Planaria EST Database


DrC_01726

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01726
         (839 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q12955|ANK3_HUMAN  Ankyrin-3 (ANK-3) (Ankyrin G)                96   1e-19
sp|Q02357|ANK1_MOUSE  Ankyrin-1 (Erythrocyte ankyrin)              86   1e-16
sp|P16157|ANK1_HUMAN  Ankyrin-1 (Erythrocyte ankyrin) (Ankyr...    86   1e-16
sp|Q01484|ANK2_HUMAN  Ankyrin-2 (Brain ankyrin) (Ankyrin B) ...    85   2e-16
sp|P53355|DAPK1_HUMAN  Death-associated protein kinase 1 (DA...    81   4e-15
sp|P57078|RIPK4_HUMAN  Serine/threonine-protein kinase RIPK4...    80   5e-15
sp|Q5GIG6|TNI3K_MOUSE  Serine/threonine-protein kinase TNNI3...    76   1e-13
sp|Q80YE7|DAPK1_MOUSE  Death-associated protein kinase 1 (DA...    75   2e-13
sp|O95271|TNKS1_HUMAN  Tankyrase 1 (TANK1) (Tankyrase I) (TN...    75   3e-13
sp|Q9H2K2|TNKS2_HUMAN  Tankyrase 2 (TANK2) (Tankyrase II) (T...    74   4e-13
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
          Length = 4377

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 40/141 (28%), Positives = 79/141 (56%)
 Frame = +2

Query: 203  IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
            +H A    ++D+V  L+ +N N+    +    P+H+A + +   +AE+L+  G +++A  
Sbjct: 668  VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727

Query: 383  KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
            K  + P+H  C+YG++K+   L+++   +     + + P+H A   GH  I+ +LL+NN 
Sbjct: 728  KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787

Query: 563  NLIALTSSGQSAFDLAKEKGY 625
            +   LT +G +A  +A+  GY
Sbjct: 788  SPNELTVNGNTALGIARRLGY 808

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 39/147 (26%), Positives = 70/147 (47%)
 Frame = +2

Query: 194  FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
            F P+H A     +++   L+ K+ + ++ G+    P+HVA  ++  ++A +L+  G +  
Sbjct: 566  FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 374  ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
            A  KN + P+H A     + +A  L+E   D           +H A   GH ++V LLL 
Sbjct: 626  AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685

Query: 554  NNCNLIALTSSGQSAFDLAKEKGYHNL 634
             N N+     SG +   LA ++   N+
Sbjct: 686  RNANVNLSNKSGLTPLHLAAQEDRVNV 712

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 38/167 (22%), Positives = 82/167 (49%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  +   P+H    S +  +V+ L+D+   I S+ +    P+H+A + +     ++L+++
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
              ++    +    +H A + GH KVA +L++ K +     ++ + P+H AC     +++
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416

Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKGYHNLLXXXXXXXXXPQKYN 679
            LLL++  ++ A+T SG +   +A   G+ N++         P   N
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN 463

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 36/148 (24%), Positives = 76/148 (51%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           + P+H +    + D+   L+D   ++    ++   P+HVA ++   E+A +L++   + +
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
           A  K+   P+H A +Y + KVAL+L++          + + P+H A      +I   LLE
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNLL 637
              +  A+T  G ++  LA ++G+ +++
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGHVDMV 680

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 31/124 (25%), Positives = 63/124 (50%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N    +H A    ++++V  L+ +  N+++  ++    +H+A      E+ ++L+  G N
Sbjct: 73  NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
           + A  +N + P++ A    HL+V   L++N           + P+  A   GH+++V LL
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192

Query: 548 LENN 559
           LEN+
Sbjct: 193 LEND 196

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 35/147 (23%), Positives = 69/147 (46%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  +D  P+H +      DIVQ L+ +  +  +       P+H++ R    ++A  L+ +
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
           G ++    K  + P+H A  YG L+VA +L++     +        P+H A    ++++ 
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614

Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEK 619
            LLL+   +  A   +G +   +A +K
Sbjct: 615 LLLLDQGASPHAAAKNGYTPLHIAAKK 641

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 37/146 (25%), Positives = 72/146 (49%), Gaps = 1/146 (0%)
 Frame = +2

Query: 188 NDFLP-IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
           ND+L  +H A    +  + + L+DK  N  ++      P+H+A + N  ++ E+L+K+G 
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424

Query: 365 NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
           +I+A  ++   PIH A   GH+ +   L+ +     T N+     +H A  +G  E+V  
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 545 LLENNCNLIALTSSGQSAFDLAKEKG 622
           L+++   + A     Q+   ++   G
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLG 510

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 32/150 (21%), Positives = 74/150 (49%)
 Frame = +2

Query: 188  NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
            N + P+H A   N +DI  +L++   +  +  ++    +H+A +    ++  +L+    N
Sbjct: 630  NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689

Query: 368  IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
            +   +K+   P+H A     + VA +L+     ++      + P+H  C  G+ +IV  L
Sbjct: 690  VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749

Query: 548  LENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            L+++  + A T +G +    A ++G+ +++
Sbjct: 750  LQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 38/148 (25%), Positives = 67/148 (45%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  N   P+H A   ++++ VQ L+  N  ++    +    +HVA      ++A++L+  
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
             N  A   N + P+H AC    +KV  +L+++   I+        PIH A   GH  IV
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449

Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKG 622
             L+ +  +       G++A  +A   G
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSG 477

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 32/136 (23%), Positives = 68/136 (50%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A  S   ++V+ L+     +E++ ++++ P+H++ R    +I + L++ G +  A  
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
            + + P+H +   GH  VA  L+++   +       + P+H A   G  E+  LLL+ + 
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589

Query: 563 NLIALTSSGQSAFDLA 610
           +  A   SG +   +A
Sbjct: 590 SPDAAGKSGLTPLHVA 605

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 32/141 (22%), Positives = 61/141 (43%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           PIH A    +++IV  L+    +  +        +H+A R    E+   L++ G  +EA 
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            K+   P+H +   G   +   L++            + P+H +   GHE++   LL++ 
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555

Query: 560 CNLIALTSSGQSAFDLAKEKG 622
            +L   T  G +   +A + G
Sbjct: 556 ASLSITTKKGFTPLHVAAKYG 576

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 38/152 (25%), Positives = 69/152 (45%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  N F P+H AC  N I +++ L+    +I++  +    PIHVA       I   L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
           G +    +      +H A   G  +V   L+++   +E        P+H +   G  +IV
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515

Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKGYHNL 634
             LL+   +  A T+SG +   L+  +G+ ++
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDV 547

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 35/147 (23%), Positives = 72/147 (48%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A    NI++   L+++   ++   + +  P+HVA +     + ++L+  G  I+
Sbjct: 236 FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
           A  ++   P+H     GH +V  +L++    I +   +   P+H A    H   V LLL+
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355

Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
           +N  +  +T+   +A  +A   G++ +
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKV 382

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 30/143 (20%), Positives = 66/143 (46%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A   ++      L+  + N + E +    P+H+A  +    +A +L+     ++   
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           +N   P+H A   G+  +  +L++    I+        P+H    +GHE++V +LL+   
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325

Query: 563 NLIALTSSGQSAFDLAKEKGYHN 631
            +++ T +G S   +A +  + N
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLN 348

