Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_F12
(823 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-acti... 109 1e-23
sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 91 3e-18
sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 85 3e-16
sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 83 8e-16
sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing... 43 0.001
sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing... 40 0.006
sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing... 37 0.050
sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing p... 37 0.050
sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing... 37 0.050
sp|P14375|ZRAR_ECOLI Transcriptional regulatory protein zraR 32 1.6
>sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-activating protein PM25)
Length = 374
Score = 109 bits (272), Expect = 1e-23
Identities = 73/253 (28%), Positives = 123/253 (48%), Gaps = 4/253 (1%)
Frame = +2
Query: 23 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 202
+P FY P + ++LR +I AKY+ ++F E PY + G L KR +D + +
Sbjct: 89 VPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLS 148
Query: 203 RFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF----IENPDSRARI 370
R F L+ + YF NR K +PK ++++ +NATF I +P
Sbjct: 149 RKFVLTEREGALKYF---------NRNDAK-EPKAVMKIEHLNATFQPAKIGHPHG---- 194
Query: 371 PDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAYVVGTGDEANELE 550
L +++ + S R+I++ ++ VDW+ +R A+F G A++ +
Sbjct: 195 ----LQVTYLKDN--STRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPG----ASDAD 244
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGERSR 730
L L+ + G+M KTG + TE ++KRW + RRL+Y PL +GE+ IG +
Sbjct: 245 LVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKES 304
Query: 731 GYGAVLSSPPNAR 769
GY + PP+ +
Sbjct: 305 GYTVLHGFPPSTQ 317
>sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2
Length = 381
Score = 91.3 bits (225), Expect = 3e-18
Identities = 74/255 (29%), Positives = 119/255 (46%), Gaps = 6/255 (2%)
Frame = +2
Query: 23 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 202
+P FY +P AN +L+ +I AKY+ ++F + + + + + G L KR +D + +
Sbjct: 93 VPAFYYIPQANDCLVLKEQWIRAKYERREF-MADGETISLPGNREGFLWKRGRDNSQFLR 151
Query: 203 RFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF----IENPDSRARI 370
R F L + YF KE S PK + + +NATF I +P
Sbjct: 152 RKFVLLAREGLLKYFTKEQGKS----------PKAVISIKDLNATFQTEKIGHPHG---- 197
Query: 371 PDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAYVVGTGDEANELE 550
L I++ R + R++++ + ++ VDW+ +R A R Y+ E E E
Sbjct: 198 ----LQITYRR--DGHTRNLFVYHESGKEIVDWFNALRAA----RLQYLKMAFPELPESE 247
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIGER 724
L LT + G+M KTG + E ++KRW L RRLLY PL +G++ +G +
Sbjct: 248 LVPFLTRNYLKQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNK 307
Query: 725 SRGYGAVLSSPPNAR 769
+GY A P R
Sbjct: 308 EQGYEAYEDLPKGIR 322
>sp|Q9JK15|CENA2_RAT Centaurin-alpha 2
Length = 376
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/244 (27%), Positives = 116/244 (47%), Gaps = 6/244 (2%)
Frame = +2
Query: 23 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 202
+P FY +P A+ +L+ +I AKY+ ++F ++ P + G L KR +D + +
Sbjct: 93 VPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSP--PGDREGFLWKRGRDNSQFLR 150
Query: 203 RFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF----IENPDSRARI 370
R F L + Y+ KE + PK + + +NATF I +P
Sbjct: 151 RRFVLLSREGLLKYYTKEEGKT----------PKAIINIKDLNATFQTEKIGHPHG---- 196
Query: 371 PDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAYVVGTGDEANELE 550
L I++ ++E R++++ ++ ++ VDW+ +R A R Y+ + E E
Sbjct: 197 ----LQITY--RKEGQTRNLFVYHDSGKEIVDWFNALRAA----RLQYLKLAFPDLPESE 246
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIGER 724
L +T + G+M KTG + E ++KRW L RRLLY PL +G++ +G
Sbjct: 247 LVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSN 306
Query: 725 SRGY 736
+GY
Sbjct: 307 EQGY 310
>sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2
Length = 381
Score = 83.2 bits (204), Expect = 8e-16
