Planaria EST Database


DrC_01426

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01426
         (828 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|O35075|DSCR3_MOUSE  Down syndrome critical region protein...   230   3e-60
sp|O14972|DSCR3_HUMAN  Down syndrome critical region protein...   222   9e-58
sp|Q5RF33|DSCR3_PONPY  Down syndrome critical region protein...   219   6e-57
sp|Q8I4T1|VPS26_PLAF7  Vacuolar protein sorting 26 homolog (...    37   0.066
sp|O33123|LEU2_MYCLE  3-isopropylmalate dehydratase large su...    33   1.3  
sp|P40336|VPS26_MOUSE  Vacuolar protein sorting 26 (Vesicle ...    32   2.8  
sp|O75436|VPS26_HUMAN  Vacuolar protein sorting 26 (Vesicle ...    32   2.8  
sp|O53237|LEU2_MYCTU  3-isopropylmalate dehydratase large su...    31   3.6  
sp|Q7TXH6|LEU2_MYCBO  3-isopropylmalate dehydratase large su...    31   3.6  
sp|Q9T091|VPS26_ARATH  Vacuolar protein sorting 26 homolog (...    30   6.2  
>sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 homolog (Down syndrome
           critical region protein A homolog)
          Length = 297

 Score =  230 bits (587), Expect = 3e-60
 Identities = 115/255 (45%), Positives = 164/255 (64%)
 Frame = +3

Query: 63  IEIRLQRINKTYIENEIIKGLVYIDSKQDFSHQGINLILSGMVNLEISSKTHGRFDAIYN 242
           ++I+++R NK Y   E++ G+V I SK    HQG++L + G VNL++S+K+ G F+A YN
Sbjct: 5   LDIKIKRANKVYHAGEMLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYN 64

Query: 243 SVKPIQLAQKTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYS 422
           SVKPIQ+   T+++ K G+IPSG  E+ FE PL +      G K L ETY GVF+NI Y+
Sbjct: 65  SVKPIQIINSTIDVLKPGKIPSGKTEVPFEFPLLVK-----GSKVLYETYHGVFVNIQYT 119

Query: 423 LTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNF 602
           L  D++RS+L K L   C+ +V          K    P++F               LP F
Sbjct: 120 LRCDMRRSLLAKDLTKTCEFIVHSAPQ---KGKLTPSPVDFTITPETLQNVKERASLPKF 176

Query: 603 SIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQ 782
            I G ++S+  ++ QP+TG L+VEH D  I+SIELQLVRVETCGCAEGY++D+TEI+N+Q
Sbjct: 177 FIRGHLNSTNCAITQPLTGELVVEHSDAAIRSIELQLVRVETCGCAEGYARDATEIQNIQ 236

Query: 783 MGDGNVFRNFEIPLY 827
           + DG++ RN  +PLY
Sbjct: 237 IADGDICRNLSVPLY 251
>sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3 (Down syndrome critical
           region protein A)
          Length = 297

 Score =  222 bits (566), Expect = 9e-58
 Identities = 112/255 (43%), Positives = 160/255 (62%)
 Frame = +3

Query: 63  IEIRLQRINKTYIENEIIKGLVYIDSKQDFSHQGINLILSGMVNLEISSKTHGRFDAIYN 242
           ++I+++R NK Y   E++ G+V I SK    HQG++L + G VNL++S+K+ G F+A YN
Sbjct: 5   LDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYN 64

Query: 243 SVKPIQLAQKTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYS 422
           SVKPIQ+   T+E+ K G+ PSG  EI FE PL +      G K L ETY GVF+NI Y+
Sbjct: 65  SVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHL-----KGNKVLYETYHGVFVNIQYT 119

Query: 423 LTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNF 602
           L  D+KRS+L K L   C+ +V          K    P++F               LP F
Sbjct: 120 LRCDMKRSLLAKDLTKTCEFIVH---SAPQKGKFTPSPVDFTITPETLQNVKERALLPKF 176

