Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_O16
(809 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosph... 153 6e-37
sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosph... 139 9e-33
sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosph... 107 3e-23
sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphod... 100 5e-21
sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphod... 99 1e-20
sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosph... 95 2e-19
sp|P06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosph... 91 3e-18
sp|Q924C3|ENPP1_RAT Ectonucleotide pyrophosphatase/phosphod... 90 6e-18
sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosph... 89 1e-17
sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphod... 85 2e-16
>sp|Q9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor
(E-NPP5) (NPP-5)
Length = 477
Score = 153 bits (386), Expect = 6e-37
Identities = 85/230 (36%), Positives = 135/230 (58%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E NLGLLY +PD +GH GP S + ++ +DK +GYL++ +K A+L + LN+++ S
Sbjct: 178 EPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYLIQMLKKAKLWNTLNLIITS 237
Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKTNESEMIANLRKIPNVVVY 363
DHGMT+ S E+ + +D Y+D + Y +S + I PK + A PN+ VY
Sbjct: 238 DHGMTQCSEERLIELDQYLDKDHYTLIDQS-PVAAILPKEGKFDEVYEALTHAHPNLTVY 296
Query: 364 EKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVAW 543
+K+++P W+Y N R+ PII +A+EGW ++ N+++ G+HGY DM IF+A
Sbjct: 297 KKEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDFLL-GNHGYDNALADMHPIFLAH 355
Query: 544 GPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLINEEM 693
GP N S A+ D++PL+ +L + +P +NGS V+ L+N M
Sbjct: 356 GPAF-RKNFSKEAMNSTDLYPLLCHLLNITAMP-HNGSFWNVQDLLNSAM 403
>sp|Q9EQG7|ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor
(E-NPP5) (NPP-5)
Length = 477
Score = 139 bits (350), Expect = 9e-33
Identities = 81/224 (36%), Positives = 128/224 (57%)
Frame = +1
Query: 13 NLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVSDHG 192
NLG LY EPD GH GP S + ++ +D +GYL++ +K A+L + +N+++ SDHG
Sbjct: 181 NLGFLYWEEPDDTGHDVGPDSPLMGSVISDVDHKLGYLIKMLKRAKLWNNVNLIVTSDHG 240
Query: 193 MTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKTNESEMIANLRKIPNVVVYEKQ 372
MT+ S ++ + +D Y+D E Y S + I PK + A PN+ VY+K+
Sbjct: 241 MTQCSKQRVIELDRYLDKEHYTLIDHS-PVAAILPKEGKFDEVYDALAGAHPNLTVYKKE 299
Query: 373 EIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRGIFVAWGPQ 552
EIP W+Y N RV PI+ +A+EGW ++ N+++ G+HGY +M IF+A GP
Sbjct: 300 EIPERWHYKHNDRVQPIVAVADEGWYILQNKSDDFLL-GNHGYDNALAEMHPIFLAHGPA 358
Query: 553 IVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLIN 684
N + A+ D++ L+ +L L LP +NGS V+ L++
Sbjct: 359 F-RKNFTKEAMNSTDLYSLLCHLLNLTALP-HNGSFWNVQDLLS 400
>sp|Q6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor
(ENPP-7) (Alkaline sphingomyelin phosphodiesterase)
(Intestinal alkaline sphingomyelinase) (Alk-SMase)
Length = 458
Score = 107 bits (268), Expect = 3e-23
Identities = 75/238 (31%), Positives = 128/238 (53%), Gaps = 9/238 (3%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E +L LY EPD GH +GP+S EM+ ++D++VGYL E I L +LN+++ S
Sbjct: 186 EDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITS 245
Query: 184 DHGMTEISNEKRVIMDNYVDPE-TYHHYQKSLTLWG----IWPKVKTNESEMIANLRKIP 348
DHGMT + +++ + P T+ + L +G + PK E A P
Sbjct: 246 DHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHP 305
Query: 349 NVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRG 528
+ VY+K+ P ++YA N RV P+++ ++ G+V+ N + NG HG+ K DM+
Sbjct: 306 KLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFN-NGEHGFDNKDMDMKT 364
Query: 529 IFVAWGPQIVASNRSGVAI---RVVDVFPLIGKILQLHRLP-SNNGSISKVRWLINEE 690
IF A GP S R+G+ + V V+ L+ ++L + +P +N+G ++ + +++ E
Sbjct: 365 IFRAVGP----SFRAGLEVEPFESVHVYELMCRLLGI--VPEANDGHLATLLPMLHTE 416
>sp|Q5EZ72|ENPP7_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor
(ENPP-7) (Alkaline sphingomyelin phosphodiesterase)
(Intestinal alkaline sphingomyelinase) (Alk-SMase)
Length = 439
Score = 100 bits (249), Expect = 5e-21
