Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_C10
(838 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5SW96|ARH_HUMAN Low density lipoprotein receptor adapte... 92 2e-18
sp|Q8C142|ARH_MOUSE Low density lipoprotein receptor adapte... 91 5e-18
sp|Q67FQ3|ARHB_XENLA Low density lipoprotein receptor adapt... 90 9e-18
sp|Q801G1|ARHA_XENLA Low density lipoprotein receptor adapt... 89 1e-17
sp|Q9QZS3|NUMB_MOUSE Protein numb homolog (m-Numb) (m-Nb) 52 2e-06
sp|P49757|NUMB_HUMAN Protein numb homolog (h-Numb) (Protein... 52 2e-06
sp|Q9Y6R0|NUMBL_HUMAN Numb-like protein (Numb-R) 50 8e-06
sp|O08919|NUMBL_MOUSE Numb-like protein 50 8e-06
sp|P16554|NUMB_DROME Protein numb 44 4e-04
sp|Q9XTY6|NUMB1_CAEEL Numb related protein 1 (Protein kinas... 44 4e-04
>sp|Q5SW96|ARH_HUMAN Low density lipoprotein receptor adapter protein 1 (Autosomal
recessive hypercholesterolemia protein)
Length = 308
Score = 92.0 bits (227), Expect = 2e-18
Identities = 65/180 (36%), Positives = 89/180 (49%)
Frame = +1
Query: 64 KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
K E +T TR G+ F LKYLG L+E+ K +S AIK I
Sbjct: 30 KLPENWTDTRETLLEGMLFSLKYLGMTLVEQPK-----GEELSAAAIKRIVATAKASGKK 84
Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
GI + D+LT+ I SI RIS+CTAD + +VFAYIA++ N+++
Sbjct: 85 LQKVTLKVSPR---GIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSL 141
Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTP 603
ECHAF CT KMA V+L V QAF VA + + + +K A+ E + + TP
Sbjct: 142 ECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTP 201
>sp|Q8C142|ARH_MOUSE Low density lipoprotein receptor adapter protein 1 (Autosomal
recessive hypercholesterolemia protein homolog)
Length = 308
Score = 90.5 bits (223), Expect = 5e-18
Identities = 64/180 (35%), Positives = 86/180 (47%)
Frame = +1
Query: 64 KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
K E +T TR G+ F LKYLG L+E K +S A+K I
Sbjct: 29 KLPENWTDTRETLLEGMVFSLKYLGMTLVERPK-----GEELSAAAVKRIVATAKASGKK 83
Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
GI + D LT I SI RIS+CTAD + +VFAYIA++ NE++
Sbjct: 84 LQKVTLKVSPR---GIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESL 140
Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTP 603
ECHAF CT K+A V+L V QAF VA + + + +K + A E + + TP
Sbjct: 141 ECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTP 200
>sp|Q67FQ3|ARHB_XENLA Low density lipoprotein receptor adapter protein 1-B (Autosomal
recessive hypercholesterolemia protein homolog beta)
(ARH beta) (xARH)
Length = 309
Score = 89.7 bits (221), Expect = 9e-18
Identities = 62/167 (37%), Positives = 84/167 (50%)
Frame = +1
Query: 64 KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
K E +T TR G+ F LKYLG L+E+ K +S A+K I
Sbjct: 29 KLPENWTDTRETLLEGMLFHLKYLGMTLVEQPK-----GEELSATAVKRIVATAKASGKK 83
Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
GI ++D ++ I SI RIS+CTAD + +VFAYIA++ NET+
Sbjct: 84 LQKVLLKVSPR---GIILYDSASNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETL 140
Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVAKDELEYKSLQIDKFKNATSE 564
ECHAF CT KMA V+L V QAF VA + + DK + + S+
Sbjct: 141 ECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSRENKDKREKSGSD 187
>sp|Q801G1|ARHA_XENLA Low density lipoprotein receptor adapter protein 1-A (Autosomal
recessive hypercholesterolemia protein homolog alpha)
(ARH alpha) (xARH) (Phosphotyrosine-binding protein)
(Xcat4)
Length = 309
Score = 89.0 bits (219), Expect = 1e-17
Identities = 59/147 (40%), Positives = 76/147 (51%)
Frame = +1
Query: 64 KNAEMYTSTRNPYEIGICFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXX 243
K E +T TR G+ F LKYLG L+E+ K +S A+K I
Sbjct: 29 KLPENWTDTRETLLEGMLFHLKYLGMTLVEQPK-----GEELSATAVKRIVATAKASGKK 83
Query: 244 XXXXXXXXXXXXXXGITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETM 423
GI ++D ++ I SI RIS+CTAD + +VFAYIA++ NET+
Sbjct: 84 LQKVILKVSPR---GIILYDSTSNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETL 140
Query: 424 ECHAFSCTNSKMAFDVSLAVNQAFHVA 504
ECHAF CT KMA V+L V QAF VA
Sbjct: 141 ECHAFLCTKRKMAQAVTLTVAQAFKVA 167
>sp|Q9QZS3|NUMB_MOUSE Protein numb homolog (m-Numb) (m-Nb)
