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Planaria EST Database

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00069
         (720 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q14669|TRI12_HUMAN  Thyroid receptor interacting protein ...   182   8e-46
sp|Q10435|YDE1_SCHPO  Probable ubiquitin fusion degradation ...   149   1e-35
sp|P33202|UFD4_YEAST  Ubiquitin fusion degradation protein 4...   143   4e-34
sp|Q8GY23|UPL1_ARATH  E3 ubiquitin protein ligase UPL1 (Ubiq...    96   1e-19
sp|Q9ULT8|HECD1_HUMAN  HECT domain containing protein 1            96   1e-19
sp|Q8H0T4|UPL2_ARATH  E3 ubiquitin protein ligase UPL2 (Ubiq...    94   3e-19
sp|P53119|HUL5_YEAST  Probable ubiquitin--protein ligase HUL5      87   4e-17
sp|Q8C863|ITCH_MOUSE  Itchy E3 ubiquitin protein ligase            87   4e-17
sp|Q96J02|ITCH_HUMAN  Itchy homolog E3 ubiquitin protein lig...    85   2e-16
sp|O13834|PTR1_SCHPO  E3 ubiquitin protein ligase ptr1 (Poly...    85   2e-16

>sp|Q14669|TRI12_HUMAN Thyroid receptor interacting protein 12 (TRIP12)
          Length = 1992

 Score =  182 bits (462), Expect = 8e-46
 Identities = 102/205 (49%), Positives = 127/205 (61%), Gaps = 1/205 (0%)
 Frame = +2

Query: 11   FVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGAR 190
            F  P +  IEL K G +  VT+H+L  YL LV    L EGV  Q +   +GF+S+ P + 
Sbjct: 1794 FTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLS- 1852

Query: 191  MHLSALFEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFT 370
             HL   +                   WD KTL E C  DHGYT +SR++  LFEI+S F 
Sbjct: 1853 -HLQYFYPEELDQLLCGSKA----DTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFD 1907

Query: 371  KEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNKK-EGGENPDNYLPSVMTCQNFLKLPD 547
             EQ+R F+QF TG+PRLPVGGFR+L PP  IV K  E  ENPD++LPSVMTC N+LKLPD
Sbjct: 1908 NEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 1967

Query: 548  YSSKEVMRQRLLYALHEGQNAFFLS 622
            YSS E+MR++LL A  EGQ +F LS
Sbjct: 1968 YSSIEIMREKLLIAAREGQQSFHLS 1992

>sp|Q10435|YDE1_SCHPO Probable ubiquitin fusion degradation protein C12B10.01c
          Length = 1647

 Score =  149 bits (375), Expect = 1e-35
 Identities = 84/205 (40%), Positives = 118/205 (57%), Gaps = 1/205 (0%)
 Frame = +2

Query: 11   FVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGAR 190
            F  P +  IELI DGA+  VT  ++S YL+ V + T+ +GV+ Q+E    GF S+ P   
Sbjct: 1450 FTLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTS 1509

Query: 191  MHLSALFEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFT 370
            + +    E               ++ W   TL +    DHGYTM S +I  L  +MS+  
Sbjct: 1510 LQVLTEHELVTLFGTV-------DEDWSYATLMKSIVADHGYTMESPTIQRLLTLMSQMN 1562

Query: 371  KEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNK-KEGGENPDNYLPSVMTCQNFLKLPD 547
             +++R F+QF TG+ +LP+GGF  L PP  +V +  E    PD+YLPSVMTC N+LKLP+
Sbjct: 1563 FQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPE 1622

Query: 548  YSSKEVMRQRLLYALHEGQNAFFLS 622
            YSS EV+  RL  A+ EGQ +F LS
Sbjct: 1623 YSSSEVLGSRLSKAILEGQGSFHLS 1647

>sp|P33202|UFD4_YEAST Ubiquitin fusion degradation protein 4 (UB fusion protein 4)
          Length = 1483

 Score =  143 bits (361), Expect = 4e-34
 Identities = 83/207 (40%), Positives = 115/207 (55%), Gaps = 1/207 (0%)
 Frame = +2

Query: 5    IVFVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPG 184
            + F  P    IELI  G N+ +   ++  Y+  V +  L +G+  Q++  IEGF  +   
Sbjct: 1284 LTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSY 1343

Query: 185  ARMHLSALFEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSE 364
             RM +  LF                 + W + TL      +HGYTM+S  I +   I+S 
Sbjct: 1344 ERMLI--LFPDELVDIFGRV-----EEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISA 1396

