Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_E04
(539 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10651|A4_CAEEL Beta-amyloid-like protein precursor 94 3e-19
sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 precursor (Amy... 88 1e-17
sp|Q06335|APLP2_MOUSE Amyloid-like protein 2 precursor (CDE... 88 2e-17
sp|P15943|APLP2_RAT Amyloid-like protein 2 precursor (Sperm... 87 3e-17
sp|P14599|A4_DROME Beta-amyloid-like protein precursor 84 2e-16
sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein h... 83 4e-16
sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (A... 83 5e-16
sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) ... 82 8e-16
sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (A... 82 8e-16
sp|Q60495|A4_CAVPO Amyloid beta A4 protein precursor (APP) ... 81 1e-15
>sp|Q10651|A4_CAEEL Beta-amyloid-like protein precursor
Length = 686
Score = 93.6 bits (231), Expect = 3e-19
Identities = 44/147 (29%), Positives = 77/147 (52%), Gaps = 8/147 (5%)
Frame = +2
Query: 116 PQVAFLCGKPSKIF-KNNQWILDFQQ--GCIKDEVKVVQFCRKSFPSLKILTAEPAITKA 286
P VAF CG ++ + W D ++ C ++ ++++CRK++PS+ I +
Sbjct: 36 PMVAFSCGYRNQYMTEEGSWKTDDERYATCFSGKLDILKYCRKAYPSMNITNIVEYSHEV 95
Query: 287 KFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWVKR 466
++WC C+ +RP+ C+D F S+AL +P +CQF H+ + +C Y+ W
Sbjct: 96 SISDWCREEGSPCKWTHSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDE 155
Query: 467 ATNQCLNK-----QDWIIKSYGMLFPC 532
A QC K +D I++S+ +L PC
Sbjct: 156 AGKQCKTKKSKGNKDMIVRSFAVLEPC 182
>sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)
(CDEI box-binding protein) (CDEBP)
Length = 763
Score = 88.2 bits (217), Expect = 1e-17
Identities = 48/145 (33%), Positives = 72/145 (49%), Gaps = 4/145 (2%)
Frame = +2
Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A CGK + + +W D + C + + +V+Q+C++ +P L+I A
Sbjct: 49 EPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQ 108
Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
+ NWC + + C+ + PFKCL F SD L++P CQF H C ++ W
Sbjct: 109 RVSIDNWCRRDKKQCKSRF-VTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 167
Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
CL Q + SYGML PCG
Sbjct: 168 TVVKEACLT-QGMTLYSYGMLLPCG 191
>sp|Q06335|APLP2_MOUSE Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP)
Length = 695
Score = 87.8 bits (216), Expect = 2e-17
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Frame = +2
Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A LCGK + + +W D + C+ + +V+Q+C++ +P L+I A
Sbjct: 49 EPQIAMLCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQ 108
Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
+WC + + C+ ++ I PFKCL F SD L++P NCQF H C ++ W
Sbjct: 109 PVNIDSWCRRDKRQCKSHIVI-PFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWH 167
Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
CL + + SYGML PCG
Sbjct: 168 TLVKEACLT-EGLTLYSYGMLLPCG 191
>sp|P15943|APLP2_RAT Amyloid-like protein 2 precursor (Sperm membrane protein YWK-II)
Length = 765
Score = 86.7 bits (213), Expect = 3e-17
Identities = 48/145 (33%), Positives = 73/145 (50%), Gaps = 4/145 (2%)
Frame = +2
Query: 113 EPQVAFLCGKPSKI--FKNNQWILD--FQQGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A CGK + + +W D + C+ + +V+Q+C++ +P L+I A
Sbjct: 49 EPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQ 108
Query: 281 KAKFTNWCDFNNQNCEVNVEIRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDWV 460
+WC + + C ++ I PFKCL F SD L++P NCQF H C ++ W
Sbjct: 109 PVNIDSWCRRDKKQCRSHIVI-PFKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWH 167
Query: 461 KRATNQCLNKQDWIIKSYGMLFPCG 535
CL + + SYGML PCG
Sbjct: 168 TVVKEACLT-EGMTLYSYGMLLPCG 191
>sp|P14599|A4_DROME Beta-amyloid-like protein precursor
Length = 887
Score = 84.3 bits (207), Expect = 2e-16
Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 14/159 (8%)
Frame = +2
Query: 101 STTYEPQVAFLCG-----KPSKIFKNNQWILDFQQG-----CIKDEVKVVQFCRKSFPSL 250
S +EPQ+A LC +P + + +W+ D + C++D++ ++ +C+K++P+
Sbjct: 29 SPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNR 88
Query: 251 KILTAEPAITKAKFTNWCD---FNNQNCEVNVE-IRPFKCLDKNFQSDALILPRNCQFGH 418
I + K WC N C+ + I+PF+CL FQSDAL++P C F H
Sbjct: 89 DITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGP-FQSDALLVPEGCLFDH 147
Query: 419 LFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 535
+ N + C + W + C ++ ++S+ ML PCG
Sbjct: 148 IHNASRCWPFVRWNQTGAAAC-QERGMQMRSFAMLLPCG 185
>sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