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/179 (20%), Positives = 77/179 (43%), Gaps = 29/179 (16%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNI-----------------------------ESE 280
           N F P++ A   N++++V+ L+D   +                              +++
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198

Query: 281 GQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENK 460
           G+     +H+A R +  + A +L++   N +   K+ + P+H A +YG++ VA +L+   
Sbjct: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258

Query: 461 CDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
             ++    +   P+H A   G+  +V LLL+    + A T  G +        G+  ++
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 29/130 (22%), Positives = 58/130 (44%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A   +N  +   L+D+  +  +  +    P+H+A + N  +IA  L++YG +  A 
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            +     +H A   GH+ +  +L+    ++   N     P+H A       +  +L+   
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720

Query: 560 CNLIALTSSG 589
            ++ A T  G
Sbjct: 721 AHVDAQTKMG 730

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 32/141 (22%), Positives = 66/141 (46%), Gaps = 1/141 (0%)
 Frame = +2

Query: 218 LSNNIDIVQSLIDKN-CNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQW 394
           L   +D +++ +D N CN     Q     +H+A +    E+   L++   N++A  K   
Sbjct: 54  LEKALDYIKNGVDINICN-----QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGN 108

Query: 395 RPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIA 574
             +H A   G  +V  +L+ N  ++   + + + P++ A    H E+V  LL+N  +   
Sbjct: 109 TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168

Query: 575 LTSSGQSAFDLAKEKGYHNLL 637
            T  G +   +A ++G+  ++
Sbjct: 169 ATEDGFTPLAVALQQGHDQVV 189

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 27/71 (38%), Positives = 36/71 (50%)
 Frame = +2

Query: 410 ACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSG 589
           A   GHL+ AL  I+N  DI  CN +    +H A   GH E+V  LL+   N+ A T  G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 590 QSAFDLAKEKG 622
            +A  +A   G
Sbjct: 108 NTALHIASLAG 118

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 19/86 (22%), Positives = 47/86 (54%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A   + +++ + L+++  +++++ +    P+HV   +   +I   L+++   + A 
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759

Query: 380 DKNQWRPIHFACNYGHLKVALILIEN 457
            KN + P+H A   GH  +  +L++N
Sbjct: 760 TKNGYTPLHQAAQQGHTHIINVLLQN 785

 Score = 33.1 bits (74), Expect = 0.98
 Identities = 17/81 (20%), Positives = 34/81 (41%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           + P+H  C   NI IV  L+  +  + ++ +    P+H A +     I  +L++   +  
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790

Query: 374 ACDKNQWRPIHFACNYGHLKV 436
               N    +  A   G++ V
Sbjct: 791 ELTVNGNTALGIARRLGYISV 811
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
          Length = 1862

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 40/142 (28%), Positives = 77/142 (54%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H A    + ++V  L+ K  N     +    P+H+  +     +A++LIK+G  ++A 
Sbjct: 634  PLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDAT 693

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
             +  + P+H A +YG++K+   L++++ D+       + P+H A   GH +IV LLL+N 
Sbjct: 694  TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 753

Query: 560  CNLIALTSSGQSAFDLAKEKGY 625
             +   ++S+G +   +AK  GY
Sbjct: 754  ASPNEVSSNGTTPLAIAKRLGY 775

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 41/146 (28%), Positives = 72/146 (49%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N   P+H A    N+ +V+ L+D+   IE+  ++   P+H A R+    I+EIL+ +G  
Sbjct: 234 NGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAP 293

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
           I+A  KN   PIH A    HL    +L++   +I+   +    P+H A   GH  +  +L
Sbjct: 294 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVL 353

Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
           L+      +   +G +   +A +K +
Sbjct: 354 LDKGAKPNSRALNGFTPLHIACKKNH 379

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 39/147 (26%), Positives = 73/147 (49%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A    N+++ Q L+++  ++    Q    P+H+A R     +  +L+  G  IE
Sbjct: 203 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 262

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
              K++  P+H A   GH++++ IL+++   I+    +   PIH A    H + V LLL+
Sbjct: 263 TRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 322

Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
            N  +  +T    +   +A   G+H +
Sbjct: 323 YNAEIDDITLDHLTPLHVAAHCGHHRV 349

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 41/159 (25%), Positives = 83/159 (52%)
 Frame = +2

Query: 149 DRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNF 328
           DR  + E R K+  +  P+H A  + ++ I + L+D    I+++ +    PIH+A + + 
Sbjct: 256 DRGAQIETRTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 313

Query: 329 GEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHF 508
            +   +L++Y   I+    +   P+H A + GH +VA +L++      +  ++ + P+H 
Sbjct: 314 LDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 373

Query: 509 ACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGY 625
           AC   H  ++ LLL+   ++ A+T SG +   +A   G+
Sbjct: 374 ACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGH 412

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 42/146 (28%), Positives = 70/146 (47%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N F P+H AC  N+I +++ L+    +I++  +    P+HVA       I + L++ G +
Sbjct: 366 NGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 425

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
               +     P+H A   GH +VA  L++NK            P+H A   GH  +V LL
Sbjct: 426 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLL 485

Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
           LEN  +    T++G +    A  +G+
Sbjct: 486 LENGASPNLATTAGHTPLHTAAREGH 511

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 40/160 (25%), Positives = 69/160 (43%)
 Frame = +2

Query: 158 YKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEI 337
           Y  E  +   +   P+H A    +  + + L+DK     S       P+H+A + N   +
Sbjct: 323 YNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRV 382

Query: 338 AEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACA 517
            E+L+K G +I+A  ++   P+H A   GHL +   L++        N+    P+H A  
Sbjct: 383 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 442

Query: 518 NGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            GH E+   LL+N     A     Q+    A   G+  ++
Sbjct: 443 AGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMV 482

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 37/151 (24%), Positives = 77/151 (50%)
 Frame = +2

Query: 185  YNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
            +N + P+H A   N I++ +SL+    +  +E  +   P+H+A +    E+  +L+    
Sbjct: 596  WNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQA 655

Query: 365  NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
            N    +K+   P+H     GH+ VA +LI++   ++      + P+H A   G+ ++V  
Sbjct: 656  NGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKF 715

Query: 545  LLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            LL++  ++ A T  G S    A ++G+ +++
Sbjct: 716  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 746

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 38/145 (26%), Positives = 67/145 (46%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N   P+H A   NN+DIV+ L+ +  +  S       P+H+A + N  E+A  L++YG +
Sbjct: 564 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGS 623

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
             A       P+H A   GH ++  +L+  + +    N     P+H     GH  +  +L
Sbjct: 624 ANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVL 683

Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
           +++   + A T  G +   +A   G
Sbjct: 684 IKHGVTVDATTRMGYTPLHVASHYG 708

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 37/144 (25%), Positives = 69/144 (47%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A     + + + L++ + +  + G+    P+HVA+ HN  +I ++L+  G +  
Sbjct: 533 FTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 592

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
           +   N + P+H A     ++VA  L++        ++    P+H A   GH E+V LLL 
Sbjct: 593 SPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLS 652

Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
              N      SG +   L  ++G+
Sbjct: 653 KQANGNLGNKSGLTPLHLVSQEGH 676