Query: 365  FTKEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNK-KEGGENPDNYLPSVMTCQNFLKL 541
            F K +RR F+QF TG+P+LP+GGF++L P F +V K  E G   D YLPSVMTC N+LKL
Sbjct: 1397 FGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKL 1456

Query: 542  PDYSSKEVMRQRLLYALHEGQNAFFLS 622
            P Y+SK++MR RL  A+ EG  AF LS
Sbjct: 1457 PKYTSKDIMRSRLCQAIEEGAGAFLLS 1483

>sp|Q8GY23|UPL1_ARATH E3 ubiquitin protein ligase UPL1 (Ubiquitin-protein ligase 1)
          Length = 3684

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 70/199 (35%), Positives = 98/199 (49%), Gaps = 4/199 (2%)
 Frame = +2

Query: 29   TQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSAL 208
            T  EL   G N  VT      Y+DLVA   L   +R Q+   +EGF+ L+P     L ++
Sbjct: 3492 TDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLEGFNELIP---RELVSI 3548

Query: 209  FEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRH 388
            F               D    D+K  TE  +    YT  S  I   +E++  F+KE    
Sbjct: 3549 FNDKELELLISGLPEIDFD--DLKANTEYTS----YTAGSPVIHWFWEVVKAFSKEDMAR 3602

Query: 389  FVQFCTGTPRLPVGGFRALR----PPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSS 556
            F+QF TGT ++P+ GF+AL+    P    ++K  G   P+  LPS  TC N L LP+Y S
Sbjct: 3603 FLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGA--PER-LPSAHTCFNQLDLPEYQS 3659

Query: 557  KEVMRQRLLYALHEGQNAF 613
            KE +++RLL A+HE    F
Sbjct: 3660 KEQLQERLLLAIHEASEGF 3678

>sp|Q9ULT8|HECD1_HUMAN HECT domain containing protein 1
          Length = 1620

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 55/191 (28%), Positives = 95/191 (49%)
 Frame = +2

Query: 26   YTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSA 205
            +T ++L   G + ++T+ +   Y+DL+ +  +  G++ QME   +GF+ + P  ++   +
Sbjct: 1433 FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFS 1492

Query: 206  LFEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRR 385
              E               +  W  + +        GYT +S   +    ++   + ++R+
Sbjct: 1493 HEEVQMILCGN------QSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERK 1546

Query: 386  HFVQFCTGTPRLPVGGFRALRPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEV 565
             F+QF TG   LP GG   L P   +V K +     D   PSV TC ++LKLP+YSS+E+
Sbjct: 1547 AFLQFTTGCSTLPPGGLANLHPRLTVVRKVDA---TDASYPSVNTCVHYLKLPEYSSEEI 1603

Query: 566  MRQRLLYALHE 598
            MR+RLL A  E
Sbjct: 1604 MRERLLAATME 1614

>sp|Q8H0T4|UPL2_ARATH E3 ubiquitin protein ligase UPL2 (Ubiquitin-protein ligase 2)
          Length = 3658

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 69/199 (34%), Positives = 100/199 (50%), Gaps = 4/199 (2%)
 Frame = +2

Query: 29   TQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSAL 208
            T  EL   G N  VT      Y+DLVA+  L   +R Q+   +EG + L+P     L ++
Sbjct: 3469 TDYELKPGGRNIRVTEETKHEYVDLVADHILTSAIRPQINAFLEGLNELIP---RELVSI 3525

Query: 209  FEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRH 388
            F               D    D+K  TE  +    YT+ S  I   +E++  F+KE    
Sbjct: 3526 FNDKELELLISGLPEIDFD--DLKANTEYTS----YTVGSPVIRWFWEVVKAFSKEDMAR 3579

Query: 389  FVQFCTGTPRLPVGGFRALR----PPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSS 556
            F+QF TGT ++P+ GF+AL+    P    ++K  G  +P+  LPS  TC N L LP+Y S
Sbjct: 3580 FLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYG--SPER-LPSAHTCFNQLDLPEYQS 3636

Query: 557  KEVMRQRLLYALHEGQNAF 613
            KE +++RLL A+HE    F
Sbjct: 3637 KEQVQERLLLAIHEANEGF 3655

>sp|P53119|HUL5_YEAST Probable ubiquitin--protein ligase HUL5
          Length = 910

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 57/190 (30%), Positives = 96/190 (50%), Gaps = 1/190 (0%)
 Frame = +2

Query: 35   IELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFE 214
            ++LI +G+   VT  ++ LY+  V +  L +     +     G   ++    M +    E
Sbjct: 728  VDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIE 787

Query: 215  AHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFV 394
                          D    D+K+ TE      GY    ++IV+ +E+++EF  E++ +F+
Sbjct: 788  LQMLISGERDNIDLD----DLKSNTEY----GGYKEEDQTIVDFWEVLNEFKFEEKLNFL 839

