Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00335 (1207 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosph... 153 1e-36 sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosph... 139 2e-32 sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosph... 107 5e-23 sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphod... 100 8e-21 sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphod... 99 2e-20 sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosph... 95 4e-19 sp|P06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosph... 91 5e-18 sp|Q924C3|ENPP1_RAT Ectonucleotide pyrophosphatase/phosphod... 90 1e-17 sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosph... 89 2e-17 sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphod... 85 4e-16
>sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (E-NPP5) (NPP-5) Length = 477 Score = 153 bits (386), Expect = 1e-36 Identities = 85/230 (36%), Positives = 135/230 (58%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E NLGLLY +PD +GH GP S + ++ +DK +GYL++ +K A+L + LN+++ S Sbjct: 178 EPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYLIQMLKKAKLWNTLNLIITS 237 Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKTNESEMIANLRKIPNVVVY 363 DHGMT+ S E+ + +D Y+D + Y +S + I PK + A PN+ VY Sbjct: 238 DHGMTQCSEERLIELDQYLDKDHYTLIDQS-PVAAILPKEGKFDEVYEALTHAHPNLTVY 296 Query: 364 EKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVAW 543 +K+++P W+Y N R+ PII +A+EGW ++ N+++ G+HGY DM IF+A Sbjct: 297 KKEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDFLL-GNHGYDNALADMHPIFLAH 355 Query: 544 GPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLINEEM 693 GP N S A+ D++PL+ +L + +P +NGS V+ L+N M Sbjct: 356 GPAF-RKNFSKEAMNSTDLYPLLCHLLNITAMP-HNGSFWNVQDLLNSAM 403
>sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (E-NPP5) (NPP-5) Length = 477 Score = 139 bits (350), Expect = 2e-32 Identities = 81/224 (36%), Positives = 128/224 (57%) Frame = +1 Query: 13 NLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVSDHG 192 NLG LY EPD GH GP S + ++ +D +GYL++ +K A+L + +N+++ SDHG Sbjct: 181 NLGFLYWEEPDDTGHDVGPDSPLMGSVISDVDHKLGYLIKMLKRAKLWNNVNLIVTSDHG 240 Query: 193 MTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKTNESEMIANLRKIPNVVVYEKQ 372 MT+ S ++ + +D Y+D E Y S + I PK + A PN+ VY+K+ Sbjct: 241 MTQCSKQRVIELDRYLDKEHYTLIDHS-PVAAILPKEGKFDEVYDALAGAHPNLTVYKKE 299 Query: 373 EIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVAWGPQ 552 EIP W+Y N RV PI+ +A+EGW ++ N+++ G+HGY +M IF+A GP Sbjct: 300 EIPERWHYKHNDRVQPIVAVADEGWYILQNKSDDFLL-GNHGYDNALAEMHPIFLAHGPA 358 Query: 553 IVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLIN 684 N + A+ D++ L+ +L L LP +NGS V+ L++ Sbjct: 359 F-RKNFTKEAMNSTDLYSLLCHLLNLTALP-HNGSFWNVQDLLS 400
>sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (ENPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase) Length = 458 Score = 107 bits (268), Expect = 5e-23 Identities = 75/238 (31%), Positives = 128/238 (53%), Gaps = 9/238 (3%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E +L LY EPD GH +GP+S EM+ ++D++VGYL E I L +LN+++ S Sbjct: 186 EDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITS 245 Query: 184 DHGMTEISNEKRVIMDNYVDPE-TYHHYQKSLTLWG----IWPKVKTNESEMIANLRKIP 348 DHGMT + +++ + P T+ + L +G + PK E A P Sbjct: 246 DHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHP 305 Query: 349 NVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRG 528 + VY+K+ P ++YA N RV P+++ ++ G+V+ N + NG HG+ K DM+ Sbjct: 306 KLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFN-NGEHGFDNKDMDMKT 364 Query: 529 IFVAWGPQIVASNRSGVAI---RVVDVFPLIGKILQLHRLP-SNNGSISKVRWLINEE 690 IF A GP S R+G+ + V V+ L+ ++L + +P +N+G ++ + +++ E Sbjct: 365 IFRAVGP----SFRAGLEVEPFESVHVYELMCRLLGI--VPEANDGHLATLLPMLHTE 416
>sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (ENPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase) Length = 439 Score = 100 bits (249), Expect = 8e-21 Identities = 59/191 (30%), Positives = 102/191 (53%), Gaps = 5/191 (2%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E +L LY EPD GH +GP+S +M+ ++D++VGYL + IK L LN+++ S Sbjct: 185 EDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITS 244 Query: 184 DHGMTEISNEKRVIMDNYVDPE-TYHHYQKSLTLWG----IWPKVKTNESEMIANLRKIP 348 DHGMT ++ + +++ + P T+ + L +G + PK E P Sbjct: 245 DHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHP 304 Query: 349 NVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRG 528 + VY+K++ P ++YA N R+ +++ ++ G+V+ N + +G HG+ + DM+ Sbjct: 305 RLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFN-SGEHGFDNQDMDMKT 363 Query: 529 IFVAWGPQIVA 561 IF A GP A Sbjct: 364 IFRAVGPSFKA 374
>sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (RB13-6 antigen) (B10) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 875 Score = 99.0 bits (245), Expect = 2e-20 Identities = 62/239 (25%), Positives = 117/239 (48%), Gaps = 13/239 (5%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E+ + +Y EPD GH GP S+ +++ L +D + G L+E +K L + +N+++++ Sbjct: 313 ERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLA 372 Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKT----------NESEMIAN 333 DHGM + S ++ M +Y ++ YQ G P+++T N E++ + Sbjct: 373 DHGMDQTSCDRVEYMTDYFPEINFYMYQ------GPAPRIRTRNIPQDFFTFNSEEIVRD 426 Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYS 504 L + + Y ++P +YAKN R+ + ++ + W+ N+ + G+HGY+ Sbjct: 427 LSCRKSDQHFKPYLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYN 486 Query: 505 MKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 681 + K M IF+A GP ++V+ L+ +L + P NNGS + L+ Sbjct: 487 NEFKSMEAIFLAHGPSF-KEKTVIEPFENIEVYNLLCDLLHIQPAP-NNGSHGSLNHLL 543
>sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 875 Score = 95.1 bits (235), Expect = 4e-19 Identities = 60/239 (25%), Positives = 115/239 (48%), Gaps = 13/239 (5%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E+ +Y EPD GH GP S+ +++ L +D + G L+E +K L + +N++L++ Sbjct: 312 ERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLA 371 Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKT----------NESEMIAN 333 DHGM + K M +Y + + + G P+++ N E++ N Sbjct: 372 DHGMDQTYCNKMEYMTDYFPRINFFYMYE-----GPAPRIRAHNIPHDFFSFNSEEIVRN 426 Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYS 504 L + + Y ++P +YAKN R+ + + ++ W+ V +++ T G+HGY+ Sbjct: 427 LSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYN 486 Query: 505 MKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 681 + + M IF+A GP ++V+ L+ +L++ P NNG+ + L+ Sbjct: 487 NEFRSMEAIFLAHGPSF-KEKTEVEPFENIEVYNLMCDLLRIQPAP-NNGTHGSLNHLL 543
>sp|P06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Ly-41) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 906 Score = 91.3 bits (225), Expect = 5e-18 Identities = 70/256 (27%), Positives = 119/256 (46%), Gaps = 21/256 (8%) Frame = +1 Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180 +E+ + LY EPD GH HGP SS +++ L K+D+ VG L++ +K L+ LN++L+ Sbjct: 344 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 403 Query: 181 SDHGMTEISNEKRVIMDNYVD--------------------PETYHHYQKSLTLWGIWPK 300 SDHGM + S +K V ++ Y+ PETY+ + + Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFN--------YEA 455 Query: 301 VKTNESEMIANLRKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENE-TI 477 + N S N P Y K +P ++AK+ R+ P+ + W L N +E Sbjct: 456 LAKNLSCREPNQHFRP----YLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKY 511 Query: 478 SANGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGS 657 +G HG +M+ +F+ +GP + ++V+ L+ +L L P NNGS Sbjct: 512 CGSGFHGSDNLFSNMQALFIGYGPAF-KHGAEVDSFENIEVYNLMCDLLGLIPAP-NNGS 569 Query: 658 ISKVRWLINEEMSDGS 705 + L+ + + + S Sbjct: 570 HGSLNHLLKKPIYNPS 585
