Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_L22
(717 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q14669|TRI12_HUMAN Thyroid receptor interacting protein ... 195 9e-50
sp|Q10435|YDE1_SCHPO Probable ubiquitin fusion degradation ... 157 3e-38
sp|P33202|UFD4_YEAST Ubiquitin fusion degradation protein 4... 154 2e-37
sp|Q9ULT8|HECD1_HUMAN HECT domain containing protein 1 107 2e-23
sp|Q8GY23|UPL1_ARATH E3 ubiquitin protein ligase UPL1 (Ubiq... 103 5e-22
sp|Q8H0T4|UPL2_ARATH E3 ubiquitin protein ligase UPL2 (Ubiq... 102 1e-21
sp|Q8C863|ITCH_MOUSE Itchy E3 ubiquitin protein ligase 99 1e-20
sp|Q96J02|ITCH_HUMAN Itchy homolog E3 ubiquitin protein lig... 97 4e-20
sp|P53119|HUL5_YEAST Probable ubiquitin--protein ligase HUL5 96 1e-19
sp|Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (E6AP ub... 94 3e-19
>sp|Q14669|TRI12_HUMAN Thyroid receptor interacting protein 12 (TRIP12)
Length = 1992
Score = 195 bits (496), Expect = 9e-50
Identities = 104/205 (50%), Positives = 135/205 (65%), Gaps = 1/205 (0%)
Frame = +2
Query: 11 FVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGAR 190
F P + IEL K G + VT+H+L YL LV L EGV Q + +GF+S+ P +
Sbjct: 1794 FTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSH 1853
Query: 191 MHLSALFEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFT 370
+ F E++++ CG + + WD KTL E C DHGYT +SR++ LFEI+S F
Sbjct: 1854 LQY---FYPEELDQLLCGSKADT---WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFD 1907
Query: 371 KEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNKK-EGGENPDNYLPSVMTCQNFLKLPD 547
EQ+R F+QF TG+PRLPVGGFR+L PP IV K E ENPD++LPSVMTC N+LKLPD
Sbjct: 1908 NEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 1967
Query: 548 YSSKEVMRQRLLYALHEGQNAFFLS 622
YSS E+MR++LL A EGQ +F LS
Sbjct: 1968 YSSIEIMREKLLIAAREGQQSFHLS 1992
>sp|Q10435|YDE1_SCHPO Probable ubiquitin fusion degradation protein C12B10.01c
Length = 1647
Score = 157 bits (396), Expect = 3e-38
Identities = 87/205 (42%), Positives = 125/205 (60%), Gaps = 1/205 (0%)
Frame = +2
Query: 11 FVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGAR 190
F P + IELI DGA+ VT ++S YL+ V + T+ +GV+ Q+E GF S+ P
Sbjct: 1450 FTLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTS 1509
Query: 191 MHLSALFEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFT 370
+ + HE+ +F G ++++ W TL + DHGYTM S +I L +MS+
Sbjct: 1510 LQV---LTEHELVTLF--GTVDED--WSYATLMKSIVADHGYTMESPTIQRLLTLMSQMN 1562
Query: 371 KEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNK-KEGGENPDNYLPSVMTCQNFLKLPD 547
+++R F+QF TG+ +LP+GGF L PP +V + E PD+YLPSVMTC N+LKLP+
Sbjct: 1563 FQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRLNEPPYVPDDYLPSVMTCVNYLKLPE 1622
Query: 548 YSSKEVMRQRLLYALHEGQNAFFLS 622
YSS EV+ RL A+ EGQ +F LS
Sbjct: 1623 YSSSEVLGSRLSKAILEGQGSFHLS 1647
>sp|P33202|UFD4_YEAST Ubiquitin fusion degradation protein 4 (UB fusion protein 4)
Length = 1483
Score = 154 bits (389), Expect = 2e-37
Identities = 89/207 (42%), Positives = 125/207 (60%), Gaps = 1/207 (0%)
Frame = +2
Query: 5 IVFVHPLYTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPG 184
+ F P IELI G N+ + ++ Y+ V + L +G+ Q++ IEGF +
Sbjct: 1284 LTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSY 1343
Query: 185 ARMHLSALFEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSE 364
RM + LF E+ +IF GR+E++ W + TL +HGYTM+S I + I+S
Sbjct: 1344 ERMLI--LFP-DELVDIF--GRVEED--WSMATLYTNLNAEHGYTMDSSIIHDFISIISA 1396
Query: 365 FTKEQRRHFVQFCTGTPRLPVGGFRALRPPFKIVNK-KEGGENPDNYLPSVMTCQNFLKL 541
F K +RR F+QF TG+P+LP+GGF++L P F +V K E G D YLPSVMTC N+LKL
