Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_L11
(802 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O89110|CASP8_MOUSE Caspase-8 precursor (CASP-8) [Contain... 46 1e-04
sp|P55214|CASP7_MESAU Caspase-7 precursor (CASP-7) (ICE-lik... 46 1e-04
sp|Q92851|CASPA_HUMAN Caspase-10 precursor (CASP-10) (ICE-l... 44 5e-04
sp|P97864|CASP7_MOUSE Caspase-7 precursor (CASP-7) (LICE2 c... 44 5e-04
sp|P55210|CASP7_HUMAN Caspase-7 precursor (CASP-7) (ICE-lik... 43 9e-04
sp|Q8MJC3|CASP3_RABIT Caspase-3 precursor (CASP-3) (Apopain... 40 0.007
sp|Q5IS54|CASP3_PANTR Caspase-3 precursor (CASP-3) [Contain... 39 0.022
sp|P70677|CASP3_MOUSE Caspase-3 precursor (CASP-3) (Apopain... 39 0.022
sp|P42574|CASP3_HUMAN Caspase-3 precursor (CASP-3) (Apopain... 38 0.028
sp|Q60431|CASP3_CRILO Caspase-3 precursor (CASP-3) (Apopain... 38 0.037
>sp|O89110|CASP8_MOUSE Caspase-8 precursor (CASP-8) [Contains: Caspase-8 subunit p18;
Caspase-8 subunit p10]
Length = 480
Score = 45.8 bits (107), Expect = 1e-04
Identities = 51/218 (23%), Positives = 94/218 (43%), Gaps = 29/218 (13%)
Frame = +2
Query: 140 QILEAEEDNAGFCLVINHKDLQ-------------------CDKDIHEIGKLFSGKLHYL 262
++ + + G+CL+IN+ D CDK+ + K F +LH+
Sbjct: 226 KVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEA--LSKTFK-ELHFE 282
Query: 263 CRRFSFTTTQNLKDMICEKLEMFKDC-HEQIVVFVFC---HGNNNLIQTNDGS-IKCGEF 427
+ T + ++ LE ++ H+ F+ C HG+ ++ DG +
Sbjct: 283 IVSYDDCTANEIHEI----LEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDL 338
Query: 428 RELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGEN-I 604
F K P +S KPK+FF+ + Q N +K D +G QQ+++ +V+ +N I
Sbjct: 339 TSYFTGSKCPSLSGKPKIFFI--QACQGSNFQKGVPDEAG-FEQQNHTLEVDSSSHKNYI 395
Query: 605 PELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE 706
P+ ++ T D +NGT +Q+L + + E
Sbjct: 396 PDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRE 433
>sp|P55214|CASP7_MESAU Caspase-7 precursor (CASP-7) (ICE-like apoptotic protease 3)
(ICE-LAP3) (Apoptotic protease Mch-3) (SREBP cleavage
activity 2) (SCA-2) [Contains: Caspase-7 subunit p20;
Caspase-7 subunit p11]
Length = 303
Score = 45.8 bits (107), Expect = 1e-04
Identities = 56/228 (24%), Positives = 94/228 (41%), Gaps = 15/228 (6%)
Frame = +2
Query: 137 TQILEAEEDNAGFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTT 286
T + + + G C++IN+K+ DKD + K F L + ++ +
Sbjct: 57 TYLYRMDFEKMGKCIIINNKNFDKVTGMDVRNGTDKDAEALFKCFRS-LGFDVVVYNDCS 115
Query: 287 TQNLKDMICEKLEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRIS 466
++D++ + E + HG NLI DG + F + +
Sbjct: 116 CAKMQDLLRKASEEDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLL 175
Query: 467 EKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSD 646
EKPKLFF IQ E + V D SG I + + + IP ++ +A T
Sbjct: 176 EKPKLFF-IQACRGTELDDGVQAD-SGPINETDANPRY------KIPVEADFLFAYSTVP 227
Query: 647 GFDSL----NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
G+ S G+ VQAL +++E K LEI + T +++ F+S
Sbjct: 228 GYYSWRNPGKGSWFVQALCSILDEHGKDLEIMQILTRVNDRVARHFES 275
>sp|Q92851|CASPA_HUMAN Caspase-10 precursor (CASP-10) (ICE-like apoptotic protease 4)
(Apoptotic protease Mch-4) (FAS-associated death domain
protein interleukin-1B-converting enzyme 2) (FLICE2)
[Contains: Caspase-10 subunit p23/17; Caspase-10 subunit
p12]
Length = 521
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/179 (24%), Positives = 77/179 (43%), Gaps = 17/179 (9%)
Frame = +2
Query: 110 LNLELDFFGTQILEAEEDNAGFCLVINHKDLQCDKD---IHEIGKLFSGKLHYLCRRFSF 280
LN E + ++ G C+++N+ KD H+ ++ S +L F+
Sbjct: 264 LNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWL--GFTV 321
Query: 281 TTTQNLKDMICEKLEMFKDC---HEQIVVFVFC---HGNNNLIQTNDGS-IKCGEFRELF 439
N+ + E + + C H FVFC HG + ++D + I E F
Sbjct: 322 HIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHF 381
Query: 440 LPGKFPRISEKPKLFFL-------IQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIG 595
+ PR++EKPKLFF+ IQ V +E ++ +N + + Q S + + L+G
