Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_E11
(839 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 96 1e-19
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 86 1e-16
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 86 1e-16
sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) ... 85 2e-16
sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DA... 81 4e-15
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 80 5e-15
sp|Q5GIG6|TNI3K_MOUSE Serine/threonine-protein kinase TNNI3... 76 1e-13
sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DA... 75 2e-13
sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TN... 75 3e-13
sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (T... 74 4e-13
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 95.9 bits (237), Expect = 1e-19
Identities = 40/141 (28%), Positives = 79/141 (56%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A ++D+V L+ +N N+ + P+H+A + + +AE+L+ G +++A
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
K + P+H C+YG++K+ L+++ + + + P+H A GH I+ +LL+NN
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787
Query: 563 NLIALTSSGQSAFDLAKEKGY 625
+ LT +G +A +A+ GY
Sbjct: 788 SPNELTVNGNTALGIARRLGY 808
Score = 76.3 bits (186), Expect = 1e-13
Identities = 39/147 (26%), Positives = 70/147 (47%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A +++ L+ K+ + ++ G+ P+HVA ++ ++A +L+ G +
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
A KN + P+H A + +A L+E D +H A GH ++V LLL
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLG 685
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
N N+ SG + LA ++ N+
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNV 712
Score = 73.2 bits (178), Expect = 9e-13
Identities = 38/167 (22%), Positives = 82/167 (49%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K + P+H S + +V+ L+D+ I S+ + P+H+A + + ++L+++
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
++ + +H A + GH KVA +L++ K + ++ + P+H AC +++
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKGYHNLLXXXXXXXXXPQKYN 679
LLL++ ++ A+T SG + +A G+ N++ P N
Sbjct: 417 ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN 463
Score = 73.2 bits (178), Expect = 9e-13
Identities = 36/148 (24%), Positives = 76/148 (51%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
+ P+H + + D+ L+D ++ ++ P+HVA ++ E+A +L++ + +
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
A K+ P+H A +Y + KVAL+L++ + + P+H A +I LLE
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNLL 637
+ A+T G ++ LA ++G+ +++
Sbjct: 653 YGADANAVTRQGIASVHLAAQEGHVDMV 680
Score = 71.2 bits (173), Expect = 3e-12
Identities = 31/124 (25%), Positives = 63/124 (50%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N +H A ++++V L+ + N+++ ++ +H+A E+ ++L+ G N
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ A +N + P++ A HL+V L++N + P+ A GH+++V LL
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 548 LENN 559
LEN+
Sbjct: 193 LEND 196
Score = 70.9 bits (172), Expect = 4e-12
Identities = 35/147 (23%), Positives = 69/147 (46%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K +D P+H + DIVQ L+ + + + P+H++ R ++A L+ +
Sbjct: 495 KAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
G ++ K + P+H A YG L+VA +L++ + P+H A ++++
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614
Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEK 619
LLL+ + A +G + +A +K
Sbjct: 615 LLLLDQGASPHAAAKNGYTPLHIAAKK 641
Score = 70.1 bits (170), Expect = 7e-12
Identities = 37/146 (25%), Positives = 72/146 (49%), Gaps = 1/146 (0%)
Frame = +2
Query: 188 NDFLP-IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
ND+L +H A + + + L+DK N ++ P+H+A + N ++ E+L+K+G
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 365 NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
+I+A ++ PIH A GH+ + L+ + T N+ +H A +G E+V
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 545 LLENNCNLIALTSSGQSAFDLAKEKG 622
L+++ + A Q+ ++ G
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLG 510
Score = 69.3 bits (168), Expect = 1e-11
Identities = 32/150 (21%), Positives = 74/150 (49%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N + P+H A N +DI +L++ + + ++ +H+A + ++ +L+ N
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ +K+ P+H A + VA +L+ ++ + P+H C G+ +IV L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
L+++ + A T +G + A ++G+ +++
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779
Score = 67.0 bits (162), Expect = 6e-11
Identities = 38/148 (25%), Positives = 67/148 (45%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K N P+H A ++++ VQ L+ N ++ + +HVA ++A++L+
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
N A N + P+H AC +KV +L+++ I+ PIH A GH IV
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKG 622
L+ + + G++A +A G
Sbjct: 450 SQLMHHGASPNTTNVRGETALHMAARSG 477
Score = 67.0 bits (162), Expect = 6e-11
Identities = 32/136 (23%), Positives = 68/136 (50%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A S ++V+ L+ +E++ ++++ P+H++ R +I + L++ G + A
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
+ + P+H + GH VA L+++ + + P+H A G E+ LLL+ +
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 563 NLIALTSSGQSAFDLA 610
+ A SG + +A
Sbjct: 590 SPDAAGKSGLTPLHVA 605
Score = 66.6 bits (161), Expect = 8e-11
Identities = 32/141 (22%), Positives = 61/141 (43%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
PIH A +++IV L+ + + +H+A R E+ L++ G +EA
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
K+ P+H + G + L++ + P+H + GHE++ LL++
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555
Query: 560 CNLIALTSSGQSAFDLAKEKG 622
+L T G + +A + G
Sbjct: 556 ASLSITTKKGFTPLHVAAKYG 576
Score = 66.2 bits (160), Expect = 1e-10
Identities = 38/152 (25%), Positives = 69/152 (45%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K N F P+H AC N I +++ L+ +I++ + PIHVA I L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
G + + +H A G +V L+++ +E P+H + G +IV
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
Query: 539 CLLLENNCNLIALTSSGQSAFDLAKEKGYHNL 634
LL+ + A T+SG + L+ +G+ ++
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDV 547
Score = 65.1 bits (157), Expect = 2e-10
Identities = 35/147 (23%), Positives = 72/147 (48%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A NI++ L+++ ++ + + P+HVA + + ++L+ G I+
Sbjct: 236 FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
A ++ P+H GH +V +L++ I + + P+H A H V LLL+
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
+N + +T+ +A +A G++ +
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKV 382
Score = 60.8 bits (146), Expect = 4e-09
Identities = 30/143 (20%), Positives = 66/143 (46%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A ++ L+ + N + E + P+H+A + +A +L+ ++
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
+N P+H A G+ + +L++ I+ P+H +GHE++V +LL+
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Query: 563 NLIALTSSGQSAFDLAKEKGYHN 631
+++ T +G S +A + + N
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLN 348
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/179 (20%), Positives = 77/179 (43%), Gaps = 29/179 (16%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNI-----------------------------ESE 280
N F P++ A N++++V+ L+D + +++
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 281 GQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENK 460
G+ +H+A R + + A +L++ N + K+ + P+H A +YG++ VA +L+
Sbjct: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
Query: 461 CDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
++ + P+H A G+ +V LLL+ + A T G + G+ ++
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/130 (22%), Positives = 58/130 (44%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A +N + L+D+ + + + P+H+A + N +IA L++YG + A