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 36/129 (27%), Positives = 61/129 (47%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  N   PIH A   +++D V+ L+  N  I+    ++  P+HVA       +A++L+  
Sbjct: 297 KTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 356

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
           G    +   N + P+H AC   H++V  +L++    I+        P+H A   GH  IV
Sbjct: 357 GAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 416

Query: 539 CLLLENNCN 565
             LL+   +
Sbjct: 417 KNLLQRGAS 425

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 35/141 (24%), Positives = 62/141 (43%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A    ++ IV++L+ +  +      +   P+H+A R    E+A+ L++      A 
Sbjct: 403 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAK 462

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            K+   P+H A   GH  +  +L+EN             P+H A   GH +    LLE  
Sbjct: 463 AKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKE 522

Query: 560 CNLIALTSSGQSAFDLAKEKG 622
            +   +T  G +   +A + G
Sbjct: 523 ASQACMTKKGFTPLHVAAKYG 543

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 33/138 (23%), Positives = 66/138 (47%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A  +++      L+  + N +   +    P+H+A  +    +A++L+  G ++    
Sbjct: 173 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 232

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           +N   P+H A   G++ +  +L++    IET       P+H A  NGH  I  +LL++  
Sbjct: 233 QNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGA 292

Query: 563 NLIALTSSGQSAFDLAKE 616
            + A T +G S   +A +
Sbjct: 293 PIQAKTKNGLSPIHMAAQ 310

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 32/146 (21%), Positives = 71/146 (48%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A    ++D   +L++K  +     ++   P+HVA ++    +AE+L+++  +  A 
Sbjct: 502 PLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAA 561

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            KN   P+H A ++ +L +  +L+       +   + + P+H A      E+   LL+  
Sbjct: 562 GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYG 621

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
            +  A +  G +   LA ++G+  ++
Sbjct: 622 GSANAESVQGVTPLHLAAQEGHTEMV 647

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 34/149 (22%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
 Frame = +2

Query: 110 FIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEG 283
           F+ A  +G++D      ++  +      N    +H A    ++ +V  L+ K   +E+  
Sbjct: 12  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 71

Query: 284 QENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKC 463
           ++    +H+A      E+   L+ YG N+ A  +  + P++ A    HL+V   L+EN  
Sbjct: 72  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 131

Query: 464 DIETCNMHAWRPIHFACANGHEEIVCLLL 550
           +        + P+  A   GHE +V  L+
Sbjct: 132 NQNVATEDGFTPLAVALQQGHENVVAHLI 160

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 33/146 (22%), Positives = 67/146 (45%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A  + + ++ + L+       ++ ++++ P+H A R     + ++L++ G +    
Sbjct: 436 PLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLA 495

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
                 P+H A   GH+  AL L+E +          + P+H A   G   +  LLLE++
Sbjct: 496 TTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHD 555

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
            +  A   +G +   +A    +HN L
Sbjct: 556 AHPNAAGKNGLTPLHVAV---HHNNL 578

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 34/144 (23%), Positives = 64/144 (44%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+  A    + ++V  LI    N  ++G+     +H+A R++    A +L++   N +
Sbjct: 141 FTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 196

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
              K  + P+H A +Y +L VA +L+     +     +   P+H A   G+  +V LLL+
Sbjct: 197 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 256

Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
               +   T    +    A   G+
Sbjct: 257 RGAQIETRTKDELTPLHCAARNGH 280

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 31/130 (23%), Positives = 58/130 (44%)
 Frame = +2

Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
           K +   K  +D  P+H A    +  +V+ L++   +          P+H A R    + A
Sbjct: 456 KAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTA 515

Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
             L++   +     K  + P+H A  YG +++A +L+E+         +   P+H A  +
Sbjct: 516 LALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHH 575

Query: 521 GHEEIVCLLL 550
            + +IV LLL
Sbjct: 576 NNLDIVKLLL 585

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 31/142 (21%), Positives = 59/142 (41%)
 Frame = +2

Query: 212 ACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQ 391
           A  S N+D     +    +I +  Q     +H+A +    ++   L+     +E   K  
Sbjct: 15  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 74

Query: 392 WRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLI 571
              +H A   G  +V   L+    ++   +   + P++ A    H E+V  LLEN  N  
Sbjct: 75  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 134

Query: 572 ALTSSGQSAFDLAKEKGYHNLL 637
             T  G +   +A ++G+ N++
Sbjct: 135 VATEDGFTPLAVALQQGHENVV 156

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 22/116 (18%), Positives = 52/116 (44%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H      ++ +   LI     +++  +    P+HVA  +   ++ + L+++  ++ A 
Sbjct: 667  PLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 726

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
             K  + P+H A   GH  +  +L++N       + +   P+  A   G+  +  +L
Sbjct: 727  TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVL 782

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 20/85 (23%), Positives = 40/85 (47%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           + P+H A    NI +V+ L+    ++ ++ +    P+H A +    +I  +L+K G +  
Sbjct: 698 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 757

Query: 374 ACDKNQWRPIHFACNYGHLKVALIL 448
               N   P+  A   G++ V  +L
Sbjct: 758 EVSSNGTTPLAIAKRLGYISVTDVL 782
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
          Length = 1881

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 40/142 (28%), Positives = 76/142 (53%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H A    + ++V  L+ K  N     +    P+H+  +     +A++LIK+G  ++A 
Sbjct: 638  PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
             +  + P+H A +YG++K+   L++++ D+       + P+H A   GH +IV LLL+N 
Sbjct: 698  TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757

Query: 560  CNLIALTSSGQSAFDLAKEKGY 625
             +   ++S G +   +AK  GY
Sbjct: 758  ASPNEVSSDGTTPLAIAKRLGY 779

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 43/146 (29%), Positives = 73/146 (50%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N F P+H AC  N++ +++ L+    +I++  +    P+HVA       I + L++ G +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
               +     P+H A   GH +VA  L++NK  +         P+H A   GH  +V LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
           LENN N    T++G +   +A  +G+
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGH 515

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 41/146 (28%), Positives = 73/146 (50%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N   P+H A    N+ +V+ L+D+   IE++ ++   P+H A R+    I+EIL+ +G  
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
           I+A  KN   PIH A    HL    +L++   +I+   +    P+H A   GH  +  +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
           L+      +   +G +   +A +K +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNH 383

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 37/153 (24%), Positives = 79/153 (51%)
 Frame = +2

Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
           +   K  ++  P+H A  + ++ I + L+D    I+++ +    PIH+A + +  +   +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGH 526
           L++Y   I+    +   P+H A + GH +VA +L++      +  ++ + P+H AC   H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 527 EEIVCLLLENNCNLIALTSSGQSAFDLAKEKGY 625
             ++ LLL+   ++ A+T SG +   +A   G+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 41/160 (25%), Positives = 71/160 (44%)
 Frame = +2

Query: 158 YKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEI 337
           Y  E  +   +   P+H A    +  + + L+DK     S       P+H+A + N   +
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386

Query: 338 AEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACA 517
            E+L+K G +I+A  ++   P+H A   GHL +   L++        N+    P+H A  
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446

Query: 518 NGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            GH E+   LL+N   + A     Q+    A   G+ N++
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 38/147 (25%), Positives = 73/147 (49%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A    N+++ Q L+++  ++    Q    P+H+A R     +  +L+  G  IE
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
              K++  P+H A   GH++++ IL+++   I+    +   PIH A    H + V LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326

Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
            +  +  +T    +   +A   G+H +
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRV 353

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 36/151 (23%), Positives = 77/151 (50%)
 Frame = +2

Query: 185  YNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
            +N + P+H A   N +++ +SL+    +  +E  +   P+H+A +    E+  +L+    
Sbjct: 600  WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 365  NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
            N    +K+   P+H     GH+ VA +LI++   ++      + P+H A   G+ ++V  
Sbjct: 660  NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719

Query: 545  LLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            LL++  ++ A T  G S    A ++G+ +++
Sbjct: 720  LLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 37/141 (26%), Positives = 65/141 (46%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A    ++ IV++L+ +  +      +   P+H+A R    E+A+ L++    + A 
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            K+   P+H A   GH  +  +L+EN  +          P+H A   GH E V  LLE  
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526

Query: 560 CNLIALTSSGQSAFDLAKEKG 622
            +   +T  G +   +A + G
Sbjct: 527 ASQACMTKKGFTPLHVAAKYG 547

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 38/145 (26%), Positives = 67/145 (46%)
 Frame = +2

Query: 188  NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
            N   P+H A   NN+DIV+ L+ +  +  S       P+H+A + N  E+A  L++YG +
Sbjct: 568  NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 368  IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
              A       P+H A   GH ++  +L+  + +    N     P+H     GH  +  +L
Sbjct: 628  ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687

Query: 548  LENNCNLIALTSSGQSAFDLAKEKG 622
            +++   + A T  G +   +A   G
Sbjct: 688  IKHGVMVDATTRMGYTPLHVASHYG 712

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 37/144 (25%), Positives = 70/144 (48%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A     + + + L++++ +  + G+    P+HVA+ HN  +I ++L+  G +  
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
           +   N + P+H A     ++VA  L++        ++    P+H A   GH E+V LLL 
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
              N      SG +   L  ++G+
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGH 680

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 35/129 (27%), Positives = 61/129 (47%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K  N   PIH A   +++D V+ L+  +  I+    ++  P+HVA       +A++L+  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
           G    +   N + P+H AC   H++V  +L++    I+        P+H A   GH  IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 539 CLLLENNCN 565
             LL+   +
Sbjct: 421 KNLLQRGAS 429

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 36/156 (23%), Positives = 68/156 (43%), Gaps = 2/156 (1%)
 Frame = +2

Query: 89  ELDNFRLFIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKN 262
           E D    F+ A  +G++D      ++  +      N    +H A    ++ +V  L+ K 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 263 CNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVAL 442
             +E+  ++    +H+A      E+   L+ YG N+ A  +  + P++ A    HL+V  
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 443 ILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
            L+EN  +        + P+  A   GHE +V  L+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 33/138 (23%), Positives = 66/138 (47%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A  +++      L+  + N +   +    P+H+A  +    +A++L+  G ++    
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           +N   P+H A   G++ +  +L++    IET       P+H A  NGH  I  +LL++  
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296

Query: 563 NLIALTSSGQSAFDLAKE 616
            + A T +G S   +A +
Sbjct: 297 PIQAKTKNGLSPIHMAAQ 314

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 32/146 (21%), Positives = 66/146 (45%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A  + + ++ + L+     + ++ ++++ P+H A R     + ++L++   N    
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
                 P+H A   GH++  L L+E +          + P+H A   G   +  LLLE +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
            +  A   +G +   +A    +HN L
Sbjct: 560 AHPNAAGKNGLTPLHVAV---HHNNL 582

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 32/146 (21%), Positives = 71/146 (48%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A    +++ V +L++K  +     ++   P+HVA ++    +AE+L++   +  A 
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            KN   P+H A ++ +L +  +L+       +   + + P+H A      E+   LL+  
Sbjct: 566 GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
            +  A +  G +   LA ++G+  ++
Sbjct: 626 GSANAESVQGVTPLHLAAQEGHAEMV 651

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 34/130 (26%), Positives = 59/130 (45%)
 Frame = +2

Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
           K +   K  +D  P+H A    + ++V+ L++ N N          P+H+A R    E  
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
             L++   +     K  + P+H A  YG ++VA +L+E          +   P+H A  +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579

Query: 521 GHEEIVCLLL 550
            + +IV LLL
Sbjct: 580 NNLDIVKLLL 589

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 34/144 (23%), Positives = 64/144 (44%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+  A    + ++V  LI    N  ++G+     +H+A R++    A +L++   N +
Sbjct: 145 FTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
              K  + P+H A +Y +L VA +L+     +     +   P+H A   G+  +V LLL+
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260

Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
               +   T    +    A   G+
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGH 284

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 37/161 (22%), Positives = 66/161 (40%), Gaps = 1/161 (0%)
 Frame = +2

Query: 158 YKDEFREKEY-NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGE 334
           Y   FRE +    FL    A  S N+D     +    +I +  Q     +H+A +    +
Sbjct: 3   YSVGFREADAATSFL---RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59

Query: 335 IAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFAC 514
           +   L+     +E   K     +H A   G  +V   L+    ++   +   + P++ A 
Sbjct: 60  MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119

Query: 515 ANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
              H E+V  LLEN  N    T  G +   +A ++G+ N++
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 22/116 (18%), Positives = 51/116 (43%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H      ++ +   LI     +++  +    P+HVA  +   ++ + L+++  ++ A 
Sbjct: 671  PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
             K  + P+H A   GH  +  +L++N       +     P+  A   G+  +  +L
Sbjct: 731  TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786

 Score = 37.7 bits (86), Expect = 0.040
 Identities = 19/85 (22%), Positives = 40/85 (47%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           + P+H A    NI +V+ L+    ++ ++ +    P+H A +    +I  +L+K G +  
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 374 ACDKNQWRPIHFACNYGHLKVALIL 448
               +   P+  A   G++ V  +L
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL 786
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
          Length = 3924

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 42/142 (29%), Positives = 77/142 (54%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H A    + D+V  L+DK  NI    +     +H+A + +   +A+IL K+G + +A 
Sbjct: 665  PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
             K  + P+  AC+YG++K+   L++   ++     + + P+H A   GH  I+ +LL++ 
Sbjct: 725  TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784

Query: 560  CNLIALTSSGQSAFDLAKEKGY 625
                A T++G +A  +AK  GY
Sbjct: 785  AKPNATTANGNTALAIAKRLGY 806

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 39/147 (26%), Positives = 74/147 (50%)
 Frame = +2

Query: 194  FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
            F P+H A    ++D+ + L+ +    +S G+    P+HVA  ++  ++A +L++ G +  
Sbjct: 564  FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623

Query: 374  ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
            A  KN + P+H A     +++A  L+    +          P+H A   GH ++V LLL+
Sbjct: 624  ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 554  NNCNLIALTSSGQSAFDLAKEKGYHNL 634
               N+   T SG ++  LA ++   N+
Sbjct: 684  KGANIHMSTKSGLTSLHLAAQEDKVNV 710

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 40/140 (28%), Positives = 68/140 (48%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A    +  + + L+DK  N  +       P+H+A + N  ++ E+L+KYG +I+A  
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           ++   PIH A   GHL + L+L++N    +  N+     +H A   G  E+V  LL N  
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488

