Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_H02
(831 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-acti... 117 4e-26
sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 102 1e-21
sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 96 1e-19
sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 96 1e-19
sp|Q9ULH1|DDEF1_HUMAN 130-kDa phosphatidylinositol 4,5-biph... 66 1e-10
sp|Q9QWY8|DDEF1_MOUSE 130-kDa phosphatidylinositol 4,5-biph... 66 1e-10
sp|O97902|DDEF1_BOVIN 130-kDa phosphatidylinositol 4,5-biph... 65 2e-10
sp|O74345|UCP3_SCHPO UBA-domain containing protein 3 60 1e-08
sp|Q8BZ05|CEND1_MOUSE Centaurin-delta 1 (Cnt-d1) 59 2e-08
sp|Q8WZ64|CEND1_HUMAN Centaurin-delta 1 (Cnt-d1) (Arf-GAP, ... 59 2e-08
>sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-activating protein PM25)
Length = 374
Score = 117 bits (293), Expect = 4e-26
Identities = 78/281 (27%), Positives = 137/281 (48%), Gaps = 5/281 (1%)
Frame = +2
Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEI 178
+L PGN CADC A P + + + IC C+G+HR++ V +VK + D + ++
Sbjct: 11 ELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQV 70
Query: 179 EEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITN 358
E + GN + + +P FY P + ++LR +I AKY+ ++F E PY
Sbjct: 71 EFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAG 130
Query: 359 QKLGLLKKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRI 538
+ G L KR +D + +R F L+ + YF NR K +PK ++++ +
Sbjct: 131 YREGFLWKRGRDNGQFLSRKFVLTEREGALKYF---------NRNDAK-EPKAVMKIEHL 180
Query: 539 NATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDLVDWYQTIRFAKF 706
NATF I +P L +++ + + S R+I++ +++VDW+ +R A+F
Sbjct: 181 NATFQPAKIGHPHG--------LQVTYLK--DNSTRNIFIYHEDGKEIVDWFNALRAARF 230
Query: 707 SLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLT 829
Y+ A++ +L L+ + G+M KTG + T
Sbjct: 231 H----YLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQT 267
>sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2
Length = 381
Score = 102 bits (255), Expect = 1e-21
Identities = 79/271 (29%), Positives = 126/271 (46%), Gaps = 5/271 (1%)
Frame = +2
Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196
GN CADC A P + I IC C GVHR+ ++ RVK + D D +E ++
Sbjct: 21 GNAHCADCGAADPDWASYKLGIFICLNCCGVHRNFPDISRVKSVRLDFWDDSIVEFMIHN 80
Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLL 376
GN + + +P FY +P AN +L+ +I AKY+ ++F + + + + + G L
Sbjct: 81 GNLRVKAKFEARVPAFYYIPQANDCLVLKEQWIRAKYERREF-MADGETISLPGNREGFL 139
Query: 377 KKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF-- 550
KR +D + + R F L + YF KE S PK + + +NATF
Sbjct: 140 WKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKS----------PKAVISIKDLNATFQT 189
Query: 551 --IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAY 724
I +P L I++ R + R++++ + +++VDW+ +R A R Y
Sbjct: 190 EKIGHPHG--------LQITYRR--DGHTRNLFVYHESGKEIVDWFNALRAA----RLQY 235
Query: 725 VVGTGDEANELELARDLTLDITMSGWMYKTG 817
+ E E EL LT + G+M KTG
Sbjct: 236 LKMAFPELPESELVPFLTRNYLKQGFMEKTG 266
>sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2
Length = 381
Score = 95.9 bits (237), Expect = 1e-19
Identities = 77/273 (28%), Positives = 126/273 (46%), Gaps = 7/273 (2%)
Frame = +2
Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196
GN CADC A P + I IC C+GVHR+ ++ +VK + D D +E +
Sbjct: 21 GNGHCADCGAADPDWASYKLGIFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHH 80
Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSV--KEVDRPYITNQKLG 370
GN + +P FY +P AN +L+ +I AKY+ ++F+ K V P + G
Sbjct: 81 GNLNVKAKFEARVPAFYYVPQANDCLVLKEQWIRAKYERQEFTAIDKAVSHP---GNREG 137
Query: 371 LLKKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF 550
L KR +D + R F L + Y+ KE + PK + + +NATF
Sbjct: 138 FLWKRGRDNAQFLRRRFVLLSREGLLKYYTKEEGKA----------PKAVISIKDLNATF 187
Query: 551 ----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRA 718
I +P L I++ ++E R++++ ++ +++VDW+ +R A R
Sbjct: 188 QTEKIGHPHG--------LQITY--RKEGHTRNLFVYHDSGKEIVDWFNALRAA----RL 233
Query: 719 AYVVGTGDEANELELARDLTLDITMSGWMYKTG 817
Y+ + E EL +T + G+M KTG
Sbjct: 234 QYLKLAFPDLPESELVPLITRNYLKQGFMEKTG 266
>sp|Q9JK15|CENA2_RAT Centaurin-alpha 2
Length = 376
Score = 95.9 bits (237), Expect = 1e-19
Identities = 73/271 (26%), Positives = 126/271 (46%), Gaps = 5/271 (1%)
Frame = +2
Query: 20 GNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMENV-RVKDLNFDKISDLEIEEVLKL 196
GN CADC A P + + IC C+GVHR+ ++ +VK + D D +E +
Sbjct: 21 GNGHCADCGAADPDWASYKLGVFICLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHN 80
Query: 197 GNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLL 376
GN + +P FY +P A+ +L+ +I AKY+ ++F ++ P + G L
Sbjct: 81 GNLSVKAKFEARVPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSP--PGDREGFL 138
Query: 377 KKRCKDKNIYNARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF-- 550
KR +D + + R F L + Y+ KE + PK + + +NATF
Sbjct: 139 WKRGRDNSQFLRRRFVLLSREGLLKYYTKEEGKT----------PKAIINIKDLNATFQT 188
Query: 551 --IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAY 724
I +P L I++ ++E R++++ ++ +++VDW+ +R A R Y
Sbjct: 189 EKIGHPHG--------LQITY--RKEGQTRNLFVYHDSGKEIVDWFNALRAA----RLQY 234
Query: 725 VVGTGDEANELELARDLTLDITMSGWMYKTG 817
+ + E EL +T + G+M KTG
Sbjct: 235 LKLAFPDLPESELVPLITRNYLKQGFMEKTG 265
>sp|Q9ULH1|DDEF1_HUMAN 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1
GTPase-activating protein (PIP2-dependent ARF1 GAP)
(ADP-ribosylation factor-directed GTPase-activating
protein 1) (ARF GTPase-activating protein 1)
(Development and differentiation-enhancing factor 1)
Length = 956
Score = 66.2 bits (160), Expect = 1e-10
Identities = 39/132 (29%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +2
Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187
+PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+
Sbjct: 275 LPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 334
Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKL 367
+GN ND LP P + +R+ +I AKY +FS K ++ KL
Sbjct: 335 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCS---TSSAKL 391
Query: 368 GLLKKRCKDKNI 403
L + K +++
Sbjct: 392 NELLEAIKSRDL 403
>sp|Q9QWY8|DDEF1_MOUSE 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1
GTPase-activating protein (PIP2-dependent ARF1 GAP)
(ADP-ribosylation factor-directed GTPase-activating
protein 1) (ARF GTPase-activating protein 1)
(Development and differentiation-enhancing factor 1)
(Differentiation-enhancing factor 1) (DEF-1)
Length = 1147
Score = 65.9 bits (159), Expect = 1e-10
Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Frame = +2
Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187
+PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+
Sbjct: 463 LPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 522
Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVK 331
+GN ND LP P + +R+ +I AKY +FS K
Sbjct: 523 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 570
>sp|O97902|DDEF1_BOVIN 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1
GTPase-activating protein (PIP2-dependent ARF1 GAP)
(ADP-ribosylation factor-directed GTPase-activating
protein 1) (ARF GTPase-activating protein 1)
(Development and differentiation-enhancing factor 1)
(Differentiation-enhancing factor 1) (DEF-1)
Length = 1129
Score = 65.5 bits (158), Expect = 2e-10
Identities = 39/132 (29%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +2
Query: 14 VPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKISDLEIEEV 187
+PGN++C DC + +P ++ + IL C +C+G+HR M R++ L DK+ E+
Sbjct: 451 LPGNDVCCDCGSAEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLA 510
Query: 188 LKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKL 367
+GN ND LP P + +R+ +I AKY +FS K ++ KL
Sbjct: 511 KNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSS---SSAKL 567
Query: 368 GLLKKRCKDKNI 403
L + K +++
Sbjct: 568 NELLEAIKSRDL 579
>sp|O74345|UCP3_SCHPO UBA-domain containing protein 3
Length = 601
Score = 59.7 bits (143), Expect = 1e-08
Identities = 42/133 (31%), Positives = 67/133 (50%), Gaps = 3/133 (2%)
Frame = +2
Query: 11 NVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSMEN--VRVKDLNFDKISDLEIEE 184
+V GN LCADC+ + + I +C +CA +HR + +VK ++ D+ S+ +IE+
Sbjct: 16 SVSGNNLCADCSTRGVQWASWNLGIFLCLRCATIHRKLGTHVSKVKSISLDEWSNDQIEK 75
Query: 185 VLKLGNKKSNDGYLKFLPIFYRLP-NANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQ 361
+ GN +N Y P+ + LP NA E + +I KY+ K F +D + TN
Sbjct: 76 MKHWGNINAN-RYWNPNPLSHPLPTNALSDEHVMEKYIRDKYERKLF----LDENHSTNS 130
Query: 362 KLGLLKKRCKDKN 400
K L R K +
Sbjct: 131 KPPSLPPRTKSSS 143
>sp|Q8BZ05|CEND1_MOUSE Centaurin-delta 1 (Cnt-d1)
Length = 1703
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/111 (33%), Positives = 61/111 (54%), Gaps = 4/111 (3%)
Frame = +2
Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKI--SD 169
K++ N CADC A P + ++ ++IC+KCAG HRS+ ++ +V+ L D S+
Sbjct: 688 KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDCKVRSLKMDASIWSN 747
Query: 170 LEIEEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQF 322
IE + +GNK++ND + L L + P R++FI KY+ +F
Sbjct: 748 ELIELFIVIGNKRANDFWAGNLQKDEEL-QVDSPVEKRKNFITQKYKEGKF 797
>sp|Q8WZ64|CEND1_HUMAN Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and
pleckstrin homology domain-containing protein 2) (PARX
protein)
Length = 1704
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/111 (33%), Positives = 62/111 (55%), Gaps = 4/111 (3%)
Frame = +2
Query: 2 KLYNVPGNELCADCNAEKPGYVVLSYNILICRKCAGVHRSM--ENVRVKDLNFDKI--SD 169
K++ N CADC A P + ++ ++IC+KCAG HRS+ ++ +V+ L D S+
Sbjct: 690 KIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSN 749
Query: 170 LEIEEVLKLGNKKSNDGYLKFLPIFYRLPNANGPEILRRSFIIAKYQLKQF 322
IE + +GNK++ND + L L + + P R++FI KY+ +F
Sbjct: 750 ELIELFIVIGNKRANDFWAGNLQKDEEL-HMDSPVEKRKNFITQKYKEGKF 799
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,895,963
Number of Sequences: 369166
Number of extensions: 1616190
Number of successful extensions: 3634
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3523
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3615
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)