Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_02284 (794 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P24155|MEPD_RAT Thimet oligopeptidase (Endo-oligopeptida... 321 1e-87 sp|P52888|MEPD_HUMAN Thimet oligopeptidase (Endopeptidase 2... 320 2e-87 sp|P47788|MEPD_PIG Thimet oligopeptidase (Endopeptidase 24.15) 320 4e-87 sp|Q02038|NEUL_PIG Neurolysin, mitochondrial precursor (Neu... 289 5e-78 sp|Q9BYT8|NEUL_HUMAN Neurolysin, mitochondrial precursor (N... 289 7e-78 sp|P42676|NEUL_RAT Neurolysin, mitochondrial precursor (Neu... 287 3e-77 sp|P42675|NEUL_RABIT Neurolysin, mitochondrial precursor (N... 285 1e-76 sp|P25375|PRTD_YEAST Saccharolysin (Protease D) (Proteinase... 187 2e-47 sp|P27298|OPDA_ECOLI Oligopeptidase A 170 5e-42 sp|P27237|OPDA_SALTY Oligopeptidase A 169 6e-42
>sp|P24155|MEPD_RAT Thimet oligopeptidase (Endo-oligopeptidase A) (Endopeptidase 24.15) (PZ-peptidase) (Soluble metallo-endopeptidase) Length = 687 Score = 321 bits (823), Expect = 1e-87 Identities = 151/264 (57%), Positives = 193/264 (73%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D+ +G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTK Sbjct: 399 VRDAASGEEIGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQLAIAAMVANFTK 454 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 PT D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W+ Sbjct: 455 PTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWE 514 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 +E L MS H++TG E LL+ L+ SR AN + N RQI LA DQ++HTQTDVDP E Sbjct: 515 KEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAE 574 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ DMF +RFK+E +L+ Sbjct: 575 EYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLS 634 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 PK G DYR +L+PG S+DAS ++ Sbjct: 635 PKVGMDYRTSILRPGGSEDASTML 658
>sp|P52888|MEPD_HUMAN Thimet oligopeptidase (Endopeptidase 24.15) (MP78) Length = 689 Score = 320 bits (821), Expect = 2e-87 Identities = 149/263 (56%), Positives = 192/263 (73%) Frame = +2 Query: 5 QDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKP 184 +D+ ++G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTKP Sbjct: 400 RDAASGEVVGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKP 455 Query: 185 TEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQE 364 T D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W++ Sbjct: 456 TADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQ 515 Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVEV 544 E L MS H++TG + +LL+ L+ SR ANT + N RQI LA DQ +HTQTD DP E Sbjct: 516 EPLLRMSRHYRTGSAVpreLLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEE 575 Query: 545 YRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLNP 724 Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ DMF +RFK+E +LN Sbjct: 576 YARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNS 635 Query: 725 KTGHDYREFVLKPGSSKDASELI 793 K G DYR +L+PG S+DAS ++ Sbjct: 636 KVGMDYRSCILRPGGSEDASAML 658
>sp|P47788|MEPD_PIG Thimet oligopeptidase (Endopeptidase 24.15) Length = 687 Score = 320 bits (819), Expect = 4e-87 Identities = 150/264 (56%), Positives = 193/264 (73%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D+ ++G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTK Sbjct: 399 VRDAASGKVIGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTK 454 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 PT D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W+ Sbjct: 455 PTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWE 514 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 E L MS H++TG I ++LL+ L+ SR ANT + N RQI LA DQ +HTQT DP E Sbjct: 515 AEPLLRMSQHYRTGSAIPQELLEKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAE 574 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ADMF +RFK+E +L+ Sbjct: 575 EYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSADMFHTRFKQEGILS 634 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 K G DYR +L+PG S+DAS ++ Sbjct: 635 GKVGMDYRSCILRPGGSEDASVML 658
>sp|Q02038|NEUL_PIG Neurolysin, mitochondrial precursor (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP) (Soluble angiotensin-binding protein) (SABP) (Endopeptidase 24.16) Length = 704 Score = 289 bits (740), Expect = 5e-78 Identities = 134/264 (50%), Positives = 177/264 (67%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++ Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQ 478 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W Sbjct: 479 PRAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 +SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT T +D Sbjct: 539 TDSLRRLSKHYKDGSPITDDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAAS 598 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N Sbjct: 599 EYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 P+ G YR +LKPG S D +++ Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|Q9BYT8|NEUL_HUMAN Neurolysin, mitochondrial precursor (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP) Length = 704 Score = 289 bits (739), Expect = 7e-78 Identities = 134/264 (50%), Positives = 176/264 (66%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D +LG F+LDL+preGKY HA LQPG C + + +R + + A++ NF++ Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMAVAALVVNFSQ 478 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 +SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT T +D Sbjct: 539 VDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAAS 598 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N Sbjct: 599 EYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 P+ G YR +LKPG