Identities = 59/191 (30%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E +L LY EPD GH +GP+S +M+ ++D++VGYL + IK L LN+++ S
Sbjct: 185 EDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITS 244
Query: 184 DHGMTEISNEKRVIMDNYVDPE-TYHHYQKSLTLWG----IWPKVKTNESEMIANLRKIP 348
DHGMT ++ + +++ + P T+ + L +G + PK E P
Sbjct: 245 DHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHP 304
Query: 349 NVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYSMKSKDMRG 528
+ VY+K++ P ++YA N R+ +++ ++ G+V+ N + +G HG+ + DM+
Sbjct: 305 RLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFN-SGEHGFDNQDMDMKT 363
Query: 529 IFVAWGPQIVA 561
IF A GP A
Sbjct: 364 IFRAVGPSFKA 374
>sp|P97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3)
(Phosphodiesterase I/nucleotide pyrophosphatase 3)
(Phosphodiesterase I beta) (PD-Ibeta) (RB13-6 antigen)
(B10) [Includes: Alkaline phosphodiesterase I ;
Nucleotide pyrophosphatase (NPPase)]
Length = 875
Score = 99.0 bits (245), Expect = 1e-20
Identities = 62/239 (25%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E+ + +Y EPD GH GP S+ +++ L +D + G L+E +K L + +N+++++
Sbjct: 313 ERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLA 372
Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKT----------NESEMIAN 333
DHGM + S ++ M +Y ++ YQ G P+++T N E++ +
Sbjct: 373 DHGMDQTSCDRVEYMTDYFPEINFYMYQ------GPAPRIRTRNIPQDFFTFNSEEIVRD 426
Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYS 504
L + + Y ++P +YAKN R+ + ++ + W+ N+ + G+HGY+
Sbjct: 427 LSCRKSDQHFKPYLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYN 486
Query: 505 MKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 681
+ K M IF+A GP ++V+ L+ +L + P NNGS + L+
Sbjct: 487 NEFKSMEAIFLAHGPSF-KEKTVIEPFENIEVYNLLCDLLHIQPAP-NNGSHGSLNHLL 543
>sp|O14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3)
(Phosphodiesterase I/nucleotide pyrophosphatase 3)
(Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen)
[Includes: Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 875
Score = 95.1 bits (235), Expect = 2e-19
Identities = 60/239 (25%), Positives = 115/239 (48%), Gaps = 13/239 (5%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E+ +Y EPD GH GP S+ +++ L +D + G L+E +K L + +N++L++
Sbjct: 312 ERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLA 371
Query: 184 DHGMTEISNEKRVIMDNYVDPETYHHYQKSLTLWGIWPKVKT----------NESEMIAN 333
DHGM + K M +Y + + + G P+++ N E++ N
Sbjct: 372 DHGMDQTYCNKMEYMTDYFPRINFFYMYE-----GPAPRIRAHNIPHDFFSFNSEEIVRN 426
Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISANGSHGYS 504
L + + Y ++P +YAKN R+ + + ++ W+ V +++ T G+HGY+
Sbjct: 427 LSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYN 486
Query: 505 MKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKVRWLI 681
+ + M IF+A GP ++V+ L+ +L++ P NNG+ + L+
Sbjct: 487 NEFRSMEAIFLAHGPSF-KEKTEVEPFENIEVYNLMCDLLRIQPAP-NNGTHGSLNHLL 543
>sp|P06802|ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1)
(Phosphodiesterase I/nucleotide pyrophosphatase 1)
(Plasma-cell membrane glycoprotein PC-1) (Ly-41)
[Includes: Alkaline phosphodiesterase I ; Nucleotide
pyrophosphatase (NPPase)]
Length = 906
Score = 91.3 bits (225), Expect = 3e-18
Identities = 70/256 (27%), Positives = 119/256 (46%), Gaps = 21/256 (8%)
Frame = +1
Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180
+E+ + LY EPD GH HGP SS +++ L K+D+ VG L++ +K L+ LN++L+
Sbjct: 344 HERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILI 403
Query: 181 SDHGMTEISNEKRVIMDNYVD--------------------PETYHHYQKSLTLWGIWPK 300
SDHGM + S +K V ++ Y+ PETY+ + +
Sbjct: 404 SDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYYSFN--------YEA 455
Query: 301 VKTNESEMIANLRKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENE-TI 477
+ N S N P Y K +P ++AK+ R+ P+ + W L N +E
Sbjct: 456 LAKNLSCREPNQHFRP----YLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKY 511
Query: 478 SANGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGS 657
+G HG +M+ +F+ +GP + ++V+ L+ +L L P NNGS
Sbjct: 512 CGSGFHGSDNLFSNMQALFIGYGPAF-KHGAEVDSFENIEVYNLMCDLLGLIPAP-NNGS 569
