Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_M07
(414 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrog... 172 3e-43
sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogen... 171 4e-43
sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrog... 169 2e-42
sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogen... 169 2e-42
sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 165 4e-41
sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogen... 160 7e-40
sp|Q9RVG1|HBD_DEIRA Probable 3-hydroxybutyryl-CoA dehydroge... 115 5e-26
sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydroge... 107 7e-24
sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Bet... 106 2e-23
sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Bet... 105 5e-23
>sp|Q16836|HCDH_HUMAN Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 172 bits (435), Expect = 3e-43
Identities = 81/125 (64%), Positives = 101/125 (80%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS +T E+L+ F+K++GK PV C+DTPGFIVNRLLVPYL EA+R+ ERG+A+ EDIDTAM
Sbjct: 189 TSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAM 248
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA +PMGPF L DYVGLDT KFI+ GWHE +N L P P L+KLV+E +FG K+G
Sbjct: 249 KLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGE 308
Query: 366 GFYEY 380
GFY+Y
Sbjct: 309 GFYKY 313
>sp|P00348|HCDH_PIG Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 171 bits (434), Expect = 4e-43
Identities = 80/125 (64%), Positives = 100/125 (80%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS +T E+L+ F+K++GK PV C+DTPGFIVNRLLVPYL EA+R+ ERG+A+ EDIDTAM
Sbjct: 189 TSQKTLESLVDFSKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLYERGDASKEDIDTAM 248
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA +PMGPF L DYVGLDT KFI+ GWHE N L P P ++KLV+E +FG K+G
Sbjct: 249 KLGAGYPMGPFELLDYVGLDTTKFIIDGWHEMDSQNPLFQPSPAMNKLVAENKFGKKTGE 308
Query: 366 GFYEY 380
GFY+Y
Sbjct: 309 GFYKY 313
>sp|Q61425|HCDH_MOUSE Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 169 bits (428), Expect = 2e-42
Identities = 79/125 (63%), Positives = 99/125 (79%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS +T E+L+ F K++GK PV C+DTPGFIVNRLLVPYL EA+R+ ERG+A+ EDIDTAM
Sbjct: 189 TSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAVRLHERGDASKEDIDTAM 248
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA +PMGPF L DYVGLDT KFIL GWHE P+N L P P ++ LV++ + G K+G
Sbjct: 249 KLGAGYPMGPFELLDYVGLDTTKFILDGWHEMEPENPLFQPSPSMNNLVAQKKLGKKTGE 308
Query: 366 GFYEY 380
GFY+Y
Sbjct: 309 GFYKY 313
>sp|Q9WVK7|HCDH_RAT Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial
precursor (HCDH) (Medium and short chain
L-3-hydroxyacyl-coenzyme A dehydrogenase)
Length = 314
Score = 169 bits (428), Expect = 2e-42
Identities = 79/125 (63%), Positives = 99/125 (79%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS +T E+L+ F K++GK PV C+DTPGFIVNRLLVPYL EA+R+ ERG+A+ EDIDTAM
Sbjct: 189 TSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAM 248
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA +PMGPF L DYVGLDT KFIL GWHE P+N L P P ++ LV++ + G K+G
Sbjct: 249 KLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGE 308
Query: 366 GFYEY 380
GFY+Y
Sbjct: 309 GFYKY 313
>sp|P34439|HCDH1_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
Length = 298
Score = 165 bits (417), Expect = 4e-41
Identities = 77/125 (61%), Positives = 96/125 (76%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS ET TL+ F +VGKT V C+D+PGFIVNRLL+PY EA RM ERG+A+ DID AM
Sbjct: 172 TSDETYATLIKFGTAVGKTTVACKDSPGFIVNRLLIPYFFEAARMYERGDASMTDIDEAM 231
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA HPMGPF LADY+GLDTVKF++ GW K+P+ +L + PL+DKLV+E + G K+G
Sbjct: 232 KLGAGHPMGPFELADYIGLDTVKFVMDGWAAKYPEVQLFEASPLVDKLVAEGKLGRKTGD 291
Query: 366 GFYEY 380
