Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_D07
(833 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P27398|CAND_DROME Calpain D (Calcium-activated neutral p... 44 7e-04
sp|Q8NEZ4|MLL3_HUMAN Myeloid/lymphoid or mixed-lineage leuk... 42 0.002
sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leuk... 42 0.002
sp|P32022|GIL1_ENTHI Galactose-inhibitable lectin 170 kDa s... 42 0.003
sp|P97953|VEGFC_MOUSE Vascular endothelial growth factor C ... 40 0.010
sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL... 40 0.010
sp|Q92832|NELL1_HUMAN Protein kinase C-binding protein NELL... 39 0.014
sp|P49792|RBP2_HUMAN Ran-binding protein 2 (RanBP2) (Nuclea... 39 0.014
sp|P49767|VEGFC_HUMAN Vascular endothelial growth factor C ... 39 0.014
sp|Q04592|PCSK5_MOUSE Proprotein convertase subtilisin/kexi... 39 0.014
>sp|P27398|CAND_DROME Calpain D (Calcium-activated neutral proteinase D) (CANP D) (Small
optic lobes protein)
Length = 1594
Score = 43.5 bits (101), Expect = 7e-04
Identities = 36/147 (24%), Positives = 50/147 (34%), Gaps = 16/147 (10%)
Frame = +2
Query: 80 GEKQQVWICYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKL------ 241
G + ++WIC C N L C+ C + K E + ++ + ++
Sbjct: 641 GSRSKMWICIKCSYAYNRLWLQTCEMC-----EAKAEQQQQQLQLQQQQQQQQQHHHHHL 695
Query: 242 ----------ETWTCCKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGD 391
E WTC KC N T C CG SK+ ISS E +
Sbjct: 696 QQQQAEAPRDEPWTCKKCTLVNYS-TAMACVVCGGSKL---------KSISSIEDMTLRK 745
Query: 392 VNKWRCKQCECVNGEECLSCKPCQSPR 472
W C C N C C+S R
Sbjct: 746 GEFWTCSHCTLKNSLHSPVCSACKSHR 772
Score = 43.5 bits (101), Expect = 7e-04
Identities = 35/156 (22%), Positives = 55/156 (35%)
Frame = +2
Query: 248 WTCCKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECV 427
W C KC + N L C+ C + K E + + +Q +
Sbjct: 647 WICIKCSYAYNRLWLQTCEMC-----EAKAEQQQQQLQLQQQ------------QQQQQQ 689
Query: 428 NGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEIIC 607
+ L + ++PR E W+CK+CT+ N + C CG I+
Sbjct: 690 HHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISS------------ 737
Query: 608 DDLCGDCLKVRNETWTCSYRFCENRNPGNVKYCKDC 715
D + E WTCS+ C +N + C C
Sbjct: 738 ---IEDMTLRKGEFWTCSH--CTLKNSLHSPVCSAC 768
>sp|Q8NEZ4|MLL3_HUMAN Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
(Histone-lysine N-methyltransferase, H3 lysine-4
specific MLL3) (Homologous to ALR protein)
Length = 4911
Score = 42.4 bits (98), Expect = 0.002
Identities = 47/198 (23%), Positives = 70/198 (35%), Gaps = 11/198 (5%)
Frame = +2
Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKLETWTC--CK----C 265
C C + + L + C C + + + DI + K W C CK C
Sbjct: 344 CAVCDSPGDLLDQFFCTTCGQ---------HYHGMCLDIAVTPLKRAGWQCPECKVCQNC 394
Query: 266 GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGEECL 445
