Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01453 (183 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9UBU6|FA8A1_HUMAN Protein FAM8A1 (Autosomal highly cons... 34 0.090 sp|Q04721|NOTC2_HUMAN Neurogenic locus notch homolog protei... 31 0.76 sp|P18168|SERR_DROME Serrate protein precursor (Beaded prot... 29 3.8 sp|Q01705|NOTC1_MOUSE Neurogenic locus notch homolog protei... 28 5.0 sp|P46531|NOTC1_HUMAN Neurogenic locus notch homolog protei... 28 5.0 sp|Q9QW30|NOTC2_RAT Neurogenic locus notch homolog protein ... 28 6.5 sp|Q9QYE5|JAG2_MOUSE Jagged-2 precursor (Jagged2) 28 6.5 sp|O35516|NOTC2_MOUSE Neurogenic locus notch homolog protei... 28 6.5 sp|Q9Y219|JAG2_HUMAN Jagged-2 precursor (Jagged2) (HJ2) 28 6.5
>sp|Q9UBU6|FA8A1_HUMAN Protein FAM8A1 (Autosomal highly conserved protein) Length = 413 Score = 34.3 bits (77), Expect = 0.090 Identities = 13/20 (65%), Positives = 17/20 (85%) Frame = +1 Query: 4 LIFNHHRTTYDLIAGTLVVK 63 L F H+RT YD++AGT+VVK Sbjct: 389 LFFQHNRTAYDIVAGTIVVK 408
>sp|Q04721|NOTC2_HUMAN Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2471 Score = 31.2 bits (69), Expect = 0.76 Identities = 15/32 (46%), Positives = 18/32 (56%), Gaps = 4/32 (12%) Frame = -2 Query: 146 TCYCPGGWFG----LRTAHPA*LSRRCLGGGT 63 TC C G+ G T+HP +SR CL GGT Sbjct: 89 TCRCASGFTGEDCQYSTSHPCFVSRPCLNGGT 120
>sp|P18168|SERR_DROME Serrate protein precursor (Beaded protein) Length = 1404 Score = 28.9 bits (63), Expect = 3.8 Identities = 15/40 (37%), Positives = 19/40 (47%), Gaps = 2/40 (5%) Frame = -2 Query: 158 DRNFTCYCPGGWFGLRTAHPA--*LSRRCLGGGTFTTKVP 45 D +FTC C GW G R + A + +C GGT P Sbjct: 814 DGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAP 853
>sp|Q01705|NOTC1_MOUSE Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain] Length = 2531 Score = 28.5 bits (62), Expect = 5.0 Identities = 15/33 (45%), Positives = 17/33 (51%), Gaps = 2/33 (6%) Frame = -2 Query: 155 RNFTCYCPGGWFGLRTAHPA*L--SRRCLGGGT 63 R F C CP G+ G + A S RCL GGT Sbjct: 1330 RGFICRCPAGFEGATCENDARTCGSLRCLNGGT 1362
>sp|P46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain] Length = 2556 Score = 28.5 bits (62), Expect = 5.0 Identities = 15/33 (45%), Positives = 17/33 (51%), Gaps = 2/33 (6%) Frame = -2 Query: 155 RNFTCYCPGGWFGLRTAHPA*L--SRRCLGGGT 63 R F C CP G+ G + A S RCL GGT Sbjct: 1331 RGFICKCPAGFEGATCENDARTCGSLRCLNGGT 1363
>sp|Q9QW30|NOTC2_RAT Neurogenic locus notch homolog protein 2 precursor (Notch 2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2471 Score = 28.1 bits (61), Expect = 6.5 Identities = 14/32 (43%), Positives = 17/32 (53%), Gaps = 4/32 (12%) Frame = -2 Query: 146 TCYCPGGWFG----LRTAHPA*LSRRCLGGGT 63 TC C G+ G T+HP +SR C GGT Sbjct: 89 TCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGT 120
>sp|Q9QYE5|JAG2_MOUSE Jagged-2 precursor (Jagged2) Length = 1247 Score = 28.1 bits (61), Expect = 6.5 Identities = 14/41 (34%), Positives = 18/41 (43%), Gaps = 2/41 (4%) Frame = -2 Query: 164 QIDRNFTCYCPGGWFGLRTA--HPA*LSRRCLGGGTFTTKV 48 ++ F C+CP GW G A S C GGT +V Sbjct: 364 EVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQV 404
>sp|O35516|NOTC2_MOUSE Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] Length = 2470 Score = 28.1 bits (61), Expect = 6.5 Identities = 14/32 (43%), Positives = 17/32 (53%), Gaps = 4/32 (12%) Frame = -2 Query: 146 TCYCPGGWFG----LRTAHPA*LSRRCLGGGT 63 TC C G+ G T+HP +SR C GGT Sbjct: 89 TCRCAPGFTGEDCQYSTSHPCFVSRPCQNGGT 120
>sp|Q9Y219|JAG2_HUMAN Jagged-2 precursor (Jagged2) (HJ2) Length = 1238 Score = 28.1 bits (61), Expect = 6.5 Identities = 14/41 (34%), Positives = 18/41 (43%), Gaps = 2/41 (4%) Frame = -2 Query: 164 QIDRNFTCYCPGGWFGLRTA--HPA*LSRRCLGGGTFTTKV 48 ++ F C+CP GW G A S C GGT +V Sbjct: 364 EVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQV 404
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,241,478 Number of Sequences: 369166 Number of extensions: 378508 Number of successful extensions: 2244 Number of sequences better than 10.0: 9 Number of HSP's better than 10.0 without gapping: 2056 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 2244 length of database: 68,354,980 effective HSP length: 33 effective length of database: 62,258,725 effective search space used: 1680985575 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)