Planaria EST Database


DrC_02025

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_02025
         (802 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|O89110|CASP8_MOUSE  Caspase-8 precursor (CASP-8) [Contain...    46   1e-04
sp|P55214|CASP7_MESAU  Caspase-7 precursor (CASP-7) (ICE-lik...    46   1e-04
sp|Q92851|CASPA_HUMAN  Caspase-10 precursor (CASP-10) (ICE-l...    44   5e-04
sp|P97864|CASP7_MOUSE  Caspase-7 precursor (CASP-7) (LICE2 c...    44   5e-04
sp|P55210|CASP7_HUMAN  Caspase-7 precursor (CASP-7) (ICE-lik...    43   9e-04
sp|Q8MJC3|CASP3_RABIT  Caspase-3 precursor (CASP-3) (Apopain...    40   0.007
sp|Q5IS54|CASP3_PANTR  Caspase-3 precursor (CASP-3) [Contain...    39   0.022
sp|P70677|CASP3_MOUSE  Caspase-3 precursor (CASP-3) (Apopain...    39   0.022
sp|P42574|CASP3_HUMAN  Caspase-3 precursor (CASP-3) (Apopain...    38   0.028
sp|Q60431|CASP3_CRILO  Caspase-3 precursor (CASP-3) (Apopain...    38   0.037
>sp|O89110|CASP8_MOUSE Caspase-8 precursor (CASP-8) [Contains: Caspase-8 subunit p18;
           Caspase-8 subunit p10]
          Length = 480

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 51/218 (23%), Positives = 94/218 (43%), Gaps = 29/218 (13%)
 Frame = +2

Query: 140 QILEAEEDNAGFCLVINHKDLQ-------------------CDKDIHEIGKLFSGKLHYL 262
           ++ + +    G+CL+IN+ D                     CDK+   + K F  +LH+ 
Sbjct: 226 KVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEA--LSKTFK-ELHFE 282

Query: 263 CRRFSFTTTQNLKDMICEKLEMFKDC-HEQIVVFVFC---HGNNNLIQTNDGS-IKCGEF 427
              +   T   + ++    LE ++   H+    F+ C   HG+  ++   DG      + 
Sbjct: 283 IVSYDDCTANEIHEI----LEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDL 338

Query: 428 RELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGEN-I 604
              F   K P +S KPK+FF+  +  Q  N +K   D +G   QQ+++ +V+    +N I
Sbjct: 339 TSYFTGSKCPSLSGKPKIFFI--QACQGSNFQKGVPDEAG-FEQQNHTLEVDSSSHKNYI 395

Query: 605 PELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE 706
           P+ ++      T        D +NGT  +Q+L + + E
Sbjct: 396 PDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRE 433
>sp|P55214|CASP7_MESAU Caspase-7 precursor (CASP-7) (ICE-like apoptotic protease 3)
           (ICE-LAP3) (Apoptotic protease Mch-3) (SREBP cleavage
           activity 2) (SCA-2) [Contains: Caspase-7 subunit p20;
           Caspase-7 subunit p11]
          Length = 303

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/228 (24%), Positives = 94/228 (41%), Gaps = 15/228 (6%)
 Frame = +2

Query: 137 TQILEAEEDNAGFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTT 286
           T +   + +  G C++IN+K+             DKD   + K F   L +    ++  +
Sbjct: 57  TYLYRMDFEKMGKCIIINNKNFDKVTGMDVRNGTDKDAEALFKCFRS-LGFDVVVYNDCS 115

Query: 287 TQNLKDMICEKLEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRIS 466
              ++D++ +  E            +  HG  NLI   DG     +    F   +   + 
Sbjct: 116 CAKMQDLLRKASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLL 175

Query: 467 EKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSD 646
           EKPKLFF IQ     E  + V  D SG I +   + +        IP  ++  +A  T  
Sbjct: 176 EKPKLFF-IQACRGTELDDGVQAD-SGPINETDANPRY------KIPVEADFLFAYSTVP 227

Query: 647 GFDSL----NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
           G+ S      G+  VQAL  +++E  K LEI  + T   +++   F+S
Sbjct: 228 GYYSWRNPGKGSWFVQALCSILDEHGKDLEIMQILTRVNDRVARHFES 275
>sp|Q92851|CASPA_HUMAN Caspase-10 precursor (CASP-10) (ICE-like apoptotic protease 4)
           (Apoptotic protease Mch-4) (FAS-associated death domain
           protein interleukin-1B-converting enzyme 2) (FLICE2)
           [Contains: Caspase-10 subunit p23/17; Caspase-10 subunit
           p12]
          Length = 521

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 44/179 (24%), Positives = 77/179 (43%), Gaps = 17/179 (9%)
 Frame = +2