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+ +H A GH+ + +L+ ++ N P+H A + +L+
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 560 CNLIALTSSG 589
++ A T G
Sbjct: 721 AHVDAQTKMG 730
Score = 55.8 bits (133), Expect = 1e-07
Identities = 32/141 (22%), Positives = 66/141 (46%), Gaps = 1/141 (0%)
Frame = +2
Query: 218 LSNNIDIVQSLIDKN-CNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQW 394
L +D +++ +D N CN Q +H+A + E+ L++ N++A K
Sbjct: 54 LEKALDYIKNGVDINICN-----QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGN 108
Query: 395 RPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIA 574
+H A G +V +L+ N ++ + + + P++ A H E+V LL+N +
Sbjct: 109 TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
Query: 575 LTSSGQSAFDLAKEKGYHNLL 637
T G + +A ++G+ ++
Sbjct: 169 ATEDGFTPLAVALQQGHDQVV 189
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/71 (38%), Positives = 36/71 (50%)
Frame = +2
Query: 410 ACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSG 589
A GHL+ AL I+N DI CN + +H A GH E+V LL+ N+ A T G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 590 QSAFDLAKEKG 622
+A +A G
Sbjct: 108 NTALHIASLAG 118
Score = 52.0 bits (123), Expect = 2e-06
Identities = 19/86 (22%), Positives = 47/86 (54%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + +++ + L+++ +++++ + P+HV + +I L+++ + A
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
Query: 380 DKNQWRPIHFACNYGHLKVALILIEN 457
KN + P+H A GH + +L++N
Sbjct: 760 TKNGYTPLHQAAQQGHTHIINVLLQN 785
Score = 33.1 bits (74), Expect = 0.98
Identities = 17/81 (20%), Positives = 34/81 (41%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
+ P+H C NI IV L+ + + ++ + P+H A + I +L++ +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 374 ACDKNQWRPIHFACNYGHLKV 436
N + A G++ V
Sbjct: 791 ELTVNGNTALGIARRLGYISV 811
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 86.3 bits (212), Expect = 1e-16
Identities = 40/142 (28%), Positives = 77/142 (54%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + ++V L+ K N + P+H+ + +A++LIK+G ++A
Sbjct: 634 PLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDAT 693
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+ + P+H A +YG++K+ L++++ D+ + P+H A GH +IV LLL+N
Sbjct: 694 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 753
Query: 560 CNLIALTSSGQSAFDLAKEKGY 625
+ ++S+G + +AK GY
Sbjct: 754 ASPNEVSSNGTTPLAIAKRLGY 775
Score = 77.8 bits (190), Expect = 3e-14
Identities = 41/146 (28%), Positives = 72/146 (49%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A N+ +V+ L+D+ IE+ ++ P+H A R+ I+EIL+ +G
Sbjct: 234 NGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAP 293
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
I+A KN PIH A HL +L++ +I+ + P+H A GH + +L
Sbjct: 294 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVL 353
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
L+ + +G + +A +K +
Sbjct: 354 LDKGAKPNSRALNGFTPLHIACKKNH 379
Score = 77.0 bits (188), Expect = 6e-14
Identities = 39/147 (26%), Positives = 73/147 (49%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A N+++ Q L+++ ++ Q P+H+A R + +L+ G IE
Sbjct: 203 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 262
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
K++ P+H A GH++++ IL+++ I+ + PIH A H + V LLL+
Sbjct: 263 TRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 322
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
N + +T + +A G+H +
Sbjct: 323 YNAEIDDITLDHLTPLHVAAHCGHHRV 349
Score = 77.0 bits (188), Expect = 6e-14
Identities = 41/159 (25%), Positives = 83/159 (52%)
Frame = +2
Query: 149 DRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNF 328
DR + E R K+ + P+H A + ++ I + L+D I+++ + PIH+A + +
Sbjct: 256 DRGAQIETRTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 313
Query: 329 GEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHF 508
+ +L++Y I+ + P+H A + GH +VA +L++ + ++ + P+H
Sbjct: 314 LDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 373
Query: 509 ACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGY 625
AC H ++ LLL+ ++ A+T SG + +A G+
Sbjct: 374 ACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGH 412
Score = 73.9 bits (180), Expect = 5e-13
Identities = 42/146 (28%), Positives = 70/146 (47%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N F P+H AC N+I +++ L+ +I++ + P+HVA I + L++ G +
Sbjct: 366 NGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 425
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ P+H A GH +VA L++NK P+H A GH +V LL
Sbjct: 426 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLL 485
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
LEN + T++G + A +G+
Sbjct: 486 LENGASPNLATTAGHTPLHTAAREGH 511
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/160 (25%), Positives = 69/160 (43%)
Frame = +2
Query: 158 YKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEI 337
Y E + + P+H A + + + L+DK S P+H+A + N +
Sbjct: 323 YNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRV 382
Query: 338 AEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACA 517
E+L+K G +I+A ++ P+H A GHL + L++ N+ P+H A
Sbjct: 383 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 442
Query: 518 NGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
GH E+ LL+N A Q+ A G+ ++
Sbjct: 443 AGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMV 482
Score = 72.8 bits (177), Expect = 1e-12
Identities = 37/151 (24%), Positives = 77/151 (50%)
Frame = +2
Query: 185 YNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
+N + P+H A N I++ +SL+ + +E + P+H+A + E+ +L+
Sbjct: 596 WNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQA 655
Query: 365 NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
N +K+ P+H GH+ VA +LI++ ++ + P+H A G+ ++V
Sbjct: 656 NGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKF 715
Query: 545 LLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
LL++ ++ A T G S A ++G+ +++
Sbjct: 716 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 746
Score = 70.9 bits (172), Expect = 4e-12
Identities = 38/145 (26%), Positives = 67/145 (46%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A NN+DIV+ L+ + + S P+H+A + N E+A L++YG +
Sbjct: 564 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGS 623
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
A P+H A GH ++ +L+ + + N P+H GH + +L
Sbjct: 624 ANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVL 683
Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
+++ + A T G + +A G
Sbjct: 684 IKHGVTVDATTRMGYTPLHVASHYG 708
Score = 70.1 bits (170), Expect = 7e-12
Identities = 37/144 (25%), Positives = 69/144 (47%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A + + + L++ + + + G+ P+HVA+ HN +I ++L+ G +
Sbjct: 533 FTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 592
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
+ N + P+H A ++VA L++ ++ P+H A GH E+V LLL
Sbjct: 593 SPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLS 652
Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
N SG + L ++G+
Sbjct: 653 KQANGNLGNKSGLTPLHLVSQEGH 676
Score = 67.0 bits (162), Expect = 6e-11
Identities = 36/129 (27%), Positives = 61/129 (47%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K N PIH A +++D V+ L+ N I+ ++ P+HVA +A++L+
Sbjct: 297 KTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 356
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
G + N + P+H AC H++V +L++ I+ P+H A GH IV
Sbjct: 357 GAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 416
Query: 539 CLLLENNCN 565
LL+ +
Sbjct: 417 KNLLQRGAS 425
Score = 65.1 bits (157), Expect = 2e-10