S D +++ Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|P42676|NEUL_RAT Neurolysin, mitochondrial precursor (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP) Length = 704 Score = 287 bits (734), Expect = 3e-77 Identities = 133/264 (50%), Positives = 177/264 (67%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++ Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQ 478 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 +SLR +S H+K G PI ++LL+ L+ SR+ NT + RQI L+ DQ +HT +D Sbjct: 539 VDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAAS 598 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N Sbjct: 599 EYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKKEGIMN 658 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 P+ G YR +LKPG S D +++ Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|P42675|NEUL_RABIT Neurolysin, mitochondrial precursor (Neurotensin endopeptidase) (Mitochondrial oligopeptidase M) (Microsomal endopeptidase) (MEP) Length = 704 Score = 285 bits (728), Expect = 1e-76 Identities = 132/264 (50%), Positives = 177/264 (67%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++ Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMLSVAALVVNFSQ 478 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361 P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538 Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541 +SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT + +D Sbjct: 539 IDSLRRLSKHYKDGNPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNSSLDAAS 598 Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721 Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N Sbjct: 599 EYARYCTDILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658 Query: 722 PKTGHDYREFVLKPGSSKDASELI 793 P+ G YR +L+PG S D +++ Sbjct: 659 PEVGMKYRNLILRPGGSLDGMDML 682
>sp|P25375|PRTD_YEAST Saccharolysin (Protease D) (Proteinase yscD) (Oligopeptidase YSCD) Length = 712 Score = 187 bits (476), Expect = 2e-47 Identities = 106/271 (39%), Positives = 158/271 (58%), Gaps = 9/271 (3%) Frame = +2 Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181 + D N +G+ + DLHPR+GKYGHA L + + + TR + A++ NF+K Sbjct: 427 MDDPKSPNFVGWIYFDLHPRDGKYGHAANFGLSSSFM----IDDTTRSYPVTALVCNFSK 482 Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCE-ADFGYLTSFNVERDFVECPSQMLENWCW 358 T+DKP+LL H+E+VTFFHE GH +H + + + + +V DFVE PSQMLE W W Sbjct: 483 STKDKPSLLKHNEIVTFFHELGHGIHDLVGQNKESRFNGPGSVPWDFVEAPSQMLEFWTW 542 Query: 359 QEESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPV 538 + L +SSH+KTGE I E L+ +L+ ++ N A+ RQ+ FD +HT D+ + Sbjct: 543 NKNELINLSSHYKTGEKIPESLINSLIKTKHVNGALFTLRQLHFGLFDMKVHTCKDLQNL 602 Query: 539 -------EVYRDITERYMGIPVTKGTNMPASFNH-MAGGYDAQYYGYLWSEVFAADMFIS 694 ++ +DI+ G ++KG + SF H M+ Y A YYGYLW+EVFA DM+ + Sbjct: 603 SICDTWNQLRQDISLISNGGTLSKGYD---SFGHIMSDSYSAGYYGYLWAEVFATDMYHT 659 Query: 695 RFKEE*LLNPKTGHDYREFVLKPGSSKDASE 787 +F ++ LN K G YR+ VL G D ++ Sbjct: 660 KFAKD-PLNAKNGIQYRDIVLARGGLYDIND 689
>sp|P27298|OPDA_ECOLI Oligopeptidase A Length = 680 Score = 170 bits (430), Expect = 5e-42 Identities = 96/267 (35%), Positives = 148/267 (55%), Gaps = 6/267 (2%) Frame = +2 Query: 8 DSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKPT 187 D N++ L G F+LDL+ RE K G A + + + + Q + + NF +P Sbjct: 398 DENNE-LRGSFYLDLYARENKRGGAWMD----DCVGQMRKADGSLQKPVAYLTCNFNRPV 452 Query: 188 EDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFN-VERDFVECPSQMLENWCWQE 364 KPAL HDEV+T FHEFGH +H + + ++ + V D VE PSQ +ENWCW+ Sbjct: 453 NGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEP 512 Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDP--- 535 E+L +S H++TGEP+ ++LL +L ++ A+ RQ+ FD +H + D Sbjct: 513 EALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFRPDQGAK 572 Query: 536 -VEVYRDITERYMGIPVTKGTNMPASFNHM-AGGYDAQYYGYLWSEVFAADMFISRFKEE 709 +E +I + +P P +F+H+ AGGY A YY YLW++V AAD F SRF+EE Sbjct: 573 ILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAF-SRFEEE 631 Query: 710 *LLNPKTGHDYREFVLKPGSSKDASEL 790 + N +TG + + +L G S++ +L Sbjct: 632 GIFNRETGQSFLDNILSRGGSEEPMDL 658
>sp|P27237|OPDA_SALTY Oligopeptidase A Length = 680 Score = 169 bits (429), Expect = 6e-42 Identities = 97/267 (36%), Positives = 148/267 (55%), Gaps = 6/267 (2%) Frame = +2 Query: 8 DSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKPT 187 D N++ L G F+LDL+ RE K G A + + + T Q + + NF +P Sbjct: 398 DENNE-LRGSFYLDLYAREHKRGGAWMD----DCVGQMRKADGTLQKPVAYLTCNFNRPV 452 Query: 188 EDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFN-VERDFVECPSQMLENWCWQE 364 KPAL HDEV+T FHEFGH +H + + ++ + V D VE PSQ +ENWCW+ Sbjct: 453 NGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEP 512 Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHT----QTDVD 532 E+L +S H++TGEP+ ++LL +L ++ A+ RQ+ FD +H Q Sbjct: 513 EALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFNPQQGAK 572 Query: 533 PVEVYRDITERYMGIPVTKGTNMPASFNHM-AGGYDAQYYGYLWSEVFAADMFISRFKEE 709 +E +I ++ +P P +F+H+ AGGY A YY YLW++V AAD + SRF+EE Sbjct: 573 ILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAY-SRFEEE 631 Query: 710 *LLNPKTGHDYREFVLKPGSSKDASEL 790 + N +TG + + +L G S++ EL Sbjct: 632 GIFNRETGQSFLDNILTRGGSEEPMEL 658
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 95,661,334 Number of Sequences: 369166 Number of extensions: 2019902 Number of successful extensions: 4746 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4555 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4715 length of database: 68,354,980 effective HSP length: 109 effective length of database: 48,218,865 effective search space used: 7473924075 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)