Planaria EST Database


DrC_01508

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01508
         (838 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q5SW96|ARH_HUMAN  Low density lipoprotein receptor adapte...    92   2e-18
sp|Q8C142|ARH_MOUSE  Low density lipoprotein receptor adapte...    91   5e-18
sp|Q67FQ3|ARHB_XENLA  Low density lipoprotein receptor adapt...    90   9e-18
sp|Q801G1|ARHA_XENLA  Low density lipoprotein receptor adapt...    89   1e-17
sp|Q9QZS3|NUMB_MOUSE  Protein numb homolog (m-Numb) (m-Nb)         52   2e-06
sp|P49757|NUMB_HUMAN  Protein numb homolog (h-Numb) (Protein...    52   2e-06
sp|Q9Y6R0|NUMBL_HUMAN  Numb-like protein (Numb-R)                  50   8e-06
sp|O08919|NUMBL_MOUSE  Numb-like protein                           50   8e-06
sp|P16554|NUMB_DROME  Protein numb                                 44   4e-04
sp|Q9XTY6|NUMB1_CAEEL  Numb related protein 1 (Protein kinas...    44   4e-04
>sp|Q5SW96|ARH_HUMAN Low density lipoprotein receptor adapter protein 1 (Autosomal
           recessive hypercholesterolemia protein)
          Length = 308

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 65/180 (36%), Positives = 89/180 (49%)
 Frame = +1

Query: 64  KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
           K  E +T TR     G+ F LKYLG  L+E+ K        +S  AIK I          
Sbjct: 30  KLPENWTDTRETLLEGMLFSLKYLGMTLVEQPK-----GEELSAAAIKRIVATAKASGKK 84

Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
                         GI + D+LT+  I   SI RIS+CTAD  + +VFAYIA++  N+++
Sbjct: 85  LQKVTLKVSPR---GIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSL 141

Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTP 603
           ECHAF CT  KMA  V+L V QAF VA +  +    + +K   A+ E   +    +  TP
Sbjct: 142 ECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTP 201
>sp|Q8C142|ARH_MOUSE Low density lipoprotein receptor adapter protein 1 (Autosomal
           recessive hypercholesterolemia protein homolog)
          Length = 308

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 64/180 (35%), Positives = 86/180 (47%)
 Frame = +1

Query: 64  KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
           K  E +T TR     G+ F LKYLG  L+E  K        +S  A+K I          
Sbjct: 29  KLPENWTDTRETLLEGMVFSLKYLGMTLVERPK-----GEELSAAAVKRIVATAKASGKK 83

Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
                         GI + D LT   I   SI RIS+CTAD  + +VFAYIA++  NE++
Sbjct: 84  LQKVTLKVSPR---GIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESL 140

Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTP 603
           ECHAF CT  K+A  V+L V QAF VA +  +    + +K + A  E   +    +  TP
Sbjct: 141 ECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTP 200
>sp|Q67FQ3|ARHB_XENLA Low density lipoprotein receptor adapter protein 1-B (Autosomal
           recessive hypercholesterolemia protein homolog beta)
           (ARH beta) (xARH)
          Length = 309

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 62/167 (37%), Positives = 84/167 (50%)
 Frame = +1

Query: 64  KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
           K  E +T TR     G+ F LKYLG  L+E+ K        +S  A+K I          
Sbjct: 29  KLPENWTDTRETLLEGMLFHLKYLGMTLVEQPK-----GEELSATAVKRIVATAKASGKK 83

Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
                         GI ++D  ++  I   SI RIS+CTAD  + +VFAYIA++  NET+
Sbjct: 84  LQKVLLKVSPR---GIILYDSASNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETL 140

Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSE 564
           ECHAF CT  KMA  V+L V QAF VA +  +      DK + + S+
Sbjct: 141 ECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSRENKDKREKSGSD 187
>sp|Q801G1|ARHA_XENLA Low density lipoprotein receptor adapter protein 1-A (Autosomal
           recessive hypercholesterolemia protein homolog alpha)
           (ARH alpha) (xARH) (Phosphotyrosine-binding protein)
           (Xcat4)
          Length = 309

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 59/147 (40%), Positives = 76/147 (51%)
 Frame = +1

Query: 64  KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
           K  E +T TR     G+ F LKYLG  L+E+ K        +S  A+K I          
Sbjct: 29  KLPENWTDTRETLLEGMLFHLKYLGMTLVEQPK-----GEELSATAVKRIVATAKASGKK 83

Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
                         GI ++D  ++  I   SI RIS+CTAD  + +VFAYIA++  NET+
Sbjct: 84  LQKVILKVSPR---GIILYDSTSNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETL 140

Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVA 504
           ECHAF CT  KMA  V+L V QAF VA
Sbjct: 141 ECHAFLCTKRKMAQAVTLTVAQAFKVA 167
>sp|Q9QZS3|NUMB_MOUSE Protein numb homolog (m-Numb) (m-Nb)
          Length = 653

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 38/149 (25%), Positives = 61/149 (40%), Gaps = 7/149 (4%)
 Frame = +1

Query: 13  MLKLRKKSNTNSEYVDPKNAE--MYTSTRNPYEIGIC-FILKYLGSHLIEEFKTGHGYSN 183
           M KLR+      +   P+ +    + +       G C F +KYLG   ++E +  H    
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMH---- 56

Query: 184 GVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX----GITVFDHLTHDTILESSIDRIS 351
            +  DA+K +K  R                        G+ V D  T D I++ +I+++S
Sbjct: 57  -ICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVS 115

Query: 352 FCTADGTYPRVFAYIARNSINETMECHAF 438
           FC  D  + R F+YI R+       CH F
Sbjct: 116 FCAPDRNFDRAFSYICRDGTTRRWICHCF 144
>sp|P49757|NUMB_HUMAN Protein numb homolog (h-Numb) (Protein S171)
          Length = 651

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 38/149 (25%), Positives = 61/149 (40%), Gaps = 7/149 (4%)
 Frame = +1

Query: 13  MLKLRKKSNTNSEYVDPKNAE--MYTSTRNPYEIGIC-FILKYLGSHLIEEFKTGHGYSN 183
           M KLR+      +   P+ +    + +       G C F +KYLG   ++E +  H    
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMH---- 56

Query: 184 GVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX----GITVFDHLTHDTILESSIDRIS 351
            +  DA+K +K  R                        G+ V D  T D I++ +I+++S
Sbjct: 57  -ICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVS 115

Query: 352 FCTADGTYPRVFAYIARNSINETMECHAF 438
           FC  D  + R F+YI R+       CH F
Sbjct: 116 FCAPDRNFDRAFSYICRDGTTRRWICHCF 144
>sp|Q9Y6R0|NUMBL_HUMAN Numb-like protein (Numb-R)
          Length = 609

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
 Frame = +1

Query: 109 GIC-FILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX 285
           G C F ++YLG   +EE +  H     V  DA+K +K M                     
Sbjct: 76  GTCSFPVRYLGHVEVEESRGMH-----VCEDAVKKLKAMGRKSVKSVLWVSAD------- 123

Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF 438
           G+ V D  T D +++ +I+++SFC  D    + F+YI R+       CH F
Sbjct: 124 GLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCF 174
>sp|O08919|NUMBL_MOUSE Numb-like protein
          Length = 604

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
 Frame = +1

Query: 109 GIC-FILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX 285
           G C F ++YLG   +EE +  H     V  DA+K +K M                     
Sbjct: 76  GTCSFPVRYLGHVEVEESRGMH-----VCEDAVKKLKAMGRKSVKSVLWVSAD------- 123

Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF 438
           G+ V D  T D +++ +I+++SFC  D    + F+YI R+       CH F
Sbjct: 124 GLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCF 174
>sp|P16554|NUMB_DROME Protein numb
          Length = 556

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
 Frame = +1

Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF-SCTNSKMA 462
           G+ V D  T   I++ +I+++SFC  D  + R F+YI R+       CH F +C +S   
Sbjct: 127 GLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDS--G 184

Query: 463 FDVSLAVNQAFHV 501
             +S AV  AF V
Sbjct: 185 ERLSHAVGCAFAV 197
>sp|Q9XTY6|NUMB1_CAEEL Numb related protein 1 (Protein kinase C adapter 1) (CKA1)
          Length = 593

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/174 (24%), Positives = 73/174 (41%), Gaps = 1/174 (0%)
 Frame = +1

Query: 115 CFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXXGIT 294
           CF +KYLGS  + E +        V   A+K++K  R                    G+ 
Sbjct: 107 CFNVKYLGSVEVYESR-----GMQVCEGALKSLKASRRKPVKAVLYVSGD-------GLR 154

Query: 295 VFDH-LTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAFSCTNSKMAFDV 471
           V D   +   +++ +I+++SFC  D    + FAYI R+  +    CH F  T  +    +
Sbjct: 155 VVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLAT-KETGERL 213

Query: 472 SLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTPVSTHDWVVFN 633
           S AV  AF          S+ ++K K    ET ++  ++   +  ST    +F+
Sbjct: 214 SHAVGCAF----------SICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFH 257
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,288,049
Number of Sequences: 369166
Number of extensions: 1656665
Number of successful extensions: 4512
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4331
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4506
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8148988185
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)