Planaria EST Database


DrC_01387

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01387
         (931 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|O35344|IMA3_MOUSE  Importin alpha-3 subunit (Karyopherin ...   428   e-119
sp|O00505|IMA3_HUMAN  Importin alpha-3 subunit (Karyopherin ...   426   e-119
sp|O35343|IMA4_MOUSE  Importin alpha-4 subunit (Karyopherin ...   421   e-117
sp|O00629|IMA4_HUMAN  Importin alpha-4 subunit (Karyopherin ...   421   e-117
sp|Q19969|IMA3_CAEEL  Importin alpha-3 subunit (Karyopherin ...   380   e-105
sp|P52170|IMA1_XENLA  Importin alpha-1 subunit (Karyopherin ...   291   2e-78
sp|P52171|IMA2_XENLA  Importin alpha-2 subunit (Karyopherin ...   285   1e-76
sp|P52292|IMA2_HUMAN  Importin alpha-2 subunit (Karyopherin ...   278   2e-74
sp|P52293|IMA2_MOUSE  Importin alpha-2 subunit (Karyopherin ...   275   2e-73
sp|O04294|IMA2_ARATH  Importin alpha-2 subunit (Karyopherin ...   267   3e-71
>sp|O35344|IMA3_MOUSE Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin
           alpha Q2)
          Length = 521

 Score =  428 bits (1100), Expect = e-119
 Identities = 211/286 (73%), Positives = 239/286 (83%)
 Frame = +3

Query: 3   EIDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVEC 182
           + D   Q   L  I+ N+T+ NP ++L A+QAARKLLSSD+NPPID LI+SGI+PILV+C
Sbjct: 63  DADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKC 122

Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
           L+ D +P++QFEAAWALTNIASGTS QT AVVQ+ AVPLFL+LL S H NVCEQAVWALG
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALG 182

Query: 363 NIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISE 542
           NIIGDGP  RDY I+LGVV PLL F+N  +PITFLRNVTWVIVNLCRNKDPPP   T+ E
Sbjct: 183 NIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQE 242

Query: 543 LLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQT 722
           +LPAL  LI + D NILVDTVWALSYLTDGGN+QIQMVI++ +V FLVPLLSH +VKVQT
Sbjct: 243 ILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQT 302

Query: 723 AALRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           AALRAVGNIVTGTDEQTQ VLN D LSHFP LL H KEKINKEAVW
Sbjct: 303 AALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVW 348

 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 5/253 (1%)
 Frame = +3

Query: 111 LSSDKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGA 290
           L  +K+PP        I+P L   + + +  NI  +  WAL+ +  G +EQ   V+ +G 
Sbjct: 227 LCRNKDPPPPMETVQEILPALCVLIYH-TDINILVDTVWALSYLTDGGNEQIQMVIDSGV 285

Query: 291 VPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLR 470
           VP  + LL      V   A+ A+GNI+          +N  V++     L+        +
Sbjct: 286 VPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKE-KINK 344

Query: 471 NVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLT-DGGNDQI 647
              W + N+             + L+P +   +   D     +  WA+S LT  G  DQ+
Sbjct: 345 EAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQV 404

Query: 648 QMVIEADIVRFLVPLLSHNDVKVQTAALRAVGN--IVTGTDEQT--QYVLNYDALSHFPQ 815
           + +++ +++     LLS  D +V    L  + N  I+ G +  T  + +     L     
Sbjct: 405 EYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEV 464

Query: 816 LLQHSKEKINKEA 854
           L QH  E I K A
Sbjct: 465 LQQHENEDIYKLA 477

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/33 (63%), Positives = 26/33 (78%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           + ++ K+   FLSNITAGNQ+QVQAVID  LIP
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDAGLIP 371
>sp|O00505|IMA3_HUMAN Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma)
          Length = 521

 Score =  426 bits (1095), Expect = e-119
 Identities = 210/286 (73%), Positives = 239/286 (83%)
 Frame = +3

Query: 3   EIDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVEC 182
           + D   Q   L  I+ N+T+ NP ++L A+QAARKLLSSD+NPPID LI+SGI+PILV+C
Sbjct: 63  DADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKC 122

Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
           L+ D +P++QFEAAWALTNIASGTS QT AVVQ+ AVPLFL+LL S H NVCEQAVWALG
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALG 182

Query: 363 NIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISE 542
           NIIGDGP  RDY I+LGVV PLL F++  +PITFLRNVTWVIVNLCRNKDPPP   T+ E
Sbjct: 183 NIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQE 242

Query: 543 LLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQT 722
           +LPAL  LI + D NILVDTVWALSYLTDGGN+QIQMVI++ +V FLVPLLSH +VKVQT
Sbjct: 243 ILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQT 302

Query: 723 AALRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           AALRAVGNIVTGTDEQTQ VLN D LSHFP LL H KEKINKEAVW
Sbjct: 303 AALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVW 348

 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 5/253 (1%)
 Frame = +3

Query: 111 LSSDKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGA 290
           L  +K+PP        I+P L   + + +  NI  +  WAL+ +  G +EQ   V+ +G 
Sbjct: 227 LCRNKDPPPPMETVQEILPALCVLIYH-TDINILVDTVWALSYLTDGGNEQIQMVIDSGV 285

Query: 291 VPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLR 470
           VP  + LL      V   A+ A+GNI+          +N  V++     L+        +
Sbjct: 286 VPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKE-KINK 344

Query: 471 NVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLT-DGGNDQI 647
              W + N+             + L+P +   +   D     +  WA+S LT  G  DQ+
Sbjct: 345 EAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQV 404

Query: 648 QMVIEADIVRFLVPLLSHNDVKVQTAALRAVGN--IVTGTDEQT--QYVLNYDALSHFPQ 815
           + +++ +++     LLS  D +V    L  + N  I+ G +  T  + +     L     
Sbjct: 405 EYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEV 464

Query: 816 LLQHSKEKINKEA 854
           L QH  E I K A
Sbjct: 465 LQQHENEDIYKLA 477

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/33 (63%), Positives = 26/33 (78%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           + ++ K+   FLSNITAGNQ+QVQAVID  LIP
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDAGLIP 371
>sp|O35343|IMA4_MOUSE Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin
           alpha Q1)
          Length = 521

 Score =  421 bits (1082), Expect = e-117
 Identities = 210/284 (73%), Positives = 239/284 (84%)
 Frame = +3

Query: 9   DEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLD 188
           D  +Q ++L  IV N+++ N  I+L A+QAARKLLSSD+NPPID LI+SGI+PILV CL+
Sbjct: 65  DYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLE 124

Query: 189 NDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
            D +P++QFEAAWALTNIASGTSEQT AVVQ+ AVPLFL+LL S H NVCEQAVWALGNI
Sbjct: 125 RDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184

Query: 369 IGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELL 548
           IGDGP  RDY I+LGVV PLL F++  +PITFLRNVTWV+VNLCR+KDPPP   TI E+L
Sbjct: 185 IGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEIL 244

Query: 549 PALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAA 728
           PAL  LI + D NILVDTVWALSYLTD GN+QIQMVI++ IV  LVPLLSH +VKVQTAA
Sbjct: 245 PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAA 304

Query: 729 LRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           LRAVGNIVTGTDEQTQ VLN DALSHFP LL H KEKINKEAVW
Sbjct: 305 LRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVW 348

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
 Frame = +3

Query: 195 SHPN--IQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
           +HP   I  EA W L+NI +G  +Q  AV+ A  VP+ + LL        ++A WA+ N+
Sbjct: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395

Query: 369 IGDGPTLR-DYAINLGVVAPLLKFL 440
              G   +  Y I   V+ P    L
Sbjct: 396 TISGRKDQVAYLIQQNVIPPFCNLL 420

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 20/33 (60%), Positives = 26/33 (78%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           + ++ K+   FLSNITAGNQ+QVQAVID  L+P
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371
>sp|O00629|IMA4_HUMAN Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1
           protein)
          Length = 521

 Score =  421 bits (1082), Expect = e-117
 Identities = 210/284 (73%), Positives = 239/284 (84%)
 Frame = +3

