Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00084 (1142 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q8NEZ4|MLL3_HUMAN Myeloid/lymphoid or mixed-lineage leuk... 45 5e-04 sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leuk... 44 9e-04 sp|P27398|CAND_DROME Calpain D (Calcium-activated neutral p... 44 0.001 sp|P32022|GIL1_ENTHI Galactose-inhibitable lectin 170 kDa s... 41 0.007 sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL... 40 0.016 sp|P97953|VEGFC_MOUSE Vascular endothelial growth factor C ... 39 0.021 sp|P49792|RBP2_HUMAN Ran-binding protein 2 (RanBP2) (Nuclea... 39 0.021 sp|P26012|ITB8_HUMAN Integrin beta-8 precursor 39 0.028 sp|P49767|VEGFC_HUMAN Vascular endothelial growth factor C ... 39 0.028 sp|Q03376|BAR3_CHITE Balbiani ring protein 3 precursor 39 0.028
>sp|Q8NEZ4|MLL3_HUMAN Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein) Length = 4911 Score = 44.7 bits (104), Expect = 5e-04 Identities = 52/220 (23%), Positives = 76/220 (34%), Gaps = 11/220 (5%) Frame = +2 Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKLETWTC--CK----C 265 C C + + L + C C + + + DI + K W C CK C Sbjct: 344 CAVCDSPGDLLDQFFCTTCGQ---------HYHGMCLDIAVTPLKRAGWQCPECKVCQNC 394 Query: 266 GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGEECL 445 S D +C C KG H V++S N W+CK C C+ Sbjct: 395 KQSGEDSKMLVCDTCD------KGY----HTFCLQPVMKSVPTNGWKCKNCRI-----CI 439 Query: 446 SCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITK---HCSECKRG-EIICDD 613 C S + +C C + ++ C CG+ + K HC+ CKR + CD Sbjct: 440 ECGTRSSSQWH-HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDK 498 Query: 614 LCGDCLKVRNK-TWTCSYRFCENRNPGNVKYCKHCGLDRD 730 L + K + C YCKH G + D Sbjct: 499 PTDHELDTQLKEEYIC-------------MYCKHLGAEMD 525
Score = 33.9 bits (76), Expect = 0.90 Identities = 26/106 (24%), Positives = 38/106 (35%), Gaps = 2/106 (1%) Frame = +2 Query: 407 CKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHCSEC 586 C QC C+S K + + W C +CT+ C ACG+ + C +C Sbjct: 977 CSQCGQCYHPYCVSIKITKVVLSKGWRCLECTV--------CEACGKATDPGRLLLCDDC 1028 Query: 587 KRGEIICDDLCGD--CLKVRNKTWTCSYRFCENRNPGNVKYCKHCG 718 +I C D V W C + +C+HCG Sbjct: 1029 ---DISYHTYCLDPPLQTVPKGGWKCKW----------CVWCRHCG 1061
>sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) Length = 4903 Score = 43.9 bits (102), Expect = 9e-04 Identities = 52/220 (23%), Positives = 76/220 (34%), Gaps = 11/220 (5%) Frame = +2 Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKLETWTC--CK----C 265 C C + + L + C C + + + DI + K W C CK C Sbjct: 343 CAVCDSPGDLLDQFFCTTCGQ---------HYHGMCLDIAVTPLKRAGWQCPECKVCQNC 393 Query: 266 GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGEECL 445 S D +C C KG H V++S N W+CK C C+ Sbjct: 394 KQSGEDSKMLVCDTCD------KGY----HTFCLQPVMKSVPTNGWKCKNCRI-----CI 438 Query: 446 SCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITK---HCSECKRG-EIICDD 613 C S + +C C + ++ C CG+ + K HC+ CKR + CD Sbjct: 439 ECGTRSSTQWH-HNCLICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDK 497 Query: 614 LCGDCLKVRNK-TWTCSYRFCENRNPGNVKYCKHCGLDRD 730 L + K + C YCKH G + D Sbjct: 498 PTDQELDSQLKEDYIC-------------MYCKHLGAEID 524
