Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_K07
(753 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrog... 271 1e-72
sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogen... 269 5e-72
sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrog... 265 1e-70
sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogen... 265 1e-70
sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 236 5e-62
sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 232 9e-61
sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Bet... 184 3e-46
sp|P77851|HBD_CLOTS 3-hydroxybutyryl-CoA dehydrogenase (Bet... 183 4e-46
sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydroge... 183 5e-46
sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Bet... 181 1e-45
>sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 271 bits (693), Expect = 1e-72
Identities = 134/214 (62%), Positives = 162/214 (75%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
I TSTD+ ++D N+ +KN+LFK LD A + IFASNTSSL I+ IANA
Sbjct: 100 IATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANA 159
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
T RQDRF GLHFFNPVPVM LVEVI T TS +T E+L+ F+K++GK PV C+DTPGFIV
Sbjct: 160 TTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIV 219
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFI+ GWHE
Sbjct: 220 NRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHE 279
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
+N L P P L+KLV+EN+FG K+G GFY+Y
Sbjct: 280 MDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKY 313
>sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 269 bits (688), Expect = 5e-72
Identities = 130/214 (60%), Positives = 162/214 (75%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
I TSTD+ ++D N+ +K++LFK LD A + IFASNTSSL I+ +ANA
Sbjct: 100 ISTSTDAASVVHSTDLVVEAIVENLKVKSELFKRLDKFAAEHTIFASNTSSLQITSLANA 159
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
T RQDRF GLHFFNPVP+M LVEV+ T TS +T E+L+ F+K++GK PV C+DTPGFIV
Sbjct: 160 TTRQDRFAGLHFFNPVPLMKLVEVVKTPMTSQKTLESLVDFSKTLGKHPVSCKDTPGFIV 219
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFI+ GWHE
Sbjct: 220 NRLLVPYLIEAVRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIIDGWHE 279
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
N LF P P ++KLV+EN+FG K+G GFY+Y
Sbjct: 280 MDSQNPLFQPSPAMNKLVAENKFGKKTGEGFYKY 313
>sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 265 bits (677), Expect = 1e-70
Identities = 129/214 (60%), Positives = 160/214 (74%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
+ TSTD+ ++D N+ +KN+LF+ LD A + IFASNTSSL I+ IANA
Sbjct: 100 LSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANA 159
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
T RQDRF GLHFFNPVP+M LVEVI T TS +T E+L+ F K++GK PV C+DTPGFIV
Sbjct: 160 TTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIV 219
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFIL GWHE
Sbjct: 220 NRLLVPYLIEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHE 279
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
P+N LF P P ++ LV++ + G K+G GFY+Y
Sbjct: 280 MEPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKY 313
>sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 265 bits (677), Expect = 1e-70
Identities = 129/214 (60%), Positives = 160/214 (74%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
+ TSTD+ ++D N+ +KN+LF+ LD A + IFASNTSSL I+ IANA
Sbjct: 100 LSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANA 159
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
T RQDRF GLHFFNPVP+M LVEVI T TS +T E+L+ F K++GK PV C+DTPGFIV
Sbjct: 160 TTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIV 219
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLLVPYL EA+R+ ERG+A+ EDIDTAM+LGA +PMGPF L DYVGLDT KFIL GWHE
Sbjct: 220 NRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHE 279
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
P+N LF P P ++ LV++ + G K+G GFY+Y
Sbjct: 280 MDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKY 313
>sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
Length = 309
Score = 236 bits (602), Expect = 5e-62
Identities = 113/214 (52%), Positives = 149/214 (69%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
IK ST+ ++ K +D N+ IK KLF ++ A P + +NTSSL +++I
Sbjct: 95 IKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLN 154
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
K + RFGGLHFFNPVP+M L+EV+ +TS T L+ + K+VGKT V C+DTPGFIV
Sbjct: 155 LKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIV 214
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLLVPY+ EA+R+ ERG+A+ EDID AM+LGA +PMGPF L+DYVGLDT KFI+ GWH
Sbjct: 215 NRLLVPYMFEALRLYERGDASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHA 274
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
++P+ F P PLL+ LV + G KSG GFY+Y
Sbjct: 275 QYPEEVAFTPSPLLNSLVDSGKNGRKSGEGFYKY 308
>sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
Length = 298
Score = 232 bits (591), Expect = 9e-61
