMPDVAMVLLPLSGGGLAA 188
Query: 541 XXXXXXKNLNPKIRVYCVE-PFGKELEESLRSGSRLWKGEQKCL-DTVAEGLKVHHPGQL 714
K L P R+ V G ++ S+ +G + E + L D++ G+ +
Sbjct: 189 GVAAAVKALRPHARIIGVTMDRGAAMKASIEAGHPVQVKEYRSLADSLGGGIGM--ANAW 246
Query: 715 TFPILCDLAERNIFSVTNSEMIEGVKMSMKYLKQVIEHAAGAAV 846
TF +C ++ V E+ G++ + ++ +Q++E A +
Sbjct: 247 TFQ-MCRALLDDVVLVNEGEIAAGIRHAYEHERQILEGAGAVGI 289
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,329,345
Number of Sequences: 369166
Number of extensions: 1702063
Number of successful extensions: 4429
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4289
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4400
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)