Length = 653
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/149 (25%), Positives = 61/149 (40%), Gaps = 7/149 (4%)
Frame = +1
Query: 13 MLKLRKKSNTNSEYVDPKNAE--MYTSTRNPYEIGIC-FILKYLGSHLIEEFKTGHGYSN 183
M KLR+ + P+ + + + G C F +KYLG ++E + H
Sbjct: 1 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMH---- 56
Query: 184 GVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX----GITVFDHLTHDTILESSIDRIS 351
+ DA+K +K R G+ V D T D I++ +I+++S
Sbjct: 57 -ICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVS 115
Query: 352 FCTADGTYPRVFAYIARNSINETMECHAF 438
FC D + R F+YI R+ CH F
Sbjct: 116 FCAPDRNFDRAFSYICRDGTTRRWICHCF 144
>sp|P49757|NUMB_HUMAN Protein numb homolog (h-Numb) (Protein S171)
Length = 651
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/149 (25%), Positives = 61/149 (40%), Gaps = 7/149 (4%)
Frame = +1
Query: 13 MLKLRKKSNTNSEYVDPKNAE--MYTSTRNPYEIGIC-FILKYLGSHLIEEFKTGHGYSN 183
M KLR+ + P+ + + + G C F +KYLG ++E + H
Sbjct: 1 MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMH---- 56
Query: 184 GVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX----GITVFDHLTHDTILESSIDRIS 351
+ DA+K +K R G+ V D T D I++ +I+++S
Sbjct: 57 -ICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVS 115
Query: 352 FCTADGTYPRVFAYIARNSINETMECHAF 438
FC D + R F+YI R+ CH F
Sbjct: 116 FCAPDRNFDRAFSYICRDGTTRRWICHCF 144
>sp|Q9Y6R0|NUMBL_HUMAN Numb-like protein (Numb-R)
Length = 609
Score = 50.1 bits (118), Expect = 8e-06
Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Frame = +1
Query: 109 GIC-FILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX 285
G C F ++YLG +EE + H V DA+K +K M
Sbjct: 76 GTCSFPVRYLGHVEVEESRGMH-----VCEDAVKKLKAMGRKSVKSVLWVSAD------- 123
Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF 438
G+ V D T D +++ +I+++SFC D + F+YI R+ CH F
Sbjct: 124 GLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCF 174
>sp|O08919|NUMBL_MOUSE Numb-like protein
Length = 604
Score = 50.1 bits (118), Expect = 8e-06
Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Frame = +1
Query: 109 GIC-FILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXX 285
G C F ++YLG +EE + H V DA+K +K M
Sbjct: 76 GTCSFPVRYLGHVEVEESRGMH-----VCEDAVKKLKAMGRKSVKSVLWVSAD------- 123
Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF 438
G+ V D T D +++ +I+++SFC D + F+YI R+ CH F
Sbjct: 124 GLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCF 174
>sp|P16554|NUMB_DROME Protein numb
Length = 556
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/73 (35%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Frame = +1
Query: 286 GITVFDHLTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAF-SCTNSKMA 462
G+ V D T I++ +I+++SFC D + R F+YI R+ CH F +C +S
Sbjct: 127 GLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDS--G 184
Query: 463 FDVSLAVNQAFHV 501
+S AV AF V
Sbjct: 185 ERLSHAVGCAFAV 197
>sp|Q9XTY6|NUMB1_CAEEL Numb related protein 1 (Protein kinase C adapter 1) (CKA1)
Length = 593
Score = 44.3 bits (103), Expect = 4e-04
Identities = 43/174 (24%), Positives = 73/174 (41%), Gaps = 1/174 (0%)
Frame = +1
Query: 115 CFILKYLGSHLIEEFKTGHGYSNGVSTDAIKAIKIMRNXXXXXXXXXXXXXXXXXXXGIT 294
CF +KYLGS + E + V A+K++K R G+
Sbjct: 107 CFNVKYLGSVEVYESR-----GMQVCEGALKSLKASRRKPVKAVLYVSGD-------GLR 154
Query: 295 VFDH-LTHDTILESSIDRISFCTADGTYPRVFAYIARNSINETMECHAFSCTNSKMAFDV 471
V D + +++ +I+++SFC D + FAYI R+ + CH F T + +
Sbjct: 155 VVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLAT-KETGERL 213
Query: 472 SLAVNQAFHVAKDELEYKSLQIDKFKNATSETNKITSENKLPTPVSTHDWVVFN 633
S AV AF S+ ++K K ET ++ ++ + ST +F+
Sbjct: 214 SHAVGCAF----------SICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFH 257
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,288,049
Number of Sequences: 369166
Number of extensions: 1656665
Number of successful extensions: 4512
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4331
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4506
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8148988185
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)