Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_M10
(794 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24155|MEPD_RAT Thimet oligopeptidase (Endo-oligopeptida... 321 1e-87
sp|P52888|MEPD_HUMAN Thimet oligopeptidase (Endopeptidase 2... 320 2e-87
sp|P47788|MEPD_PIG Thimet oligopeptidase (Endopeptidase 24.15) 320 4e-87
sp|Q02038|NEUL_PIG Neurolysin, mitochondrial precursor (Neu... 289 5e-78
sp|Q9BYT8|NEUL_HUMAN Neurolysin, mitochondrial precursor (N... 289 7e-78
sp|P42676|NEUL_RAT Neurolysin, mitochondrial precursor (Neu... 287 3e-77
sp|P42675|NEUL_RABIT Neurolysin, mitochondrial precursor (N... 285 1e-76
sp|P25375|PRTD_YEAST Saccharolysin (Protease D) (Proteinase... 187 2e-47
sp|P27298|OPDA_ECOLI Oligopeptidase A 170 5e-42
sp|P27237|OPDA_SALTY Oligopeptidase A 169 6e-42
>sp|P24155|MEPD_RAT Thimet oligopeptidase (Endo-oligopeptidase A) (Endopeptidase 24.15)
(PZ-peptidase) (Soluble metallo-endopeptidase)
Length = 687
Score = 321 bits (823), Expect = 1e-87
Identities = 151/264 (57%), Positives = 193/264 (73%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D+ +G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTK
Sbjct: 399 VRDAASGEEIGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQLAIAAMVANFTK 454
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
PT D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W+
Sbjct: 455 PTPDVPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWE 514
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
+E L MS H++TG E LL+ L+ SR AN + N RQI LA DQ++HTQTDVDP E
Sbjct: 515 KEPLMRMSQHYRTGGEAPEDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDVDPAE 574
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ DMF +RFK+E +L+
Sbjct: 575 EYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLS 634
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
PK G DYR +L+PG S+DAS ++
Sbjct: 635 PKVGMDYRTSILRPGGSEDASTML 658
>sp|P52888|MEPD_HUMAN Thimet oligopeptidase (Endopeptidase 24.15) (MP78)
Length = 689
Score = 320 bits (821), Expect = 2e-87
Identities = 149/263 (56%), Positives = 192/263 (73%)
Frame = +2
Query: 5 QDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKP 184
+D+ ++G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTKP
Sbjct: 400 RDAASGEVVGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTKP 455
Query: 185 TEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQE 364
T D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W++
Sbjct: 456 TADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQ 515
Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVEV 544
E L MS H++TG + +LL+ L+ SR ANT + N RQI LA DQ +HTQTD DP E
Sbjct: 516 EPLLRMSRHYRTGSAVpreLLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEE 575
Query: 545 YRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLNP 724
Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ DMF +RFK+E +LN
Sbjct: 576 YARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNS 635
Query: 725 KTGHDYREFVLKPGSSKDASELI 793
K G DYR +L+PG S+DAS ++
Sbjct: 636 KVGMDYRSCILRPGGSEDASAML 658
>sp|P47788|MEPD_PIG Thimet oligopeptidase (Endopeptidase 24.15)
Length = 687
Score = 320 bits (819), Expect = 4e-87
Identities = 150/264 (56%), Positives = 193/264 (73%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D+ ++G F+LDL+preGKYGHA LQPG C + +RQ+ I AM+ANFTK
Sbjct: 399 VRDAASGKVIGKFYLDLYpreGKYGHAACFGLQPG----CLRQDGSRQIAIAAMVANFTK 454
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
PT D P+LL HDEV T+FHEFGHVMH +C +A+F + +VERDFVE PSQMLENW W+
Sbjct: 455 PTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWE 514
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
E L MS H++TG I ++LL+ L+ SR ANT + N RQI LA DQ +HTQT DP E
Sbjct: 515 AEPLLRMSQHYRTGSAIPQELLEKLIKSRQANTGLFNLRQIVLAKVDQALHTQTAADPAE 574
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y + + +G+P T GTNMPA+F H+AGGYDAQYYGYLWSEV++ADMF +RFK+E +L+
