Planarian EST Database

DrC_00213

Cluster detail
GO Category :
Consensus Sequence :
>DrC_00213 GGAATTTTTTAATTCTTAATAAATATTTGAAAATATGTCTTTGAATTGTTTAATTTTCTG TCTGAGTATTTTCAATATTTATTTATCTTTTCATCAAGTATCAACCACTTATGAACCACA AGTTGCTTTTTTATGTGGAAAACCTTCAAAAATATTTAAGAATAATCAATGGATATTAGA TTTTCAACAAGGCTGTATTAAAGATGAAGTGAAAGTTGTACAATTTTGTCGAAAATCATT TCCTTCATTGAAAATTCTTACTGCTGAACCAGCAATAACGAAAGCTAAATTTACGAATTG GTGTGACTTCAACAATCAAAATTGTGAAGTTAATGTGGAAATTCGACCTTTCAAATGCTT GGATAAAAACTTTCAATCTGATGCTTTAATTCTACCTCGAAATTGTCAATTTGGCCATTT GTTTAATGAAACTGAATGTTTAATTTATAAAGATTGGGTAAAACGAGCTACTAATCAATG TCTTAACAAGCAAGATTGGATAATTAAATCATACGGAATGTTGTTTCCGTGCGGTAATC

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00213
         (539 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q10651|A4_CAEEL  Beta-amyloid-like protein precursor            94   3e-19
sp|Q06481|APLP2_HUMAN  Amyloid-like protein 2 precursor (Amy...    88   1e-17
sp|Q06335|APLP2_MOUSE  Amyloid-like protein 2 precursor (CDE...    88   2e-17
sp|P15943|APLP2_RAT  Amyloid-like protein 2 precursor (Sperm...    87   3e-17
sp|P14599|A4_DROME  Beta-amyloid-like protein precursor            84   2e-16
sp|O93279|A4_FUGRU  Alzheimer's disease amyloid A4 protein h...    83   4e-16
sp|P79307|A4_PIG  Amyloid beta A4 protein precursor (APP) (A...    83   5e-16
sp|P12023|A4_MOUSE  Amyloid beta A4 protein precursor (APP) ...    82   8e-16
sp|P08592|A4_RAT  Amyloid beta A4 protein precursor (APP) (A...    82   8e-16
sp|Q60495|A4_CAVPO  Amyloid beta A4 protein precursor (APP) ...    81   1e-15

>sp|Q10651|A4_CAEEL Beta-amyloid-like protein precursor
          Length = 686

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 44/147 (29%), Positives = 77/147 (52%), Gaps = 8/147 (5%)
 Frame = +2

Query: 116 PQVAFLCGKPSKIF-KNNQWILDFQQ--GCIKDEVKVVQFCRKSFPSLKILTAEPAITKA 286
           P VAF CG  ++   +   W  D ++   C   ++ ++++CRK++PS+ I        + 
Sbjct: 36  PMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEV 95

Query: 287 KFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWVKR 466
             ++WC      C+    +RP+ C+D  F S+AL +P +CQF H+ +  +C  Y+ W   
Sbjct: 96  SISDWCREEGSPCKWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDE 155

Query: 467 ATNQCLNK-----QDWIIKSYGMLFPC 532
           A  QC  K     +D I++S+ +L PC
Sbjct: 156 AGKQCKTKKSKGNKDMIVRSFAVLEPC 182

>sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)
           (CDEI box-binding protein) (CDEBP)
          Length = 763

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 48/145 (33%), Positives = 72/145 (49%), Gaps = 4/145 (2%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A  CGK +     +  +W  D    + C + + +V+Q+C++ +P L+I     A  
Sbjct: 49  EPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQ 108

Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
           +    NWC  + + C+    + PFKCL   F SD L++P  CQF H      C  ++ W 
Sbjct: 109 RVSIDNWCRRDKKQCKSRF-VTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 167

Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
                 CL  Q   + SYGML PCG
Sbjct: 168 TVVKEACLT-QGMTLYSYGMLLPCG 191

>sp|Q06335|APLP2_MOUSE Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP)
          Length = 695

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A LCGK +     +  +W  D    + C+  + +V+Q+C++ +P L+I     A  
Sbjct: 49  EPQIAMLCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQ 108

Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
                +WC  + + C+ ++ I PFKCL   F SD L++P NCQF H      C  ++ W 
Sbjct: 109 PVNIDSWCRRDKRQCKSHIVI-PFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWH 167

Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
                 CL  +   + SYGML PCG
Sbjct: 168 TLVKEACLT-EGLTLYSYGMLLPCG 191

>sp|P15943|APLP2_RAT Amyloid-like protein 2 precursor (Sperm membrane protein YWK-II)
          Length = 765

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 48/145 (33%), Positives = 73/145 (50%), Gaps = 4/145 (2%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A  CGK +     +  +W  D    + C+  + +V+Q+C++ +P L+I     A  
Sbjct: 49  EPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQ 108

Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
                +WC  + + C  ++ I PFKCL   F SD L++P NCQF H      C  ++ W 
Sbjct: 109 PVNIDSWCRRDKKQCRSHIVI-PFKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWH 167

Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
                 CL  +   + SYGML PCG
Sbjct: 168 TVVKEACLT-EGMTLYSYGMLLPCG 191

>sp|P14599|A4_DROME Beta-amyloid-like protein precursor
          Length = 887

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 14/159 (8%)
 Frame = +2

Query: 101 STTYEPQVAFLCG-----KPSKIFKNNQWILDFQQG-----CIKDEVKVVQFCRKSFPSL 250
           S  +EPQ+A LC      +P  + +  +W+ D  +      C++D++ ++ +C+K++P+ 
Sbjct: 29  SPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNR 88

Query: 251 KILTAEPAITKAKFTNWCD---FNNQNCEVNVE-IRPFKCLDKNFQSDALILPRNCQFGH 418
            I     +    K   WC     N   C+ +   I+PF+CL   FQSDAL++P  C F H
Sbjct: 89  DITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGP-FQSDALLVPEGCLFDH 147

Query: 419 LFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 535
           + N + C  +  W +     C  ++   ++S+ ML PCG
Sbjct: 148 IHNASRCWPFVRWNQTGAAAC-QERGMQMRSFAMLLPCG 185

>sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
           Beta-amyloid protein (Beta-APP) (A-beta)]
          Length = 737

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQVA  CGK +     +N +W  D    + C+  +  ++Q+C++ +P L+I     A  
Sbjct: 32  EPQVAMFCGKLNMHINVQNGKWESDPSGTKSCLNTKEGILQYCQEVYPELQITNVVEANQ 91

Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
                NWC    + C  +  I  P++CL   F SDAL++P  C+F H     +C  +  W
Sbjct: 92  PVSIQNWCKKGRKQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHW 151

Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
              A   C   +   +  YGML PCG
Sbjct: 152 HTVAKESC-GDRSMNLHDYGMLLPCG 176

>sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
           amyloid protein homolog) [Contains: Soluble APP-alpha
           (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
           Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
           protein 40 (Beta-APP40); C83; P3(42); P3(40);
           Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
           Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
           Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
           C31]
          Length = 770

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQVA  CGK +     +N +W  D    + CI  +  ++Q+C++ +P L+I     A  
Sbjct: 31  EPQVAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90

Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
                NWC  + + C+ +  I  P++CL   F SDAL++P  C+F H      C  +  W
Sbjct: 91  PVTIQNWCKRSRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150

Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
              A   C  K    +  YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175

>sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
           amyloid protein homolog) (Amyloidogenic glycoprotein)
           (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
           APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid
           protein 42 (Beta-APP42); Beta-amyloid protein 40
           (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59)
           (Gamma-secretase C-terminal fragment 59) (Amyloid
           intracellular domain 59) (AID(59)) (APP-C59);
           Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57)
           (Amyloid intracellular domain 57) (AID(57)) (APP-C57);
           Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50)
           (Amyloid intracellular domain 50) (AID(50)); C31]
          Length = 770

 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A  CGK +     +N +W  D    + CI  +  ++Q+C++ +P L+I     A  
Sbjct: 31  EPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90

Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
                NWC    + C+ +  I  P++CL   F SDAL++P  C+F H      C  +  W
Sbjct: 91  PVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150

Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
              A   C  K    +  YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175

>sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (Alzheimer's disease
           amyloid protein homolog) (Amyloidogenic glycoprotein)
           (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
           APP-beta (S-APP-beta); C99; Beta-amyloid protein 42
           (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83;
           P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase
           C-terminal fragment 59); Gamma-CTF(57) (Gamma-secretase
           C-terminal fragment 57); Gamma-CTF(50) (Gamma-secretase
           C-terminal fragment 50); C31]
          Length = 770

 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A  CGK +     +N +W  D    + CI  +  ++Q+C++ +P L+I     A  
Sbjct: 31  EPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90

Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
                NWC    + C+ +  I  P++CL   F SDAL++P  C+F H      C  +  W
Sbjct: 91  PVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150

Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
              A   C  K    +  YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175

>sp|Q60495|A4_CAVPO Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
           amyloid protein homolog) [Contains: Soluble APP-alpha
           (S-APP-alpha); Soluble APP-beta (S-APP-beta); CTF-alpha;
           CTF-beta; Beta-amyloid protein 42 (Beta-APP42);
           Beta-amyloid protein 40 (Beta-APP40); P3(42); P3(40);
           Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
           Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
           C31]
          Length = 770

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
 Frame = +2

Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
           EPQ+A  CGK +     +N +W  D    + CI  +  ++Q+C++ +P L+I     A  
Sbjct: 31  EPQIAMFCGKLNMHMNVQNGKWEPDPSGTKTCIGSKEGILQYCQEVYPELQITNVVEANQ 90

Query: 281 KAKFTNWCDFNNQNCEVNVE-IRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
                NWC  + + C+ +   + P++CL   F SDAL++P  C+F H      C  +  W
Sbjct: 91  PVTIQNWCKRSRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150

Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
              A   C  K    +  YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,312,760
Number of Sequences: 369166
Number of extensions: 1019154
Number of successful extensions: 2350
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2248
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2306
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3685690500
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

DrC_00213

Planaria EST Database

DrC_00213

BLASTX 2.2.13 [Nov-27-2005]

Cluster detail