Identities = 35/141 (24%), Positives = 62/141 (43%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A ++ IV++L+ + + + P+H+A R E+A+ L++ A
Sbjct: 403 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAK 462
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
K+ P+H A GH + +L+EN P+H A GH + LLE
Sbjct: 463 AKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKE 522
Query: 560 CNLIALTSSGQSAFDLAKEKG 622
+ +T G + +A + G
Sbjct: 523 ASQACMTKKGFTPLHVAAKYG 543
Score = 60.5 bits (145), Expect = 6e-09
Identities = 33/138 (23%), Positives = 66/138 (47%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A +++ L+ + N + + P+H+A + +A++L+ G ++
Sbjct: 173 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 232
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
+N P+H A G++ + +L++ IET P+H A NGH I +LL++
Sbjct: 233 QNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGA 292
Query: 563 NLIALTSSGQSAFDLAKE 616
+ A T +G S +A +
Sbjct: 293 PIQAKTKNGLSPIHMAAQ 310
Score = 60.5 bits (145), Expect = 6e-09
Identities = 32/146 (21%), Positives = 71/146 (48%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A ++D +L++K + ++ P+HVA ++ +AE+L+++ + A
Sbjct: 502 PLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAA 561
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
KN P+H A ++ +L + +L+ + + + P+H A E+ LL+
Sbjct: 562 GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYG 621
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
+ A + G + LA ++G+ ++
Sbjct: 622 GSANAESVQGVTPLHLAAQEGHTEMV 647
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/149 (22%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Frame = +2
Query: 110 FIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEG 283
F+ A +G++D ++ + N +H A ++ +V L+ K +E+
Sbjct: 12 FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 71
Query: 284 QENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKC 463
++ +H+A E+ L+ YG N+ A + + P++ A HL+V L+EN
Sbjct: 72 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 131
Query: 464 DIETCNMHAWRPIHFACANGHEEIVCLLL 550
+ + P+ A GHE +V L+
Sbjct: 132 NQNVATEDGFTPLAVALQQGHENVVAHLI 160
Score = 57.4 bits (137), Expect = 5e-08
Identities = 33/146 (22%), Positives = 67/146 (45%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + + ++ + L+ ++ ++++ P+H A R + ++L++ G +
Sbjct: 436 PLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLA 495
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
P+H A GH+ AL L+E + + P+H A G + LLLE++
Sbjct: 496 TTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHD 555
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
+ A +G + +A +HN L
Sbjct: 556 AHPNAAGKNGLTPLHVAV---HHNNL 578
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/144 (23%), Positives = 64/144 (44%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+ A + ++V LI N ++G+ +H+A R++ A +L++ N +
Sbjct: 141 FTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 196
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
K + P+H A +Y +L VA +L+ + + P+H A G+ +V LLL+
Sbjct: 197 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 256
Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
+ T + A G+
Sbjct: 257 RGAQIETRTKDELTPLHCAARNGH 280
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/130 (23%), Positives = 58/130 (44%)
Frame = +2
Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
K + K +D P+H A + +V+ L++ + P+H A R + A
Sbjct: 456 KAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTA 515
Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
L++ + K + P+H A YG +++A +L+E+ + P+H A +
Sbjct: 516 LALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHH 575
Query: 521 GHEEIVCLLL 550
+ +IV LLL
Sbjct: 576 NNLDIVKLLL 585
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/142 (21%), Positives = 59/142 (41%)
Frame = +2
Query: 212 ACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQ 391
A S N+D + +I + Q +H+A + ++ L+ +E K
Sbjct: 15 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 74
Query: 392 WRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLI 571
+H A G +V L+ ++ + + P++ A H E+V LLEN N
Sbjct: 75 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 134
Query: 572 ALTSSGQSAFDLAKEKGYHNLL 637
T G + +A ++G+ N++
Sbjct: 135 VATEDGFTPLAVALQQGHENVV 156
Score = 43.5 bits (101), Expect = 7e-04
Identities = 22/116 (18%), Positives = 52/116 (44%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H ++ + LI +++ + P+HVA + ++ + L+++ ++ A
Sbjct: 667 PLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 726
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
K + P+H A GH + +L++N + + P+ A G+ + +L
Sbjct: 727 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVL 782
Score = 39.7 bits (91), Expect = 0.010
Identities = 20/85 (23%), Positives = 40/85 (47%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
+ P+H A NI +V+ L+ ++ ++ + P+H A + +I +L+K G +
Sbjct: 698 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 757
Query: 374 ACDKNQWRPIHFACNYGHLKVALIL 448
N P+ A G++ V +L
Sbjct: 758 EVSSNGTTPLAIAKRLGYISVTDVL 782
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 86.3 bits (212), Expect = 1e-16
Identities = 40/142 (28%), Positives = 76/142 (53%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + ++V L+ K N + P+H+ + +A++LIK+G ++A
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+ + P+H A +YG++K+ L++++ D+ + P+H A GH +IV LLL+N
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 560 CNLIALTSSGQSAFDLAKEKGY 625
+ ++S G + +AK GY
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGY 779
Score = 81.3 bits (199), Expect = 3e-15
Identities = 43/146 (29%), Positives = 73/146 (50%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N F P+H AC N++ +++ L+ +I++ + P+HVA I + L++ G +
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ P+H A GH +VA L++NK + P+H A GH +V LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
LENN N T++G + +A +G+
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGH 515
Score = 77.8 bits (190), Expect = 3e-14
Identities = 41/146 (28%), Positives = 73/146 (50%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A N+ +V+ L+D+ IE++ ++ P+H A R+ I+EIL+ +G
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
I+A KN PIH A HL +L++ +I+ + P+H A GH + +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGY 625
L+ + +G + +A +K +
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNH 383
Score = 76.6 bits (187), Expect = 8e-14
Identities = 37/153 (24%), Positives = 79/153 (51%)
Frame = +2
Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
+ K ++ P+H A + ++ I + L+D I+++ + PIH+A + + + +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGH 526
L++Y I+ + P+H A + GH +VA +L++ + ++ + P+H AC H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 527 EEIVCLLLENNCNLIALTSSGQSAFDLAKEKGY 625
++ LLL+ ++ A+T SG + +A G+
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 75.9 bits (185), Expect = 1e-13
Identities = 41/160 (25%), Positives = 71/160 (44%)
Frame = +2
Query: 158 YKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEI 337
Y E + + P+H A + + + L+DK S P+H+A + N +
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 338 AEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACA 517
E+L+K G +I+A ++ P+H A GHL + L++ N+ P+H A
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 518 NGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
GH E+ LL+N + A Q+ A G+ N++
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Score = 75.1 bits (183), Expect = 2e-13
Identities = 38/147 (25%), Positives = 73/147 (49%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A N+++ Q L+++ ++ Q P+H+A R + +L+ G IE
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
K++ P+H A GH++++ IL+++ I+ + PIH A H + V LLL+
Sbjct: 267 TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