Query: 9   DEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLD 188
           D  +Q ++L  IV N+++ N  I+L A+QAARKLLSSD+NPPID LI+SGI+PILV CL+
Sbjct: 65  DYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLE 124

Query: 189 NDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
            D +P++QFEAAWALTNIASGTSEQT AVVQ+ AVPLFL+LL S H NVCEQAVWALGNI
Sbjct: 125 RDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184

Query: 369 IGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELL 548
           IGDGP  RDY I+LGVV PLL F++  +PITFLRNVTWV+VNLCR+KDPPP   TI E+L
Sbjct: 185 IGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEIL 244

Query: 549 PALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAA 728
           PAL  LI + D NILVDTVWALSYLTD GN+QIQMVI++ IV  LVPLLSH +VKVQTAA
Sbjct: 245 PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAA 304

Query: 729 LRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           LRAVGNIVTGTDEQTQ VLN DALSHFP LL H KEKINKEAVW
Sbjct: 305 LRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVW 348

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
 Frame = +3

Query: 195 SHPN--IQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
           +HP   I  EA W L+NI +G  +Q  AV+ A  VP+ + LL        ++A WA+ N+
Sbjct: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395

Query: 369 IGDGPTLR-DYAINLGVVAPLLKFL 440
              G   +  Y I   V+ P    L
Sbjct: 396 TISGRKDQVAYLIQQNVIPPFCNLL 420

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 20/33 (60%), Positives = 26/33 (78%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           + ++ K+   FLSNITAGNQ+QVQAVID  L+P
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371
>sp|Q19969|IMA3_CAEEL Importin alpha-3 subunit (Karyopherin alpha-3 subunit)
          Length = 514

 Score =  380 bits (977), Expect = e-105
 Identities = 191/282 (67%), Positives = 223/282 (79%)
 Frame = +3

Query: 15  PIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDND 194
           P   + L   V  + + +P  +L A+Q ARK+LS+D+NPPID LI SGI+P+LV+CL + 
Sbjct: 61  PFDANLLRLTVAAAQSSDPAEQLTAVQQARKMLSTDRNPPIDDLIGSGILPVLVQCLSS- 119

Query: 195 SHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIG 374
           + PN+QFEAAWALTNIASGTSEQT AVV AGAVPLFL+LL   + NVCEQ+VWALGNIIG
Sbjct: 120 TDPNLQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNIIG 179

Query: 375 DGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPA 554
           DGP  RDY + LG++ PLL+F+N ++PI FLRNVTWVIVNLCR KDP PSP  +  +LPA
Sbjct: 180 DGPHFRDYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPA 239

Query: 555 LRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALR 734
           L  LI + DTNIL+DTVWALSYLTDGGN+ IQMVIEA +V  LVPLL H DVKVQTAALR
Sbjct: 240 LSLLIHHQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALR 299

Query: 735 AVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           AVGNIVTGTDEQTQ VL+   L   P LL H KEKINKEAVW
Sbjct: 300 AVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVW 341

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/239 (22%), Positives = 95/239 (39%), Gaps = 4/239 (1%)
 Frame = +3

Query: 138 DSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLG 317
           D  ++ GI+  L++ ++ +          W + N+        +  V    +P    L+ 
Sbjct: 186 DYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIH 245

Query: 318 SAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVA---PLLKFLNTDVPITFLRNVTWVI 488
              +N+    VWAL  +   G       I   VV    PLL  ++  V    LR V    
Sbjct: 246 HQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVG--- 302

Query: 489 VNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEAD 668
            N+    D        S +L  +  L+ +    I  + VW +S +T G   Q+Q V +A 
Sbjct: 303 -NIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQDVFDAG 361

Query: 669 IVRFLVPLLSHNDVKVQTAALRAVGNI-VTGTDEQTQYVLNYDALSHFPQLLQHSKEKI 842
           I+  ++ LL   D   Q  A  A+ N+ ++G   Q + ++    L  F  +L  +  +I
Sbjct: 362 IMPMIIHLLDRGDFPTQKEAAWAISNVTISGRPNQVEQMVKLGVLRPFCAMLSCTDSQI 420