Sbjct: 382 TALQCPRLAEKPKLFFIQACQGEEIQPSVSIE-ADALNPEQAPTSLQDSIPAEADFLLG 439
>sp|P97864|CASP7_MOUSE Caspase-7 precursor (CASP-7) (LICE2 cysteine protease) (Apoptotic
protease Mch-3) [Contains: Caspase-7 subunit p20;
Caspase-7 subunit p11]
Length = 303
Score = 43.9 bits (102), Expect = 5e-04
Identities = 55/231 (23%), Positives = 94/231 (40%), Gaps = 18/231 (7%)
Frame = +2
Query: 137 TQILEAEEDNAGFCLVINHK--DLQCDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMI 310
T + + G C++IN+K D D+ +G L + F T + D
Sbjct: 57 TYLYRMDFQKMGKCIIINNKNFDKATGMDVRNGTDKDAGALFKCFQNLGFEVTVH-NDCS 115
Query: 311 CEKLEMF-----KDCHEQIVVF---VFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRIS 466
C K++ ++ H F + HG +LI DG + F + +
Sbjct: 116 CAKMQDLLRKASEEDHSNSACFACVLLSHGEEDLIYGKDGVTPIKDLTAHFRGDRCKTLL 175
Query: 467 EKPKLFFLIQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIG---ENIPELSNVYWASL 637
EKPKLFF +Q ++++ Q++S +ND+ IP ++ +A
Sbjct: 176 EKPKLFF-----IQACRGTELDDG------IQADSGPINDIDANPRNKIPVEADFLFAYS 224
Query: 638 TSDGFDSL----NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
T G+ S G+ VQAL ++ E K LEI + T +++ F+S
Sbjct: 225 TVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFES 275
>sp|P55210|CASP7_HUMAN Caspase-7 precursor (CASP-7) (ICE-like apoptotic protease 3)
(ICE-LAP3) (Apoptotic protease Mch-3) (CMH-1) [Contains:
Caspase-7 subunit p20; Caspase-7 subunit p11]
Length = 303
Score = 43.1 bits (100), Expect = 9e-04
Identities = 52/220 (23%), Positives = 89/220 (40%), Gaps = 15/220 (6%)
Frame = +2
Query: 161 DNAGFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMI 310
+ G C++IN+K+ DKD + K F L + ++ + ++D++
Sbjct: 65 EKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRS-LGFDVIVYNDCSCAKMQDLL 123
Query: 311 CEKLEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFL 490
+ E + HG N+I DG + F + + EKPKLFF
Sbjct: 124 KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFF- 182
Query: 491 IQKEVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSDGFDSL--- 661
IQ E + + D+ +N + IP ++ +A T G+ S
Sbjct: 183 IQACRGTELDDGIQADSGPINDTDANPR-------YKIPVEADFLFAYSTVPGYYSWRSP 235
Query: 662 -NGTPCVQALLKVIEEDPK-LEITDLKTETCNKMKELFQS 775
G+ VQAL ++EE K LEI + T +++ F+S
Sbjct: 236 GRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFES 275
>sp|Q8MJC3|CASP3_RABIT Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]
Length = 277
Score = 40.0 bits (92), Expect = 0.007
Identities = 45/217 (20%), Positives = 89/217 (41%), Gaps = 15/217 (6%)
Frame = +2
Query: 170 GFCLVINHKDLQ----------CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEK 319
G C++IN+K+ D + +G+ F L Y R + T + + +++
Sbjct: 45 GLCIIINNKNFHKNTGMSSRSGTDVNAANLGETFMN-LKYEVRNKNDLTREEIMELMYNV 103
Query: 320 LEMFKDCHEQIVVFVFCHGNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQK 499
+ + + HG+ +I +G I+ + F ++ KPKL F+IQ
Sbjct: 104 SKEDHSKRSSFICVILSHGDEGVIYGTNGPIELKKLTSFFRGDYCRSLTGKPKL-FIIQA 162
Query: 500 EVQVENSEKVNEDNSGNIPQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNG 667
E + D+ + D+ + IP ++ +A T+ G+ +S G
Sbjct: 163 CRGTELDSGIETDSGVDY----------DMACQKIPVEADFLYAYSTAPGYYSWRNSEEG 212
Query: 668 TPCVQALLKVIEE-DPKLEITDLKTETCNKMKELFQS 775
+ +Q+L +++E KLE + T K+ F+S
Sbjct: 213 SWFIQSLCAMLKEYAHKLEFMHILTRVNRKVATEFES 249
>sp|Q5IS54|CASP3_PANTR Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 38.5 bits (88), Expect = 0.022
Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
Frame = +2
Query: 44 SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
++ENS++ + +N K +++ + + G C++IN+K+
Sbjct: 3 NTENSVDSKSIKNLEPKIIHGSQSMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMT 62
Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
D D + + F L Y R + T + + +++ + + V + H
Sbjct: 63 SRSGTDVDAANLRETFRN-LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSH 121
Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
G +I +G + + F + ++ KPKL F+IQ E + D+ +