Query: 603 SIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQ 782
            + G ++S+   + QP+TG L+VE  +  I+S+ELQLVRVETCGCAEGY++D+TEI+N+Q
Sbjct: 177 LLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQ 236

Query: 783 MGDGNVFRNFEIPLY 827
           + DG+V R   +P+Y
Sbjct: 237 IADGDVCRGLSVPIY 251
>sp|Q5RF33|DSCR3_PONPY Down syndrome critical region protein 3 homolog
          Length = 297

 Score =  219 bits (559), Expect = 6e-57
 Identities = 111/255 (43%), Positives = 159/255 (62%)
 Frame = +3

Query: 63  IEIRLQRINKTYIENEIIKGLVYIDSKQDFSHQGINLILSGMVNLEISSKTHGRFDAIYN 242
           ++I+++R NK Y   E++ G+V I SK    HQG++L + G VNL++S+K+ G F+A YN
Sbjct: 5   LDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYN 64

Query: 243 SVKPIQLAQKTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYS 422
           SVKPIQ+    +E+ K G+ PSG  EI FE PL +      G K L ETY GVF+NI Y+
Sbjct: 65  SVKPIQIINSNIEMVKPGKFPSGKTEIPFEFPLHV-----KGNKVLYETYHGVFVNIQYT 119

Query: 423 LTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNF 602
           L  D+KRS+L K L   C+ +V          K +  P+ F               LP F
Sbjct: 120 LRCDMKRSLLAKDLTKTCEFIVH---SAPQKGKFSPSPVHFTITPETLQNARERALLPKF 176

Query: 603 SIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQ 782
            + G ++S+   + QP+TG L+VE  +  I+S+ELQLVRVETCGCAEGY++D+TEI+N+Q
Sbjct: 177 LLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQ 236

Query: 783 MGDGNVFRNFEIPLY 827
           + DG+V R   +P+Y
Sbjct: 237 IADGDVCRGLSVPIY 251
>sp|Q8I4T1|VPS26_PLAF7 Vacuolar protein sorting 26 homolog (VPS26 protein homolog)
          Length = 297

 Score = 37.0 bits (84), Expect = 0.066
 Identities = 49/245 (20%), Positives = 93/245 (37%), Gaps = 2/245 (0%)
 Frame = +3

Query: 96  YIENEIIKGLVYIDSK--QDFSHQGINLILSGMVNLEISSKTHGRFDAIYNSVKPIQLAQ 269
           + + E I G   I  K  + F H GI L L G +N+         F +I   ++P     
Sbjct: 39  FSDGEDINGTATISLKPGKKFEHYGIKLELIGQINILNDKANSYDFFSISKDLEP----- 93

Query: 270 KTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYSLTVDIKRSI 449
                      P  +VE       +      S + +  E+Y G  + + Y + ++I +  
Sbjct: 94  -----------PGFLVES------KQFKWKFSAVDKQHESYFGTNVQLRYFVRLNIIKGY 136

Query: 450 LQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNFSIVGKIDSS 629
              ++Q + D +VQ   I          P E                     I  + D S
Sbjct: 137 -SGNIQKEIDFIVQNLCI----------PPEINNTIKMEVGIEDC-----LHIEFEYDKS 180

Query: 630 EISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQMGDGNVFRN 809
           +  +K  + G +        IK +EL ++++ET G  + Y+ ++  +   ++ DG+  ++
Sbjct: 181 KYHLKDVVVGKVYFLLVRIKIKHMELDIIKMETSGVGKNYTTETVTLSKFEIMDGSPIKS 240

Query: 810 FEIPL 824
             IP+
Sbjct: 241 ECIPV 245
>sp|O33123|LEU2_MYCLE 3-isopropylmalate dehydratase large subunit (Isopropylmalate
           isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 476

 Score = 32.7 bits (73), Expect = 1.3
 Identities = 35/166 (21%), Positives = 73/166 (43%), Gaps = 21/166 (12%)
 Frame = +3