Score = 34.3 bits (77), Expect = 0.69 Identities = 38/160 (23%), Positives = 54/160 (33%), Gaps = 24/160 (15%) Frame = +2 Query: 311 GVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECV------NGEE-----CLSCKP 457 GVS DI D + V+ +K+ +Q CV G E C C Sbjct: 916 GVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQ 975 Query: 458 CQSP---RLEI--------WSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEII 604 C P ++I W C +CT+ C ACG+ + C +C +I Sbjct: 976 CYHPYCVSIKITKVVLSKGWRCLECTV--------CEACGKATDPGRLLLCDDC---DIS 1024 Query: 605 CDDLCGD--CLKVRNKTWTCSYRFCENRNPGNVKYCKHCG 718 C D V W C + +C+HCG Sbjct: 1025 YHTYCLDPPLQTVPKGGWKCKW----------CVWCRHCG 1054
>sp|P27398|CAND_DROME Calpain D (Calcium-activated neutral proteinase D) (CANP D) (Small optic lobes protein) Length = 1594 Score = 43.5 bits (101), Expect = 0.001 Identities = 36/147 (24%), Positives = 50/147 (34%), Gaps = 16/147 (10%) Frame = +2 Query: 80 GEKQQVWICYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKL------ 241 G + ++WIC C N L C+ C + K E + ++ + ++ Sbjct: 641 GSRSKMWICIKCSYAYNRLWLQTCEMC-----EAKAEQQQQQLQLQQQQQQQQQHHHHHL 695 Query: 242 ----------ETWTCCKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGD 391 E WTC KC N T C CG SK+ ISS E + Sbjct: 696 QQQQAEAPRDEPWTCKKCTLVNYS-TAMACVVCGGSKL---------KSISSIEDMTLRK 745 Query: 392 VNKWRCKQCECVNGEECLSCKPCQSPR 472 W C C N C C+S R Sbjct: 746 GEFWTCSHCTLKNSLHSPVCSACKSHR 772
Score = 42.0 bits (97), Expect = 0.003 Identities = 34/156 (21%), Positives = 55/156 (35%) Frame = +2 Query: 248 WTCCKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECV 427 W C KC + N L C+ C + K E + + +Q + Sbjct: 647 WICIKCSYAYNRLWLQTCEMC-----EAKAEQQQQQLQLQQQ------------QQQQQQ 689 Query: 428 NGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEIIC 607 + L + ++PR E W+CK+CT+ N + C CG I+ Sbjct: 690 HHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISS------------ 737 Query: 608 DDLCGDCLKVRNKTWTCSYRFCENRNPGNVKYCKHC 715 D + + WTCS+ C +N + C C Sbjct: 738 ---IEDMTLRKGEFWTCSH--CTLKNSLHSPVCSAC 768
>sp|P32022|GIL1_ENTHI Galactose-inhibitable lectin 170 kDa subunit Length = 1276 Score = 40.8 bits (94), Expect = 0.007 Identities = 40/181 (22%), Positives = 70/181 (38%), Gaps = 7/181 (3%) Frame = +2 Query: 194 NKDKINADINKSCEKLETWTCCKCGNSNNDLTRSIC--QRCGVSKVDIKGESDVDHIISS 367 N + N+ ++ C+ T CK N DL R C +RC + E+ VD + Sbjct: 602 NGNYCNSKNHEICDYTGTTPQCKVSNCTEDLVRDGCLIKRCNETSKTTYWEN-VDCSNTK 660 Query: 368 YEVIESGDVNKWRCKQ---CECVNGEECLSCKPCQSPRLEIWSCKQCTMR--NKISEDHC 532 E + D ++ CKQ C+NG+ C ++ +S C Sbjct: 661 IEFAKD-DKSETMCKQYYSTTCLNGK--------------------CVVQAVGDVSNVGC 699 Query: 533 AACGEVNENRITKHCSECKRGEIICDDLCGDCLKVRNKTWTCSYRFCENRNPGNVKYCKH 712 C +N IT H +C + C + G C+K + +++C + + + + C Sbjct: 700 GYCSMGTDNIITYH-DDCNSRKSQCGNFNGKCIKGSDNSYSCVFEKDKTSSKSDNDICAE 758 Query: 713 C 715 C Sbjct: 759 C 759
>sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein) Length = 816 Score = 39.7 bits (91), Expect = 0.016 Identities = 42/143 (29%), Positives = 56/143 (39%), Gaps = 26/143 (18%) Frame = +2 Query: 257 CKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGE 436 C C N +DL S C C D + S H + V SGD C+QC C+ GE Sbjct: 677 CDCENPTDDL--SCCPEC-----DPRLSSQCLHQ-NGETVYNSGDTWVQDCRQCRCLQGE 728 Query: 437 ECLSCKPCQSPRLEI--------WSCKQC--------TMRNKISEDHCAACGEVNENRIT 568 + C P P +E C +C T+RN I++ E+N R T Sbjct: 729 --VDCWPLACPEVECEFSVLPENECCPRCVTDPCQADTIRNDITK---TCLDEMNVVRFT 783 Query: 569 -----KHCSE-----CKRGEIIC 607 KH +E CK G + C Sbjct: 784 GSSWIKHGTECTLCQCKNGHLCC 806