Sbjct: 575 EYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSADMFHTRFKQEGILS 634
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
K G DYR +L+PG S+DAS ++
Sbjct: 635 GKVGMDYRSCILRPGGSEDASVML 658
>sp|Q02038|NEUL_PIG Neurolysin, mitochondrial precursor (Neurotensin endopeptidase)
(Mitochondrial oligopeptidase M) (Microsomal
endopeptidase) (MEP) (Soluble angiotensin-binding
protein) (SABP) (Endopeptidase 24.16)
Length = 704
Score = 289 bits (740), Expect = 5e-78
Identities = 134/264 (50%), Positives = 177/264 (67%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++
Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQ 478
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W
Sbjct: 479 PRAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
+SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT T +D
Sbjct: 539 TDSLRRLSKHYKDGSPITDDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAAS 598
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N
Sbjct: 599 EYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
P+ G YR +LKPG S D +++
Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|Q9BYT8|NEUL_HUMAN Neurolysin, mitochondrial precursor (Neurotensin endopeptidase)
(Mitochondrial oligopeptidase M) (Microsomal
endopeptidase) (MEP)
Length = 704
Score = 289 bits (739), Expect = 7e-78
Identities = 134/264 (50%), Positives = 176/264 (66%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D +LG F+LDL+preGKY HA LQPG C + + +R + + A++ NF++
Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMAVAALVVNFSQ 478
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W
Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
+SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT T +D
Sbjct: 539 VDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAAS 598
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N
Sbjct: 599 EYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
P+ G YR +LKPG S D +++
Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|P42676|NEUL_RAT Neurolysin, mitochondrial precursor (Neurotensin endopeptidase)
(Mitochondrial oligopeptidase M) (Microsomal
endopeptidase) (MEP)
Length = 704
Score = 287 bits (734), Expect = 3e-77
Identities = 133/264 (50%), Positives = 177/264 (67%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++
Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMMSVAALVVNFSQ 478
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W
Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
+SLR +S H+K G PI ++LL+ L+ SR+ NT + RQI L+ DQ +HT +D
Sbjct: 539 VDSLRKLSKHYKDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAAS 598
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N
Sbjct: 599 EYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFKKEGIMN 658
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
P+ G YR +LKPG S D +++
Sbjct: 659 PEVGMKYRNLILKPGGSLDGMDML 682
>sp|P42675|NEUL_RABIT Neurolysin, mitochondrial precursor (Neurotensin endopeptidase)
(Mitochondrial oligopeptidase M) (Microsomal
endopeptidase) (MEP)
Length = 704
Score = 285 bits (728), Expect = 1e-76
Identities = 132/264 (50%), Positives = 177/264 (67%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
V+D +LG F+LDL+preGKY HA LQPG C + + +R +++ A++ NF++
Sbjct: 423 VKDKATGEVLGQFYLDLYpreGKYNHAACFGLQPG----CLLPDGSRMLSVAALVVNFSQ 478
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFNVERDFVECPSQMLENWCWQ 361
P +P+LL HDEV T+FHEFGHVMH IC + DF + NVE DFVE PSQMLENW W
Sbjct: 479 PVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD 538
Query: 362 EESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPVE 541
+SLR +S H+K G PI + LL+ L+ SR+ NT + RQI L+ DQ +HT + +D
Sbjct: 539 IDSLRRLSKHYKDGNPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNSSLDAAS 598
Query: 542 VYRDITERYMGIPVTKGTNMPASFNHMAGGYDAQYYGYLWSEVFAADMFISRFKEE*LLN 721
Y +G+ T GTNMPA+F H+AGGYD QYYGYLWSEVF+ DMF S FK+E ++N
