Planaria EST Database


DrC_02510

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_02510
         (490 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q8VI47|MRP2_MOUSE  Canalicular multispecific organic anio...    80   3e-15
sp|Q92887|MRP2_HUMAN  Canalicular multispecific organic anio...    79   4e-15
sp|Q63120|MRP2_RAT  Canalicular multispecific organic anion ...    77   2e-14
sp|O15438|MRP3_HUMAN  Canalicular multispecific organic anio...    76   4e-14
sp|Q28689|MRP2_RABIT  Canalicular multispecific organic anio...    75   8e-14
sp|O35379|MRP1_MOUSE  Multidrug resistance-associated protei...    70   3e-12
sp|P33527|MRP1_HUMAN  Multidrug resistance-associated protei...    69   6e-12
sp|P39109|YCFI_YEAST  Metal resistance protein YCF1 (Yeast c...    69   6e-12
sp|O88563|MRP3_RAT  Canalicular multispecific organic anion ...    69   6e-12
sp|Q09428|ABCC8_HUMAN  Sulfonylurea receptor 1                     65   8e-11
>sp|Q8VI47|MRP2_MOUSE Canalicular multispecific organic anion transporter 1 (ATP-binding
           cassette sub-family C member 2)
          Length = 1543

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 44/123 (35%), Positives = 65/123 (52%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD+R+ I+ EIL+GIK++K +AWE  F  ++ SIRK+E++N+   S    +L  +  L P
Sbjct: 493 KDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTP 552

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
            LV  ITF+ Y+       +NAEK F S                  +  I A VS  R+E
Sbjct: 553 TLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLE 612

Query: 477 NFL 485
            +L
Sbjct: 613 RYL 615
>sp|Q92887|MRP2_HUMAN Canalicular multispecific organic anion transporter 1 (ATP-binding
           cassette sub-family C member 2) (Multidrug
           resistance-associated protein 2) (Canalicular multidrug
           resistance protein)
          Length = 1545

 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 40/123 (32%), Positives = 69/123 (56%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD+R+ I+ EIL+GIK++K +AWE  F  +++++RK+E+KN+   S   C++  +F L P
Sbjct: 495 KDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTP 554

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
            LV  +TF+ Y+    +  ++A+K F S                  +  + A VS  R+E
Sbjct: 555 VLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLE 614

Query: 477 NFL 485
            +L
Sbjct: 615 KYL 617
>sp|Q63120|MRP2_RAT Canalicular multispecific organic anion transporter 1 (ATP-binding
           cassette sub-family C member 2) (Multidrug
           resistance-associated protein 2) (Canalicular multidrug
           resistance protein)
          Length = 1541

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 41/123 (33%), Positives = 64/123 (52%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD+R+ I+ EIL+GIK++K +AWE  F  +++ IRK+E+KN+        LL  +  + P
Sbjct: 491 KDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITP 550

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
            LV  +TF+ Y+       +NAEK F S                  +  + A VS  R+E
Sbjct: 551 ILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLE 610

Query: 477 NFL 485
            +L
Sbjct: 611 RYL 613
>sp|O15438|MRP3_HUMAN Canalicular multispecific organic anion transporter 2 (Multidrug
           resistance-associated protein 3) (Multi-specific organic
           anion tranporter-D) (MOAT-D)
          Length = 1527

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 43/123 (34%), Positives = 65/123 (52%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD R+ +++EILNGIK++K+YAWE  F  ++E IR+ E++ +R  +      +  +   P
Sbjct: 484 KDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSP 543

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
           FLV  IT   Y+Y  P+  ++AEK FVS                  +    A VS  RI+
Sbjct: 544 FLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQ 603

Query: 477 NFL 485
            FL
Sbjct: 604 QFL 606
>sp|Q28689|MRP2_RABIT Canalicular multispecific organic anion transporter 1 (ATP-binding
           cassette sub-family C member 2) (Multidrug
           resistance-associated protein 2) (Canalicular multidrug
           resistance protein) (Epithelial basolateral chloride
           conductance regulator)
          Length = 1564

 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 38/124 (30%), Positives = 67/124 (54%)
 Frame = +3

Query: 114 WKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLI 293
           +KD+R+ I+ EIL+G+K++K +AWE  F  ++ ++RK+E+KN+R  +    ++  +  L 
Sbjct: 492 YKDKRLRIMNEILSGMKILKYFAWEPSFKDQVHNLRKKELKNLRTFAYMQSVVMFLLYLT 551

