Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_02646 (205 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P16333|NCK1_HUMAN Cytoplasmic protein NCK1 (NCK adaptor ... 65 5e-11 sp|O43639|NCK2_HUMAN Cytoplasmic protein NCK2 (NCK adaptor ... 62 3e-10 sp|P08630|BTKL_DROME Tyrosine-protein kinase Btk29A (Dsrc28C) 54 1e-07 sp|Q08509|EPS8_MOUSE Epidermal growth factor receptor kinas... 53 2e-07 sp|Q12929|EPS8_HUMAN Epidermal growth factor receptor kinas... 52 4e-07 sp|Q5R4H4|EPS8_PONPY Epidermal growth factor receptor kinas... 52 4e-07 sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T-cell... 50 1e-06 sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec 50 2e-06 sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec 49 4e-06 sp|P06241|FYN_HUMAN Proto-oncogene tyrosine-protein kinase ... 49 5e-06
>sp|P16333|NCK1_HUMAN Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha) Length = 377 Score = 65.1 bits (157), Expect = 5e-11 Identities = 29/50 (58%), Positives = 37/50 (74%) Frame = +2 Query: 53 MAVAKFDYKAVDLHELNINKGEKLTLVDDSQHWWQVMNSKGETGYVPSNY 202 + VAKFDY A EL+I K E+L L+DDS+ WW+V NS +TG+VPSNY Sbjct: 6 VVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNY 55
Score = 33.9 bits (76), Expect = 0.12 Identities = 15/57 (26%), Positives = 29/57 (50%), Gaps = 3/57 (5%) Frame = +2 Query: 41 QPVGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQH---WWQVMNSKGETGYVPSNY 202 Q + + A + + + + ELN KG+ + +++ ++ WW+ G G VP NY Sbjct: 190 QVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNY 246
>sp|O43639|NCK2_HUMAN Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2) Length = 380 Score = 62.4 bits (150), Expect = 3e-10 Identities = 27/50 (54%), Positives = 36/50 (72%) Frame = +2 Query: 53 MAVAKFDYKAVDLHELNINKGEKLTLVDDSQHWWQVMNSKGETGYVPSNY 202 + +AK+DY A EL+I K E+L L+DDS+ WW+V N+ TGYVPSNY Sbjct: 6 IVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNY 55
Score = 42.0 bits (97), Expect = 4e-04 Identities = 16/48 (33%), Positives = 29/48 (60%), Gaps = 3/48 (6%) Frame = +2 Query: 68 FDYKAVDLHELNINKGEKLTLVDDSQH---WWQVMNSKGETGYVPSNY 202 + + +V ELN KGE + +++ ++ WW+ N++G+ G VP NY Sbjct: 204 YPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNY 251
>sp|P08630|BTKL_DROME Tyrosine-protein kinase Btk29A (Dsrc28C) Length = 786 Score = 53.9 bits (128), Expect = 1e-07 Identities = 22/53 (41%), Positives = 37/53 (69%), Gaps = 1/53 (1%) Frame = +2 Query: 47 VGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQ-HWWQVMNSKGETGYVPSNY 202 V + VA + +KA++ +L++ K + ++DDSQ HWW+V ++ G GY+PSNY Sbjct: 344 VKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNY 396
>sp|Q08509|EPS8_MOUSE Epidermal growth factor receptor kinase substrate 8 Length = 821 Score = 53.1 bits (126), Expect = 2e-07 Identities = 21/53 (39%), Positives = 37/53 (69%) Frame = +2 Query: 41 QPVGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQHWWQVMNSKGETGYVPSN 199 QP A +K+D+ A + EL++ K + L ++DD + WW+V N+ G++G+VP+N Sbjct: 530 QPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRRQWWKVRNASGDSGFVPNN 582
>sp|Q12929|EPS8_HUMAN Epidermal growth factor receptor kinase substrate 8 Length = 822 Score = 52.0 bits (123), Expect = 4e-07 Identities = 21/53 (39%), Positives = 37/53 (69%) Frame = +2 Query: 41 QPVGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQHWWQVMNSKGETGYVPSN 199 QP A +K+D+ A + EL++ K + L ++DD + WW+V N+ G++G+VP+N Sbjct: 531 QPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNN 583
>sp|Q5R4H4|EPS8_PONPY Epidermal growth factor receptor kinase substrate 8 Length = 822 Score = 52.0 bits (123), Expect = 4e-07 Identities = 21/53 (39%), Positives = 37/53 (69%) Frame = +2 Query: 41 QPVGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQHWWQVMNSKGETGYVPSN 199 QP A +K+D+ A + EL++ K + L ++DD + WW+V N+ G++G+VP+N Sbjct: 531 QPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNN 583
>sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 50.4 bits (119), Expect = 1e-06 Identities = 21/51 (41%), Positives = 33/51 (64%), Gaps = 1/51 (1%) Frame = +2 Query: 53 MAVAKFDYKAVDLHELNINKGEKLTLVDDSQ-HWWQVMNSKGETGYVPSNY 202 + +A +DY+ D EL + + E+ L+D S+ HWW+V + G GYVPS+Y Sbjct: 175 VVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSY 225
>sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec Length = 630 Score = 50.1 bits (118), Expect = 2e-06 Identities = 17/51 (33%), Positives = 34/51 (66%), Gaps = 1/51 (1%) Frame = +2 Query: 53 MAVAKFDYKAVDLHELNINKGEKLTLVDDSQ-HWWQVMNSKGETGYVPSNY 202 + VA +D++A + H+L + +G++ +++ + HWW+ + G GY+PSNY Sbjct: 182 IVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYGSEGYIPSNY 232
>sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec Length = 631 Score = 48.9 bits (115), Expect = 4e-06 Identities = 17/51 (33%), Positives = 34/51 (66%), Gaps = 1/51 (1%) Frame = +2 Query: 53 MAVAKFDYKAVDLHELNINKGEKLTLVDDSQ-HWWQVMNSKGETGYVPSNY 202 + VA +D++A + H+L + +G++ +++ + HWW+ + G GY+PSNY Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNY 233
>sp|P06241|FYN_HUMAN Proto-oncogene tyrosine-protein kinase Fyn (p59-Fyn) (Protooncogene Syn) (SLK) Length = 537 Score = 48.5 bits (114), Expect = 5e-06 Identities = 23/54 (42%), Positives = 37/54 (68%), Gaps = 2/54 (3%) Frame = +2 Query: 47 VGMAVAKFDYKAVDLHELNINKGEKLTLVDDSQ-HWWQVMN-SKGETGYVPSNY 202 V + VA +DY+A +L+ +KGEK +++ S+ WW+ + + GETGY+PSNY Sbjct: 84 VTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNY 137
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,562,997 Number of Sequences: 369166 Number of extensions: 376954 Number of successful extensions: 1290 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 1191 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 1230 length of database: 68,354,980 effective HSP length: 39 effective length of database: 61,150,315 effective search space used: 1712208820 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)