Beta-amyloid protein (Beta-APP) (A-beta)]
Length = 737
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Frame = +2
Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQVA CGK + +N +W D + C+ + ++Q+C++ +P L+I A
Sbjct: 32 EPQVAMFCGKLNMHINVQNGKWESDPSGTKSCLNTKEGILQYCQEVYPELQITNVVEANQ 91
Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
NWC + C + I P++CL F SDAL++P C+F H +C + W
Sbjct: 92 PVSIQNWCKKGRKQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMNQCESHLHW 151
Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
A C + + YGML PCG
Sbjct: 152 HTVAKESC-GDRSMNLHDYGMLLPCG 176
>sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 770
Score = 82.8 bits (203), Expect = 5e-16
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
Frame = +2
Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQVA CGK + +N +W D + CI + ++Q+C++ +P L+I A
Sbjct: 31 EPQVAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90
Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
NWC + + C+ + I P++CL F SDAL++P C+F H C + W
Sbjct: 91 PVTIQNWCKRSRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150
Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
A C K + YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175
>sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid
protein 42 (Beta-APP42); Beta-amyloid protein 40
(Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59)
(Gamma-secretase C-terminal fragment 59) (Amyloid
intracellular domain 59) (AID(59)) (APP-C59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57)
(Amyloid intracellular domain 57) (AID(57)) (APP-C57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50)
(Amyloid intracellular domain 50) (AID(50)); C31]
Length = 770
Score = 82.0 bits (201), Expect = 8e-16
Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Frame = +2
Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A CGK + +N +W D + CI + ++Q+C++ +P L+I A
Sbjct: 31 EPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90
Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
NWC + C+ + I P++CL F SDAL++P C+F H C + W
Sbjct: 91 PVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150
Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
A C K + YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175
>sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99; Beta-amyloid protein 42
(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83;
P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase
C-terminal fragment 59); Gamma-CTF(57) (Gamma-secretase
C-terminal fragment 57); Gamma-CTF(50) (Gamma-secretase
C-terminal fragment 50); C31]
Length = 770
Score = 82.0 bits (201), Expect = 8e-16
Identities = 47/146 (32%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Frame = +2
Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A CGK + +N +W D + CI + ++Q+C++ +P L+I A
Sbjct: 31 EPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQ 90
Query: 281 KAKFTNWCDFNNQNCEVNVEIR-PFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
NWC + C+ + I P++CL F SDAL++P C+F H C + W
Sbjct: 91 PVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150
Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
A C K + YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175
>sp|Q60495|A4_CAVPO Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); CTF-alpha;
CTF-beta; Beta-amyloid protein 42 (Beta-APP42);
Beta-amyloid protein 40 (Beta-APP40); P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
C31]
Length = 770
Score = 81.3 bits (199), Expect = 1e-15
Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
Frame = +2
Query: 113 EPQVAFLCGKPSKIF--KNNQWILDFQ--QGCIKDEVKVVQFCRKSFPSLKILTAEPAIT 280
EPQ+A CGK + +N +W D + CI + ++Q+C++ +P L+I A
Sbjct: 31 EPQIAMFCGKLNMHMNVQNGKWEPDPSGTKTCIGSKEGILQYCQEVYPELQITNVVEANQ 90
Query: 281 KAKFTNWCDFNNQNCEVNVE-IRPFKCLDKNFQSDALILPRNCQFGHLFNETECLIYKDW 457
NWC + + C+ + + P++CL F SDAL++P C+F H C + W
Sbjct: 91 PVTIQNWCKRSRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHW 150
Query: 458 VKRATNQCLNKQDWIIKSYGMLFPCG 535
A C K + YGML PCG
Sbjct: 151 HTVAKETCSEKST-NLHDYGMLLPCG 175
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,312,760
Number of Sequences: 369166
Number of extensions: 1019154
Number of successful extensions: 2350
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2248
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2306
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3685690500
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)