Query: 36  IEFQMAQPLIEIRLQRINKTYIE--------NEIIKGLVYIDSKQ-DFSHQGINLILSGM 188
           I+  +A P+  I+++ + +   E         +I +G+V++   Q   +  G+ ++    
Sbjct: 80  IDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLTQPGMTIVCG-- 137

Query: 189 VNLEISSKTHGRFDAIYNSVKPIQLAQ------------KTVELNKSGRIPSGVVEIVFE 332
              +  + THG F AI   +   ++              KT+ +   GR+P+GV      
Sbjct: 138 ---DSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAGVTAKDII 194

Query: 333 IPLQMNVSSTSGIKRLLETYRGVFINISYSLTVDIKRSILQKSLQA 470
           + L   + +  G   +LE YRG  I    S++++ + +I   S++A
Sbjct: 195 LALIAKIGTGGGQGYVLE-YRGSVIE---SMSMEGRMTICNMSIEA 236
>sp|P40336|VPS26_MOUSE Vacuolar protein sorting 26 (Vesicle protein sorting 26) (H58
           protein) (H beta 58)
          Length = 327

 Score = 31.6 bits (70), Expect = 2.8
 Identities = 55/254 (21%), Positives = 95/254 (37%), Gaps = 6/254 (2%)
 Frame = +3

Query: 81  RINKTYI--ENEIIKGLVYIDSKQD---FSHQGINLILSGMVNL-EISSKTHGRFDAIYN 242
           ++ K Y+  + E + G V +  KQ      HQGI +   G + L    S TH   + +  
Sbjct: 35  KVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKE 94

Query: 243 SVKPIQLAQKTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYS 422
              P +L Q                   FE            +++  E+Y G  + + Y 
Sbjct: 95  LALPGELTQSR--------------SYDFEF---------MQVEKPYESYIGANVRLRYF 131

Query: 423 LTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNF 602
           L V I R +    L  + D++V +Q   + D   +IK ME                    
Sbjct: 132 LKVTIVRRLTD--LVKEYDLIV-HQLATYPDVNNSIK-MEVGIEDC-------------L 174

Query: 603 SIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQ 782
            I  + + S+  +K  I G +        I+ +ELQL++ E  G     + ++  I   +
Sbjct: 175 HIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYE 234

Query: 783 MGDGNVFRNFEIPL 824
           + DG   +   IP+
Sbjct: 235 IMDGAPVKGESIPI 248
>sp|O75436|VPS26_HUMAN Vacuolar protein sorting 26 (Vesicle protein sorting 26) (hVPS26)
          Length = 327

 Score = 31.6 bits (70), Expect = 2.8
 Identities = 55/254 (21%), Positives = 95/254 (37%), Gaps = 6/254 (2%)
 Frame = +3

Query: 81  RINKTYI--ENEIIKGLVYIDSKQD---FSHQGINLILSGMVNL-EISSKTHGRFDAIYN 242
           ++ K Y+  + E + G V +  KQ      HQGI +   G + L    S TH   + +  
Sbjct: 35  KVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKE 94

Query: 243 SVKPIQLAQKTVELNKSGRIPSGVVEIVFEIPLQMNVSSTSGIKRLLETYRGVFINISYS 422
              P +L Q                   FE            +++  E+Y G  + + Y 
Sbjct: 95  LALPGELTQSR--------------SYDFEF---------MQVEKPYESYIGANVRLRYF 131

Query: 423 LTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXXXXXXXXSPKLPNF 602
           L V I R +    L  + D++V +Q   + D   +IK ME                    
Sbjct: 132 LKVTIVRRLTD--LVKEYDLIV-HQLATYPDVNNSIK-MEVGIEDC-------------L 174

Query: 603 SIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAEGYSKDSTEIENLQ 782
            I  + + S+  +K  I G +        I+ +ELQL++ E  G     + ++  I   +
Sbjct: 175 HIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYE 234

