Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_I10
(356 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10651|A4_CAEEL Beta-amyloid-like protein precursor 87 2e-17
sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 precursor (Amy... 80 1e-15
sp|P15943|APLP2_RAT Amyloid-like protein 2 precursor (Sperm... 79 3e-15
sp|Q06335|APLP2_MOUSE Amyloid-like protein 2 precursor (CDE... 79 4e-15
sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein h... 72 3e-13
sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (A... 72 4e-13
sp|P14599|A4_DROME Beta-amyloid-like protein precursor 72 4e-13
sp|O73683|A4_TETFL Alzheimer's disease amyloid A4 protein h... 72 4e-13
sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) ... 72 5e-13
sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (A... 72 5e-13
>sp|Q10651|A4_CAEEL Beta-amyloid-like protein precursor
Length = 686
Score = 86.7 bits (213), Expect = 2e-17
Identities = 36/118 (30%), Positives = 64/118 (54%), Gaps = 5/118 (4%)
Frame = +2
Query: 11 CIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIRPFKCLDKNF 190
C ++ ++++CRK++PS+ I + ++WC C+ +RP+ C+D F
Sbjct: 65 CFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDWCREEGSPCKWTHSVRPYHCIDGEF 124
Query: 191 QSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNK-----QDWIIKSYGMLFPC 349
S+AL +P +CQF H+ + +C Y+ W A QC K +D I++S+ +L PC
Sbjct: 125 HSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKKSKGNKDMIVRSFAVLEPC 182
>sp|Q06481|APLP2_HUMAN Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH)
(CDEI box-binding protein) (CDEBP)
Length = 763
Score = 80.5 bits (197), Expect = 1e-15
Identities = 39/117 (33%), Positives = 60/117 (51%)
Frame = +2
Query: 2 SQGCIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIRPFKCLD 181
++ C + + +V+Q+C++ +P L+I A + NWC + + C+ + PFKCL
Sbjct: 77 TKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRF-VTPFKCLV 135
Query: 182 KNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SD L++P CQF H C ++ W CL Q + SYGML PCG
Sbjct: 136 GEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLT-QGMTLYSYGMLLPCG 191
>sp|P15943|APLP2_RAT Amyloid-like protein 2 precursor (Sperm membrane protein YWK-II)
Length = 765
Score = 79.0 bits (193), Expect = 3e-15
Identities = 39/117 (33%), Positives = 61/117 (52%)
Frame = +2
Query: 2 SQGCIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIRPFKCLD 181
++ C+ + +V+Q+C++ +P L+I A +WC + + C ++ I PFKCL
Sbjct: 77 TKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKKQCRSHIVI-PFKCLV 135
Query: 182 KNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SD L++P NCQF H C ++ W CL + + SYGML PCG
Sbjct: 136 GEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLT-EGMTLYSYGMLLPCG 191
>sp|Q06335|APLP2_MOUSE Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP)
Length = 695
Score = 78.6 bits (192), Expect = 4e-15
Identities = 39/117 (33%), Positives = 62/117 (52%)
Frame = +2
Query: 2 SQGCIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIRPFKCLD 181
++ C+ + +V+Q+C++ +P L+I A +WC + + C+ ++ I PFKCL
Sbjct: 77 TKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVI-PFKCLV 135
Query: 182 KNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SD L++P NCQF H C ++ W CL + + SYGML PCG
Sbjct: 136 GEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLT-EGLTLYSYGMLLPCG 191
>sp|O93279|A4_FUGRU Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
Beta-amyloid protein (Beta-APP) (A-beta)]
Length = 737
Score = 72.4 bits (176), Expect = 3e-13
Identities = 35/118 (29%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Frame = +2
Query: 2 SQGCIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIR-PFKCL 178
++ C+ + ++Q+C++ +P L+I A NWC + C + I P++CL
Sbjct: 60 TKSCLNTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHTHIVVPYRCL 119
Query: 179 DKNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SDAL++P C+F H +C + W A C + + YGML PCG
Sbjct: 120 VGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESC-GDRSMNLHDYGMLLPCG 176
>sp|P79307|A4_PIG Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) [Contains: Soluble APP-alpha
(S-APP-alpha); Soluble APP-beta (S-APP-beta); C99;
Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid
protein 40 (Beta-APP40); C83; P3(42); P3(40);
Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50);
