Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_E24
(490 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VI47|MRP2_MOUSE Canalicular multispecific organic anio... 80 3e-15
sp|Q92887|MRP2_HUMAN Canalicular multispecific organic anio... 79 4e-15
sp|Q63120|MRP2_RAT Canalicular multispecific organic anion ... 77 2e-14
sp|O15438|MRP3_HUMAN Canalicular multispecific organic anio... 76 4e-14
sp|Q28689|MRP2_RABIT Canalicular multispecific organic anio... 75 8e-14
sp|O35379|MRP1_MOUSE Multidrug resistance-associated protei... 70 3e-12
sp|P33527|MRP1_HUMAN Multidrug resistance-associated protei... 69 6e-12
sp|P39109|YCFI_YEAST Metal resistance protein YCF1 (Yeast c... 69 6e-12
sp|O88563|MRP3_RAT Canalicular multispecific organic anion ... 69 6e-12
sp|Q09428|ABCC8_HUMAN Sulfonylurea receptor 1 65 8e-11
>sp|Q8VI47|MRP2_MOUSE Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2)
Length = 1543
Score = 79.7 bits (195), Expect = 3e-15
Identities = 44/123 (35%), Positives = 65/123 (52%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD+R+ I+ EIL+GIK++K +AWE F ++ SIRK+E++N+ S +L + L P
Sbjct: 493 KDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTP 552
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
LV ITF+ Y+ +NAEK F S + I A VS R+E
Sbjct: 553 TLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLE 612
Query: 477 NFL 485
+L
Sbjct: 613 RYL 615
>sp|Q92887|MRP2_HUMAN Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein)
Length = 1545
Score = 79.3 bits (194), Expect = 4e-15
Identities = 40/123 (32%), Positives = 69/123 (56%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD+R+ I+ EIL+GIK++K +AWE F +++++RK+E+KN+ S C++ +F L P
Sbjct: 495 KDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTP 554
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
LV +TF+ Y+ + ++A+K F S + + A VS R+E
Sbjct: 555 VLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLE 614
Query: 477 NFL 485
+L
Sbjct: 615 KYL 617
>sp|Q63120|MRP2_RAT Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein)
Length = 1541
Score = 77.4 bits (189), Expect = 2e-14
Identities = 41/123 (33%), Positives = 64/123 (52%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD+R+ I+ EIL+GIK++K +AWE F +++ IRK+E+KN+ LL + + P
Sbjct: 491 KDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITP 550
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
LV +TF+ Y+ +NAEK F S + + A VS R+E
Sbjct: 551 ILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLE 610
Query: 477 NFL 485
+L
Sbjct: 611 RYL 613
>sp|O15438|MRP3_HUMAN Canalicular multispecific organic anion transporter 2 (Multidrug
resistance-associated protein 3) (Multi-specific organic
anion tranporter-D) (MOAT-D)
Length = 1527
Score = 76.3 bits (186), Expect = 4e-14
Identities = 43/123 (34%), Positives = 65/123 (52%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD R+ +++EILNGIK++K+YAWE F ++E IR+ E++ +R + + + P
Sbjct: 484 KDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSP 543
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
FLV IT Y+Y P+ ++AEK FVS + A VS RI+
Sbjct: 544 FLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQ 603
Query: 477 NFL 485
FL
Sbjct: 604 QFL 606
>sp|Q28689|MRP2_RABIT Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein) (Epithelial basolateral chloride
conductance regulator)
Length = 1564
Score = 75.1 bits (183), Expect = 8e-14
Identities = 38/124 (30%), Positives = 67/124 (54%)
Frame = +3
Query: 114 WKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLI 293
+KD+R+ I+ EIL+G+K++K +AWE F ++ ++RK+E+KN+R + ++ + L
Sbjct: 492 YKDKRLRIMNEILSGMKILKYFAWEPSFKDQVHNLRKKELKNLRTFAYMQSVVMFLLYLT 551
Query: 294 PFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRI 473
P LV TF+ Y+ + ++AEK F S + + A VS R+
Sbjct: 552 PVLVSVTTFSVYVLVDSNNILDAEKAFTSITLFNILRFPMSMLPNVISAMLQASVSVDRL 611
Query: 474 ENFL 485
E +L