Query: 395  QFCTGTPRLPVGGFRALRPPFKIVNKKEGGENPDNY-LPSVMTCQNFLKLPDYSSKEVMR 571
            +F T  P+ P+ GF+AL P F I N        + Y LP+  TC N LKLPDY +K ++R
Sbjct: 840  KFVTSVPQAPLQGFKALDPKFGIRN-----AGTEKYRLPTASTCVNLLKLPDYRNKTILR 894

Query: 572  QRLLYALHEG 601
            ++LLYA++ G
Sbjct: 895  EKLLYAINSG 904

>sp|Q8C863|ITCH_MOUSE Itchy E3 ubiquitin protein ligase
          Length = 864

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 62/190 (32%), Positives = 89/190 (46%), Gaps = 3/190 (1%)
 Frame = +2

Query: 38   ELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFEA 217
            +L  +G N +VT  +   Y+ +VA   L  GV  Q +   EGF+ +LP   +     F+A
Sbjct: 680  DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY---FDA 736

Query: 218  HXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFVQ 397
                         D   W    +         YT  S+ I+  ++ + E   E+R   +Q
Sbjct: 737  KELEVLLCGMQEIDLNDWQRHAIYR------HYTRTSKQIMWFWQFVKEIDNEKRMRLLQ 790

Query: 398  FCTGTPRLPVGGFRAL---RPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEVM 568
            F TGT RLPVGGF  L     P K   +K G E   N+LP   TC N L LP Y S E +
Sbjct: 791  FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE---NWLPRSHTCFNRLDLPPYKSYEQL 847

Query: 569  RQRLLYALHE 598
            +++LL+A+ E
Sbjct: 848  KEKLLFAIEE 857

>sp|Q96J02|ITCH_HUMAN Itchy homolog E3 ubiquitin protein ligase (Itch)
            (Atrophin-1-interacting protein 4) (AIP4)
            (NFE2-associated polypeptide 1) (NAPP1)
          Length = 903

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 61/190 (32%), Positives = 88/190 (46%), Gaps = 3/190 (1%)
 Frame = +2

Query: 38   ELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFEA 217
            +L  +G N +VT  +   Y+ +VA   L  GV  Q +   EGF+ +LP   +     F+A
Sbjct: 719  DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY---FDA 775

Query: 218  HXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFVQ 397
                         D   W    +         Y   S+ I+  ++ + E   E+R   +Q
Sbjct: 776  KELEVLLCGMQEIDLNDWQRHAIYR------HYARTSKQIMWFWQFVKEIDNEKRMRLLQ 829

Query: 398  FCTGTPRLPVGGFRAL---RPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEVM 568
            F TGT RLPVGGF  L     P K   +K G E   N+LP   TC N L LP Y S E +
Sbjct: 830  FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE---NWLPRSHTCFNRLDLPPYKSYEQL 886

Query: 569  RQRLLYALHE 598
            +++LL+A+ E
Sbjct: 887  KEKLLFAIEE 896

>sp|O13834|PTR1_SCHPO E3 ubiquitin protein ligase ptr1 (Poly(A)+ RNA transport protein 1)
          Length = 3227

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 4/199 (2%)
 Frame = +2

Query: 29   TQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSAL 208
            T ++LI +G N  VT  +   Y++ + +  L E V+ Q++ +++GF  ++P    HL  +
Sbjct: 3038 TVVDLIPNGRNIPVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGFSDIIPS---HLIQI 3094

Query: 209  FEAHXXXXXXXXXXXXDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRH 388
            F               D   W  K  TE     HGY ++S  +   +  +  F +E+R  
Sbjct: 3095 FNEQELELLISGLPEIDIDDW--KNNTEY----HGYNVSSPQVQWFWRAVRSFDEEERAK 3148

Query: 389  FVQFCTGTPRLPVGGFRALRPPFKI----VNKKEGGENPDNYLPSVMTCQNFLKLPDYSS 556
             +QF TGT ++P+ GF+ L          ++K  G     N LP   TC N L LP+Y +
Sbjct: 3149 LLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSL---NRLPQSHTCFNQLDLPEYDT 3205

Query: 557  KEVMRQRLLYALHEGQNAF 613
             E +R  LL A++EG   F
Sbjct: 3206 YEQLRSMLLTAINEGSEGF 3224

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,872,642
Number of Sequences: 369166
Number of extensions: 1583053
Number of successful extensions: 3854
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3640
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3776
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6413660220
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

1. Dr_sW_002_L22
2. Dr_sW_005_D02