C31]
Length = 770
Score = 72.0 bits (175), Expect = 4e-13
Identities = 37/115 (32%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Frame = +2
Query: 11 CIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIR-PFKCLDKN 187
CI + ++Q+C++ +P L+I A NWC + + C+ + I P++CL
Sbjct: 62 CIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRSRKQCKTHTHIVIPYRCLVGE 121
Query: 188 FQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SDAL++P C+F H C + W A C K + YGML PCG
Sbjct: 122 FVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKST-NLHDYGMLLPCG 175
>sp|P14599|A4_DROME Beta-amyloid-like protein precursor
Length = 887
Score = 72.0 bits (175), Expect = 4e-13
Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 4/118 (3%)
Frame = +2
Query: 11 CIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCD---FNNQNCEVNVE-IRPFKCL 178
C++D++ ++ +C+K++P+ I + K WC N C+ + I+PF+CL
Sbjct: 70 CLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCL 129
Query: 179 DKNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
FQSDAL++P C F H+ N + C + W + C ++ ++S+ ML PCG
Sbjct: 130 GP-FQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAAC-QERGMQMRSFAMLLPCG 185
>sp|O73683|A4_TETFL Alzheimer's disease amyloid A4 protein homolog precursor [Contains:
Beta-amyloid protein (Beta-APP) (A-beta)]
Length = 780
Score = 72.0 bits (175), Expect = 4e-13
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 1/118 (0%)
Frame = +2
Query: 2 SQGCIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIR-PFKCL 178
++ CI + ++Q+C++ +P L+I A NWC + C ++ I P++CL
Sbjct: 60 TKSCIGTKEGILQYCQEVYPELQITNVVEANQPVSIQNWCKKGRKQCRSHMHIVVPYRCL 119
Query: 179 DKNFQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SDAL++P C+F H +C + W A C + + YGML PCG
Sbjct: 120 VGEFVSDALLVPDKCKFLHQERMNQCESHLHWHTVAKESC-GDRAMNLHDYGMLLPCG 176
>sp|P12023|A4_MOUSE Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid
protein 42 (Beta-APP42); Beta-amyloid protein 40
(Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59)
(Gamma-secretase C-terminal fragment 59) (Amyloid
intracellular domain 59) (AID(59)) (APP-C59);
Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57)
(Amyloid intracellular domain 57) (AID(57)) (APP-C57);
Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50)
(Amyloid intracellular domain 50) (AID(50)); C31]
Length = 770
Score = 71.6 bits (174), Expect = 5e-13
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Frame = +2
Query: 11 CIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIR-PFKCLDKN 187
CI + ++Q+C++ +P L+I A NWC + C+ + I P++CL
Sbjct: 62 CIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGE 121
Query: 188 FQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SDAL++P C+F H C + W A C K + YGML PCG
Sbjct: 122 FVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKST-NLHDYGMLLPCG 175
>sp|P08592|A4_RAT Amyloid beta A4 protein precursor (APP) (Alzheimer's disease
amyloid protein homolog) (Amyloidogenic glycoprotein)
(AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble
APP-beta (S-APP-beta); C99; Beta-amyloid protein 42
(Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83;
P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase
C-terminal fragment 59); Gamma-CTF(57) (Gamma-secretase
C-terminal fragment 57); Gamma-CTF(50) (Gamma-secretase
C-terminal fragment 50); C31]
Length = 770
Score = 71.6 bits (174), Expect = 5e-13
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 1/115 (0%)
Frame = +2
Query: 11 CIKDEVKVVQFCRKSFPSLKILTAEPAITKAKFTNWCDFNNQNCEVNVEIR-PFKCLDKN 187
CI + ++Q+C++ +P L+I A NWC + C+ + I P++CL
Sbjct: 62 CIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGE 121
Query: 188 FQSDALILPRNCQFGHLFNETECLIYKDWVKRATNQCLNKQDWIIKSYGMLFPCG 352
F SDAL++P C+F H C + W A C K + YGML PCG
Sbjct: 122 FVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKST-NLHDYGMLLPCG 175
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,227,309
Number of Sequences: 369166
Number of extensions: 613972
Number of successful extensions: 1418
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1374
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1387
length of database: 68,354,980
effective HSP length: 86
effective length of database: 52,467,770
effective search space used: 1678968640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)