GFY Y
Sbjct: 292 GFYSY 296
>sp|P41938|HCDH2_CAEEL Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
Length = 309
Score = 160 bits (406), Expect = 7e-40
Identities = 75/126 (59%), Positives = 95/126 (75%)
Frame = +3
Query: 3 KTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTA 182
+TS T L+ + K+VGKT V C+DTPGFIVNRLLVPY+ EA+R+ ERG+A+ EDID A
Sbjct: 183 ETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFEALRLYERGDASMEDIDVA 242
Query: 183 MRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSG 362
M+LGA +PMGPF L+DYVGLDT KFI+ GWH ++P+ P PLL+ LV + G KSG
Sbjct: 243 MKLGAGYPMGPFELSDYVGLDTCKFIMDGWHAQYPEEVAFTPSPLLNSLVDSGKNGRKSG 302
Query: 363 RGFYEY 380
GFY+Y
Sbjct: 303 EGFYKY 308
>sp|Q9RVG1|HBD_DEIRA Probable 3-hydroxybutyryl-CoA dehydrogenase
(Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Length = 278
Score = 115 bits (287), Expect = 5e-26
Identities = 59/126 (46%), Positives = 81/126 (64%)
Frame = +3
Query: 3 KTSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTA 182
+TS ET+ + A+ +GKTP+ C D PGF+ NR+L+P L EA++ + G A E ID
Sbjct: 154 QTSDETARIVTETAEKLGKTPLSCNDFPGFVSNRILMPMLNEAIQCVMEGVAEPEAIDGI 213
Query: 183 MRLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSG 362
M+LG +HPMGP TLAD++GLDT I+ H+ D++ P PLL K+V G KSG
Sbjct: 214 MKLGMNHPMGPLTLADFIGLDTCLAIMEVLHQGLGDDKY-RPSPLLRKMVQAGLLGRKSG 272
Query: 363 RGFYEY 380
GFY+Y
Sbjct: 273 EGFYKY 278
>sp|P45856|HBD_BACSU Probable 3-hydroxybutyryl-CoA dehydrogenase
(Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Length = 287
Score = 107 bits (268), Expect = 7e-24
Identities = 57/125 (45%), Positives = 77/125 (61%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS ET+ ++ A+ +GKT V+ D PGF+ NR+L+P + EA+ + G A E ID M
Sbjct: 159 TSEETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM 218
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LG +HPMGP LAD++GLDT I+ H D++ P PLL K V G KSGR
Sbjct: 219 KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKY-RPCPLLRKYVKAGWLGKKSGR 277
Query: 366 GFYEY 380
GFY+Y
Sbjct: 278 GFYDY 282
>sp|P52041|HBD_CLOAB 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA
dehydrogenase) (BHBD)
Length = 282
Score = 106 bits (264), Expect = 2e-23
Identities = 55/125 (44%), Positives = 80/125 (64%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS ET + + + ++GK PV+ + PGF+VNR+L+P + EA+ +L G A+ EDID AM
Sbjct: 157 TSQETFDAVKETSIAIGKDPVEVAEAPGFVVNRILIPMINEAVGILAEGIASVEDIDKAM 216
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA+HPMGP L D++GLD I+ + + D++ P LL K V G KSG+
Sbjct: 217 KLGANHPMGPLELGDFIGLDICLAIMDVLYSETGDSKY-RPHTLLKKYVRAGWLGRKSGK 275
Query: 366 GFYEY 380
GFY+Y
Sbjct: 276 GFYDY 280
>sp|P45364|HBD_CLODI 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA
dehydrogenase) (BHBD)
Length = 281
Score = 105 bits (261), Expect = 5e-23
Identities = 54/125 (43%), Positives = 80/125 (64%)
Frame = +3
Query: 6 TSPETSETLLTFAKSVGKTPVKCRDTPGFIVNRLLVPYLAEAMRMLERGEATCEDIDTAM 185
TS T +T+ +KS+ K PV ++PGF+VNR+L+P + EA+ + G A+ E+ID AM
Sbjct: 156 TSKVTFDTVFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAM 215
Query: 186 RLGASHPMGPFTLADYVGLDTVKFILSGWHEKFPDNRLCDPIPLLDKLVSEIRFGVKSGR 365
+LGA+HPMGP L D +GLD V I++ + +F D + PLL K+V + G K+
Sbjct: 216 KLGANHPMGPLALGDLIGLDVVLAIMNVLYTEFGDTKY-TAHPLLAKMVRANQLGRKTKI 274
Query: 366 GFYEY 380
GFY+Y
Sbjct: 275 GFYDY 279
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,986,929
Number of Sequences: 369166
Number of extensions: 1091078
Number of successful extensions: 2777
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2709
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2745
length of database: 68,354,980
effective HSP length: 99
effective length of database: 50,066,215
effective search space used: 1902516170
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)