Sbjct: 1397 FGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKL 1456
Query: 542 PDYSSKEVMRQRLLYALHEGQNAFFLS 622
P Y+SK++MR RL A+ EG AF LS
Sbjct: 1457 PKYTSKDIMRSRLCQAIEEGAGAFLLS 1483
>sp|Q9ULT8|HECD1_HUMAN HECT domain containing protein 1
Length = 1620
Score = 107 bits (268), Expect = 2e-23
Identities = 60/191 (31%), Positives = 101/191 (52%)
Frame = +2
Query: 26 YTQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSA 205
+T ++L G + ++T+ + Y+DL+ + + G++ QME +GF+ + P M +
Sbjct: 1433 FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFP---MEKLS 1489
Query: 206 LFEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRR 385
F E++ I CG + + W + + GYT +S + ++ + ++R+
Sbjct: 1490 SFSHEEVQMILCGNQ---SPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERK 1546
Query: 386 HFVQFCTGTPRLPVGGFRALRPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEV 565
F+QF TG LP GG L P +V K + D PSV TC ++LKLP+YSS+E+
Sbjct: 1547 AFLQFTTGCSTLPPGGLANLHPRLTVVRKVDA---TDASYPSVNTCVHYLKLPEYSSEEI 1603
Query: 566 MRQRLLYALHE 598
MR+RLL A E
Sbjct: 1604 MRERLLAATME 1614
>sp|Q8GY23|UPL1_ARATH E3 ubiquitin protein ligase UPL1 (Ubiquitin-protein ligase 1)
Length = 3684
Score = 103 bits (257), Expect = 5e-22
Identities = 72/199 (36%), Positives = 104/199 (52%), Gaps = 4/199 (2%)
Frame = +2
Query: 29 TQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSAL 208
T EL G N VT Y+DLVA L +R Q+ +EGF+ L+P L ++
Sbjct: 3492 TDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLEGFNELIP---RELVSI 3548
Query: 209 FEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRH 388
F E+E + G + + D+K TE + YT S I +E++ F+KE
Sbjct: 3549 FNDKELELLISG--LPEIDFDDLKANTEYTS----YTAGSPVIHWFWEVVKAFSKEDMAR 3602
Query: 389 FVQFCTGTPRLPVGGFRALR----PPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSS 556
F+QF TGT ++P+ GF+AL+ P ++K G P+ LPS TC N L LP+Y S
Sbjct: 3603 FLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGA--PER-LPSAHTCFNQLDLPEYQS 3659
Query: 557 KEVMRQRLLYALHEGQNAF 613
KE +++RLL A+HE F
Sbjct: 3660 KEQLQERLLLAIHEASEGF 3678
>sp|Q8H0T4|UPL2_ARATH E3 ubiquitin protein ligase UPL2 (Ubiquitin-protein ligase 2)
Length = 3658
Score = 102 bits (254), Expect = 1e-21
Identities = 71/199 (35%), Positives = 106/199 (53%), Gaps = 4/199 (2%)
Frame = +2
Query: 29 TQIELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSAL 208
T EL G N VT Y+DLVA+ L +R Q+ +EG + L+P L ++
Sbjct: 3469 TDYELKPGGRNIRVTEETKHEYVDLVADHILTSAIRPQINAFLEGLNELIP---RELVSI 3525
Query: 209 FEAHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRH 388
F E+E + G + + D+K TE + YT+ S I +E++ F+KE
Sbjct: 3526 FNDKELELLISG--LPEIDFDDLKANTEYTS----YTVGSPVIRWFWEVVKAFSKEDMAR 3579
Query: 389 FVQFCTGTPRLPVGGFRALR----PPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSS 556
F+QF TGT ++P+ GF+AL+ P ++K G +P+ LPS TC N L LP+Y S
Sbjct: 3580 FLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYG--SPER-LPSAHTCFNQLDLPEYQS 3636
Query: 557 KEVMRQRLLYALHEGQNAF 613
KE +++RLL A+HE F
Sbjct: 3637 KEQVQERLLLAIHEANEGF 3655
>sp|Q8C863|ITCH_MOUSE Itchy E3 ubiquitin protein ligase
Length = 864
Score = 99.0 bits (245), Expect = 1e-20
Identities = 66/190 (34%), Positives = 96/190 (50%), Gaps = 3/190 (1%)
Frame = +2
Query: 38 ELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFEA 217
+L +G N +VT + Y+ +VA L GV Q + EGF+ +LP + F+A
Sbjct: 680 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY---FDA 736
Query: 218 HEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFVQ 397
E+E + CG + D W + YT S+ I+ ++ + E E+R +Q
Sbjct: 737 KELEVLLCGMQEIDLNDWQRHAIYR------HYTRTSKQIMWFWQFVKEIDNEKRMRLLQ 790