Query: 563 NLIALTSSGQSAFDLAKEKG 622
            + A     Q+   +A   G
Sbjct: 489 LVDARAREEQTPLHIASRLG 508

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
 Frame = +2

Query: 95  DNFRLFIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCN 268
           D+   F+ A   G++D    + K   +      N    +H A    ++ +VQ L+ +  +
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 269 IESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALIL 448
           ++S  ++    +H+A      E+ ++L+K G NI A  +N + P++ A    H+ V   L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 449 IENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
           +EN  +  T     + P+  A   GH + V +LLEN+
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 37/144 (25%), Positives = 71/144 (49%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N   P+H A    N ++V+ L+D+   I+++ ++   P+H A R    ++ E+L++ G  
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
           + A  KN   P+H A    H++    L+++K  ++   +     +H A   GH  +  LL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 548 LENNCNLIALTSSGQSAFDLAKEK 619
           L+   N  A   +G +   +A +K
Sbjct: 385 LDKRANPNARALNGFTPLHIACKK 408

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 34/150 (22%), Positives = 71/150 (47%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N + P+H +     +D+   L++         ++   P+HVA ++   ++A++L++    
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
            ++  KN   P+H A +Y + KVAL+L+E          + + P+H A      +I   L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648

Query: 548 LENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
           L        +T  G +   LA ++G+ +++
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMV 678

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 34/140 (24%), Positives = 67/140 (47%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A      +IVQ L+    + ++       P+H++ R    ++A +L++ G      
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            K  + P+H A  YG L VA +L++ +   ++   +   P+H A    ++++  LLLE  
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619

Query: 560 CNLIALTSSGQSAFDLAKEK 619
            +  A   +G +   +A +K
Sbjct: 620 ASPHATAKNGYTPLHIAAKK 639

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 37/145 (25%), Positives = 64/145 (44%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N   P+H A   ++++ V+ L+     ++    +    +HVA       + ++L+    N
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
             A   N + P+H AC    +KV  +L++    I+        PIH A   GH  IV LL
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
           L+N  +       G++A  +A   G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAG 475

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 38/145 (26%), Positives = 69/145 (47%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N F P+H AC  N I +++ L+    +I++  +    PIHVA       I  +L++ G +
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
            +  +      +H A   G ++V   L+ N   ++        P+H A   G  EIV LL
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516

Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
           L++  +  A T++G +   ++  +G
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREG 541

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 34/147 (23%), Positives = 69/147 (46%)
 Frame = +2

Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
           F P+H A    N+++   L+++   ++   +    P+HVA +     + ++L+  G  I+
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293

Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
           A  ++   P+H A   GH +V  +L+E    +     +   P+H A    H E V  LL+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353

Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
           +   +  +T    +A  +A   G++ +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRV 380

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 31/131 (23%), Positives = 66/131 (50%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A  +  +++V+ L+     +++  +E + P+H+A R    EI ++L+++  + +A  
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
            N + P+H +   G + VA +L+E            + P+H A   G  ++  LLL+   
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587

Query: 563 NLIALTSSGQS 595
              A  S+G++
Sbjct: 588 ---AADSAGKN 595

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/183 (21%), Positives = 73/183 (39%), Gaps = 33/183 (18%)
 Frame = +2

Query: 188  NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
            N   P+H A   +N  +   L++K  +  +  +    P+H+A + N  +IA  L+ YG  
Sbjct: 595  NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654

Query: 368  IEACDKNQWRPIHFACNYGH---------------------------------LKVALIL 448
                 K    P+H A   GH                                 + VA IL
Sbjct: 655  TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714

Query: 449  IENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYH 628
             ++  D +      + P+  AC  G+ ++V  LL+   N+ A T +G +    A ++G+ 
Sbjct: 715  TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHT 774

Query: 629  NLL 637
            +++
Sbjct: 775  HII 777

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 35/170 (20%), Positives = 76/170 (44%)
 Frame = +2

Query: 119 AIETGSVDNFDRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRR 298
           A ++ S + F+   +   R K+ +       A  + N+D V   +    +I +  Q    
Sbjct: 7   AQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLN 66

Query: 299 PIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETC 478
            +H+A +     + + L+  G ++++  K     +H A   G  +V  +L++   +I   
Sbjct: 67  ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126

Query: 479 NMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYH 628
           + + + P++ A    H ++V  LLEN  N    T  G +   +A ++G++
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 29/141 (20%), Positives = 62/141 (43%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           PIH A    +++IV  L+    + +         +H+A R    E+   L++ G  ++A 
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
            + +  P+H A   G  ++  +L+++    +    + + P+H +   G  ++  +LLE  
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553

Query: 560 CNLIALTSSGQSAFDLAKEKG 622
                 T  G +   +A + G
Sbjct: 554 AAHSLATKKGFTPLHVAAKYG 574

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 39/187 (20%), Positives = 77/187 (41%), Gaps = 37/187 (19%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPI--------------------- 304
           N F P++ A   N+ID+V+ L++   N  +  ++   P+                     
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188

Query: 305 --------HVAIRHNFGEIAEILIKYGCNIEACDK--------NQWRPIHFACNYGHLKV 436
                   H+A R +  + A +L++   N +   K        + + P+H A +YG++ V
Sbjct: 189 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 248

Query: 437 ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
           A +L+     ++    +   P+H A   G+  +V LLL+    + A T  G +    A  
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308

Query: 617 KGYHNLL 637
            G+  ++
Sbjct: 309 SGHDQVV 315
>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
          Length = 1432

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 40/141 (28%), Positives = 68/141 (48%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A       + ++L +  CN+  + +E   P+  A    + +I E L ++G ++ AC
Sbjct: 483 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 542

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
           DK+    +H A     ++V   L+   C ++  + H   P+H AC +G+  IV  L E N
Sbjct: 543 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 602

Query: 560 CNLIALTSSGQSAFDLAKEKG 622
           CNL      G++   LA   G
Sbjct: 603 CNLDISNKYGRTPLHLAANNG 623

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 36/134 (26%), Positives = 75/134 (55%)
 Frame = +2

Query: 233 DIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
           DIV+ L +   ++ +  ++    +H+A+R    E+ + L+  GC ++  D++   P+H A
Sbjct: 527 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 586

Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
           C  G++ + + L E  C+++  N +   P+H A  NG  ++V  L     ++ ALT+ G+
Sbjct: 587 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 646

Query: 593 SAFDLAKEKGYHNL 634
           +A DLA+ + + ++
Sbjct: 647 TAEDLARSEQHEHV 660

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 38/138 (27%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI--LIKYGCNIEA 376
           ++ A    ++D ++ L +  C ++ + +     +HVA R+   ++A++  L  +G N   
Sbjct: 416 VYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNI 475

Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
            DK +  P+H A  +G+  VA  L E  C++   N     P+  A A G+ +IV  L E+
Sbjct: 476 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 535

Query: 557 NCNLIALTSSGQSAFDLA 610
             +L A    G  A  LA
Sbjct: 536 GADLNACDKDGHIALHLA 553

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/171 (23%), Positives = 74/171 (43%), Gaps = 2/171 (1%)
 Frame = +2

Query: 131 GSVDNFDRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHV 310
           GS+ N+D        +   +   P+  A    NI I+Q LI +   I+ + +     ++ 
Sbjct: 365 GSLSNYD------VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYW 418