+ + +T + +A G+H +
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRV 353
Score = 73.2 bits (178), Expect = 9e-13
Identities = 36/151 (23%), Positives = 77/151 (50%)
Frame = +2
Query: 185 YNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC 364
+N + P+H A N +++ +SL+ + +E + P+H+A + E+ +L+
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 365 NIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCL 544
N +K+ P+H GH+ VA +LI++ ++ + P+H A G+ ++V
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 545 LLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
LL++ ++ A T G S A ++G+ +++
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Score = 72.0 bits (175), Expect = 2e-12
Identities = 37/141 (26%), Positives = 65/141 (46%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A ++ IV++L+ + + + P+H+A R E+A+ L++ + A
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
K+ P+H A GH + +L+EN + P+H A GH E V LLE
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 560 CNLIALTSSGQSAFDLAKEKG 622
+ +T G + +A + G
Sbjct: 527 ASQACMTKKGFTPLHVAAKYG 547
Score = 71.6 bits (174), Expect = 2e-12
Identities = 38/145 (26%), Positives = 67/145 (46%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A NN+DIV+ L+ + + S P+H+A + N E+A L++YG +
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
A P+H A GH ++ +L+ + + N P+H GH + +L
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
+++ + A T G + +A G
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYG 712
Score = 70.9 bits (172), Expect = 4e-12
Identities = 37/144 (25%), Positives = 70/144 (48%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A + + + L++++ + + G+ P+HVA+ HN +I ++L+ G +
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
+ N + P+H A ++VA L++ ++ P+H A GH E+V LLL
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
N SG + L ++G+
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGH 680
Score = 64.7 bits (156), Expect = 3e-10
Identities = 35/129 (27%), Positives = 61/129 (47%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K N PIH A +++D V+ L+ + I+ ++ P+HVA +A++L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIV 538
G + N + P+H AC H++V +L++ I+ P+H A GH IV
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 539 CLLLENNCN 565
LL+ +
Sbjct: 421 KNLLQRGAS 429
Score = 60.8 bits (146), Expect = 4e-09
Identities = 36/156 (23%), Positives = 68/156 (43%), Gaps = 2/156 (1%)
Frame = +2
Query: 89 ELDNFRLFIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKN 262
E D F+ A +G++D ++ + N +H A ++ +V L+ K
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 263 CNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVAL 442
+E+ ++ +H+A E+ L+ YG N+ A + + P++ A HL+V
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 443 ILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
L+EN + + P+ A GHE +V L+
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 60.5 bits (145), Expect = 6e-09
Identities = 33/138 (23%), Positives = 66/138 (47%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A +++ L+ + N + + P+H+A + +A++L+ G ++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
+N P+H A G++ + +L++ IET P+H A NGH I +LL++
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 563 NLIALTSSGQSAFDLAKE 616
+ A T +G S +A +
Sbjct: 297 PIQAKTKNGLSPIHMAAQ 314
Score = 59.3 bits (142), Expect = 1e-08
Identities = 32/146 (21%), Positives = 66/146 (45%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + + ++ + L+ + ++ ++++ P+H A R + ++L++ N
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
P+H A GH++ L L+E + + P+H A G + LLLE +
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
+ A +G + +A +HN L
Sbjct: 560 AHPNAAGKNGLTPLHVAV---HHNNL 582
Score = 59.3 bits (142), Expect = 1e-08
Identities = 32/146 (21%), Positives = 71/146 (48%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A +++ V +L++K + ++ P+HVA ++ +AE+L++ + A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA 565
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
KN P+H A ++ +L + +L+ + + + P+H A E+ LL+
Sbjct: 566 GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
+ A + G + LA ++G+ ++
Sbjct: 626 GSANAESVQGVTPLHLAAQEGHAEMV 651
Score = 58.5 bits (140), Expect = 2e-08
Identities = 34/130 (26%), Positives = 59/130 (45%)
Frame = +2
Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
K + K +D P+H A + ++V+ L++ N N P+H+A R E
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519
Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
L++ + K + P+H A YG ++VA +L+E + P+H A +
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHH 579
Query: 521 GHEEIVCLLL 550
+ +IV LLL
Sbjct: 580 NNLDIVKLLL 589
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/144 (23%), Positives = 64/144 (44%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+ A + ++V LI N ++G+ +H+A R++ A +L++ N +
Sbjct: 145 FTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
K + P+H A +Y +L VA +L+ + + P+H A G+ +V LLL+
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Query: 554 NNCNLIALTSSGQSAFDLAKEKGY 625
+ T + A G+
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGH 284
Score = 47.8 bits (112), Expect = 4e-05
Identities = 37/161 (22%), Positives = 66/161 (40%), Gaps = 1/161 (0%)
Frame = +2
Query: 158 YKDEFREKEY-NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGE 334
Y FRE + FL A S N+D + +I + Q +H+A + +
Sbjct: 3 YSVGFREADAATSFL---RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 59
Query: 335 IAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFAC 514
+ L+ +E K +H A G +V L+ ++ + + P++ A
Sbjct: 60 MVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAA 119
Query: 515 ANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
H E+V LLEN N T G + +A ++G+ N++
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Score = 43.5 bits (101), Expect = 7e-04
Identities = 22/116 (18%), Positives = 51/116 (43%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H ++ + LI +++ + P+HVA + ++ + L+++ ++ A
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
K + P+H A GH + +L++N + P+ A G+ + +L
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 37.7 bits (86), Expect = 0.040
Identities = 19/85 (22%), Positives = 40/85 (47%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
+ P+H A NI +V+ L+ ++ ++ + P+H A + +I +L+K G +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 374 ACDKNQWRPIHFACNYGHLKVALIL 448
+ P+ A G++ V +L
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL 786
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length = 3924
Score = 85.1 bits (209), Expect = 2e-16
Identities = 42/142 (29%), Positives = 77/142 (54%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + D+V L+DK NI + +H+A + + +A+IL K+G + +A
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
K + P+ AC+YG++K+ L++ ++ + + P+H A GH I+ +LL++
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Query: 560 CNLIALTSSGQSAFDLAKEKGY 625
A T++G +A +AK GY
Sbjct: 785 AKPNATTANGNTALAIAKRLGY 806
Score = 79.3 bits (194), Expect = 1e-14
Identities = 39/147 (26%), Positives = 74/147 (50%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A ++D+ + L+ + +S G+ P+HVA ++ ++A +L++ G +
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
A KN + P+H A +++A L+ + P+H A GH ++V LLL+
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
N+ T SG ++ LA ++ N+
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNV 710
Score = 77.0 bits (188), Expect = 6e-14
Identities = 40/140 (28%), Positives = 68/140 (48%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A + + + L+DK N + P+H+A + N ++ E+L+KYG +I+A
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
++ PIH A GHL + L+L++N + N+ +H A G E+V LL N
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 563 NLIALTSSGQSAFDLAKEKG 622