Query: 398 FCTGTPRLPVGGFRAL---RPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEVM 568
F TGT RLPVGGF L P K +K G E N+LP TC N L LP Y S E +
Sbjct: 791 FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE---NWLPRSHTCFNRLDLPPYKSYEQL 847
Query: 569 RQRLLYALHE 598
+++LL+A+ E
Sbjct: 848 KEKLLFAIEE 857
>sp|Q96J02|ITCH_HUMAN Itchy homolog E3 ubiquitin protein ligase (Itch)
(Atrophin-1-interacting protein 4) (AIP4)
(NFE2-associated polypeptide 1) (NAPP1)
Length = 903
Score = 97.1 bits (240), Expect = 4e-20
Identities = 65/190 (34%), Positives = 95/190 (50%), Gaps = 3/190 (1%)
Frame = +2
Query: 38 ELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFEA 217
+L +G N +VT + Y+ +VA L GV Q + EGF+ +LP + F+A
Sbjct: 719 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY---FDA 775
Query: 218 HEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFVQ 397
E+E + CG + D W + Y S+ I+ ++ + E E+R +Q
Sbjct: 776 KELEVLLCGMQEIDLNDWQRHAIYR------HYARTSKQIMWFWQFVKEIDNEKRMRLLQ 829
Query: 398 FCTGTPRLPVGGFRAL---RPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEVM 568
F TGT RLPVGGF L P K +K G E N+LP TC N L LP Y S E +
Sbjct: 830 FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE---NWLPRSHTCFNRLDLPPYKSYEQL 886
Query: 569 RQRLLYALHE 598
+++LL+A+ E
Sbjct: 887 KEKLLFAIEE 896
>sp|P53119|HUL5_YEAST Probable ubiquitin--protein ligase HUL5
Length = 910
Score = 95.5 bits (236), Expect = 1e-19
Identities = 60/190 (31%), Positives = 105/190 (55%), Gaps = 1/190 (0%)
Frame = +2
Query: 35 IELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFE 214
++LI +G+ VT ++ LY+ V + L + + G ++ H +F
Sbjct: 728 VDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAP---HWMEMFN 784
Query: 215 AHEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFV 394
+ E++ + G R ++ L D+K+ TE GY ++IV+ +E+++EF E++ +F+
Sbjct: 785 SIELQMLISGER-DNIDLDDLKSNTEY----GGYKEEDQTIVDFWEVLNEFKFEEKLNFL 839
Query: 395 QFCTGTPRLPVGGFRALRPPFKIVNKKEGGENPDNY-LPSVMTCQNFLKLPDYSSKEVMR 571
+F T P+ P+ GF+AL P F I N + Y LP+ TC N LKLPDY +K ++R
Sbjct: 840 KFVTSVPQAPLQGFKALDPKFGIRN-----AGTEKYRLPTASTCVNLLKLPDYRNKTILR 894
Query: 572 QRLLYALHEG 601
++LLYA++ G
Sbjct: 895 EKLLYAINSG 904
>sp|Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (E6AP ubiquitin-protein ligase)
(Oncogenic protein-associated protein E6-AP) (Human
papillomavirus E6-associated protein)
Length = 875
Score = 94.4 bits (233), Expect = 3e-19
Identities = 67/185 (36%), Positives = 96/185 (51%)
Frame = +2
Query: 38 ELIKDGANRVVTVHDLSLYLDLVANVTLIEGVRAQMECVIEGFDSLLPGARMHLSALFEA 217
+L ++G +T + +++L ++ L + V Q + GF + + L LF
Sbjct: 695 DLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESP--LKYLFRP 752
Query: 218 HEIEEIFCGGRIEDNQLWDVKTLTEVCTCDHGYTMNSRSIVNLFEIMSEFTKEQRRHFVQ 397
EIE + CG R D Q L E D GYT +S I +EI+ FT EQ+R F+Q
Sbjct: 753 EEIELLICGSRNLDFQ-----ALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 807
Query: 398 FCTGTPRLPVGGFRALRPPFKIVNKKEGGENPDNYLPSVMTCQNFLKLPDYSSKEVMRQR 577
F TGT R PVGG L K++ K G + LP+ TC N L LP+YSSKE +++R
Sbjct: 808 FTTGTDRAPVGGLGKL----KMIIAKNGPDT--ERLPTSHTCFNVLLLPEYSSKEKLKER 861
Query: 578 LLYAL 592
LL A+
Sbjct: 862 LLKAI 866
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,414,839
Number of Sequences: 369166
Number of extensions: 1691103
Number of successful extensions: 4377
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4135
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4288
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6365071885
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)