S D +C C KG H V++S N W+CK C C+
Sbjct: 395 KQSGEDSKMLVCDTCD------KGY----HTFCLQPVMKSVPTNGWKCKNCRI-----CI 439
Query: 446 SCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITK---HCSECKRG-EIICDD 613
C S + +C C + ++ C CG+ + K HC+ CKR + CD
Sbjct: 440 ECGTRSSSQWH-HNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDK 498
Query: 614 LCGDCLKVR-NETWTCSY 664
L + E + C Y
Sbjct: 499 PTDHELDTQLKEEYICMY 516
Score = 30.4 bits (67), Expect = 6.3
Identities = 25/106 (23%), Positives = 37/106 (34%), Gaps = 2/106 (1%)
Frame = +2
Query: 407 CKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHCSEC 586
C QC C+S K + + W C +CT+ C ACG+ + C +C
Sbjct: 977 CSQCGQCYHPYCVSIKITKVVLSKGWRCLECTV--------CEACGKATDPGRLLLCDDC 1028
Query: 587 KRGEIICDDLCGD--CLKVRNETWTCSYRFCENRNPGNVKYCKDCG 718
+I C D V W C + +C+ CG
Sbjct: 1029 ---DISYHTYCLDPPLQTVPKGGWKCKW----------CVWCRHCG 1061
>sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
(Histone-lysine N-methyltransferase, H3 lysine-4
specific MLL3)
Length = 4903
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/172 (23%), Positives = 61/172 (35%), Gaps = 9/172 (5%)
Frame = +2
Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKGESNKDKINADINKSCEKLETWTC--CK----C 265
C C + + L + C C + + + DI + K W C CK C
Sbjct: 343 CAVCDSPGDLLDQFFCTTCGQ---------HYHGMCLDIAVTPLKRAGWQCPECKVCQNC 393
Query: 266 GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGEECL 445
S D +C C KG H V++S N W+CK C C+
Sbjct: 394 KQSGEDSKMLVCDTCD------KGY----HTFCLQPVMKSVPTNGWKCKNCRI-----CI 438
Query: 446 SCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITK---HCSECKR 592
C S + +C C + ++ C CG+ + K HC+ CKR
Sbjct: 439 ECGTRSSTQWH-HNCLICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKR 489
Score = 30.8 bits (68), Expect = 4.8
Identities = 37/160 (23%), Positives = 53/160 (33%), Gaps = 24/160 (15%)
Frame = +2
Query: 311 GVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECV------NGEE-----CLSCKP 457
GVS DI D + V+ +K+ +Q CV G E C C
Sbjct: 916 GVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQ 975
Query: 458 CQSP---RLEI--------WSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEII 604
C P ++I W C +CT+ C ACG+ + C +C +I
Sbjct: 976 CYHPYCVSIKITKVVLSKGWRCLECTV--------CEACGKATDPGRLLLCDDC---DIS 1024
Query: 605 CDDLCGD--CLKVRNETWTCSYRFCENRNPGNVKYCKDCG 718
C D V W C + +C+ CG
Sbjct: 1025 YHTYCLDPPLQTVPKGGWKCKW----------CVWCRHCG 1054
>sp|P32022|GIL1_ENTHI Galactose-inhibitable lectin 170 kDa subunit
Length = 1276
Score = 41.6 bits (96), Expect = 0.003
Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 7/181 (3%)
Frame = +2
Query: 194 NKDKINADINKSCEKLETWTCCKCGNSNNDLTRSIC--QRCGVSKVDIKGESDVDHIISS 367
N + N+ ++ C+ T CK N DL R C +RC + E+ VD +
Sbjct: 602 NGNYCNSKNHEICDYTGTTPQCKVSNCTEDLVRDGCLIKRCNETSKTTYWEN-VDCSNTK 660