+ A Q+ +A G
Sbjct: 489 LVDARAREEQTPLHIASRLG 508
Score = 76.3 bits (186), Expect = 1e-13
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 2/157 (1%)
Frame = +2
Query: 95 DNFRLFIDAIETGSVDNFDRFYKD--EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCN 268
D+ F+ A G++D + K + N +H A ++ +VQ L+ + +
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 269 IESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALIL 448
++S ++ +H+A E+ ++L+K G NI A +N + P++ A H+ V L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 449 IENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+EN + T + P+ A GH + V +LLEN+
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Score = 70.1 bits (170), Expect = 7e-12
Identities = 37/144 (25%), Positives = 71/144 (49%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A N ++V+ L+D+ I+++ ++ P+H A R ++ E+L++ G
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ A KN P+H A H++ L+++K ++ + +H A GH + LL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 548 LENNCNLIALTSSGQSAFDLAKEK 619
L+ N A +G + +A +K
Sbjct: 385 LDKRANPNARALNGFTPLHIACKK 408
Score = 69.7 bits (169), Expect = 9e-12
Identities = 34/150 (22%), Positives = 71/150 (47%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N + P+H + +D+ L++ ++ P+HVA ++ ++A++L++
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
++ KN P+H A +Y + KVAL+L+E + + P+H A +I L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Query: 548 LENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
L +T G + LA ++G+ +++
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMV 678
Score = 67.0 bits (162), Expect = 6e-11
Identities = 34/140 (24%), Positives = 67/140 (47%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A +IVQ L+ + ++ P+H++ R ++A +L++ G
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLA 559
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
K + P+H A YG L VA +L++ + ++ + P+H A ++++ LLLE
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Query: 560 CNLIALTSSGQSAFDLAKEK 619
+ A +G + +A +K
Sbjct: 620 ASPHATAKNGYTPLHIAAKK 639
Score = 65.5 bits (158), Expect = 2e-10
Identities = 37/145 (25%), Positives = 64/145 (44%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A ++++ V+ L+ ++ + +HVA + ++L+ N
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
A N + P+H AC +KV +L++ I+ PIH A GH IV LL
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
L+N + G++A +A G
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAG 475
Score = 65.1 bits (157), Expect = 2e-10
Identities = 38/145 (26%), Positives = 69/145 (47%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N F P+H AC N I +++ L+ +I++ + PIHVA I +L++ G +
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ + +H A G ++V L+ N ++ P+H A G EIV LL
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 548 LENNCNLIALTSSGQSAFDLAKEKG 622
L++ + A T++G + ++ +G
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREG 541
Score = 61.2 bits (147), Expect = 3e-09
Identities = 34/147 (23%), Positives = 69/147 (46%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIE 373
F P+H A N+++ L+++ ++ + P+HVA + + ++L+ G I+
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 374 ACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
A ++ P+H A GH +V +L+E + + P+H A H E V LL+
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Query: 554 NNCNLIALTSSGQSAFDLAKEKGYHNL 634
+ + +T +A +A G++ +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRV 380
Score = 61.2 bits (147), Expect = 3e-09
Identities = 31/131 (23%), Positives = 66/131 (50%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A + +++V+ L+ +++ +E + P+H+A R EI ++L+++ + +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
N + P+H + G + VA +L+E + P+H A G ++ LLL+
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 563 NLIALTSSGQS 595
A S+G++
Sbjct: 588 ---AADSAGKN 595
Score = 57.0 bits (136), Expect = 6e-08
Identities = 40/183 (21%), Positives = 73/183 (39%), Gaps = 33/183 (18%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N P+H A +N + L++K + + + P+H+A + N +IA L+ YG
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Query: 368 IEACDKNQWRPIHFACNYGH---------------------------------LKVALIL 448
K P+H A GH + VA IL
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Query: 449 IENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYH 628
++ D + + P+ AC G+ ++V LL+ N+ A T +G + A ++G+
Sbjct: 715 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHT 774
Query: 629 NLL 637
+++
Sbjct: 775 HII 777
Score = 56.6 bits (135), Expect = 8e-08
Identities = 35/170 (20%), Positives = 76/170 (44%)
Frame = +2
Query: 119 AIETGSVDNFDRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRR 298
A ++ S + F+ + R K+ + A + N+D V + +I + Q
Sbjct: 7 AQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLN 66
Query: 299 PIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETC 478
+H+A + + + L+ G ++++ K +H A G +V +L++ +I
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 479 NMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYH 628
+ + + P++ A H ++V LLEN N T G + +A ++G++
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Score = 56.6 bits (135), Expect = 8e-08
Identities = 29/141 (20%), Positives = 62/141 (43%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
PIH A +++IV L+ + + +H+A R E+ L++ G ++A
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+ + P+H A G ++ +L+++ + + + P+H + G ++ +LLE
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 560 CNLIALTSSGQSAFDLAKEKG 622
T G + +A + G
Sbjct: 554 AAHSLATKKGFTPLHVAAKYG 574
Score = 54.7 bits (130), Expect = 3e-07
Identities = 39/187 (20%), Positives = 77/187 (41%), Gaps = 37/187 (19%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPI--------------------- 304
N F P++ A N+ID+V+ L++ N + ++ P+
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Query: 305 --------HVAIRHNFGEIAEILIKYGCNIEACDK--------NQWRPIHFACNYGHLKV 436
H+A R + + A +L++ N + K + + P+H A +YG++ V
Sbjct: 189 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 248
Query: 437 ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
A +L+ ++ + P+H A G+ +V LLL+ + A T G + A
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 617 KGYHNLL 637
G+ ++
Sbjct: 309 SGHDQVV 315
>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
Length = 1432
Score = 80.9 bits (198), Expect = 4e-15
Identities = 40/141 (28%), Positives = 68/141 (48%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + ++L + CN+ + +E P+ A + +I E L ++G ++ AC
Sbjct: 483 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 542
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
DK+ +H A ++V L+ C ++ + H P+H AC +G+ IV L E N
Sbjct: 543 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 602
Query: 560 CNLIALTSSGQSAFDLAKEKG 622
CNL G++ LA G
Sbjct: 603 CNLDISNKYGRTPLHLAANNG 623
Score = 75.5 bits (184), Expect = 2e-13
Identities = 36/134 (26%), Positives = 75/134 (55%)
Frame = +2
Query: 233 DIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
DIV+ L + ++ + ++ +H+A+R E+ + L+ GC ++ D++ P+H A
Sbjct: 527 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 586
Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
C G++ + + L E C+++ N + P+H A NG ++V L ++ ALT+ G+
Sbjct: 587 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 646
Query: 593 SAFDLAKEKGYHNL 634
+A DLA+ + + ++
Sbjct: 647 TAEDLARSEQHEHV 660
Score = 67.4 bits (163), Expect = 5e-11
Identities = 38/138 (27%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI--LIKYGCNIEA 376
++ A ++D ++ L + C ++ + + +HVA R+ ++A++ L +G N
Sbjct: 416 VYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNI 475
Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