 Score = 38.1 bits (87), Expect = 0.036
 Identities = 16/33 (48%), Positives = 24/33 (72%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           + ++ K+   F+SNITAGNQ+QVQ V D  ++P
Sbjct: 332 KEKINKEAVWFVSNITAGNQQQVQDVFDAGIMP 364
>sp|P52170|IMA1_XENLA Importin alpha-1 subunit (Karyopherin alpha-1 subunit)
          Length = 522

 Score =  291 bits (744), Expect = 2e-78
 Identities = 140/277 (50%), Positives = 192/277 (69%)
 Frame = +3

Query: 30  NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
           +L EIV    + +P   L   QAARK+LS ++NPP++ +I++G++P LVE L    +  +
Sbjct: 74  SLEEIVQGMNSGDPENELRCTQAARKMLSRERNPPLNDIIEAGLIPKLVEFLSRHDNSTL 133

Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
           QFEAAWALTNIASGTS+QT +VV  GA+P F+ L+ S H ++ EQAVWALGNI GDGP  
Sbjct: 134 QFEAAWALTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY 193

Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
           RD  IN  V+ PLL  +N   P+ +LRN+TW++ NLCRNK+P P  + + ++LP L  L+
Sbjct: 194 RDALINCNVIPPLLALVNPQTPLGYLRNITWMLSNLCRNKNPYPPMSAVLQILPVLTQLM 253

Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
            + D +IL DT WA+SYLTDG ND+I +V++  IV  L+ L+   ++ + T +LR VGNI
Sbjct: 254 HHDDKDILSDTCWAMSYLTDGSNDRIDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNI 313

Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           VTGTD+QTQ  ++   LS  PQLL+H K  I KEA W
Sbjct: 314 VTGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAW 350

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 38/147 (25%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
 Frame = +3

Query: 6   IDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLS-SDKNPPIDSLIQSGIMPILVEC 182
           ID  ++   +  ++    +P  +I   +++    +++ +DK     + I +G++ +L + 
Sbjct: 279 IDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNIVTGTDKQT--QAAIDAGVLSVLPQL 336

Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
           L +   P+IQ EAAWA++NIA+G + Q   ++  G +   + LL        ++AVWA+ 
Sbjct: 337 LRHQK-PSIQKEAAWAISNIAAGPAPQIQQMITCGLLSPLVDLLNKGDFKAQKEAVWAVT 395

Query: 363 NIIGDGPTLR-DYAINLGVVAPLLKFL 440
           N    G   +    +  GV+ PLL  L
Sbjct: 396 NYTSGGTVEQVVQLVQCGVLEPLLNLL 422
>sp|P52171|IMA2_XENLA Importin alpha-2 subunit (Karyopherin alpha-2 subunit)
          Length = 523

 Score =  285 bits (729), Expect = 1e-76
 Identities = 137/277 (49%), Positives = 192/277 (69%)
 Frame = +3

Query: 30  NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
           +L EIV    + +    L + QAARK+LS ++NPP++ +I++G++P LVE L   ++  +
Sbjct: 74  SLEEIVQGMNSGDNENELRSTQAARKMLSKERNPPLNDIIEAGLIPKLVEFLSYHNNSTL 133

Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
           QFEAAWALTNIASGTS+QT +VV  GA+P F+ L+ S H ++ EQAVWALGNI GDGP  
Sbjct: 134 QFEAAWALTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY 193

Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
           RD  I+  V+ PLL  +N   P+ +LRN+TW + NLCRNK+P P  + + ++LP L  L+
Sbjct: 194 RDALISCNVIPPLLTLVNPQTPLGYLRNITWTLSNLCRNKNPYPPMSAVLQILPVLTQLM 253

Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
            + D +IL DT WA+SYLTDG ND+I +V++  +V  L+ L+   ++ + T +LR VGNI
Sbjct: 254 LHEDKDILSDTCWAMSYLTDGSNDRIDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNI 313

Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           VTGTD+QTQ  ++   LS  PQLL+H K  I KEA W
Sbjct: 314 VTGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAW 350

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 39/147 (26%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
 Frame = +3