Query: 368 YEVIESGDVNKWRCKQ---CECVNGEECLSCKPCQSPRLEIWSCKQCTMR--NKISEDHC 532
E + D ++ CKQ C+NG+ C ++ +S C
Sbjct: 661 IEFAKD-DKSETMCKQYYSTTCLNGK--------------------CVVQAVGDVSNVGC 699
Query: 533 AACGEVNENRITKHCSECKRGEIICDDLCGDCLKVRNETWTCSYRFCENRNPGNVKYCKD 712
C +N IT H +C + C + G C+K + +++C + + + + C +
Sbjct: 700 GYCSMGTDNIITYH-DDCNSRKSQCGNFNGKCIKGSDNSYSCVFEKDKTSSKSDNDICAE 758
Query: 713 C 715
C
Sbjct: 759 C 759
>sp|P97953|VEGFC_MOUSE Vascular endothelial growth factor C precursor (VEGF-C) (Vascular
endothelial growth factor related protein) (VRP) (Flt4
ligand) (Flt4-L)
Length = 415
Score = 39.7 bits (91), Expect = 0.010
Identities = 51/191 (26%), Positives = 69/191 (36%), Gaps = 24/191 (12%)
Frame = +2
Query: 221 NKSCEKLETWT--CCKC---------GNSNNDLTRSICQRCGVSKVDIKGESDVDHIISS 367
NK+C W C+C N +D T CG +K E D D
Sbjct: 236 NKTCPTNYVWNNYMCRCLAQQDFIFYSNVEDDSTNGFHDVCGPNK-----ELDEDTC--- 287
Query: 368 YEVIESGDVNKWRCKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGE 547
QC C G SC P + L+ SC QC +NK+ + C A E
Sbjct: 288 ---------------QCVCKGGLRPSSCGPHKE--LDRDSC-QCVCKNKLFPNSCGANRE 329
Query: 548 VNENRITKHCSE-CKRGEIICDDLCG-DCL-----------KVRNETWTCSYRFCENRNP 688
+EN C C R + + C +C K ++T +C R C NR
Sbjct: 330 FDENTCQCVCKRTCPRNQPLNPGKCACECTENTQKCFLKGKKFHHQTCSCYRRPCANR-- 387
Query: 689 GNVKYCKDCGL 721
+K+C D GL
Sbjct: 388 --LKHC-DPGL 395
>sp|Q61220|NELL2_MOUSE Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2)
(MEL91 protein)
Length = 816
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/143 (29%), Positives = 56/143 (39%), Gaps = 26/143 (18%)
Frame = +2
Query: 257 CKCGNSNNDLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGE 436
C C N +DL S C C D + S H + V SGD C+QC C+ GE
Sbjct: 677 CDCENPTDDL--SCCPEC-----DPRLSSQCLHQ-NGETVYNSGDTWVQDCRQCRCLQGE 728
Query: 437 ECLSCKPCQSPRLEI--------WSCKQC--------TMRNKISEDHCAACGEVNENRIT 568
+ C P P +E C +C T+RN I++ E+N R T
Sbjct: 729 --VDCWPLACPEVECEFSVLPENECCPRCVTDPCQADTIRNDITK---TCLDEMNVVRFT 783
Query: 569 -----KHCSE-----CKRGEIIC 607
KH +E CK G + C
Sbjct: 784 GSSWIKHGTECTLCQCKNGHLCC 806
>sp|Q92832|NELL1_HUMAN Protein kinase C-binding protein NELL1 precursor (NEL-like protein
1) (Nel-related protein 1)
Length = 810
Score = 39.3 bits (90), Expect = 0.014
Identities = 51/209 (24%), Positives = 76/209 (36%), Gaps = 18/209 (8%)
Frame = +2
Query: 113 CGNINNDLSRLLCQKCFEWKVDVKGESNKD----KINADINKSCEKLETWTCCKCGNSNN 280
C N+N+ C C ++ V+G + K+ A +N + +L C C +
Sbjct: 220 CPNLNHT-----CPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKT-- 272
Query: 281 DLTRSICQRCGVSKVDIKGESDVDHIISSYEVIESGDVNKWRCKQCECVNGE-EC--LSC 451
CQ G+ D D DH C+ C C +G EC +SC
Sbjct: 273 ------CQVSGLLYRDQDSWVDGDH-----------------CRNCTCKSGAVECRRMSC 309
