Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_L04
(889 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosph... 86 2e-16
sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosph... 80 8e-15
sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosph... 56 2e-07
sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosph... 53 1e-06
sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphod... 52 3e-06
sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphod... 49 2e-05
sp|P25353|YCR6_YEAST Hypothetical protein YCR026C 43 0.001
sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphod... 43 0.001
sp|Q13822|ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosph... 42 0.002
sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosph... 42 0.003
>sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor
(E-NPP5) (NPP-5)
Length = 477
Score = 85.5 bits (210), Expect = 2e-16
Identities = 44/116 (37%), Positives = 70/116 (60%)
Frame = +1
Query: 28 PNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMR 207
PN+ VY+K+++P W+Y N R+ PII +A+EGW ++ N+++ G+HGY DM
Sbjct: 291 PNLTVYKKEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDFLL-GNHGYDNALADMH 349
Query: 208 GIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLINEEM 375
IF+A GP N S A+ D++PL+ +L + +P +NGS V+ L+N M
Sbjct: 350 PIFLAHGPAF-RKNFSKEAMNSTDLYPLLCHLLNITAMP-HNGSFWNVQDLLNSAM 403
>sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor
(E-NPP5) (NPP-5)
Length = 477
Score = 80.1 bits (196), Expect = 8e-15
Identities = 43/113 (38%), Positives = 68/113 (60%)
Frame = +1
Query: 28 PNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMR 207
PN+ VY+K+EIP W+Y N RV PI+ +A+EGW ++ N+++ G+HGY +M
Sbjct: 291 PNLTVYKKEEIPERWHYKHNDRVQPIVAVADEGWYILQNKSDDFLL-GNHGYDNALAEMH 349
Query: 208 GIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLIN 366
IF+A GP N + A+ D++ L+ +L L LP +NGS V+ L++
Sbjct: 350 PIFLAHGPAF-RKNFTKEAMNSTDLYSLLCHLLNLTALP-HNGSFWNVQDLLS 400
>sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor
(ENPP-7) (Alkaline sphingomyelin phosphodiesterase)
(Intestinal alkaline sphingomyelinase) (Alk-SMase)
Length = 458
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/119 (31%), Positives = 69/119 (57%), Gaps = 4/119 (3%)
Frame = +1
Query: 28 PNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMR 207
P + VY+K+ P ++YA N RV P+++ ++ G+V+ N + NG HG+ K DM+
Sbjct: 305 PKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFN-NGEHGFDNKDMDMK 363
Query: 208 GIFVAWGPQIVASNRSGVAI---RVVDVFPLIGKILQLHRLP-SNNGSISKVRWLINEE 372
IF A GP S R+G+ + V V+ L+ ++L + +P +N+G ++ + +++ E
Sbjct: 364 TIFRAVGP----SFRAGLEVEPFESVHVYELMCRLLGI--VPEANDGHLATLLPMLHTE 416
>sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3)
(Phosphodiesterase I/nucleotide pyrophosphatase 3)
(Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen)
[Includes: Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 875
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/107 (26%), Positives = 55/107 (51%)
Frame = +1
Query: 43 YEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVA 222
Y ++P +YAKN R+ + + ++ W+ V +++ T G+HGY+ + + M IF+A
Sbjct: 439 YLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLA 498
Query: 223 WGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 363
GP ++V+ L+ +L++ P NNG+ + L+
Sbjct: 499 HGPSF-KEKTEVEPFENIEVYNLMCDLLRIQPAP-NNGTHGSLNHLL 543
>sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3)
(Phosphodiesterase I/nucleotide pyrophosphatase 3)
(Phosphodiesterase I beta) (PD-Ibeta) (RB13-6 antigen)
(B10) [Includes: Alkaline phosphodiesterase I ;
Nucleotide pyrophosphatase (NPPase)]
Length = 875
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/107 (27%), Positives = 52/107 (48%)
Frame = +1
Query: 43 YEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVA 222
Y ++P +YAKN R+ + ++ + W+ N+ + G+HGY+ + K M IF+A
Sbjct: 439 YLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEAIFLA 498
Query: 223 WGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 363
GP ++V+ L+ +L + P NNGS + L+
Sbjct: 499 HGPSF-KEKTVIEPFENIEVYNLLCDLLHIQPAP-NNGSHGSLNHLL 543
>sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor
(ENPP-7) (Alkaline sphingomyelin phosphodiesterase)
(Intestinal alkaline sphingomyelinase) (Alk-SMase)
Length = 439
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/72 (31%), Positives = 42/72 (58%)
Frame = +1
Query: 28 PNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMR 207
P + VY+K++ P ++YA N R+ +++ ++ G+V+ N + +G HG+ + DM+
Sbjct: 304 PRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFN-SGEHGFDNQDMDMK 362
Query: 208 GIFVAWGPQIVA 243
IF A GP A
Sbjct: 363 TIFRAVGPSFKA 374
>sp|P25353|YCR6_YEAST Hypothetical protein YCR026C
Length = 742
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 16/80 (20%)
Frame = +1
Query: 40 VYEKQEIPTEWNY--AKNRRVAPIIVLANEGWVLVNNEN--------------ETISANG 171
VY P EWN+ KN +A I ++ G+ ++ E + + G
Sbjct: 481 VYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIG 540
Query: 172 SHGYSMKSKDMRGIFVAWGP 231
SHGY + DMR +F+ GP
Sbjct: 541 SHGYDNNAIDMRSVFIGMGP 560
>sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2)
(Phosphodiesterase I/nucleotide pyrophosphatase 2)
(Phosphodiesterase I alpha) (PD-Ialpha) [Includes:
Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 885
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 7/114 (6%)
Frame = +1
Query: 43 YEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA-------NGSHGYSMKSKD 201
Y KQ +P +YA NRR+ I +L + W + + G HG+ K
Sbjct: 421 YMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNS 480
Query: 202 MRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 363
M+ +FV +GP + ++++ ++ +L L P NNG+ + L+
Sbjct: 481 MQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHGSLNHLL 532
>sp|Q13822|ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2)
(Phosphodiesterase I/nucleotide pyrophosphatase 2)
(Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin)
[Includes: Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 863
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Frame = +1
Query: 43 YEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA-------NGSHGYSMKSKD 201
Y KQ +P +YA NRR+ I +L W + + G HG+ K
Sbjct: 424 YLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNS 483
Query: 202 MRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 363
M+ +FV +GP + ++++ ++ +L L P NNG+ + L+
Sbjct: 484 MQTVFVGYGPTFKYKTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHGSLNHLL 535
>sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2)
(Phosphodiesterase I/nucleotide pyrophosphatase 2)
(Phosphodiesterase I alpha) (PD-Ialpha) [Includes:
Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 862
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Frame = +1
Query: 43 YEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA-------NGSHGYSMKSKD 201
Y KQ +P +YA NRR+ + +L W + + G HG+ K
Sbjct: 423 YMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNS 482
Query: 202 MRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 363
M+ +FV +GP + ++++ ++ +L L P NNG+ + L+
Sbjct: 483 MQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHGSLNHLL 534
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,937,407
Number of Sequences: 369166
Number of extensions: 1910247
Number of successful extensions: 4940
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4753
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4928
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)