Sbjct: 612 EKYL 615
>sp|O35379|MRP1_MOUSE Multidrug resistance-associated protein 1 (ATP-binding cassette
sub-family C member 1)
Length = 1528
Score = 69.7 bits (169), Expect = 3e-12
Identities = 40/123 (32%), Positives = 63/123 (51%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD R+ ++ EILNGIK++K+YAWE F K+ SIR+EE+K ++ + + + + P
Sbjct: 499 KDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTP 558
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
FLV TF ++ ++A+K FVS + + A VS R+
Sbjct: 559 FLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLR 618
Query: 477 NFL 485
FL
Sbjct: 619 IFL 621
>sp|P33527|MRP1_HUMAN Multidrug resistance-associated protein 1 (ATP-binding cassette
sub-family C member 1)
Length = 1531
Score = 68.9 bits (167), Expect = 6e-12
Identities = 39/123 (31%), Positives = 63/123 (51%)
Frame = +3
Query: 117 KDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIP 296
KD R+ ++ EILNGIK++K+YAWE F K+ +IR+EE+K ++ + + + + P
Sbjct: 498 KDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTP 557
Query: 297 FLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIE 476
FLV TF Y+ + ++A+ FVS + + A VS R+
Sbjct: 558 FLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLR 617
Query: 477 NFL 485
FL
Sbjct: 618 IFL 620
>sp|P39109|YCFI_YEAST Metal resistance protein YCF1 (Yeast cadmium factor 1)
Length = 1515
Score = 68.9 bits (167), Expect = 6e-12
Identities = 38/128 (29%), Positives = 64/128 (50%), Gaps = 1/128 (0%)
Frame = +3
Query: 102 AELIWKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIR-KEEIKNIRNVSIGWCLLSV 278
+++ +KD R +++EILN IK +K+YAWE + K+E +R +E+KN+ + + S
Sbjct: 475 SQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYMAVTSF 534
Query: 279 MFDLIPFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVV 458
F+++PFLV TF ++Y + + VF + I A V
Sbjct: 535 QFNIVPFLVSCCTFAVFVY-TEDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASV 593
Query: 459 SFGRIENF 482
S GR+ F
Sbjct: 594 SIGRLFTF 601
>sp|O88563|MRP3_RAT Canalicular multispecific organic anion transporter 2 (Multidrug
resistance-associated protein 3) (MRP-like protein 2)
(MLP-2)
Length = 1522
Score = 68.9 bits (167), Expect = 6e-12
Identities = 39/127 (30%), Positives = 68/127 (53%)
Frame = +3
Query: 105 ELIWKDRRMNILTEILNGIKLIKMYAWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMF 284
++ +KD R+ +++EILNGIK++K+YAWE F ++E IR+ E++ +R + + + ++
Sbjct: 478 QMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQGELQLLRKGAYLQAISTFIW 537
Query: 285 DLIPFLVMYITFTCYIYFVPHFNVNAEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSF 464
PF+V IT Y+ + ++AEK FVS + VS
Sbjct: 538 VCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSL 597
Query: 465 GRIENFL 485
RI++FL
Sbjct: 598 KRIQDFL 604
>sp|Q09428|ABCC8_HUMAN Sulfonylurea receptor 1
Length = 1581
Score = 65.1 bits (157), Expect = 8e-11
Identities = 42/162 (25%), Positives = 74/162 (45%), Gaps = 8/162 (4%)
Frame = +3
Query: 24 YPLLFMNYLVNLFVLELFNIVVYI*GAELI--------WKDRRMNILTEILNGIKLIKMY 179
Y +L ++ L+ V+ L V Y +L + + R+ E+L GIKL+K+Y
Sbjct: 453 YYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLY 512
Query: 180 AWENCFNSKIESIRKEEIKNIRNVSIGWCLLSVMFDLIPFLVMYITFTCYIYFVPHFNVN 359
AWEN F +++E+ R++E+ ++R +I + M IP + ITF ++ F + +
Sbjct: 513 AWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFS 572
Query: 360 AEKVFVSXXXXXXXXXXXXXXXXXXTQTISAVVSFGRIENFL 485
F S T+ A+VS ++ FL
Sbjct: 573 PSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFL 614
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,878,022
Number of Sequences: 369166
Number of extensions: 846181
Number of successful extensions: 2313
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2278
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2309
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2970720600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)