DrC_00177
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00177 (1033 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-acti... 153 9e-37 sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 130 5e-30 sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 120 5e-27 sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 119 1e-26 sp|Q9ULH1|DDEF1_HUMAN 130-kDa phosphatidylinositol 4,5-biph... 66 1e-10 sp|Q9QWY8|DDEF1_MOUSE 130-kDa phosphatidylinositol 4,5-biph... 66 2e-10 sp|O97902|DDEF1_BOVIN 130-kDa phosphatidylinositol 4,5-biph... 65 2e-10 sp|O74345|UCP3_SCHPO UBA-domain containing protein 3 60 1e-08 sp|Q8BZ05|CEND1_MOUSE Centaurin-delta 1 (Cnt-d1) 59 2e-08 sp|Q8WZ64|CEND1_HUMAN Centaurin-delta 1 (Cnt-d1) (Arf-GAP, ... 59 3e-08
>sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-activating protein PM25) Length = 374 Score = 153 bits (386), Expect = 9e-37 Identities = 96/331 (29%), Positives = 162/331 (48%), Gaps = 5/331 (1%) Frame = +2 Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEI 178 +L PGN CADC A P + + + IC C+G+HR++ V +VK + D + ++ Sbjct: 11 ELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQV 70 Query: 179 EEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITN 358 E + GN + + +P FY P + ++LR +I AKY+ ++F E PY Sbjct: 71 EFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAG 130 Query: 359 QKLGLLKKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRI 538 + G L KR +D + +R F L+ + YF NR K +PK ++++ + Sbjct: 131 YREGFLWKRGRDNGQFLSRKFVLTEREGALKYF---------NRNDAK-EPKAVMKIEHL 180 Query: 539 NATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKF 706 NATF I +P L +++ + S R+I++ ++ VDW+ +R A+F Sbjct: 181 NATFQPAKIGHPHG--------LQVTYLKDN--STRNIFIYHEDGKEIVDWFNALRAARF 230 Query: 707 SLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSS 886 G A++ +L L+ + G+M KTG + TE ++KRW + RRL+Y Sbjct: 231 HYLQVAFPG----ASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFK 286 Query: 887 GPLSPCGKGEIVIGERSRGYGAVLSSPPNAR 979 PL +GE+ IG + GY + PP+ + Sbjct: 287 DPLDAFARGEVFIGSKESGYTVLHGFPPSTQ 317
>sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 Length = 381 Score = 130 bits (328), Expect = 5e-30 Identities = 98/327 (29%), Positives = 153/327 (46%), Gaps = 7/327 (2%) Frame = +2 Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196 GN CADC A P + I IC C GVHR+ ++ RVK + D D +E ++ Sbjct: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHN 80 Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLL 376 GN + + +P FY +P AN +L+ +I AKY+ ++F + + + + + G L Sbjct: 81 GNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREF-MADGETISLPGNREGFL 139 Query: 377 KKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF-- 550 KR +D + + R F L + YF KE S PK + + +NATF Sbjct: 140 WKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKS----------PKAVISIKDLNATFQT 189 Query: 551 --IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAY 724 I +P L I++ R + R++++ + ++ VDW+ +R A R Y Sbjct: 190 EKIGHPHG--------LQITYRR--DGHTRNLFVYHESGKEIVDWFNALRAA----RLQY 235 Query: 725 VVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLS 898 + E E EL LT + G+M KTG + E ++KRW L RRLLY PL Sbjct: 236 LKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLD 295 Query: 899 PCGKGEIVIGERSRGYGAVLSSPPNAR 979 +G++ +G + +GY A P R Sbjct: 296 AFEQGQVFLGNKEQGYEAYEDLPKGIR 322
>sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 Length = 376 Score = 120 bits (302), Expect = 5e-27 Identities = 89/316 (28%), Positives = 149/316 (47%), Gaps = 7/316 (2%) Frame = +2 Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196 GN CADC A P + + IC C+GVHR+ ++ +VK + D D +E + Sbjct: 21 GNGHCADCGAADPDWASYKLGVFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHN 80 Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLL 376 GN + +P FY +P A+ +L+ +I AKY+ ++F ++ P + G L Sbjct: 81 GNLSVKAKFEARVPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSP--PGDREGFL 138 Query: 377 KKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF-- 550 KR +D + + R F L + Y+ KE + PK + + +NATF Sbjct: 139 WKRGRDNSQFLRRRFVLLSREGLLKYYTKEEGKT----------PKAIINIKDLNATFQT 188 Query: 551 --IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAY 724 I +P L I++ ++E R++++ ++ ++ VDW+ +R A R Y Sbjct: 189 EKIGHPHG--------LQITY--RKEGQTRNLFVYHDSGKEIVDWFNALRAA----RLQY 234 Query: 725 VVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLS 898 + + E EL +T + G+M KTG + E ++KRW L RRLLY PL Sbjct: 235 LKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLD 294 Query: 899 PCGKGEIVIGERSRGY 946 +G++ +G +GY Sbjct: 295 AFEQGQVFLGSNEQGY 310
>sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 Length = 381 Score = 119 bits (299), Expect = 1e-26 Identities = 93/318 (29%), Positives = 148/318 (46%), Gaps = 9/318 (2%) Frame = +2 Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196 GN CADC A P + I IC C+GVHR+ ++ +VK + D D +E + Sbjct: 21 GNGHCADCGAADPDWASYKLGIFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHH 80 Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSV--KEVDRPYITNQKLG 370 GN + +P FY +P AN +L+ +I AKY+ ++F+ K V P + G Sbjct: 81 GNLNVKAKFEARVPAFYYVPQANDCLVLKEQWIRAKYERQEFTAIDKAVSHP---GNREG 137 Query: 371 LLKKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF 550 L KR +D + R F L + Y+ KE + PK + + +NATF Sbjct: 138 FLWKRGRDNAQFLRRRFVLLSREGLLKYYTKEEGKA----------PKAVISIKDLNATF 187 Query: 551 ----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRA 718 I +P L I++ ++E R++++ ++ ++ VDW+ +R A R Sbjct: 188 QTEKIGHPHG--------LQITY--RKEGHTRNLFVYHDSGKEIVDWFNALRAA----RL 233 Query: 719 AYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGP 892 Y+ + E EL +T + G+M KTG + E ++KRW L RRLLY P Sbjct: 234 QYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNP 293 Query: 893 LSPCGKGEIVIGERSRGY 946 L G++ +G +GY Sbjct: 294 LDAFELGQVFLGSNEQGY 311
>sp|Q9ULH1|DDEF1_HUMAN 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) Length = 956 Score = 66.2 bits (160), Expect = 1e-10 Identities = 39/132 (29%), Positives = 66/132 (50%), Gaps = 2/132 (1%) Frame = +2 Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187 +PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+ Sbjct: 275 LPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 334 Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKL 367 +GN ND LP P + +R+ +I AKY +FS K ++ KL Sbjct: 335 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCS---TSSAKL 391 Query: 368 GLLKKRCKDKNI 403 L + K +++ Sbjct: 392 NELLEAIKSRDL 403
>sp|Q9QWY8|DDEF1_MOUSE 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1) Length = 1147 Score = 65.9 bits (159), Expect = 2e-10 Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 2/108 (1%) Frame = +2 Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187 +PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+ Sbjct: 463 LPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 522 Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVK 331 +GN ND LP P + +R+ +I AKY +FS K Sbjct: 523 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 570
>sp|O97902|DDEF1_BOVIN 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1) Length = 1129 Score = 65.5 bits (158), Expect = 2e-10 Identities = 39/132 (29%), Positives = 66/132 (50%), Gaps = 2/132 (1%) Frame = +2 Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187 +PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+ Sbjct: 451 LPGNDVCCDCGSAEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 510 Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKL 367 +GN ND LP P + +R+ +I AKY +FS K ++ KL Sbjct: 511 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSS---SSAKL 567 Query: 368 GLLKKRCKDKNI 403 L + K +++ Sbjct: 568 NELLEAIKSRDL 579
>sp|O74345|UCP3_SCHPO UBA-domain containing protein 3 Length = 601 Score = 59.7 bits (143), Expect = 1e-08 Identities = 42/133 (31%), Positives = 67/133 (50%), Gaps = 3/133 (2%) Frame = +2 Query: 11 NVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMEN--VRVKDLNFDKISDLEIEE 184 +V GN LCADC+ + + I +C +CA +HR + +VK ++ D+ S+ +IE+ Sbjct: 16 SVSGNNLCADCSTRGVQWASWNLGIFLCLRCATIHRKLGTHVSKVKSISLDEWSNDQIEK 75 Query: 185 VLKLGNKKSNDGYLKFLPIFYRLP-NANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQ 361 + GN +N Y P+ + LP NA E + +I KY+ K F +D + TN Sbjct: 76 MKHWGNINAN-RYWNPNPLSHPLPTNALSDEHVMEKYIRDKYERKLF----LDENHSTNS 130 Query: 362 KLGLLKKRCKDKN 400 K L R K + Sbjct: 131 KPPSLPPRTKSSS 143
>sp|Q8BZ05|CEND1_MOUSE Centaurin-delta 1 (Cnt-d1) Length = 1703 Score = 58.9 bits (141), Expect = 2e-08 Identities = 37/111 (33%), Positives = 61/111 (54%), Gaps = 4/111 (3%) Frame = +2 Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKI--SD 169 K++ N CADC A P + ++ ++IC+KCAG HRS+ ++ +V+ L D S+ Sbjct: 688 KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDCKVRSLKMDASIWSN 747 Query: 170 LEIEEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQF 322 IE + +GNK++ND + L L + P R++FI KY+ +F Sbjct: 748 ELIELFIVIGNKRANDFWAGNLQKDEEL-QVDSPVEKRKNFITQKYKEGKF 797
>sp|Q8WZ64|CEND1_HUMAN Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein) Length = 1704 Score = 58.5 bits (140), Expect = 3e-08 Identities = 37/111 (33%), Positives = 62/111 (55%), Gaps = 4/111 (3%) Frame = +2 Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKI--SD 169 K++ N CADC A P + ++ ++IC+KCAG HRS+ ++ +V+ L D S+ Sbjct: 690 KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSN 749 Query: 170 LEIEEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQF 322 IE + +GNK++ND + L L + + P R++FI KY+ +F Sbjct: 750 ELIELFIVIGNKRANDFWAGNLQKDEEL-HMDSPVEKRKNFITQKYKEGKF 799
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114,393,337
Number of Sequences: 369166
Number of extensions: 2287695
Number of successful extensions: 5320
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5085
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5298
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 11101059640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