Identities = 70/246 (28%), Positives = 115/246 (46%), Gaps = 8/246 (3%)
Frame = +2
Query: 23 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSV--KEVDRPYITNQKLGLLKKRCKDKNIY 196
+P FY +P AN +L+ +I AKY+ ++F+ K V P + G L KR +D +
Sbjct: 93 VPAFYYVPQANDCLVLKEQWIRAKYERQEFTAIDKAVSHP---GNREGFLWKRGRDNAQF 149
Query: 197 NARFFRLSISDITFNYFIKETDASSYNRPQMKLDPKRNLRLDRINATF----IENPDSRA 364
R F L + Y+ KE + PK + + +NATF I +P
Sbjct: 150 LRRRFVLLSREGLLKYYTKEEGKA----------PKAVISIKDLNATFQTEKIGHPHG-- 197
Query: 365 RIPDELLMISFFRQEEASWRHIYLKSNTPEDPVDWYQTIRFAKFSLRAAYVVGTGDEANE 544
L I++ ++E R++++ ++ ++ VDW+ +R A R Y+ + E
Sbjct: 198 ------LQITY--RKEGHTRNLFVYHDSGKEIVDWFNALRAA----RLQYLKLAFPDLPE 245
Query: 545 LELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIG 718
EL +T + G+M KTG + E ++KRW L RRLLY PL G++ +G
Sbjct: 246 SELVPLITRNYLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFELGQVFLG 305
Query: 719 ERSRGY 736
+GY
Sbjct: 306 SNEQGY 311
>sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing protein family A member 6
(Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Length = 1173
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/82 (32%), Positives = 40/82 (48%)
Frame = +2
Query: 425 HIYLKSNTPEDPVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKT 604
H + PE P IR + S +A + G A+ ++ R+ +T +GW+YK
Sbjct: 20 HNMVSEVPPERP-----NIRATRTSRKA---IAFGKRAHSMK--RNPNAPVTKAGWLYKQ 69
Query: 605 GSQLTEQWQKRWCVLLGRRLLY 670
S +QW KRW VL+ R L Y
Sbjct: 70 ASSGVKQWNKRWFVLVDRCLFY 91
>sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing protein family A member 6
(Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Length = 1048
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/40 (40%), Positives = 24/40 (60%)
Frame = +2
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLY 670
+ R+ +T +GW++K S +QW KRW VL+ R L Y
Sbjct: 52 MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFY 91
>sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 779
Score = 37.4 bits (85), Expect = 0.050
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Frame = +2
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGE--- 721
L RD L + + GW++K S W++RW VL G L Y G +++
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNI 106
Query: 722 RSRGYGAVLSSPPNARSVMTDQSP 793
R G GA P R T + P
Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP 126
>sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 779
Score = 37.4 bits (85), Expect = 0.050
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Frame = +2
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVI---GE 721
L RD L + + GW++K S W++RW VL G L Y G +++
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSV 106
Query: 722 RSRGYGAVLSSPPNARSVMTDQSP 793
R G GA P R T + P
Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP 126
>sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 588
Score = 37.4 bits (85), Expect = 0.050
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Frame = +2
Query: 551 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVI---GE 721
L RD L + + GW++K S W++RW VL G L Y G +++
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSV 106
Query: 722 RSRGYGAVLSSPPNARSVMTDQSP 793
R G GA P R T + P
Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP 126
>sp|P14375|ZRAR_ECOLI Transcriptional regulatory protein zraR
Length = 441
Score = 32.3 bits (72), Expect = 1.6
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 5/82 (6%)
Frame = +2
Query: 323 RINATFIENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDP-----VDWYQTIRF 487
R+N IE P R R D L+ F Q A +K TP+ DW IR
Sbjct: 301 RLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE 360
Query: 488 AKFSLRAAYVVGTGDEANELEL 553
+ ++ A V+ TG+ +E EL
Sbjct: 361 LENAVERAVVLLTGEYISEREL 382
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,108,888
Number of Sequences: 369166
Number of extensions: 1879350
Number of successful extensions: 4105
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3963
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4096
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)