Query: 658 ISKVRWLINEEMSDGS 705
+ L+ + + + S
Sbjct: 570 HGSLNHLLKKPIYNPS 585
>sp|Q924C3|ENPP1_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1)
(Phosphodiesterase I/nucleotide pyrophosphatase 1)
(Plasma-cell membrane glycoprotein PC-1) [Includes:
Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase
(NPPase)]
Length = 906
Score = 90.1 bits (222), Expect = 6e-18
Identities = 68/243 (27%), Positives = 113/243 (46%), Gaps = 23/243 (9%)
Frame = +1
Query: 4 EKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLVS 183
E+ + LY EPD GH HGP SS +++ L K+D VG L++ +K L+ LN++L+S
Sbjct: 345 ERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILIS 404
Query: 184 DHGMTEISNEKRVIMDNYVD--------------------PETYHHYQKSLTLWGIWPKV 303
DHGM + S +K V ++ Y+ PETY+ + + +
Sbjct: 405 DHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFN--------YEAL 456
Query: 304 KTNESEMIANLRKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENE-TIS 480
N S N P Y K +P ++AKN R+ P+ + W L N +E
Sbjct: 457 AKNLSCRETNQHFRP----YLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSERKYC 512
Query: 481 ANGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSN--NG 654
+G HG +M+ +F+ +GP + ++V+ L+ +L L P+N +G
Sbjct: 513 GSGFHGSDNLFSNMQALFIGYGPAF-KHGAEVDSFENIEVYNLMCDLLGLIPAPNNESHG 571
Query: 655 SIS 663
S++
Sbjct: 572 SLN 574
>sp|Q9R1E6|ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2)
(Phosphodiesterase I/nucleotide pyrophosphatase 2)
(Phosphodiesterase I alpha) (PD-Ialpha) [Includes:
Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase
(NPPase)]
Length = 862
Score = 89.4 bits (220), Expect = 1e-17
Identities = 66/244 (27%), Positives = 113/244 (46%), Gaps = 17/244 (6%)
Frame = +1
Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180
NE+ ++ Y +PD GH +GP + L ++DK+VG L++ +K +L +NV+ V
Sbjct: 297 NERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFV 356
Query: 181 SDHGMTEISNEKRVIMDNY---VDPETYHHYQKSLTLWGIWPKVKTN----ESEMIANL- 336
DHGM +++ ++ + NY VD T TL I PK+ N +IANL
Sbjct: 357 GDHGMEDVTCDRTEFLSNYLTNVDDITL----VPGTLGRIRPKIPNNLKYDPKAIIANLT 412
Query: 337 --RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA-------NG 489
+ + Y KQ +P +YA NRR+ + +L W + + G
Sbjct: 413 CKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQG 472
Query: 490 SHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSISKV 669
HG+ K M+ +FV +GP + ++++ ++ +L L P NNG+ +
Sbjct: 473 DHGFDNKVNSMQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHGSL 530
Query: 670 RWLI 681
L+
Sbjct: 531 NHLL 534
>sp|Q64610|ENPP2_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2)
(Phosphodiesterase I/nucleotide pyrophosphatase 2)
(Phosphodiesterase I alpha) (PD-Ialpha) [Includes:
Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase
(NPPase)]
Length = 885
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/246 (25%), Positives = 112/246 (45%), Gaps = 19/246 (7%)
Frame = +1
Query: 1 NEKTNLGLLYHPEPDGIGHLHGPKSSNILEMLLKLDKSVGYLLEKIKLAELESKLNVLLV 180
NE+ ++ Y +PD GH +GP + L ++DK+VG L++ +K L +NV+ V
Sbjct: 295 NERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFV 354
Query: 181 SDHGMTEISNEKRVIMDNYVD--------PETYHHYQ-KSLTLWGIWPKVKTNESEMIAN 333
DHGM +++ ++ + NY+ P T + KS+ K + +IAN
Sbjct: 355 GDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSIN------NSKYDPKTIIAN 408
Query: 334 L---RKIPNVVVYEKQEIPTEWNYAKNRRVAPIIVLANEGWVLVNNENETISA------- 483
L + + Y KQ +P +YA NRR+ I +L + W + +
Sbjct: 409 LTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFF 468
Query: 484 NGSHGYSMKSKDMRGIFVAWGPQIVASNRSGVAIRVVDVFPLIGKILQLHRLPSNNGSIS 663
G HG+ K M+ +FV +GP + ++++ ++ +L L P NNG+
Sbjct: 469 QGDHGFDNKVNSMQTVFVGYGPTFKYRTKV-PPFENIELYNVMCDLLGLKPAP-NNGTHG 526
Query: 664 KVRWLI 681
+ L+
Sbjct: 527 SLNHLL 532
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,158,550
Number of Sequences: 369166
Number of extensions: 2041675
Number of successful extensions: 5577
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5369
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5553
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)