Query: 294 PFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRI 473
           P LV   TF+ Y+    +  ++AEK F S                  +  + A VS  R+
Sbjct: 552 PVLVSVTTFSVYVLVDSNNILDAEKAFTSITLFNILRFPMSMLPNVISAMLQASVSVDRL 611

Query: 474 ENFL 485
           E +L
Sbjct: 612 EKYL 615
>sp|O35379|MRP1_MOUSE Multidrug resistance-associated protein 1 (ATP-binding cassette
           sub-family C member 1)
          Length = 1528

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 40/123 (32%), Positives = 63/123 (51%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD R+ ++ EILNGIK++K+YAWE  F  K+ SIR+EE+K ++  +    + +  +   P
Sbjct: 499 KDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTP 558

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
           FLV   TF  ++       ++A+K FVS                  +  + A VS  R+ 
Sbjct: 559 FLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLR 618

Query: 477 NFL 485
            FL
Sbjct: 619 IFL 621
>sp|P33527|MRP1_HUMAN Multidrug resistance-associated protein 1 (ATP-binding cassette
           sub-family C member 1)
          Length = 1531

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 39/123 (31%), Positives = 63/123 (51%)
 Frame = +3

Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
           KD R+ ++ EILNGIK++K+YAWE  F  K+ +IR+EE+K ++  +    + +  +   P
Sbjct: 498 KDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTP 557

Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
           FLV   TF  Y+    +  ++A+  FVS                  +  + A VS  R+ 
Sbjct: 558 FLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLR 617

Query: 477 NFL 485
            FL
Sbjct: 618 IFL 620
>sp|P39109|YCFI_YEAST Metal resistance protein YCF1 (Yeast cadmium factor 1)
          Length = 1515

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 38/128 (29%), Positives = 64/128 (50%), Gaps = 1/128 (0%)
 Frame = +3

Query: 102 AELIWKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIR-KEEIKNIRNVSIGWCLLSV 278
           +++ +KD R  +++EILN IK +K+YAWE  +  K+E +R  +E+KN+  +     + S 
Sbjct: 475 SQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSF 534

Query: 279 MFDLIPFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVV 458
            F+++PFLV   TF  ++Y      +  + VF +                     I A V
Sbjct: 535 QFNIVPFLVSCCTFAVFVY-TEDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASV 593

Query: 459 SFGRIENF 482
           S GR+  F
Sbjct: 594 SIGRLFTF 601
>sp|O88563|MRP3_RAT Canalicular multispecific organic anion transporter 2 (Multidrug
           resistance-associated protein 3) (MRP-like protein 2)
           (MLP-2)
          Length = 1522

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 39/127 (30%), Positives = 68/127 (53%)
 Frame = +3

Query: 105 ELIWKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMF 284
           ++ +KD R+ +++EILNGIK++K+YAWE  F  ++E IR+ E++ +R  +    + + ++
Sbjct: 478 QMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQGELQLLRKGAYLQAISTFIW 537

Query: 285 DLIPFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSF 464
              PF+V  IT   Y+    +  ++AEK FVS                  +      VS 
Sbjct: 538 VCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSL 597

Query: 465 GRIENFL 485
            RI++FL
Sbjct: 598 KRIQDFL 604
>sp|Q09428|ABCC8_HUMAN Sulfonylurea receptor 1
          Length = 1581

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 42/162 (25%), Positives = 74/162 (45%), Gaps = 8/162 (4%)
 Frame = +3

Query: 24  YPLLFMNYLVNLFVLELFNIVVYI*GAELI--------WKDRRMNILTEILNGIKLIKMY 179
           Y +L ++ L+   V+ L   V Y    +L         + + R+    E+L GIKL+K+Y
Sbjct: 453 YYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLY 512

Query: 180 AWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIPFLVMYITFTCYIYFVPHFNVN 359
           AWEN F +++E+ R++E+ ++R  +I   +   M   IP   + ITF  ++ F    + +
Sbjct: 513 AWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFS 572

Query: 360 AEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIENFL 485
               F S                    T+ A+VS  ++  FL
Sbjct: 573 PSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFL 614
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,878,022
Number of Sequences: 369166
Number of extensions: 846181
Number of successful extensions: 2313
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2278
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2309
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2970720600
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)