Query: 6   IDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLS-SDKNPPIDSLIQSGIMPILVEC 182
           ID  ++   +  ++    +P  +I   +++    +++ +DK     + I +G++ +L + 
Sbjct: 279 IDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNIVTGTDKQT--QAAIDAGVLSVLPQL 336

Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
           L +   P+IQ EAAWAL+NIA+G + Q   ++  G +   + LL        ++AVWA+ 
Sbjct: 337 LRHQK-PSIQKEAAWALSNIAAGPAPQIQQMITCGLLSPLVDLLKKGDFKAQKEAVWAVT 395

Query: 363 NIIGDGPTLR-DYAINLGVVAPLLKFL 440
           N    G   +    +  GV+ PLL  L
Sbjct: 396 NYTSGGTVEQVVQLVQCGVLEPLLNLL 422
>sp|P52292|IMA2_HUMAN Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha)
           (RAG cohort protein 1)
          Length = 529

 Score =  278 bits (710), Expect = 2e-74
 Identities = 143/281 (50%), Positives = 189/281 (67%), Gaps = 4/281 (1%)
 Frame = +3

Query: 30  NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
           ++ +IV    + N   +L+A QAARKLLS +K PPID++I++G++P  V  L       I
Sbjct: 77  SVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPI 136

Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
           QFE+AWALTNIASGTSEQT AVV  GA+P F+ LL S H+++ EQAVWALGNI GDG   
Sbjct: 137 QFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVF 196

Query: 390 RDYAINLGVVAPLLKFL----NTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPAL 557
           RD  I  G V PLL  L     + +   +LRN+TW + NLCRNK+P P    + ++LP L
Sbjct: 197 RDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTL 256

Query: 558 RFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRA 737
             L+ + D  +L DT WA+SYLTDG N++I MV++  +V  LV LL  +++ + T ALRA
Sbjct: 257 VRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRA 316

Query: 738 VGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           +GNIVTGTDEQTQ V++  AL+ FP LL + K  I KEA W
Sbjct: 317 IGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATW 357

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
 Frame = +3

Query: 144 LIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSA 323
           +I +G + +    L N    NIQ EA W ++NI +G  +Q   VV  G VP  + +L  A
Sbjct: 331 VIDAGALAVFPSLLTNPK-TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKA 389

Query: 324 HSNVCEQAVWALGNIIGDGPTLR-DYAINLGVVAPLLKFL 440
                ++AVWA+ N    G   +  Y ++ G++ PL+  L
Sbjct: 390 DFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLL 429

 Score = 33.5 bits (75), Expect = 0.88
 Identities = 13/33 (39%), Positives = 23/33 (69%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           +  + K+    +SNITAG Q+Q+Q V+++ L+P
Sbjct: 348 KTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
>sp|P52293|IMA2_MOUSE Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha)
           (RAG cohort protein 1) (Pendulin) (Pore targeting
           complex 58 kDa subunit) (PTAC58) (Importin alpha P1)
          Length = 529

 Score =  275 bits (702), Expect = 2e-73
 Identities = 141/281 (50%), Positives = 189/281 (67%), Gaps = 4/281 (1%)
 Frame = +3

Query: 30  NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
           ++ +IV    + N   +L+A QAARKLLS +K PPID++I++G++P  V  L       I
Sbjct: 77  SVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPI 136

Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
           QFE+AWALTNIASGTSEQT AVV  GA+P F+ LL S H+++ EQAVWALGNI GDG   
Sbjct: 137 QFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAF 196

Query: 390 RDYAINLGVVAPLLKFLN----TDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPAL 557
           RD  I  G + PLL  L     + +   +LRN+TW + NLCRNK+P P    + ++LP L
Sbjct: 197 RDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTL 256

Query: 558 RFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRA 737
             L+ + D  +L D+ WA+SYLTDG N++I+MV++  +V  LV LL   ++ + T ALRA
Sbjct: 257 VRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRA 316

Query: 738 VGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
           +GNIVTGTDEQTQ V++  AL+ FP LL + K  I KEA W
Sbjct: 317 IGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATW 357

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 1/101 (0%)
 Frame = +3

Query: 144 LIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSA 323
           +I +G + +    L N    NIQ EA W ++NI +G  +Q   VV  G VP  + +L  A
Sbjct: 331 VIDAGALAVFPSLLTNPK-TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKA 389