>sp|Q924C3|ENPP1_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 906 Score = 90.1 bits (222), Expect = 1e-17 Identities = 68/243 (27%), Positives = 113/243 (46%), Gaps = 23/243 (9%) Frame = +1 Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183 E+ + LY EPD GH HGP SS +++ L K+D VG L++ +K L+ LN++L+S Sbjct: 345 ERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILIS 404 Query: 184 DHGMTEISNEKRVIMDNYVD--------------------PETYHHYQKSLTLWGIWPKV 303 DHGM + S +K V ++ Y+ PETY+ + + + Sbjct: 405 DHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFN--------YEAL 456 Query: 304 KTNESEMIANLRKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENE-TIS 480 N S N P Y K +P ++AKN R+ P+ + W L N +E Sbjct: 457 AKNLSCRETNQHFRP----YLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSERKYC 512 Query: 481 ANGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSN--NG 654 +G HG +M+ +F+ +GP + ++V+ L+ +L L P+N +G Sbjct: 513 GSGFHGSDNLFSNMQALFIGYGPAF-KHGAEVDSFENIEVYNLMCDLLGLIPAPNNESHG 571 Query: 655 SIS 663 S++ Sbjct: 572 SLN 574
>sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 862 Score = 89.4 bits (220), Expect = 2e-17 Identities = 66/244 (27%), Positives = 113/244 (46%), Gaps = 17/244 (6%) Frame = +1 Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180 NE+ ++ Y +PD GH +GP + L ++DK+VG L++ +K +L +NV+ V Sbjct: 297 NERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFV 356 Query: 181 SDHGMTEISNEKRVIMDNY---VDPETYHHYQKSLTLWGIWPKVKTN----ESEMIANL- 336 DHGM +++ ++ + NY VD T TL I PK+ N +IANL Sbjct: 357 GDHGMEDVTCDRTEFLSNYLTNVDDITL----VPGTLGRIRPKIPNNLKYDPKAIIANLT 412 Query: 337 --RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA-------NG 489 + + Y KQ +P +YA NRR+ + +L W + + G Sbjct: 413 CKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQG 472 Query: 490 SHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKV 669 HG+ K M+ +FV +GP + ++++ ++ +L L P NNG+ + Sbjct: 473 DHGFDNKVNSMQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHGSL 530 Query: 670 RWLI 681 L+ Sbjct: 531 NHLL 534
>sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] Length = 885 Score = 85.1 bits (209), Expect = 4e-16 Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 19/246 (7%) Frame = +1 Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180 NE+ ++ Y +PD GH +GP + L ++DK+VG L++ +K L +NV+ V Sbjct: 295 NERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFV 354 Query: 181 SDHGMTEISNEKRVIMDNYVD--------PETYHHYQ-KSLTLWGIWPKVKTNESEMIAN 333 DHGM +++ ++ + NY+ P T + KS+ K + +IAN Sbjct: 355 GDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSIN------NSKYDPKTIIAN 408 Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA------- 483 L + + Y KQ +P +YA NRR+ I +L + W + + Sbjct: 409 LTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFF 468 Query: 484 NGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSIS 663 G HG+ K M+ +FV +GP + ++++ ++ +L L P NNG+ Sbjct: 469 QGDHGFDNKVNSMQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHG 526 Query: 664 KVRWLI 681 + L+ Sbjct: 527 SLNHLL 532
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 137,558,550 Number of Sequences: 369166 Number of extensions: 2836839 Number of successful extensions: 7524 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 7127 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7499 length of database: 68,354,980 effective HSP length: 113 effective length of database: 47,479,925 effective search space used: 13674218400 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)