Query: 452 KP--CQSPRLEIWSCKQCTMRNKISEDHCAACGEV---NENRITKHCSECKRGEII---- 604
P C L + QC K+ C G+V + +TK C EC+ G ++
Sbjct: 310 PPLNCSPDSLPVHIAGQCC---KVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITE 366
Query: 605 -CDDL-CGDCLKVRNETWTCSYRFCENRN 685
C L C + + E C R C N
Sbjct: 367 MCPPLNCSEKDHILPENQCC--RVCRGHN 393
Score = 33.5 bits (75), Expect = 0.74
Identities = 42/169 (24%), Positives = 61/169 (36%), Gaps = 11/169 (6%)
Frame = +2
Query: 251 TCCKCGNSNNDLTRSICQRCGVSKVDIKGESD-VDHIISSYEVIESGDVNKWRCKQCECV 427
T C C N + DL C C D + S +D + +++ SGD C+QC C+
Sbjct: 669 TACDCQNPSADLF--CCPEC-----DTRVTSQCLDQ--NGHKLYRSGDNWTHSCQQCRCL 719
Query: 428 NGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEIIC 607
GE + C P P L SC+ I E C C C +
Sbjct: 720 EGE--VDCWPLTCPNL---SCEY----TAILEGEC--------------CPRCVSDPCLA 756
Query: 608 DDLCGD----CL------KVRNETWTCSYRFCENRNPGNVKYCKDCGLD 724
D++ D CL ++ WT + C N + C C +D
Sbjct: 757 DNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVC--CSVD 803
Score = 30.4 bits (67), Expect = 6.3
Identities = 36/161 (22%), Positives = 58/161 (36%), Gaps = 4/161 (2%)
Frame = +2
Query: 188 ESNKDKINADINKSCEKLETWTCCKCGNS-NNDLTRSICQRCGVSKVDIKGESDVDHIIS 364
E ++ I + C L W C+C + ++D T S+ G S +DI + H
Sbjct: 552 ECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLS---GESCIDIDECALRTHTCW 608
Query: 365 SYEVIESGDVNKWRCKQCECVNGEECLSCKPCQSPRL---EIWSCKQCTMRNKISEDHCA 535
+ +S +N C C +G C P + ++W+ K ED C+
Sbjct: 609 N----DSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLK---------EDRCS 655
Query: 536 ACGEVNENRITKHCSECKRGEIICDDLCGDCLKVRNETWTC 658
C CK G+I C DC + + C
Sbjct: 656 VCS-------------CKDGKIFCRRTACDCQNPSADLFCC 683
>sp|P49792|RBP2_HUMAN Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358)
(Nucleoporin Nup358) (358 kDa nucleoporin) (P270)
Length = 3224
Score = 39.3 bits (90), Expect = 0.014
Identities = 59/285 (20%), Positives = 87/285 (30%), Gaps = 58/285 (20%)
Frame = +2
Query: 77 FGEKQQVWICYACGNINNDLSRLLCQKC-----------------FEWKVDVKGESNKDK 205
F +K+ W C +C + N+ + C C F++ ++ K
Sbjct: 1540 FAKKEGQWDCSSC-LVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSG 1598
Query: 206 INADINKSCEKLETWTCCKCGNSNN-DLTRSI-CQRCG-----VSKVDIKGESDVDHIIS 364
K K W C C N T+ I CQ G S V S+
Sbjct: 1599 FEGMFTK---KEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPK 1655
Query: 365 S-YEVIESGDVNKWRCKQCECVNGEECLSCKPCQSPRLEI-------------------- 481
S +E + + +W C C N C CQ+P +
Sbjct: 1656 SGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKS 1715
Query: 482 ------------WSCKQCTMRNKISEDHCAACGEVNENRITKHCSECKRGEIICDDLCG- 622
W C C +RN+ S C AC ++ T S EI G
Sbjct: 1716 GFEGMFTKKEGQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGF 1775
Query: 623 DCLKVRNETWTCSYRFCENRNPGNVKYCKDCGLDRDARKIDIGAP 757