Query: 311 AIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVA--LILIENKCDIETCNM 484
           A RH   +  + L +  C ++  DK+    +H A  YGH  VA   +L     +    + 
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDK 478

Query: 485 HAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
               P+H A  +G+  +   L E  CN+      G++    A  +GYH+++
Sbjct: 479 EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 529

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDK--NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
           I HA   +N+  +Q L+    N ++    +    P+ +A      +I ++LIK G  I+ 
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407

Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEI 535
            DK     +++A  +GH+     L ENKC ++  +      +H A   GH ++
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/117 (23%), Positives = 51/117 (43%)
 Frame = +2

Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
           + +H A     ++++++L+ + C ++ + +    P+HVA +     I   L +  CN++ 
Sbjct: 548 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 607

Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
            +K    P+H A N G L V   L      +E            A +  HE +  LL
Sbjct: 608 SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 664
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
            serine/threonine-protein kinase 4) (Ankyrin repeat domain
            protein 3) (PKC-delta-interacting protein kinase)
          Length = 832

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 34/183 (18%)
 Frame = +2

Query: 179  KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
            K+ + +  +H A  + +    + L++KN ++     E R P+HVA +H    I  IL++ 
Sbjct: 548  KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 607

Query: 359  GCNIEACDKNQWRPIHFACNYGHL----------------------------------KV 436
            G ++    K+ W P+H+A   GHL                                  +V
Sbjct: 608  GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 667

Query: 437  ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
            A ILI+   D+  C++ A  P+H A   GH     LLL       A+TS G +A  LA  
Sbjct: 668  ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 727

Query: 617  KGY 625
             G+
Sbjct: 728  NGH 730

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 39/149 (26%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
 Frame = +2

Query: 194  FLPIHHACLSNNIDIVQSLIDK-NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNI 370
            +LP+H+A    ++ IV+ L  +   ++ ++  + R P+H+A +     +A ILI    ++
Sbjct: 619  WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 678

Query: 371  EACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
              C      P+H A   GH   A +L+      E      +  +H A  NGH   V LL+
Sbjct: 679  NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 738

Query: 551  ENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
            E   +++A     Q+A  LA   G+  ++
Sbjct: 739  EEKADVLARGPLNQTALHLAAAHGHSEVV 767

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 34/146 (23%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A       +V+ L+ +  ++ ++ ++    +H A ++       +L++   ++   
Sbjct: 522 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 581

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN- 556
           D     P+H AC +G   +  IL+    D+      AW P+H+A   GH  IV LL +  
Sbjct: 582 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 641

Query: 557 NCNLIALTSSGQSAFDLAKEKGYHNL 634
             ++ A T  G++   LA ++G++ +
Sbjct: 642 GVSVNAQTLDGRTPLHLAAQRGHYRV 667

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 30/122 (24%), Positives = 56/122 (45%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           +H A  +   +  + L+  N N     +    P+H+A+      + E+L+    ++ A D
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           ++QW  +HFA   G      +L+E    +   +     P+H AC +G E IV +LL    
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 609

Query: 563 NL 568
           ++
Sbjct: 610 DV 611

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 28/112 (25%), Positives = 50/112 (44%)
 Frame = +2

Query: 302 IHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCN 481
           +H+A+     E A+ L+    N    ++    P+H A       V  +L+  K  +   +
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549

Query: 482 MHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
              W  +HFA  NG E    LLLE N ++  +   G++   +A + G  N++
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 601

 Score = 33.5 bits (75), Expect = 0.75
 Identities = 23/123 (18%), Positives = 51/123 (41%)
 Frame = +2

Query: 200  PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
            P+H A  + +    + L+ +    E+   +    +H+A R+      ++L++   ++ A 
Sbjct: 688  PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 747

Query: 380  DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
                   +H A  +GH +V   L+     I+  +      +H A    H + V  LL + 
Sbjct: 748  GPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHG 806

Query: 560  CNL 568
             ++
Sbjct: 807  AHI 809
>sp|Q5GIG6|TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
           (Cardiac ankyrin repeat kinase)
          Length = 834

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 40/151 (26%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
 Frame = +2

Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
           N F  +H A   ++++++ SL+    +++  G      +H+A      E  E+L+++G N
Sbjct: 100 NGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGAN 159

Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
           +   D   + P+H A  YGH +V  +L++   D+        RP+H A A G   IV LL
Sbjct: 160 VNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLL 219

Query: 548 LE-NNCNLIALTSSGQSAFDLAKEKGYHNLL 637
           +E N  ++ A  +            G+HN++
Sbjct: 220 VEGNKADVNAQDNEDHVPLHFCSRFGHHNIV 250

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 1/132 (0%)
 Frame = +2

Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
           + ++  Y     +H A ++ + + V+ L+    N+  +      P+H+A  +   ++  +
Sbjct: 126 DVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSV 185

Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIE-NKCDIETCNMHAWRPIHFACANG 523
           L+K+G ++    +   RP+H A   G   +  +L+E NK D+   +     P+HF    G
Sbjct: 186 LLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFG 245

Query: 524 HEEIVCLLLENN 559
           H  IV  LL+++
Sbjct: 246 HHNIVSYLLQSD 257

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 15/170 (8%)
 Frame = +2

Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESE--GQENRRPIHVAIRHNFGE 334
           K +   ++  D +P+H      + +IV  L+  +  ++          P+H+A  +   E
Sbjct: 224 KADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFE 283

Query: 335 IAEILIKYGCNIEACDKNQWRP--IHFACNYGHL--KVALILIENKCDIETCNMHAWRPI 502
           +A+ ++          +N +     H AC YG     V  +L +N  +I          +
Sbjct: 284 VAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGL 343

Query: 503 HFACANGHEEIVCLLLEN--NCNLIAL---TSSG----QSAFDLAKEKGY 625
           H AC +GH  +V  LL+N  + NL+A     SSG    Q+    A EKG+
Sbjct: 344 HSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 393

 Score = 33.9 bits (76), Expect = 0.57
 Identities = 29/136 (21%), Positives = 59/136 (43%)
 Frame = +2

Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
           +D+ + KE N+F  + H   S+     ++  + + N  +E   +   +  A   N   I 
Sbjct: 32  EDDLQIKE-NEFQELRHIFGSD-----EAFSEVSLNYRTERGLSLLHLCCACGGNKSHIR 85

Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
            +++K G       +N +  +H A     L++   L+ +  D++         +H A   
Sbjct: 86  ALMLK-GLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIA 144

Query: 521 GHEEIVCLLLENNCNL 568
           GH E V +LL++  N+
Sbjct: 145 GHPEAVEVLLQHGANV 160
>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
          Length = 1442

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/134 (28%), Positives = 73/134 (54%)
 Frame = +2

Query: 233 DIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
           DIV+ L +   ++ +  ++    +H+A+R    E+ + L+ +G  ++  D++   P+H A
Sbjct: 525 DIVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVA 584

Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
           C  G   + + L E  C+++  N +   P+H A  NG  ++V  L     N+ ALTS G+
Sbjct: 585 CKDGSAPIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGK 644

Query: 593 SAFDLAKEKGYHNL 634
           +A DLAK + + ++
Sbjct: 645 TAEDLAKAEQHEHV 658

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 40/152 (26%), Positives = 73/152 (48%)
 Frame = +2

Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
           +F++KE  +  P+H A       + ++L +  CN+  + +E   P+  A    + +I E 
Sbjct: 472 DFQDKE--EETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVEC 529

Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGH 526
           L ++G ++ A DK+    +H A     ++V   L+ +   ++  + H   P+H AC +G 
Sbjct: 530 LAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGS 589

Query: 527 EEIVCLLLENNCNLIALTSSGQSAFDLAKEKG 622
             IV  L E +CNL      G++   LA   G
Sbjct: 590 APIVVALCEASCNLDISNKYGRTPLHLAANNG 621

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 38/136 (27%), Positives = 67/136 (49%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
           I+ A    ++D ++ L +  C ++ + +     +HVA R+   ++ ++L  +G N +  D
Sbjct: 416 IYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQD 475

Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
           K +  P+H A  +G+  VA  L E  C++   N     P+  A A G+ +IV  L E+  
Sbjct: 476 KEEETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGA 535

Query: 563 NLIALTSSGQSAFDLA 610
           +L A    G  A  LA
Sbjct: 536 DLNASDKDGHIALHLA 551

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 36/146 (24%), Positives = 66/146 (45%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+  A    NI ++Q LI +   I+ + +     I+ A RH   +  + L +  C ++  
Sbjct: 382 PLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVK 441

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
           DK+    +H A  YGH  V  +L     + +  +     P+H A  +G+  +   L E  
Sbjct: 442 DKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVG 501

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
           CN+      G++    A  +GYH+++
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIV 527

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/146 (23%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLIDK--NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
           I HA   +N+  +Q L+    + ++    +    P+ +A      ++ ++LIK G  I+ 
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDV 407

Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
            DK     I++A  +GH+     L ENKC ++  +      +H A   GH ++V LL   
Sbjct: 408 QDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSF 467

Query: 557 NCNLIALTSSGQSAFDLAKEKGYHNL 634
             N        ++    A   GY+++
Sbjct: 468 GSNPDFQDKEEETPLHCAAWHGYYSV 493

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 27/117 (23%), Positives = 50/117 (42%)
 Frame = +2

Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
           + +H A     ++++++L+     ++ + +    P+HVA +     I   L +  CN++ 
Sbjct: 546 IALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDI 605

Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
            +K    P+H A N G L V   L     ++E            A A  HE +  LL
Sbjct: 606 SNKYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLL 662

 Score = 37.4 bits (85), Expect = 0.052
 Identities = 21/86 (24%), Positives = 44/86 (51%)
 Frame = +2

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
           +K+   P+  A   G++++  +LI+    I+  +      I++A  +GH + +  L EN 
Sbjct: 376 NKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENK 435

Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
           C L     SG++A  +A   G+ +++
Sbjct: 436 CPLDVKDKSGETALHVAARYGHADVV 461
>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
            ankyrin-related ADP-ribose polymerase)
          Length = 1327

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 43/142 (30%), Positives = 70/142 (49%)
 Frame = +2

Query: 191  DFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNI 370
            D   +   C S N+         NC  + EG+ +  P+H A  +N   + E L+ +G ++
Sbjct: 662  DLETVKQLCSSQNV---------NCR-DLEGRHST-PLHFAAGYNRVSVVEYLLHHGADV 710

Query: 371  EACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
             A DK    P+H AC+YGH +VA +L+ +   +   ++  + P+H A A G  EI  LLL
Sbjct: 711  HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770

Query: 551  ENNCNLIALTSSGQSAFDLAKE 616
            ++  +       G +  DL KE
Sbjct: 771  KHGADPTKKNRDGNTPLDLVKE 792

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 39/127 (30%), Positives = 64/127 (50%)
 Frame = +2

Query: 257  KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKV 436
            +N N       N  P+H+A  +N  E+AE L+++G ++ A DK    P+H A +YGH+ +
Sbjct: 826  ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885

Query: 437  ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
            A +LI+    +   +  A+ P+H A   G  ++  LLL +  +       GQ+  DLA  
Sbjct: 886  AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945

Query: 617  KGYHNLL 637
                 LL
Sbjct: 946  DDIRALL 952

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 38/143 (26%), Positives = 71/143 (49%)
 Frame = +2

Query: 182 EYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYG 361
           EY     +  A   N   ++  L   N N  +       P+H+A  +N   I ++L+++G
Sbjct: 333 EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392

Query: 362 CNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVC 541
            ++ A DK    P+H AC+YGH +V  +L+++   +   ++  + P+H A +    E+  
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCS 452

Query: 542 LLLENNCNLIALTSSGQSAFDLA 610
           LLL +  +   +   G+SA D+A
Sbjct: 453 LLLSHGADPTLVNCHGKSAVDMA 475

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
 Frame = +2

Query: 212 ACLSNNIDIVQSLIDK-NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKN 388
           AC + ++  V+ L+D  N N +        P+H A      ++ E L++ G N+ A D  
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248

Query: 389 QWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNL 568
              P+H AC++GH +V  +L+    D    +   + P+H A   G  ++  +LL++  + 
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308

Query: 569 IALTSSGQSAFDLA 610
               + G+SA DLA
Sbjct: 309 NIRNTDGKSALDLA 322

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 36/150 (24%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
 Frame = +2

Query: 113  IDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEG 283
            +DA + G +    +    E    R+ +  +  P+H A   NN+++ + L++   ++ ++ 
Sbjct: 808  LDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQD 867

Query: 284  QENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKC 463
            +    P+H A  +   +IA +LIKY   + A DK  + P+H A   G  ++  +L+ +  
Sbjct: 868  KGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927

Query: 464  DIETCNMHAWRPIHFACANGHEEIVCLLLE 553
            D    N     P+  A A   ++I  LL++
Sbjct: 928  DPTMKNQEGQTPLDLATA---DDIRALLID 954

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 29/132 (21%), Positives = 69/132 (52%), Gaps = 3/132 (2%)
 Frame = +2

Query: 80   KMSELDNFRLFIDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSL 250
            + S++D +RL ++A + G ++   +    +    R+ E     P+H A   N + +V+ L
Sbjct: 646  RTSDVD-YRL-LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 251  IDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHL 430
            +    ++ ++ +    P+H A  +   E+AE+L+++G ++   D  ++ P+H A   G  
Sbjct: 704  LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763

Query: 431  KVALILIENKCD 466
            ++  +L+++  D
Sbjct: 764  EICKLLLKHGAD 775

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 22/89 (24%), Positives = 41/89 (46%)
 Frame = +2

Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           P+H A      D+V+ L+    N+ +       P+H A      E+  +L+  G +  A 
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCD 466
           D   + P+H A   G + V ++L+++  D
Sbjct: 279 DNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 25/107 (23%), Positives = 49/107 (45%)
 Frame = +2

Query: 236 IVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFAC 415
           + + L+ K  N+  + ++   P+HVA      ++ E+L K+G  + A D      +H A 
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 416 NYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
             GHL+   +L+    D    ++  +     A   G+E +  +L E+
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSES 642

 Score = 36.6 bits (83), Expect = 0.089
 Identities = 21/95 (22%), Positives = 42/95 (44%)
 Frame = +2

Query: 332 EIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
           ++ E+L++ G N+   +K+   P+H A    H  V  +L ++   +   +      +H A
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598