>sp|P97953|VEGFC_MOUSE Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor related protein) (VRP) (Flt4 ligand) (Flt4-L) Length = 415 Score = 39.3 bits (90), Expect = 0.021 Identities = 49/189 (25%), Positives = 65/189 (34%), Gaps = 24/189 (12%) Frame = +2 Query: 221 NKSCEKLETWT--CCKC---------GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISS 367 NK+C W C+C N +D T CG +K E D D Sbjct: 236 NKTCPTNYVWNNYMCRCLAQQDFIFYSNVEDDSTNGFHDVCGPNK-----ELDEDTC--- 287 Query: 368 YEVIESGDVNKWRCKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGE 547 QC C G SC P + L+ SC QC +NK+ + C A E Sbjct: 288 ---------------QCVCKGGLRPSSCGPHKE--LDRDSC-QCVCKNKLFPNSCGANRE 329 Query: 548 VNENRITKHCSE-CKRGEIICDDLCG-DCL-----------KVRNKTWTCSYRFCENRNP 688 +EN C C R + + C +C K ++T +C R C NR Sbjct: 330 FDENTCQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCANR-- 387 Query: 689 GNVKYCKHC 715 KHC Sbjct: 388 -----LKHC 391
>sp|P49792|RBP2_HUMAN Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270) Length = 3224 Score = 39.3 bits (90), Expect = 0.021 Identities = 59/285 (20%), Positives = 87/285 (30%), Gaps = 58/285 (20%) Frame = +2 Query: 77 FGEKQQVWICYACGNINNDLSRLLCQKC-----------------FEWKVDVKGESNKDK 205 F +K+ W C +C + N+ + C C F++ ++ K Sbjct: 1540 FAKKEGQWDCSSC-LVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSG 1598 Query: 206 INADINKSCEKLETWTCCKCGNSNN-DLTRSI-CQRCG-----VSKVDIKGESDVDHIIS 364 K K W C C N T+ I CQ G S V S+ Sbjct: 1599 FEGMFTK---KEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPK 1655 Query: 365 S-YEVIESGDVNKWRCKQCECVNGEECLSCKPCQSPRLEI-------------------- 481 S +E + + +W C C N C CQ+P + Sbjct: 1656 SGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKS 1715 Query: 482 ------------WSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEIICDDLCG- 622 W C C +RN+ S C AC ++ T S EI G Sbjct: 1716 GFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGF 1775 Query: 623 DCLKVRNKTWTCSYRFCENRNPGNVKYCKHCGLDRDARKIDIGAP 757 + + +R W CS C +N + C C + K AP Sbjct: 1776 EGMFIRKGQWDCS--VCCVQNESSSLKCVACDASKPTHKPIAEAP 1818
Score = 35.8 bits (81), Expect = 0.24 Identities = 43/199 (21%), Positives = 59/199 (29%), Gaps = 53/199 (26%) Frame = +2 Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKG--ESNKDKINADINKSCEKLETWTCCKCGNSN 277 C +C N+N L+ E K E+ +D+ K K W C C Sbjct: 1372 CVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPK---KEGHWDCSIC-LVR 1427 Query: 278 NDLTRSICQRCGVSKVDIKGESDVDH--------------IISSYEVIESGDVNKWRCKQ 415 N+ T S C C +K K S H I S + + S +W C Sbjct: 1428 NEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSA 1487 Query: 416 CECVNGEECLSCKPCQSPRLEI-------------------------------------W 484 C N C CQ+PR + W Sbjct: 1488 CLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQW 1547 Query: 485 SCKQCTMRNKISEDHCAAC 541 C C +RN+ + C AC Sbjct: 1548 DCSSCLVRNEANATRCVAC 1566
Score = 30.8 bits (68), Expect = 7.6 Identities = 31/146 (21%), Positives = 46/146 (31%), Gaps = 25/146 (17%) Frame = +2 Query: 482 WSCKQCTMRNKISEDHCAACGEVNENR-------ITKHCSECKRGEIICDDLCGDCLKVR 640 W C C+++N + C +C +N + + + K D + Sbjct: 1356 WHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKK 1415 Query: 641 NKTWTCSYRFCENRNPGNVKYCKHCGLDRDARKIDIG----APMWRCTGDVpreI----- 793 W CS C RN V C C + A K A GD+P+ I Sbjct: 1416 EGHWDCS--ICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFR 1473 Query: 794 ---------WICDKCYDINDISHSYC 844 W C C N+ S + C Sbjct: 1474 SVFSTKEGQWDCSACLVQNEGSSTKC 1499