Sbjct: 599 EYARYCTDILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMN 658
Query: 722 PKTGHDYREFVLKPGSSKDASELI 793
P+ G YR +L+PG S D +++
Sbjct: 659 PEVGMKYRNLILRPGGSLDGMDML 682
>sp|P25375|PRTD_YEAST Saccharolysin (Protease D) (Proteinase yscD) (Oligopeptidase YSCD)
Length = 712
Score = 187 bits (476), Expect = 2e-47
Identities = 106/271 (39%), Positives = 158/271 (58%), Gaps = 9/271 (3%)
Frame = +2
Query: 2 VQDSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTK 181
+ D N +G+ + DLHPR+GKYGHA L + + + TR + A++ NF+K
Sbjct: 427 MDDPKSPNFVGWIYFDLHPRDGKYGHAANFGLSSSFM----IDDTTRSYPVTALVCNFSK 482
Query: 182 PTEDKPALLNHDEVVTFFHEFGHVMHSICCE-ADFGYLTSFNVERDFVECPSQMLENWCW 358
T+DKP+LL H+E+VTFFHE GH +H + + + + +V DFVE PSQMLE W W
Sbjct: 483 STKDKPSLLKHNEIVTFFHELGHGIHDLVGQNKESRFNGPGSVPWDFVEAPSQMLEFWTW 542
Query: 359 QEESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDPV 538
+ L +SSH+KTGE I E L+ +L+ ++ N A+ RQ+ FD +HT D+ +
Sbjct: 543 NKNELINLSSHYKTGEKIPESLINSLIKTKHVNGALFTLRQLHFGLFDMKVHTCKDLQNL 602
Query: 539 -------EVYRDITERYMGIPVTKGTNMPASFNH-MAGGYDAQYYGYLWSEVFAADMFIS 694
++ +DI+ G ++KG + SF H M+ Y A YYGYLW+EVFA DM+ +
Sbjct: 603 SICDTWNQLRQDISLISNGGTLSKGYD---SFGHIMSDSYSAGYYGYLWAEVFATDMYHT 659
Query: 695 RFKEE*LLNPKTGHDYREFVLKPGSSKDASE 787
+F ++ LN K G YR+ VL G D ++
Sbjct: 660 KFAKD-PLNAKNGIQYRDIVLARGGLYDIND 689
>sp|P27298|OPDA_ECOLI Oligopeptidase A
Length = 680
Score = 170 bits (430), Expect = 5e-42
Identities = 96/267 (35%), Positives = 148/267 (55%), Gaps = 6/267 (2%)
Frame = +2
Query: 8 DSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKPT 187
D N++ L G F+LDL+ RE K G A + + + + Q + + NF +P
Sbjct: 398 DENNE-LRGSFYLDLYARENKRGGAWMD----DCVGQMRKADGSLQKPVAYLTCNFNRPV 452
Query: 188 EDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFN-VERDFVECPSQMLENWCWQE 364
KPAL HDEV+T FHEFGH +H + + ++ + V D VE PSQ +ENWCW+
Sbjct: 453 NGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEP 512
Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHTQTDVDP--- 535
E+L +S H++TGEP+ ++LL +L ++ A+ RQ+ FD +H + D
Sbjct: 513 EALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFRPDQGAK 572
Query: 536 -VEVYRDITERYMGIPVTKGTNMPASFNHM-AGGYDAQYYGYLWSEVFAADMFISRFKEE 709
+E +I + +P P +F+H+ AGGY A YY YLW++V AAD F SRF+EE
Sbjct: 573 ILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAF-SRFEEE 631
Query: 710 *LLNPKTGHDYREFVLKPGSSKDASEL 790
+ N +TG + + +L G S++ +L
Sbjct: 632 GIFNRETGQSFLDNILSRGGSEEPMDL 658
>sp|P27237|OPDA_SALTY Oligopeptidase A
Length = 680
Score = 169 bits (429), Expect = 6e-42
Identities = 97/267 (36%), Positives = 148/267 (55%), Gaps = 6/267 (2%)
Frame = +2
Query: 8 DSNDKNLLGYFFLDLHpreGKYGHAQVTLLQPGGLNMCEMGEPTRQVTIVAMLANFTKPT 187
D N++ L G F+LDL+ RE K G A + + + T Q + + NF +P
Sbjct: 398 DENNE-LRGSFYLDLYAREHKRGGAWMD----DCVGQMRKADGTLQKPVAYLTCNFNRPV 452
Query: 188 EDKPALLNHDEVVTFFHEFGHVMHSICCEADFGYLTSFN-VERDFVECPSQMLENWCWQE 364
KPAL HDEV+T FHEFGH +H + + ++ + V D VE PSQ +ENWCW+
Sbjct: 453 NGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEP 512
Query: 365 ESLRMMSSHHKTGEPIDEQLLKNLLLSRIANTAVHNTRQICLASFDQIIHT----QTDVD 532
E+L +S H++TGEP+ ++LL +L ++ A+ RQ+ FD +H Q
Sbjct: 513 EALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFNPQQGAK 572
Query: 533 PVEVYRDITERYMGIPVTKGTNMPASFNHM-AGGYDAQYYGYLWSEVFAADMFISRFKEE 709
+E +I ++ +P P +F+H+ AGGY A YY YLW++V AAD + SRF+EE
Sbjct: 573 ILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAY-SRFEEE 631
Query: 710 *LLNPKTGHDYREFVLKPGSSKDASEL 790
+ N +TG + + +L G S++ EL
Sbjct: 632 GIFNRETGQSFLDNILTRGGSEEPMEL 658
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,661,334
Number of Sequences: 369166
Number of extensions: 2019902
Number of successful extensions: 4746
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4555
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4715
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)