Query: 512 CANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
              GH +   LLL    +   ++  G +A  +  E
Sbjct: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633

 Score = 35.0 bits (79), Expect = 0.26
 Identities = 31/181 (17%), Positives = 67/181 (37%), Gaps = 54/181 (29%)
 Frame = +2

Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC--NI 370
           +P+H+AC   + ++V  L+ +  +  +    N  P+H A      ++  +L+++G   NI
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNI 310

Query: 371 EACDKNQ-------------------------------------WRPIHFACN------- 418
              D                                          P++  C+       
Sbjct: 311 RNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS 370

Query: 419 --------YGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIA 574
                   Y  +++  +L+++  D+   +     P+H AC+ GH E+  LLL++   + A
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430

Query: 575 L 577
           +
Sbjct: 431 M 431

 Score = 32.7 bits (73), Expect = 1.3
 Identities = 22/111 (19%), Positives = 41/111 (36%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K+    +P+H+AC                                  +   E+ E+L+K+
Sbjct: 398 KDKGGLVPLHNAC---------------------------------SYGHYEVTELLLKH 424

Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
           G  + A D  Q+ P+H A +   ++V  +L+ +  D    N H    +  A
Sbjct: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475

 Score = 30.0 bits (66), Expect = 8.3
 Identities = 15/65 (23%), Positives = 31/65 (47%)
 Frame = +2

Query: 431 KVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLA 610
           +V  +L+    ++   N     P+H A    H +++ +L ++   + AL + GQ+A   A
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598

Query: 611 KEKGY 625
              G+
Sbjct: 599 ALAGH 603
>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
           ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
           protein) (Tankyrase-related protein)
          Length = 1166

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 39/128 (30%), Positives = 70/128 (54%), Gaps = 6/128 (4%)
 Frame = +2

Query: 251 IDKNCNIES------EGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
           + K C ++S      EG+++  P+H A  +N   + E L+++G ++ A DK    P+H A
Sbjct: 508 VKKLCTVQSVNCRDIEGRQST-PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566

Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
           C+YGH +VA +L+++   +   ++  + P+H A A G  EI  LLL++  +       G 
Sbjct: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626

Query: 593 SAFDLAKE 616
           +  DL K+
Sbjct: 627 TPLDLVKD 634

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 41/143 (28%), Positives = 65/143 (45%)
 Frame = +2

Query: 260  NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVA 439
            N N       +  P+H+A  +N  E+AE L+++G ++ A DK    P+H A +YGH+ VA
Sbjct: 669  NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVA 728

Query: 440  LILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEK 619
             +LI+    +   +  A+ P+H A   G  ++  LLL +  +       GQ+  DL    
Sbjct: 729  ALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788

Query: 620  GYHNLLXXXXXXXXXPQKYNKMV 688
                LL         P  Y   V
Sbjct: 789  DVSALLTAAMPPSALPSCYKPQV 811

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 39/143 (27%), Positives = 70/143 (48%)
 Frame = +2

Query: 182 EYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYG 361
           EY     +  A   N   ++  L   N N  +       P+H+A  +N  +I ++L+++G
Sbjct: 175 EYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234

Query: 362 CNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVC 541
            ++ A DK    P+H AC+YGH +V  +L+++   +   ++  + P+H A +    E+  
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCS 294

Query: 542 LLLENNCNLIALTSSGQSAFDLA 610
           LLL    +   L    +SA DLA
Sbjct: 295 LLLSYGADPTLLNCHNKSAIDLA 317

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/137 (24%), Positives = 67/137 (48%), Gaps = 1/137 (0%)
 Frame = +2

Query: 203 IHHACLSNNIDIVQSLID-KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
           +  AC + +++ V+ L+  +  N          P+H A      ++ E L++ G N++A 
Sbjct: 28  LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
           D     P+H AC++GH +V  +L+ +  D    +   + P+H A   G  ++  +LL++ 
Sbjct: 88  DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 147

Query: 560 CNLIALTSSGQSAFDLA 610
                  + G++A DLA
Sbjct: 148 AEPTIRNTDGRTALDLA 164

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 27/116 (23%), Positives = 55/116 (47%)
 Frame = +2

Query: 173  REKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILI 352
            R+ +     P+H A   NN+++ + L+    ++ ++ +    P+H A  +   ++A +LI
Sbjct: 673  RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732

Query: 353  KYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
            KY   + A DK  + P+H A   G  ++  +L+ +  D    N     P+    A+
Sbjct: 733  KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 31/130 (23%), Positives = 64/130 (49%), Gaps = 3/130 (2%)
 Frame = +2

Query: 86  SELDNFRLFIDAIETGSVDNFDRFYKDEF---REKEYNDFLPIHHACLSNNIDIVQSLID 256
           SE D  R  ++A + G V+   +    +    R+ E     P+H A   N + +V+ L+ 
Sbjct: 490 SEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547

Query: 257 KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKV 436
              ++ ++ +    P+H A  +   E+AE+L+K+G  +   D  ++ P+H A   G  ++
Sbjct: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607

Query: 437 ALILIENKCD 466
             +L+++  D
Sbjct: 608 CKLLLQHGAD 617

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 28/121 (23%), Positives = 53/121 (43%), Gaps = 3/121 (2%)
 Frame = +2

Query: 104 RLFIDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIE 274
           R   +A   G V+   R    E    R+       P+H A      D+V+ L+    N++
Sbjct: 26  RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85

Query: 275 SEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIE 454
           +       P+H A      E+  +L+++G +  A D   + P+H A   G + V ++L++
Sbjct: 86  ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145

Query: 455 N 457
           +
Sbjct: 146 H 146

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 27/106 (25%), Positives = 49/106 (46%)
 Frame = +2

Query: 236 IVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFAC 415
           I + L+ K  NI  + +E   P+HVA      ++ E+++K+   + A D      +H A 
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 416 NYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
             GHL+   +L+   CD    ++  +  +      G+E +  LL E
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLLQE 483

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 30/148 (20%), Positives = 61/148 (41%)
 Frame = +2

Query: 239 VQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACN 418
           VQ L+ +  ++    + +R+ +  A   +   + ++      N    +  Q  P+HFA  
Sbjct: 477 VQQLLQEGISL-GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG 535

Query: 419 YGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSA 598
           Y  + V   L+++  D+   +     P+H AC+ GH E+  LL+++   +        + 
Sbjct: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595

Query: 599 FDLAKEKGYHNLLXXXXXXXXXPQKYNK 682
              A  KG + +          P K N+
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNR 623

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 23/95 (24%), Positives = 43/95 (45%)
 Frame = +2

Query: 332 EIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
           +I E+L++ G NI    K    P+H A    H  V  ++++++  +   +      +H A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440

Query: 512 CANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
              GH +   LLL   C+   ++  G +A  +  E
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNE 475

 Score = 37.0 bits (84), Expect = 0.068
 Identities = 15/63 (23%), Positives = 31/63 (49%)
 Frame = +2

Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
           K+  D +P+H+AC   + ++ + L+     + +       P+H A   N  E+  +L+ Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299

Query: 359 GCN 367
           G +
Sbjct: 300 GAD 302
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,892,618
Number of Sequences: 369166
Number of extensions: 1833684
Number of successful extensions: 6866
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5048
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6184
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)