DK + P+H A +G+ VA L E C++ N P+ A A G+ +IV L E+
Sbjct: 476 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 535
Query: 557 NCNLIALTSSGQSAFDLA 610
+L A G A LA
Sbjct: 536 GADLNACDKDGHIALHLA 553
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/171 (23%), Positives = 74/171 (43%), Gaps = 2/171 (1%)
Frame = +2
Query: 131 GSVDNFDRFYKDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHV 310
GS+ N+D + + P+ A NI I+Q LI + I+ + + ++
Sbjct: 365 GSLSNYD------VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYW 418
Query: 311 AIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVA--LILIENKCDIETCNM 484
A RH + + L + C ++ DK+ +H A YGH VA +L + +
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDK 478
Query: 485 HAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
P+H A +G+ + L E CN+ G++ A +GYH+++
Sbjct: 479 EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 529
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDK--NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
I HA +N+ +Q L+ N ++ + P+ +A +I ++LIK G I+
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEI 535
DK +++A +GH+ L ENKC ++ + +H A GH ++
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADV 460
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/117 (23%), Positives = 51/117 (43%)
Frame = +2
Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
+ +H A ++++++L+ + C ++ + + P+HVA + I L + CN++
Sbjct: 548 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 607
Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+K P+H A N G L V L +E A + HE + LL
Sbjct: 608 SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 664
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 80.5 bits (197), Expect = 5e-15
Identities = 49/183 (26%), Positives = 78/183 (42%), Gaps = 34/183 (18%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K+ + + +H A + + + L++KN ++ E R P+HVA +H I IL++
Sbjct: 548 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 607
Query: 359 GCNIEACDKNQWRPIHFACNYGHL----------------------------------KV 436
G ++ K+ W P+H+A GHL +V
Sbjct: 608 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 667
Query: 437 ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
A ILI+ D+ C++ A P+H A GH LLL A+TS G +A LA
Sbjct: 668 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 727
Query: 617 KGY 625
G+
Sbjct: 728 NGH 730
Score = 71.2 bits (173), Expect = 3e-12
Identities = 39/149 (26%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
Frame = +2
Query: 194 FLPIHHACLSNNIDIVQSLIDK-NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNI 370
+LP+H+A ++ IV+ L + ++ ++ + R P+H+A + +A ILI ++
Sbjct: 619 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 678
Query: 371 EACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
C P+H A GH A +L+ E + +H A NGH V LL+
Sbjct: 679 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 738
Query: 551 ENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
E +++A Q+A LA G+ ++
Sbjct: 739 EEKADVLARGPLNQTALHLAAAHGHSEVV 767
Score = 64.7 bits (156), Expect = 3e-10
Identities = 34/146 (23%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A +V+ L+ + ++ ++ ++ +H A ++ +L++ ++
Sbjct: 522 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV 581
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN- 556
D P+H AC +G + IL+ D+ AW P+H+A GH IV LL +
Sbjct: 582 DFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQP 641
Query: 557 NCNLIALTSSGQSAFDLAKEKGYHNL 634
++ A T G++ LA ++G++ +
Sbjct: 642 GVSVNAQTLDGRTPLHLAAQRGHYRV 667
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/122 (24%), Positives = 56/122 (45%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
+H A + + + L+ N N + P+H+A+ + E+L+ ++ A D
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
++QW +HFA G +L+E + + P+H AC +G E IV +LL
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 609
Query: 563 NL 568
++
Sbjct: 610 DV 611
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/112 (25%), Positives = 50/112 (44%)
Frame = +2
Query: 302 IHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCN 481
+H+A+ E A+ L+ N ++ P+H A V +L+ K + +
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549
Query: 482 MHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEKGYHNLL 637
W +HFA NG E LLLE N ++ + G++ +A + G N++
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 601
Score = 33.5 bits (75), Expect = 0.75
Identities = 23/123 (18%), Positives = 51/123 (41%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A + + + L+ + E+ + +H+A R+ ++L++ ++ A
Sbjct: 688 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 747
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+H A +GH +V L+ I+ + +H A H + V LL +
Sbjct: 748 GPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHG 806
Query: 560 CNL 568
++
Sbjct: 807 AHI 809
>sp|Q5GIG6|TNI3K_MOUSE Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
(Cardiac ankyrin repeat kinase)
Length = 834
Score = 75.9 bits (185), Expect = 1e-13
Identities = 40/151 (26%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
Frame = +2
Query: 188 NDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCN 367
N F +H A ++++++ SL+ +++ G +H+A E E+L+++G N
Sbjct: 100 NGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGAN 159
Query: 368 IEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+ D + P+H A YGH +V +L++ D+ RP+H A A G IV LL
Sbjct: 160 VNVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLL 219
Query: 548 LE-NNCNLIALTSSGQSAFDLAKEKGYHNLL 637
+E N ++ A + G+HN++
Sbjct: 220 VEGNKADVNAQDNEDHVPLHFCSRFGHHNIV 250
Score = 64.3 bits (155), Expect = 4e-10
Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 1/132 (0%)
Frame = +2
Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
+ ++ Y +H A ++ + + V+ L+ N+ + P+H+A + ++ +
Sbjct: 126 DVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVTSV 185
Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIE-NKCDIETCNMHAWRPIHFACANG 523
L+K+G ++ + RP+H A G + +L+E NK D+ + P+HF G
Sbjct: 186 LLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPLHFCSRFG 245
Query: 524 HEEIVCLLLENN 559
H IV LL+++
Sbjct: 246 HHNIVSYLLQSD 257
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 15/170 (8%)
Frame = +2
Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESE--GQENRRPIHVAIRHNFGE 334
K + ++ D +P+H + +IV L+ + ++ P+H+A + E
Sbjct: 224 KADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGNFE 283
Query: 335 IAEILIKYGCNIEACDKNQWRP--IHFACNYGHL--KVALILIENKCDIETCNMHAWRPI 502
+A+ ++ +N + H AC YG V +L +N +I +
Sbjct: 284 VAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGL 343
Query: 503 HFACANGHEEIVCLLLEN--NCNLIAL---TSSG----QSAFDLAKEKGY 625
H AC +GH +V LL+N + NL+A SSG Q+ A EKG+
Sbjct: 344 HSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 393
Score = 33.9 bits (76), Expect = 0.57
Identities = 29/136 (21%), Positives = 59/136 (43%)
Frame = +2
Query: 161 KDEFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIA 340
+D+ + KE N+F + H S+ ++ + + N +E + + A N I
Sbjct: 32 EDDLQIKE-NEFQELRHIFGSD-----EAFSEVSLNYRTERGLSLLHLCCACGGNKSHIR 85
Query: 341 EILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
+++K G +N + +H A L++ L+ + D++ +H A
Sbjct: 86 ALMLK-GLRPSRLTRNGFPALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIA 144
Query: 521 GHEEIVCLLLENNCNL 568
GH E V +LL++ N+
Sbjct: 145 GHPEAVEVLLQHGANV 160
>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
Length = 1442
Score = 75.5 bits (184), Expect = 2e-13
Identities = 38/134 (28%), Positives = 73/134 (54%)
Frame = +2
Query: 233 DIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
DIV+ L + ++ + ++ +H+A+R E+ + L+ +G ++ D++ P+H A
Sbjct: 525 DIVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVA 584
Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
C G + + L E C+++ N + P+H A NG ++V L N+ ALTS G+
Sbjct: 585 CKDGSAPIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGK 644
Query: 593 SAFDLAKEKGYHNL 634
+A DLAK + + ++
Sbjct: 645 TAEDLAKAEQHEHV 658
Score = 72.4 bits (176), Expect = 1e-12
Identities = 40/152 (26%), Positives = 73/152 (48%)
Frame = +2
Query: 167 EFREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEI 346
+F++KE + P+H A + ++L + CN+ + +E P+ A + +I E
Sbjct: 472 DFQDKE--EETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 347 LIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGH 526
L ++G ++ A DK+ +H A ++V L+ + ++ + H P+H AC +G
Sbjct: 530 LAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGS 589
Query: 527 EEIVCLLLENNCNLIALTSSGQSAFDLAKEKG 622
IV L E +CNL G++ LA G
Sbjct: 590 APIVVALCEASCNLDISNKYGRTPLHLAANNG 621
Score = 69.7 bits (169), Expect = 9e-12
Identities = 38/136 (27%), Positives = 67/136 (49%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACD 382
I+ A ++D ++ L + C ++ + + +HVA R+ ++ ++L +G N + D
Sbjct: 416 IYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQD 475
Query: 383 KNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNC 562
K + P+H A +G+ VA L E C++ N P+ A A G+ +IV L E+
Sbjct: 476 KEEETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGA 535
Query: 563 NLIALTSSGQSAFDLA 610
+L A G A LA
Sbjct: 536 DLNASDKDGHIALHLA 551
Score = 60.5 bits (145), Expect = 6e-09
Identities = 36/146 (24%), Positives = 66/146 (45%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+ A NI ++Q LI + I+ + + I+ A RH + + L + C ++
Sbjct: 382 PLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVK 441
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
DK+ +H A YGH V +L + + + P+H A +G+ + L E
Sbjct: 442 DKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVG 501
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
CN+ G++ A +GYH+++
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIV 527
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/146 (23%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLIDK--NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
I HA +N+ +Q L+ + ++ + P+ +A ++ ++LIK G I+
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDV 407
Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
DK I++A +GH+ L ENKC ++ + +H A GH ++V LL
Sbjct: 408 QDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSF 467
Query: 557 NCNLIALTSSGQSAFDLAKEKGYHNL 634
N ++ A GY+++
Sbjct: 468 GSNPDFQDKEEETPLHCAAWHGYYSV 493
Score = 46.6 bits (109), Expect = 9e-05
Identities = 27/117 (23%), Positives = 50/117 (42%)
Frame = +2
Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEA 376
+ +H A ++++++L+ ++ + + P+HVA + I L + CN++
Sbjct: 546 IALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDI 605
Query: 377 CDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLL 547
+K P+H A N G L V L ++E A A HE + LL
Sbjct: 606 SNKYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLL 662
Score = 37.4 bits (85), Expect = 0.052
Identities = 21/86 (24%), Positives = 44/86 (51%)
Frame = +2
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
+K+ P+ A G++++ +LI+ I+ + I++A +GH + + L EN
Sbjct: 376 NKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENK 435
Query: 560 CNLIALTSSGQSAFDLAKEKGYHNLL 637
C L SG++A +A G+ +++
Sbjct: 436 CPLDVKDKSGETALHVAARYGHADVV 461
>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
ankyrin-related ADP-ribose polymerase)
Length = 1327
Score = 74.7 bits (182), Expect = 3e-13
Identities = 43/142 (30%), Positives = 70/142 (49%)
Frame = +2
Query: 191 DFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNI 370
D + C S N+ NC + EG+ + P+H A +N + E L+ +G ++
Sbjct: 662 DLETVKQLCSSQNV---------NCR-DLEGRHST-PLHFAAGYNRVSVVEYLLHHGADV 710
Query: 371 EACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLL 550
A DK P+H AC+YGH +VA +L+ + + ++ + P+H A A G EI LLL
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 551 ENNCNLIALTSSGQSAFDLAKE 616
++ + G + DL KE
Sbjct: 771 KHGADPTKKNRDGNTPLDLVKE 792
Score = 74.7 bits (182), Expect = 3e-13
Identities = 39/127 (30%), Positives = 64/127 (50%)
Frame = +2
Query: 257 KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKV 436
+N N N P+H+A +N E+AE L+++G ++ A DK P+H A +YGH+ +
Sbjct: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885
Query: 437 ALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
A +LI+ + + A+ P+H A G ++ LLL + + GQ+ DLA
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Query: 617 KGYHNLL 637
LL
Sbjct: 946 DDIRALL 952
Score = 72.4 bits (176), Expect = 1e-12
Identities = 38/143 (26%), Positives = 71/143 (49%)
Frame = +2
Query: 182 EYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYG 361
EY + A N ++ L N N + P+H+A +N I ++L+++G
Sbjct: 333 EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392
Query: 362 CNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVC 541
++ A DK P+H AC+YGH +V +L+++ + ++ + P+H A + E+
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCS 452
Query: 542 LLLENNCNLIALTSSGQSAFDLA 610
LLL + + + G+SA D+A
Sbjct: 453 LLLSHGADPTLVNCHGKSAVDMA 475
Score = 66.6 bits (161), Expect = 8e-11
Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Frame = +2
Query: 212 ACLSNNIDIVQSLIDK-NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKN 388
AC + ++ V+ L+D N N + P+H A ++ E L++ G N+ A D
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 389 QWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNL 568
P+H AC++GH +V +L+ D + + P+H A G ++ +LL++ +
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Query: 569 IALTSSGQSAFDLA 610
+ G+SA DLA
Sbjct: 309 NIRNTDGKSALDLA 322
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/150 (24%), Positives = 72/150 (48%), Gaps = 3/150 (2%)
Frame = +2
Query: 113 IDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEG 283
+DA + G + + E R+ + + P+H A NN+++ + L++ ++ ++
Sbjct: 808 LDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQD 867
Query: 284 QENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKC 463
+ P+H A + +IA +LIKY + A DK + P+H A G ++ +L+ +
Sbjct: 868 KGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Query: 464 DIETCNMHAWRPIHFACANGHEEIVCLLLE 553
D N P+ A A ++I LL++
Sbjct: 928 DPTMKNQEGQTPLDLATA---DDIRALLID 954
Score = 53.1 bits (126), Expect = 9e-07
Identities = 29/132 (21%), Positives = 69/132 (52%), Gaps = 3/132 (2%)
Frame = +2
Query: 80 KMSELDNFRLFIDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSL 250
+ S++D +RL ++A + G ++ + + R+ E P+H A N + +V+ L
Sbjct: 646 RTSDVD-YRL-LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
Query: 251 IDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHL 430
+ ++ ++ + P+H A + E+AE+L+++G ++ D ++ P+H A G
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
Query: 431 KVALILIENKCD 466
++ +L+++ D
Sbjct: 764 EICKLLLKHGAD 775
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/89 (24%), Positives = 41/89 (46%)
Frame = +2
Query: 200 PIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
P+H A D+V+ L+ N+ + P+H A E+ +L+ G + A
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCD 466
D + P+H A G + V ++L+++ D
Sbjct: 279 DNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/107 (23%), Positives = 49/107 (45%)
Frame = +2
Query: 236 IVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFAC 415
+ + L+ K N+ + ++ P+HVA ++ E+L K+G + A D +H A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 416 NYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLEN 556
GHL+ +L+ D ++ + A G+E + +L E+
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSES 642
Score = 36.6 bits (83), Expect = 0.089
Identities = 21/95 (22%), Positives = 42/95 (44%)
Frame = +2
Query: 332 EIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