Query: 110 LNLELDFFGTQILEAEEDNAGFCLVINHKDLQCDKD---IHEIGKLFSGKLHYLCRRFSF 280
           LN E       +     ++ G C+++N+      KD    H+  ++ S    +L   F+ 
Sbjct: 264 LNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWL--GFTV 321

Query: 281 TTTQNLKDMICEKLEMFKDC---HEQIVVFVFC---HGNNNLIQTNDGS-IKCGEFRELF 439
               N+  +  E +   + C   H     FVFC   HG    + ++D + I   E    F
Sbjct: 322 HIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHF 381

Query: 440 LPGKFPRISEKPKLFFL-------IQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIG 595
              + PR++EKPKLFF+       IQ  V +E ++ +N + +    Q S   + + L+G
Sbjct: 382 TALQCPRLAEKPKLFFIQACQGEEIQPSVSIE-ADALNPEQAPTSLQDSIPAEADFLLG 439
>sp|P97864|CASP7_MOUSE Caspase-7 precursor (CASP-7) (LICE2 cysteine protease) (Apoptotic
           protease Mch-3) [Contains: Caspase-7 subunit p20;
           Caspase-7 subunit p11]
          Length = 303

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 55/231 (23%), Positives = 94/231 (40%), Gaps = 18/231 (7%)
 Frame = +2

Query: 137 TQILEAEEDNAGFCLVINHK--DLQCDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMI 310
           T +   +    G C++IN+K  D     D+       +G L    +   F  T +  D  
Sbjct: 57  TYLYRMDFQKMGKCIIINNKNFDKATGMDVRNGTDKDAGALFKCFQNLGFEVTVH-NDCS 115

Query: 311 CEKLEMF-----KDCHEQIVVF---VFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRIS 466
           C K++       ++ H     F   +  HG  +LI   DG     +    F   +   + 
Sbjct: 116 CAKMQDLLRKASEEDHSNSACFACVLLSHGEEDLIYGKDGVTPIKDLTAHFRGDRCKTLL 175

Query: 467 EKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIG---ENIPELSNVYWASL 637
           EKPKLFF     +Q     ++++        Q++S  +ND+       IP  ++  +A  
Sbjct: 176 EKPKLFF-----IQACRGTELDDG------IQADSGPINDIDANPRNKIPVEADFLFAYS 224

Query: 638 TSDGFDSL----NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
           T  G+ S      G+  VQAL  ++ E  K LEI  + T   +++   F+S
Sbjct: 225 TVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFES 275
>sp|P55210|CASP7_HUMAN Caspase-7 precursor (CASP-7) (ICE-like apoptotic protease 3)
           (ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains:
           Caspase-7 subunit p20; Caspase-7 subunit p11]
          Length = 303

 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 52/220 (23%), Positives = 89/220 (40%), Gaps = 15/220 (6%)
 Frame = +2

Query: 161 DNAGFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMI 310
           +  G C++IN+K+             DKD   + K F   L +    ++  +   ++D++
Sbjct: 65  EKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRS-LGFDVIVYNDCSCAKMQDLL 123

Query: 311 CEKLEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFL 490
            +  E            +  HG  N+I   DG     +    F   +   + EKPKLFF 
Sbjct: 124 KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFF- 182

Query: 491 IQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSDGFDSL--- 661
           IQ     E  + +  D+       +N +         IP  ++  +A  T  G+ S    
Sbjct: 183 IQACRGTELDDGIQADSGPINDTDANPR-------YKIPVEADFLFAYSTVPGYYSWRSP 235

Query: 662 -NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
             G+  VQAL  ++EE  K LEI  + T   +++   F+S
Sbjct: 236 GRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFES 275
>sp|Q8MJC3|CASP3_RABIT Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
           [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]
          Length = 277

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 45/217 (20%), Positives = 89/217 (41%), Gaps = 15/217 (6%)
 Frame = +2

Query: 170 GFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEK 319
           G C++IN+K+             D +   +G+ F   L Y  R  +  T + + +++   
Sbjct: 45  GLCIIINNKNFHKNTGMSSRSGTDVNAANLGETFMN-LKYEVRNKNDLTREEIMELMYNV 103

Query: 320 LEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQK 499
            +         +  +  HG+  +I   +G I+  +    F       ++ KPKL F+IQ 
Sbjct: 104 SKEDHSKRSSFICVILSHGDEGVIYGTNGPIELKKLTSFFRGDYCRSLTGKPKL-FIIQA 162

Query: 500 EVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNG 667
               E    +  D+  +           D+  + IP  ++  +A  T+ G+    +S  G
Sbjct: 163 CRGTELDSGIETDSGVDY----------DMACQKIPVEADFLYAYSTAPGYYSWRNSEEG 212