Query: 324 HSNVCEQAVWALGNIIGDGPTLR-DYAINLGVVAPLLKFLN 443
                ++A WA+ N    G   +  Y ++ G++ PL+  L+
Sbjct: 390 DFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLS 430

 Score = 33.5 bits (75), Expect = 0.88
 Identities = 13/33 (39%), Positives = 23/33 (69%)
 Frame = +1

Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
           +  + K+    +SNITAG Q+Q+Q V+++ L+P
Sbjct: 348 KTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
>sp|O04294|IMA2_ARATH Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (KAP alpha)
          Length = 531

 Score =  267 bits (683), Expect = 3e-71
 Identities = 137/278 (49%), Positives = 183/278 (65%), Gaps = 1/278 (0%)
 Frame = +3

Query: 30  NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
           NL  +V    + +   +LEA    RKLLS ++NPPI+ ++QSG++P +V+ L  D  P +
Sbjct: 76  NLPAMVAGIWSEDSNSQLEATNLLRKLLSIEQNPPINEVVQSGVVPRVVKFLSRDDFPKL 135

Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
           QFEAAWALTNIASGTSE TN ++++GAVP+F++LL SA  +V EQAVWALGN+ GD P  
Sbjct: 136 QFEAAWALTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKC 195

Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
           RD  ++ G + PLL   N +  ++ LRN TW + N CR K PPP+       LP L  L+
Sbjct: 196 RDLVLSYGAMTPLLSQFNENTKLSMLRNATWTLSNFCRGK-PPPAFEQTQPALPVLERLV 254

Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
           Q++D  +L D  WALSYL+D  ND+IQ VIEA +V  L+ LL H+   V   ALR +GNI
Sbjct: 255 QSMDEEVLTDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNI 314

Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHS-KEKINKEAVW 860
           VTG D QTQ VL+  AL     LL+++ K+ I KEA W
Sbjct: 315 VTGDDLQTQMVLDQQALPCLLNLLKNNYKKSIKKEACW 352

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 68/280 (24%), Positives = 124/280 (44%), Gaps = 16/280 (5%)
 Frame = +3

Query: 66   NPTIRLEAIQAARKLLSS---DKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALT 236
            N   +L  ++ A   LS+    K PP     Q  + P+L E L       +  +A WAL+
Sbjct: 213  NENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPAL-PVL-ERLVQSMDEEVLTDACWALS 270

Query: 237  NIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGV 416
             ++  ++++  AV++AG VP  ++LLG +  +V   A+  +GNI+          ++   
Sbjct: 271  YLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQMVLDQQA 330

Query: 417  VAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILV 596
            +  LL  L  +   +  +   W I N+             + ++ +L +++Q+ +  +  
Sbjct: 331  LPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQSAEFEVKK 390

Query: 597  DTVWALSYLTDGG-NDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNIV------- 752
            +  W +S  T GG +DQI+ ++    ++ L  LL+  D+KV T  L A+ NI+       
Sbjct: 391  EAAWGISNATSGGTHDQIKFMVSQGCIKPLCDLLTCPDLKVVTVCLEALENILVVGEAEK 450

Query: 753  ----TGTDE-QTQYVLNYDALSHFPQLLQHSKEKINKEAV 857
                TG D    Q +   + L     L  H    I  +AV
Sbjct: 451  NLGHTGEDNLYAQMIDEAEGLEKIENLQSHDNNDIYDKAV 490

 Score = 36.6 bits (83), Expect = 0.10
 Identities = 19/43 (44%), Positives = 29/43 (67%)
 Frame = +1

Query: 799 CLISLSYYNIQRRRLTKKQFGFLSNITAGNQEQVQAVIDYALI 927
           CL++L   N  ++ + K+    +SNITAGN +Q+QAVID  +I
Sbjct: 333 CLLNLLKNNY-KKSIKKEACWTISNITAGNADQIQAVIDAGII 374
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,447,240
Number of Sequences: 369166
Number of extensions: 2270267
Number of successful extensions: 5782
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5258
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5560
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9558791870
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)