++ E+L++ G N+ +K+ P+H A H V +L ++ + + +H A
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598
Query: 512 CANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
GH + LLL + ++ G +A + E
Sbjct: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633
Score = 35.0 bits (79), Expect = 0.26
Identities = 31/181 (17%), Positives = 67/181 (37%), Gaps = 54/181 (29%)
Frame = +2
Query: 197 LPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGC--NI 370
+P+H+AC + ++V L+ + + + N P+H A ++ +L+++G NI
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNI 310
Query: 371 EACDKNQ-------------------------------------WRPIHFACN------- 418
D P++ C+
Sbjct: 311 RNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS 370
Query: 419 --------YGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIA 574
Y +++ +L+++ D+ + P+H AC+ GH E+ LLL++ + A
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
Query: 575 L 577
+
Sbjct: 431 M 431
Score = 32.7 bits (73), Expect = 1.3
Identities = 22/111 (19%), Positives = 41/111 (36%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K+ +P+H+AC + E+ E+L+K+
Sbjct: 398 KDKGGLVPLHNAC---------------------------------SYGHYEVTELLLKH 424
Query: 359 GCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
G + A D Q+ P+H A + ++V +L+ + D N H + A
Sbjct: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 30.0 bits (66), Expect = 8.3
Identities = 15/65 (23%), Positives = 31/65 (47%)
Frame = +2
Query: 431 KVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLA 610
+V +L+ ++ N P+H A H +++ +L ++ + AL + GQ+A A
Sbjct: 539 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598
Query: 611 KEKGY 625
G+
Sbjct: 599 ALAGH 603
>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
protein) (Tankyrase-related protein)
Length = 1166
Score = 74.3 bits (181), Expect = 4e-13
Identities = 39/128 (30%), Positives = 70/128 (54%), Gaps = 6/128 (4%)
Frame = +2
Query: 251 IDKNCNIES------EGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFA 412
+ K C ++S EG+++ P+H A +N + E L+++G ++ A DK P+H A
Sbjct: 508 VKKLCTVQSVNCRDIEGRQST-PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566
Query: 413 CNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQ 592
C+YGH +VA +L+++ + ++ + P+H A A G EI LLL++ + G
Sbjct: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626
Query: 593 SAFDLAKE 616
+ DL K+
Sbjct: 627 TPLDLVKD 634
Score = 73.6 bits (179), Expect = 7e-13
Identities = 41/143 (28%), Positives = 65/143 (45%)
Frame = +2
Query: 260 NCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVA 439
N N + P+H+A +N E+AE L+++G ++ A DK P+H A +YGH+ VA
Sbjct: 669 NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVA 728
Query: 440 LILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKEK 619
+LI+ + + A+ P+H A G ++ LLL + + GQ+ DL
Sbjct: 729 ALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
Query: 620 GYHNLLXXXXXXXXXPQKYNKMV 688
LL P Y V
Sbjct: 789 DVSALLTAAMPPSALPSCYKPQV 811
Score = 72.8 bits (177), Expect = 1e-12
Identities = 39/143 (27%), Positives = 70/143 (48%)
Frame = +2
Query: 182 EYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYG 361
EY + A N ++ L N N + P+H+A +N +I ++L+++G
Sbjct: 175 EYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234
Query: 362 CNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVC 541
++ A DK P+H AC+YGH +V +L+++ + ++ + P+H A + E+
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCS 294
Query: 542 LLLENNCNLIALTSSGQSAFDLA 610
LLL + L +SA DLA
Sbjct: 295 LLLSYGADPTLLNCHNKSAIDLA 317
Score = 65.1 bits (157), Expect = 2e-10
Identities = 34/137 (24%), Positives = 67/137 (48%), Gaps = 1/137 (0%)
Frame = +2
Query: 203 IHHACLSNNIDIVQSLID-KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEAC 379
+ AC + +++ V+ L+ + N P+H A ++ E L++ G N++A
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 380 DKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENN 559
D P+H AC++GH +V +L+ + D + + P+H A G ++ +LL++
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 147
Query: 560 CNLIALTSSGQSAFDLA 610
+ G++A DLA
Sbjct: 148 AEPTIRNTDGRTALDLA 164
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/116 (23%), Positives = 55/116 (47%)
Frame = +2
Query: 173 REKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILI 352
R+ + P+H A NN+++ + L+ ++ ++ + P+H A + ++A +LI
Sbjct: 673 RDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLI 732
Query: 353 KYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFACAN 520
KY + A DK + P+H A G ++ +L+ + D N P+ A+
Sbjct: 733 KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/130 (23%), Positives = 64/130 (49%), Gaps = 3/130 (2%)
Frame = +2
Query: 86 SELDNFRLFIDAIETGSVDNFDRFYKDEF---REKEYNDFLPIHHACLSNNIDIVQSLID 256
SE D R ++A + G V+ + + R+ E P+H A N + +V+ L+
Sbjct: 490 SEAD--RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
Query: 257 KNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKV 436
++ ++ + P+H A + E+AE+L+K+G + D ++ P+H A G ++
Sbjct: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
Query: 437 ALILIENKCD 466
+L+++ D
Sbjct: 608 CKLLLQHGAD 617
Score = 50.4 bits (119), Expect = 6e-06
Identities = 28/121 (23%), Positives = 53/121 (43%), Gaps = 3/121 (2%)
Frame = +2
Query: 104 RLFIDAIETGSVDNFDRFYKDE---FREKEYNDFLPIHHACLSNNIDIVQSLIDKNCNIE 274
R +A G V+ R E R+ P+H A D+V+ L+ N++
Sbjct: 26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 275 SEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIE 454
+ P+H A E+ +L+++G + A D + P+H A G + V ++L++
Sbjct: 86 ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 455 N 457
+
Sbjct: 146 H 146
Score = 48.1 bits (113), Expect = 3e-05
Identities = 27/106 (25%), Positives = 49/106 (46%)
Frame = +2
Query: 236 IVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFAC 415
I + L+ K NI + +E P+HVA ++ E+++K+ + A D +H A
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 416 NYGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLE 553
GHL+ +L+ CD ++ + + G+E + LL E
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQLLQE 483
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/148 (20%), Positives = 61/148 (41%)
Frame = +2
Query: 239 VQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKYGCNIEACDKNQWRPIHFACN 418
VQ L+ + ++ + +R+ + A + + ++ N + Q P+HFA
Sbjct: 477 VQQLLQEGISL-GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG 535
Query: 419 YGHLKVALILIENKCDIETCNMHAWRPIHFACANGHEEIVCLLLENNCNLIALTSSGQSA 598
Y + V L+++ D+ + P+H AC+ GH E+ LL+++ + +
Sbjct: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
Query: 599 FDLAKEKGYHNLLXXXXXXXXXPQKYNK 682
A KG + + P K N+
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNR 623
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/95 (24%), Positives = 43/95 (45%)
Frame = +2
Query: 332 EIAEILIKYGCNIEACDKNQWRPIHFACNYGHLKVALILIENKCDIETCNMHAWRPIHFA 511
+I E+L++ G NI K P+H A H V ++++++ + + +H A
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Query: 512 CANGHEEIVCLLLENNCNLIALTSSGQSAFDLAKE 616
GH + LLL C+ ++ G +A + E
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNE 475
Score = 37.0 bits (84), Expect = 0.068
Identities = 15/63 (23%), Positives = 31/63 (49%)
Frame = +2
Query: 179 KEYNDFLPIHHACLSNNIDIVQSLIDKNCNIESEGQENRRPIHVAIRHNFGEIAEILIKY 358
K+ D +P+H+AC + ++ + L+ + + P+H A N E+ +L+ Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 359 GCN 367
G +
Sbjct: 300 GAD 302
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,892,618
Number of Sequences: 369166
Number of extensions: 1833684
Number of successful extensions: 6866
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5048
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6184
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)