Query: 668 TPCVQALLKVIEE-DPKLEITDLKTETCNKMKELFQS 775
           +  +Q+L  +++E   KLE   + T    K+   F+S
Sbjct: 213 SWFIQSLCAMLKEYAHKLEFMHILTRVNRKVATEFES 249
>sp|Q5IS54|CASP3_PANTR Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
           Caspase-3 p12 subunit]
          Length = 277

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
 Frame = +2

Query: 44  SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
           ++ENS++  + +N   K      +++         + +    G C++IN+K+        
Sbjct: 3   NTENSVDSKSIKNLEPKIIHGSQSMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMT 62

Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
                D D   + + F   L Y  R  +  T + + +++ +  +         V  +  H
Sbjct: 63  SRSGTDVDAANLRETFRN-LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSH 121

Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
           G   +I   +G +   +    F   +   ++ KPKL F+IQ     E    +  D+  + 
Sbjct: 122 GEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKL-FIIQACRGTELDCGIETDSGVD- 179

Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE-DPKL 718
                    +D+    IP  ++  +A  T+ G+    +S +G+  +Q+L  ++++   KL
Sbjct: 180 ---------DDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230

Query: 719 EITDLKTETCNKMKELFQS 775
           E   + T    K+   F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|P70677|CASP3_MOUSE Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
           (Yama protein) (CPP-32) (SREBP cleavage activity 1)
           (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit;
           Caspase-3 p12 subunit]
          Length = 277

 Score = 38.5 bits (88), Expect = 0.022
 Identities = 47/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
 Frame = +2

Query: 44  SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
           +++ S++  +  N   K      +++   +     + +    G C++IN+K+        
Sbjct: 3   NNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMS 62

Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
                D D   + + F G L Y  R  +  T +++ +++    +         V  +  H
Sbjct: 63  SRSGTDVDAANLRETFMG-LKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSH 121

Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
           G+  +I   +G ++  +    F       ++ KPKL F+IQ     E    +  D+  + 
Sbjct: 122 GDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKL-FIIQACRGTELDCGIETDSGTD- 179

Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIE-EDPKL 718
                     ++  + IP  ++  +A  T+ G+    +S +G+  +Q+L  +++    KL
Sbjct: 180 ---------EEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKL 230

Query: 719 EITDLKTETCNKMKELFQS 775
           E   + T    K+   F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|P42574|CASP3_HUMAN Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
           (Yama protein) (CPP-32) (SREBP cleavage activity 1)
           (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
           subunit]
          Length = 277

 Score = 38.1 bits (87), Expect = 0.028
 Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
 Frame = +2

Query: 44  SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
           ++ENS++  + +N   K      +++         + +    G C++IN+K+        
Sbjct: 3   NTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMT 62

Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
                D D   + + F   L Y  R  +  T + + +++ +  +         V  +  H
Sbjct: 63  SRSGTDVDAANLRETFRN-LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSH 121

Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
           G   +I   +G +   +    F   +   ++ KPKL F+IQ     E    +  D+  + 
Sbjct: 122 GEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKL-FIIQACRGTELDCGIETDSGVD- 179

Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE-DPKL 718
                    +D+    IP  ++  +A  T+ G+    +S +G+  +Q+L  ++++   KL
Sbjct: 180 ---------DDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230

Query: 719 EITDLKTETCNKMKELFQS 775
           E   + T    K+   F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|Q60431|CASP3_CRILO Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
           (Yama protein) (CPP-32) (SREBP cleavage activity 1)
           (SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
           subunit]
          Length = 277

 Score = 37.7 bits (86), Expect = 0.037
 Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
 Frame = +2

Query: 44  SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
           ++E S++  + +N   K      +++   +     + +    G C++IN+K+        
Sbjct: 3   NNETSVDSKSIKNFEVKTIHGSKSMDSGIYLDSSYKMDYPEMGVCIIINNKNFHKSTGMT 62

Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
                D D  ++ + F   L Y  R  +  T + + +++    +         V  +  H
Sbjct: 63  PRSGTDVDAAKLRETFMA-LKYEVRNKNDLTREEIVELMKNASKEDHSKRSSFVCVILSH 121

Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
           G+  +I   DG I   +    F       +  KPKLF +         + +  E + G  
Sbjct: 122 GDEGVIFGTDGPIDLKKLTSYFRGDYCRSLIGKPKLFII--------QACRGTELDCG-- 171

Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGFDS----LNGTPCVQALLKVIE-EDPKL 718
             +++S   +D+  + IP  ++  +A  T+ G+ S     +G+  +Q+L  +++    KL
Sbjct: 172 -IETDSGTEDDMTCQKIPVEADFLYAYSTAPGYYSWRNPKDGSWFIQSLCSMLKLYAHKL 230

Query: 719 EITDLKTETCNKMKELFQS 775
           E   + T    K+   F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,501,849
Number of Sequences: 369166
Number of extensions: 1783876
Number of successful extensions: 4767
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4601
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4760
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)