>sp|P26012|ITB8_HUMAN Integrin beta-8 precursor Length = 769 Score = 38.9 bits (89), Expect = 0.028 Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 8/68 (11%) Frame = +2 Query: 407 CKQCECVN----GEECLSCKPCQSPRLEIWSCKQCTMRNKISE---DHC-AACGEVNENR 562 C +CEC + G C C C + E W+C QC + +S+ D C +C + + Sbjct: 609 CGRCECTDPRSIGRFCEHCPTCYTACKENWNCMQCLHPHNLSQAILDQCKTSCALMEQQH 668 Query: 563 ITKHCSEC 586 SEC Sbjct: 669 YVDQTSEC 676
Score = 30.8 bits (68), Expect = 7.6 Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 44/214 (20%) Frame = +2 Query: 389 DVNKWRCKQCECVNGEECLSCKPCQSPRLE-------IWSCKQCTMRN----KISEDHCA 535 D ++C + +C E+ S + C+S + + + C +C+ K+ +C Sbjct: 488 DSKCFQCDENKCHFDEDQFSSESCKSHKDQPVCSGRGVCVCGKCSCHKIKLGKVYGKYCE 547 Query: 536 ----ACGEVNENRITKHCSECKRGEIIC-----DDLCG-------DCLKVRNKTW----T 655 +C + N H EC+ G C D C C+ + + T Sbjct: 548 KDDFSCPYHHGNLCAGH-GECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRGT 606 Query: 656 CSYRFCENRNPGNV-KYCKHCGLDRDARKIDIGAPMWRCTGDVpreIWICDKCYDINDIS 832 C CE +P ++ ++C+HC A K E W C +C +++S Sbjct: 607 CVCGRCECTDPRSIGRFCEHCPTCYTACK----------------ENWNCMQCLHPHNLS 650 Query: 833 HSYC------------RHKISHYSTCFNKPKYTK 898 + +H + S CF+ P Y + Sbjct: 651 QAILDQCKTSCALMEQQHYVDQTSECFSSPSYLR 684
>sp|P49767|VEGFC_HUMAN Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor related protein) (VRP) (Flt4 ligand) (Flt4-L) Length = 419 Score = 38.9 bits (89), Expect = 0.028 Identities = 46/168 (27%), Positives = 67/168 (39%), Gaps = 14/168 (8%) Frame = +2 Query: 221 NKSCEKLETWTCCKCGNSNNDLTRSICQRCGVSKVDIKGES-DVDHIISSYEVIESGDVN 397 NK+C W NN + R + Q + D +S D H I + +++ Sbjct: 240 NKTCPTNYMW--------NNHICRCLAQEDFMFSSDAGDDSTDGFHDICG----PNKELD 287 Query: 398 KWRCKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHC 577 + C QC C G SC P + L+ SC QC +NK+ C A E +EN C Sbjct: 288 EETC-QCVCRAGLRPASCGPHKE--LDRNSC-QCVCKNKLFPSQCGANREFDENTCQCVC 343 Query: 578 SE-CKRGEII--------CDDLCGDCL----KVRNKTWTCSYRFCENR 682 C R + + C + CL K ++T +C R C NR Sbjct: 344 KRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNR 391
>sp|Q03376|BAR3_CHITE Balbiani ring protein 3 precursor Length = 1700 Score = 38.9 bits (89), Expect = 0.028 Identities = 64/238 (26%), Positives = 84/238 (35%), Gaps = 53/238 (22%) Frame = +2 Query: 128 NDLSRLLCQKCFEW-KVDVKGESNKDKINADINKSCEKLETWTC--CKCGNSN------- 277 N S C EW KV + N K + C + W CKCG N Sbjct: 842 NSASMKTCLSPKEWNKVTCTCDCNPPKPDC-----CPGTQKWMDDKCKCGCPNAQTDCAG 896 Query: 278 ----NDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCK----------Q 415 ND T S C K+D G + + GDVN+ C Q Sbjct: 897 GKKFNDFTCSC--GCPSGKLDCTGNTKWS---AETCTCGCGDVNR-NCGNLKNFNDNLCQ 950 Query: 416 CECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHC----------AACG------- 544 CEC N +E +CK SPR + +C +N D C CG Sbjct: 951 CECKNKQEMANCK---SPRTWNYDTCKCVCKNADDSDDCVKPQIWLDDQCKCGCPASAQM 1007 Query: 545 --EVNENRITKHCS-ECK--------RGEIICDDLC-GDCLKVRNKTWTCSYRFCENR 682 N+ I K CS ECK +G+ +D C +C V KT R+C+N+ Sbjct: 1008 TCPANKRFIEKSCSCECKSPMPSPIPQGKKWNEDKCVVECANV--KTCEGPQRWCDNQ 1063
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 127,944,451 Number of Sequences: 369166 Number of extensions: 2756493 Number of successful extensions: 8973 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 7897 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8889 length of database: 68,354,980 effective HSP length: 112 effective length of database: 47,664,660 effective search space used: 12774128880 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)