DrC_00277
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00277 (753 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrog... 270 2e-72 sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogen... 266 4e-71 sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrog... 262 8e-70 sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogen... 262 8e-70 sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 233 4e-61 sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 229 8e-60 sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydroge... 182 6e-46 sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Bet... 182 8e-46 sp|P77851|HBD_CLOTS 3-hydroxybutyryl-CoA dehydrogenase (Bet... 182 1e-45 sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Bet... 180 4e-45
>sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase) Length = 314 Score = 270 bits (691), Expect = 2e-72 Identities = 134/214 (62%), Positives = 162/214 (75%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 I TSTD+ ++D N+ +KN+LFK LD A + IFASNTSSL I+ IANA Sbjct: 100 IATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANA 159 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 T RQDRF GLHFFNPVPVM LVEVI T TS +T E+L+ F+K++GK PV C+DTPGFIV Sbjct: 160 TTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIV 219 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFI+ GWHE Sbjct: 220 NRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHE 279 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 +N L P P L+KLV+EN+FG K+G GFY+Y Sbjct: 280 MDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKY 313
>sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase) Length = 314 Score = 266 bits (680), Expect = 4e-71 Identities = 129/214 (60%), Positives = 161/214 (75%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 I TSTD+ ++D N+ +K++LFK LD A + IFASNTSSL I+ +ANA Sbjct: 100 ISTSTDAASVVHSTDLVVEAIVENLKVKSELFKRLDKFAAEHTIFASNTSSLQITSLANA 159 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 T RQDRF GLHFFNPVP+M LVEV+ T TS +T E+L+ F+K++GK PV C+DTPGFIV Sbjct: 160 TTRQDRFAGLHFFNPVPLMKLVEVVKTPMTSQKTLESLVDFSKTLGKHPVSCKDTPGFIV 219 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFI+ GWHE Sbjct: 220 NRLLVPYLIEAVRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIIDGWHE 279 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 N L P P ++KLV+EN+FG K+G GFY+Y Sbjct: 280 MDSQNPLFQPSPAMNKLVAENKFGKKTGEGFYKY 313
>sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase) Length = 314 Score = 262 bits (669), Expect = 8e-70 Identities = 128/214 (59%), Positives = 159/214 (74%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 + TSTD+ ++D N+ +KN+LF+ LD A + IFASNTSSL I+ IANA Sbjct: 100 LSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANA 159 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 T RQDRF GLHFFNPVP+M LVEVI T TS +T E+L+ F K++GK PV C+DTPGFIV Sbjct: 160 TTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIV 219 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFIL GWHE Sbjct: 220 NRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHE 279 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 P+N L P P ++ LV++ + G K+G GFY+Y Sbjct: 280 MEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKY 313
>sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase) Length = 314 Score = 262 bits (669), Expect = 8e-70 Identities = 128/214 (59%), Positives = 159/214 (74%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 + TSTD+ ++D N+ +KN+LF+ LD A + IFASNTSSL I+ IANA Sbjct: 100 LSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANA 159 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 T RQDRF GLHFFNPVP+M LVEVI T TS +T E+L+ F K++GK PV C+DTPGFIV Sbjct: 160 TTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIV 219 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFIL GWHE Sbjct: 220 NRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHE 279 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 P+N L P P ++ LV++ + G K+G GFY+Y Sbjct: 280 MDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKY 313
>sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3 Length = 309 Score = 233 bits (594), Expect = 4e-61 Identities = 112/214 (52%), Positives = 148/214 (69%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 IK ST+ ++ K +D N+ IK KLF ++ A P + +NTSSL +++I Sbjct: 95 IKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLN 154 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 K + RFGGLHFFNPVP+M L+EV+ +TS T L+ + K+VGKT V C+DTPGFIV Sbjct: 155 LKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIV 214 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLLVPY+ EA+R+ ERG+A+ EDID AM+LGA +PMGPF L+DYVGLDT KFI+ GWH Sbjct: 215 NRLLVPYMFEALRLYERGDASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHA 274 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 ++P+ P PLL+ LV + G KSG GFY+Y Sbjct: 275 QYPEEVAFTPSPLLNSLVDSGKNGRKSGEGFYKY 308
>sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 Length = 298 Score = 229 bits (583), Expect = 8e-60 Identities = 110/214 (51%), Positives = 145/214 (67%) Frame = +3 Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191 IKT + A +D N+ +K +F ++ + I +NTSS + ++A Sbjct: 83 IKTCNNVSTAVADADLIIEAAIENIDLKRGIFAQIEQSCKKDSILTTNTSSFLLEDVAKG 142 Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371 + + RFGGLHFFNPVPVM L+EVI +D TS ET TL+ F +VGKT V C+D+PGFIV Sbjct: 143 LQDKTRFGGLHFFNPVPVMKLLEVIRSDDTSDETYATLIKFGTAVGKTTVACKDSPGFIV 202 Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551 NRLL+PY EA RM ERG+A+ DID AM+LGA HPMGPF LADY+GLDTVKF++ GW Sbjct: 203 NRLLIPYFFEAARMYERGDASMTDIDEAMKLGAGHPMGPFELADYIGLDTVKFVMDGWAA 262 Query: 552 KFPDNRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 K+P+ +L + PL+DKLV+E + G K+G GFY Y Sbjct: 263 KYPEVQLFEASPLVDKLVAEGKLGRKTGDGFYSY 296
>sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) Length = 287 Score = 182 bits (463), Expect = 6e-46 Identities = 98/213 (46%), Positives = 131/213 (61%) Frame = +3 Query: 24 TDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATKRQ 203 + ++E A+ +D N+ K ++FK+LD + PP+ I ASNTSSL I+EIA T R Sbjct: 74 SQTLEEAEHADIVIEAIAENMAAKTEMFKTLDRICPPHTILASNTSSLPITEIAAVTNRP 133 Query: 204 DRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLL 383 R G+HF NPVPVM LVEVI TS ET+ ++ A+ +GKT V+ D PGF+ NR+L Sbjct: 134 QRVIGMHFMNPVPVMKLVEVIRGLATSEETALDVMALAEKMGKTAVEVNDFPGFVSNRVL 193 Query: 384 VPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPD 563 +P + EA+ + G A E ID M+LG +HPMGP LAD++GLDT I+ H D Sbjct: 194 LPMINEAIYCVYEGVAKPEAIDEVMKLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGD 253 Query: 564 NRLCDPIPLLDKLVSENRFGVKSGRGFYEYSGK 662 ++ P PLL K V G KSGRGFY+Y K Sbjct: 254 SKY-RPCPLLRKYVKAGWLGKKSGRGFYDYEEK 285
>sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) Length = 281 Score = 182 bits (462), Expect = 8e-46 Identities = 97/213 (45%), Positives = 138/213 (64%) Frame = +3 Query: 18 TSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATK 197 +ST + E K D ++ IK +FK LD + + I A+NTSSLSI+EIA++TK Sbjct: 69 SSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTK 128 Query: 198 RQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNR 377 R D+ G+HFFNPVP+M LVEVIS TS T +T+ +KS+ K PV ++PGF+VNR Sbjct: 129 RPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSESPGFVVNR 188 Query: 378 LLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKF 557 +L+P + EA+ + G A+ E+ID AM+LGA+HPMGP L D +GLD V I++ + +F Sbjct: 189 ILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAIMNVLYTEF 248 Query: 558 PDNRLCDPIPLLDKLVSENRFGVKSGRGFYEYS 656 D + PLL K+V N+ G K+ GFY+Y+ Sbjct: 249 GDTKY-TAHPLLAKMVRANQLGRKTKIGFYDYN 280
>sp|P77851|HBD_CLOTS 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) Length = 289 Score = 182 bits (461), Expect = 1e-45 Identities = 96/210 (45%), Positives = 138/210 (65%) Frame = +3 Query: 24 TDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATKRQ 203 T ++E AK +D N+ +K ++FK LD + I ASNTSSLSI+EIA+ATKR Sbjct: 71 TTNLEDAKEADFVVEAAIENMDLKKQIFKELDEICKMETILASNTSSLSITEIASATKRP 130 Query: 204 DRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLL 383 ++ G+HFFNPVPVM LVEVI KTS +T + A V KTP++ ++ PGF+VNR+L Sbjct: 131 EKVIGMHFFNPVPVMKLVEVIKGLKTSEQTFNVVRELALKVDKTPIEVKEAPGFVVNRIL 190 Query: 384 VPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPD 563 +P + EA+ +L AT + ID AM+LGA+HP+GP L+ +G D V I++ +E++ D Sbjct: 191 IPMINEAIGILAVVLATDKSIDEAMKLGANHPIGPLALSSLIGNDVVLAIMNVLYEEYGD 250 Query: 564 NRLCDPIPLLDKLVSENRFGVKSGRGFYEY 653 ++ P PLL K+V G K+G+GF+EY Sbjct: 251 SKY-RPHPLLKKVVRGGLLGRKTGKGFFEY 279
>sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) Length = 282 Score = 180 bits (456), Expect = 4e-45 Identities = 96/213 (45%), Positives = 132/213 (61%) Frame = +3 Query: 18 TSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATK 197 + T + A D + IK ++F LD + P I ASNTSSLSI+E+A+ATK Sbjct: 70 SGTVDLNMAADCDLVIEAAVERMDIKKQIFADLDNICKPETILASNTSSLSITEVASATK 129 Query: 198 RQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNR 377 R D+ G+HFFNP PVM LVEVI TS ET + + + ++GK PV+ + PGF+VNR Sbjct: 130 RPDKVIGMHFFNPAPVMKLVEVIRGIATSQETFDAVKETSIAIGKDPVEVAEAPGFVVNR 189 Query: 378 LLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKF 557 +L+P + EA+ +L G A+ EDID AM+LGA+HPMGP L D++GLD I+ + + Sbjct: 190 ILIPMINEAVGILAEGIASVEDIDKAMKLGANHPMGPLELGDFIGLDICLAIMDVLYSET 249 Query: 558 PDNRLCDPIPLLDKLVSENRFGVKSGRGFYEYS 656 D++ P LL K V G KSG+GFY+YS Sbjct: 250 GDSKY-RPHTLLKKYVRAGWLGRKSGKGFYDYS 281
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,156,683
Number of Sequences: 369166
Number of extensions: 1867980
Number of successful extensions: 4568
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4408
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4536
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