+ + +R W CS C +N + C C + K AP
Sbjct: 1776 EGMFIRKGQWDCS--VCCVQNESSSLKCVACDASKPTHKPIAEAP 1818
Score = 35.8 bits (81), Expect = 0.15
Identities = 43/199 (21%), Positives = 59/199 (29%), Gaps = 53/199 (26%)
Frame = +2
Query: 104 CYACGNINNDLSRLLCQKCFEWKVDVKG--ESNKDKINADINKSCEKLETWTCCKCGNSN 277
C +C N+N L+ E K E+ +D+ K K W C C
Sbjct: 1372 CVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPK---KEGHWDCSIC-LVR 1427
Query: 278 NDLTRSICQRCGVSKVDIKGESDVDH--------------IISSYEVIESGDVNKWRCKQ 415
N+ T S C C +K K S H I S + + S +W C
Sbjct: 1428 NEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQWDCSA 1487
Query: 416 CECVNGEECLSCKPCQSPRLEI-------------------------------------W 484
C N C CQ+PR + W
Sbjct: 1488 CLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQW 1547
Query: 485 SCKQCTMRNKISEDHCAAC 541
C C +RN+ + C AC
Sbjct: 1548 DCSSCLVRNEANATRCVAC 1566
>sp|P49767|VEGFC_HUMAN Vascular endothelial growth factor C precursor (VEGF-C) (Vascular
endothelial growth factor related protein) (VRP) (Flt4
ligand) (Flt4-L)
Length = 419
Score = 39.3 bits (90), Expect = 0.014
Identities = 46/168 (27%), Positives = 67/168 (39%), Gaps = 14/168 (8%)
Frame = +2
Query: 221 NKSCEKLETWTCCKCGNSNNDLTRSICQRCGVSKVDIKGES-DVDHIISSYEVIESGDVN 397
NK+C W NN + R + Q + D +S D H I + +++
Sbjct: 240 NKTCPTNYMW--------NNHICRCLAQEDFMFSSDAGDDSTDGFHDICG----PNKELD 287
Query: 398 KWRCKQCECVNGEECLSCKPCQSPRLEIWSCKQCTMRNKISEDHCAACGEVNENRITKHC 577
+ C QC C G SC P + L+ SC QC +NK+ C A E +EN C
Sbjct: 288 EETC-QCVCRAGLRPASCGPHKE--LDRNSC-QCVCKNKLFPSQCGANREFDENTCQCVC 343
Query: 578 SE-CKRGEII--------CDDLCGDCL----KVRNETWTCSYRFCENR 682
C R + + C + CL K ++T +C R C NR
Sbjct: 344 KRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNR 391
>sp|Q04592|PCSK5_MOUSE Proprotein convertase subtilisin/kexin type 5 precursor (Proprotein
convertase PC5) (Subtilisin/kexin-like protease PC5)
(PC6) (Subtilisin-like proprotein convertase 6) (SPC6)
Length = 1877
Score = 39.3 bits (90), Expect = 0.014
Identities = 32/111 (28%), Positives = 44/111 (39%), Gaps = 8/111 (7%)
Frame = +2
Query: 407 CKQCECVNGEECLSCKPCQSPRLEIWSC-KQCT--MRNKISEDHCAACGEVNENRITKH- 574
C+ C +G++CLSCK E SC QC I ++ C C E + I H
Sbjct: 695 CESCFGSHGDQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHN 754
Query: 575 CSECKRGEII----CDDLCGDCLKVRNETWTCSYRFCENRNPGNVKYCKDC 715
C+ECK G + C C D +RFC + C +C
Sbjct: 755 CTECKGGLSLQGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINC 805
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,321,747
Number of Sequences: 369166
Number of extensions: 2154142
Number of successful extensions: 7579
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6761
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7504
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)