Query: 783 MGDGNVFRNFEIPL 824
           + DG   +   IP+
Sbjct: 235 IMDGAPVKGESIPI 248
>sp|O53237|LEU2_MYCTU 3-isopropylmalate dehydratase large subunit (Isopropylmalate
           isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 473

 Score = 31.2 bits (69), Expect = 3.6
 Identities = 34/166 (20%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
 Frame = +3

Query: 36  IEFQMAQPLIEIRLQRINKTYIE--------NEIIKGLVYIDSKQ-DFSHQGINLILSGM 188
           I+  +A P+   +++ + +   E         +I +G+V++   Q   +  G+ ++    
Sbjct: 77  IDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCG-- 134

Query: 189 VNLEISSKTHGRFDAIYNSVKPIQLAQ------------KTVELNKSGRIPSGVVEIVFE 332
              +  + THG F A+   +   ++              KT+ +N  GR+P GV      
Sbjct: 135 ---DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDII 191

Query: 333 IPLQMNVSSTSGIKRLLETYRGVFINISYSLTVDIKRSILQKSLQA 470
           + L   + +  G   ++E YRG  I    SL+++ + +I   S++A
Sbjct: 192 LALIAKIGTGGGQGHVIE-YRGSAIE---SLSMEGRMTICNMSIEA 233
>sp|Q7TXH6|LEU2_MYCBO 3-isopropylmalate dehydratase large subunit (Isopropylmalate
           isomerase) (Alpha-IPM isomerase) (IPMI)
          Length = 473

 Score = 31.2 bits (69), Expect = 3.6
 Identities = 34/166 (20%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
 Frame = +3

Query: 36  IEFQMAQPLIEIRLQRINKTYIE--------NEIIKGLVYIDSKQ-DFSHQGINLILSGM 188
           I+  +A P+   +++ + +   E         +I +G+V++   Q   +  G+ ++    
Sbjct: 77  IDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCG-- 134

Query: 189 VNLEISSKTHGRFDAIYNSVKPIQLAQ------------KTVELNKSGRIPSGVVEIVFE 332
              +  + THG F A+   +   ++              KT+ +N  GR+P GV      
Sbjct: 135 ---DSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDII 191

Query: 333 IPLQMNVSSTSGIKRLLETYRGVFINISYSLTVDIKRSILQKSLQA 470
           + L   + +  G   ++E YRG  I    SL+++ + +I   S++A
Sbjct: 192 LALIAKIGTGGGQGHVIE-YRGSAIE---SLSMEGRMTICNMSIEA 233
>sp|Q9T091|VPS26_ARATH Vacuolar protein sorting 26 homolog (VPS26 protein homolog)
          Length = 303

 Score = 30.4 bits (67), Expect = 6.2
 Identities = 32/147 (21%), Positives = 60/147 (40%)
 Frame = +3

Query: 384 ETYRGVFINISYSLTVDIKRSILQKSLQAQCDILVQYQDIGHIDDKAAIKPMEFXXXXXX 563
           ETY GV + + Y L V + R      L+ Q  ++  Y  +  I++  +IK ME       
Sbjct: 118 ETYNGVNVRLRYVLKVTVTRGYAGSILEYQELVVRNYAPLPDINN--SIK-MEVGIEDC- 173

Query: 564 XXXXXXSPKLPNFSIVGKIDSSEISMKQPITGHLIVEHCDRPIKSIELQLVRVETCGCAE 743
                         I  + + S+  +K  I G +        +K+++L++ R E+ G   
Sbjct: 174 ------------LHIEFEYNKSKYHLKDVILGKIYFLLVRIKMKNMDLEIRRRESTGAGA 221

Query: 744 GYSKDSTEIENLQMGDGNVFRNFEIPL 824
               ++  +   ++ DG   R   IP+
Sbjct: 222 NTHVETETLAKFELMDGTPVRGESIPV 248
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,634,827
Number of Sequences: 369166
Number of extensions: 1751090
Number of successful extensions: 4163
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4047
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4157
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)