Identities = 111/214 (51%), Positives = 146/214 (68%)
Frame = +3
Query: 12 IKTSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANA 191
IKT + A +D N+ +K +F ++ + I +NTSS + ++A
Sbjct: 83 IKTCNNVSTAVADADLIIEAAIENIDLKRGIFAQIEQSCKKDSILTTNTSSFLLEDVAKG 142
Query: 192 TKRQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIV 371
+ + RFGGLHFFNPVPVM L+EVI +D TS ET TL+ F +VGKT V C+D+PGFIV
Sbjct: 143 LQDKTRFGGLHFFNPVPVMKLLEVIRSDDTSDETYATLIKFGTAVGKTTVACKDSPGFIV 202
Query: 372 NRLLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHE 551
NRLL+PY EA RM ERG+A+ DID AM+LGA HPMGPF LADY+GLDTVKF++ GW
Sbjct: 203 NRLLIPYFFEAARMYERGDASMTDIDEAMKLGAGHPMGPFELADYIGLDTVKFVMDGWAA 262
Query: 552 KFPDNRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
K+P+ +LF+ PL+DKLV+E + G K+G GFY Y
Sbjct: 263 KYPEVQLFEASPLVDKLVAEGKLGRKTGDGFYSY 296
>sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA
dehydrogenase) (BHBD)
Length = 281
Score = 184 bits (466), Expect = 3e-46
Identities = 97/213 (45%), Positives = 139/213 (65%)
Frame = +3
Query: 18 TSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATK 197
+ST + E K D ++ IK +FK LD + + I A+NTSSLSI+EIA++TK
Sbjct: 69 SSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDELCKEDTILATNTSSLSITEIASSTK 128
Query: 198 RQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNR 377
R D+ G+HFFNPVP+M LVEVIS TS T +T+ +KS+ K PV ++PGF+VNR
Sbjct: 129 RPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDTVFELSKSINKVPVDVSESPGFVVNR 188
Query: 378 LLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKF 557
+L+P + EA+ + G A+ E+ID AM+LGA+HPMGP L D +GLD V I++ + +F
Sbjct: 189 ILIPMINEAVGIYADGVASKEEIDEAMKLGANHPMGPLALGDLIGLDVVLAIMNVLYTEF 248
Query: 558 PDNRLFDPIPLLDKLVSENRFGVKSGRGFYEYS 656
D + + PLL K+V N+ G K+ GFY+Y+
Sbjct: 249 GDTK-YTAHPLLAKMVRANQLGRKTKIGFYDYN 280
>sp|P77851|HBD_CLOTS 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA
dehydrogenase) (BHBD)
Length = 289
Score = 183 bits (465), Expect = 4e-46
Identities = 96/210 (45%), Positives = 139/210 (66%)
Frame = +3
Query: 24 TDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATKRQ 203
T ++E AK +D N+ +K ++FK LD + I ASNTSSLSI+EIA+ATKR
Sbjct: 71 TTNLEDAKEADFVVEAAIENMDLKKQIFKELDEICKMETILASNTSSLSITEIASATKRP 130
Query: 204 DRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLL 383
++ G+HFFNPVPVM LVEVI KTS +T + A V KTP++ ++ PGF+VNR+L
Sbjct: 131 EKVIGMHFFNPVPVMKLVEVIKGLKTSEQTFNVVRELALKVDKTPIEVKEAPGFVVNRIL 190
Query: 384 VPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPD 563
+P + EA+ +L AT + ID AM+LGA+HP+GP L+ +G D V I++ +E++ D
Sbjct: 191 IPMINEAIGILAVVLATDKSIDEAMKLGANHPIGPLALSSLIGNDVVLAIMNVLYEEYGD 250
Query: 564 NRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
++ + P PLL K+V G K+G+GF+EY
Sbjct: 251 SK-YRPHPLLKKVVRGGLLGRKTGKGFFEY 279
>sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydrogenase
(Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Length = 287
Score = 183 bits (464), Expect = 5e-46
Identities = 97/210 (46%), Positives = 131/210 (62%)
Frame = +3
Query: 24 TDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATKRQ 203
+ ++E A+ +D N+ K ++FK+LD + PP+ I ASNTSSL I+EIA T R
Sbjct: 74 SQTLEEAEHADIVIEAIAENMAAKTEMFKTLDRICPPHTILASNTSSLPITEIAAVTNRP 133
Query: 204 DRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLL 383
R G+HF NPVPVM LVEVI TS ET+ ++ A+ +GKT V+ D PGF+ NR+L
Sbjct: 134 QRVIGMHFMNPVPVMKLVEVIRGLATSEETALDVMALAEKMGKTAVEVNDFPGFVSNRVL 193
Query: 384 VPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPD 563
+P + EA+ + G A E ID M+LG +HPMGP LAD++GLDT I+ H D
Sbjct: 194 LPMINEAIYCVYEGVAKPEAIDEVMKLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGD 253
Query: 564 NRLFDPIPLLDKLVSENRFGVKSGRGFYEY 653
++ + P PLL K V G KSGRGFY+Y
Sbjct: 254 SK-YRPCPLLRKYVKAGWLGKKSGRGFYDY 282
>sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA
dehydrogenase) (BHBD)
Length = 282
Score = 181 bits (460), Expect = 1e-45
Identities = 96/213 (45%), Positives = 133/213 (62%)
Frame = +3
Query: 18 TSTDSIEAAKTSDXXXXXXXXNVGIKNKLFKSLDAVAPPNCIFASNTSSLSISEIANATK 197
+ T + A D + IK ++F LD + P I ASNTSSLSI+E+A+ATK
Sbjct: 70 SGTVDLNMAADCDLVIEAAVERMDIKKQIFADLDNICKPETILASNTSSLSITEVASATK 129
Query: 198 RQDRFGGLHFFNPVPVMALVEVISTDKTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNR 377
R D+ G+HFFNP PVM LVEVI TS ET + + + ++GK PV+ + PGF+VNR
Sbjct: 130 RPDKVIGMHFFNPAPVMKLVEVIRGIATSQETFDAVKETSIAIGKDPVEVAEAPGFVVNR 189
Query: 378 LLVPYLAEAMRMLERGEATCEDIDTAMRLGASHPMGPFTLADYVGLDTVKFILSGWHEKF 557
+L+P + EA+ +L G A+ EDID AM+LGA+HPMGP L D++GLD I+ + +
Sbjct: 190 ILIPMINEAVGILAEGIASVEDIDKAMKLGANHPMGPLELGDFIGLDICLAIMDVLYSET 249
Query: 558 PDNRLFDPIPLLDKLVSENRFGVKSGRGFYEYS 656
D++ + P LL K V G KSG+GFY+YS
Sbjct: 250 GDSK-YRPHTLLKKYVRAGWLGRKSGKGFYDYS 281
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,680,910
Number of Sequences: 369166
Number of extensions: 1815827
Number of successful extensions: 4487
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4341
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4455
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)