Sbjct: 122 GEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKL-FIIQACRGTELDCGIETDSGVD- 179
Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE-DPKL 718
+D+ IP ++ +A T+ G+ +S +G+ +Q+L ++++ KL
Sbjct: 180 ---------DDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230
Query: 719 EITDLKTETCNKMKELFQS 775
E + T K+ F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|P70677|CASP3_MOUSE Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) (LICE) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 38.5 bits (88), Expect = 0.022
Identities = 47/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
Frame = +2
Query: 44 SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
+++ S++ + N K +++ + + + G C++IN+K+
Sbjct: 3 NNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMS 62
Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
D D + + F G L Y R + T +++ +++ + V + H
Sbjct: 63 SRSGTDVDAANLRETFMG-LKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSH 121
Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
G+ +I +G ++ + F ++ KPKL F+IQ E + D+ +
Sbjct: 122 GDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKL-FIIQACRGTELDCGIETDSGTD- 179
Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIE-EDPKL 718
++ + IP ++ +A T+ G+ +S +G+ +Q+L +++ KL
Sbjct: 180 ---------EEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKL 230
Query: 719 EITDLKTETCNKMKELFQS 775
E + T K+ F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|P42574|CASP3_HUMAN Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
subunit]
Length = 277
Score = 38.1 bits (87), Expect = 0.028
Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
Frame = +2
Query: 44 SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
++ENS++ + +N K +++ + + G C++IN+K+
Sbjct: 3 NTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMT 62
Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
D D + + F L Y R + T + + +++ + + V + H
Sbjct: 63 SRSGTDVDAANLRETFRN-LKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSH 121
Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
G +I +G + + F + ++ KPKL F+IQ E + D+ +
Sbjct: 122 GEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKL-FIIQACRGTELDCGIETDSGVD- 179
Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGF----DSLNGTPCVQALLKVIEE-DPKL 718
+D+ IP ++ +A T+ G+ +S +G+ +Q+L ++++ KL
Sbjct: 180 ---------DDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230
Query: 719 EITDLKTETCNKMKELFQS 775
E + T K+ F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
>sp|Q60431|CASP3_CRILO Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
subunit]
Length = 277
Score = 37.7 bits (86), Expect = 0.037
Identities = 49/259 (18%), Positives = 105/259 (40%), Gaps = 15/259 (5%)
Frame = +2
Query: 44 SSENSIEDSNPQNKVFKNTEERLNLELDFFGTQILEAEEDNAGFCLVINHKDLQ------ 205
++E S++ + +N K +++ + + + G C++IN+K+
Sbjct: 3 NNETSVDSKSIKNFEVKTIHGSKSMDSGIYLDSSYKMDYPEMGVCIIINNKNFHKSTGMT 62
Query: 206 ----CDKDIHEIGKLFSGKLHYLCRRFSFTTTQNLKDMICEKLEMFKDCHEQIVVFVFCH 373
D D ++ + F L Y R + T + + +++ + V + H
Sbjct: 63 PRSGTDVDAAKLRETFMA-LKYEVRNKNDLTREEIVELMKNASKEDHSKRSSFVCVILSH 121
Query: 374 GNNNLIQTNDGSIKCGEFRELFLPGKFPRISEKPKLFFLIQKEVQVENSEKVNEDNSGNI 553
G+ +I DG I + F + KPKLF + + + E + G
Sbjct: 122 GDEGVIFGTDGPIDLKKLTSYFRGDYCRSLIGKPKLFII--------QACRGTELDCG-- 171
Query: 554 PQQSNSKKVNDLIGENIPELSNVYWASLTSDGFDS----LNGTPCVQALLKVIE-EDPKL 718
+++S +D+ + IP ++ +A T+ G+ S +G+ +Q+L +++ KL
Sbjct: 172 -IETDSGTEDDMTCQKIPVEADFLYAYSTAPGYYSWRNPKDGSWFIQSLCSMLKLYAHKL 230
Query: 719 EITDLKTETCNKMKELFQS 775
E + T K+ F+S
Sbjct: 231 EFMHILTRVNRKVATEFES 249
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,501,849
Number of Sequences: 369166
Number of extensions: 1783876
Number of successful extensions: 4767
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4601
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4760
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)