Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_E01
(931 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35344|IMA3_MOUSE Importin alpha-3 subunit (Karyopherin ... 428 e-119
sp|O00505|IMA3_HUMAN Importin alpha-3 subunit (Karyopherin ... 426 e-119
sp|O35343|IMA4_MOUSE Importin alpha-4 subunit (Karyopherin ... 421 e-117
sp|O00629|IMA4_HUMAN Importin alpha-4 subunit (Karyopherin ... 421 e-117
sp|Q19969|IMA3_CAEEL Importin alpha-3 subunit (Karyopherin ... 380 e-105
sp|P52170|IMA1_XENLA Importin alpha-1 subunit (Karyopherin ... 291 2e-78
sp|P52171|IMA2_XENLA Importin alpha-2 subunit (Karyopherin ... 285 1e-76
sp|P52292|IMA2_HUMAN Importin alpha-2 subunit (Karyopherin ... 278 2e-74
sp|P52293|IMA2_MOUSE Importin alpha-2 subunit (Karyopherin ... 275 2e-73
sp|O04294|IMA2_ARATH Importin alpha-2 subunit (Karyopherin ... 267 3e-71
>sp|O35344|IMA3_MOUSE Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (Importin
alpha Q2)
Length = 521
Score = 428 bits (1100), Expect = e-119
Identities = 211/286 (73%), Positives = 239/286 (83%)
Frame = +3
Query: 3 EIDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVEC 182
+ D Q L I+ N+T+ NP ++L A+QAARKLLSSD+NPPID LI+SGI+PILV+C
Sbjct: 63 DADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKC 122
Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
L+ D +P++QFEAAWALTNIASGTS QT AVVQ+ AVPLFL+LL S H NVCEQAVWALG
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALG 182
Query: 363 NIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISE 542
NIIGDGP RDY I+LGVV PLL F+N +PITFLRNVTWVIVNLCRNKDPPP T+ E
Sbjct: 183 NIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQE 242
Query: 543 LLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQT 722
+LPAL LI + D NILVDTVWALSYLTDGGN+QIQMVI++ +V FLVPLLSH +VKVQT
Sbjct: 243 ILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQT 302
Query: 723 AALRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
AALRAVGNIVTGTDEQTQ VLN D LSHFP LL H KEKINKEAVW
Sbjct: 303 AALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVW 348
Score = 70.9 bits (172), Expect = 5e-12
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 5/253 (1%)
Frame = +3
Query: 111 LSSDKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGA 290
L +K+PP I+P L + + + NI + WAL+ + G +EQ V+ +G
Sbjct: 227 LCRNKDPPPPMETVQEILPALCVLIYH-TDINILVDTVWALSYLTDGGNEQIQMVIDSGV 285
Query: 291 VPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLR 470
VP + LL V A+ A+GNI+ +N V++ L+ +
Sbjct: 286 VPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKE-KINK 344
Query: 471 NVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLT-DGGNDQI 647
W + N+ + L+P + + D + WA+S LT G DQ+
Sbjct: 345 EAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQV 404
Query: 648 QMVIEADIVRFLVPLLSHNDVKVQTAALRAVGN--IVTGTDEQT--QYVLNYDALSHFPQ 815
+ +++ +++ LLS D +V L + N I+ G + T + + L
Sbjct: 405 EYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEV 464
Query: 816 LLQHSKEKINKEA 854
L QH E I K A
Sbjct: 465 LQQHENEDIYKLA 477
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/33 (63%), Positives = 26/33 (78%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ ++ K+ FLSNITAGNQ+QVQAVID LIP
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDAGLIP 371
>sp|O00505|IMA3_HUMAN Importin alpha-3 subunit (Karyopherin alpha-3 subunit) (SRP1-gamma)
Length = 521
Score = 426 bits (1095), Expect = e-119
Identities = 210/286 (73%), Positives = 239/286 (83%)
Frame = +3
Query: 3 EIDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVEC 182
+ D Q L I+ N+T+ NP ++L A+QAARKLLSSD+NPPID LI+SGI+PILV+C
Sbjct: 63 DADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKC 122
Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
L+ D +P++QFEAAWALTNIASGTS QT AVVQ+ AVPLFL+LL S H NVCEQAVWALG
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALG 182
Query: 363 NIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISE 542
NIIGDGP RDY I+LGVV PLL F++ +PITFLRNVTWVIVNLCRNKDPPP T+ E
Sbjct: 183 NIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQE 242
Query: 543 LLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQT 722
+LPAL LI + D NILVDTVWALSYLTDGGN+QIQMVI++ +V FLVPLLSH +VKVQT
Sbjct: 243 ILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQT 302
Query: 723 AALRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
AALRAVGNIVTGTDEQTQ VLN D LSHFP LL H KEKINKEAVW
Sbjct: 303 AALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVW 348
Score = 70.9 bits (172), Expect = 5e-12
Identities = 61/253 (24%), Positives = 104/253 (41%), Gaps = 5/253 (1%)
Frame = +3
Query: 111 LSSDKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGA 290
L +K+PP I+P L + + + NI + WAL+ + G +EQ V+ +G
Sbjct: 227 LCRNKDPPPPMETVQEILPALCVLIYH-TDINILVDTVWALSYLTDGGNEQIQMVIDSGV 285
Query: 291 VPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLR 470
VP + LL V A+ A+GNI+ +N V++ L+ +
Sbjct: 286 VPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKE-KINK 344
Query: 471 NVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLT-DGGNDQI 647
W + N+ + L+P + + D + WA+S LT G DQ+
Sbjct: 345 EAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQV 404
Query: 648 QMVIEADIVRFLVPLLSHNDVKVQTAALRAVGN--IVTGTDEQT--QYVLNYDALSHFPQ 815
+ +++ +++ LLS D +V L + N I+ G + T + + L
Sbjct: 405 EYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEV 464
Query: 816 LLQHSKEKINKEA 854
L QH E I K A
Sbjct: 465 LQQHENEDIYKLA 477
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/33 (63%), Positives = 26/33 (78%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ ++ K+ FLSNITAGNQ+QVQAVID LIP
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDAGLIP 371
>sp|O35343|IMA4_MOUSE Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Importin
alpha Q1)
Length = 521
Score = 421 bits (1082), Expect = e-117
Identities = 210/284 (73%), Positives = 239/284 (84%)
Frame = +3
Query: 9 DEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLD 188
D +Q ++L IV N+++ N I+L A+QAARKLLSSD+NPPID LI+SGI+PILV CL+
Sbjct: 65 DYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLE 124
Query: 189 NDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
D +P++QFEAAWALTNIASGTSEQT AVVQ+ AVPLFL+LL S H NVCEQAVWALGNI
Sbjct: 125 RDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Query: 369 IGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELL 548
IGDGP RDY I+LGVV PLL F++ +PITFLRNVTWV+VNLCR+KDPPP TI E+L
Sbjct: 185 IGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEIL 244
Query: 549 PALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAA 728
PAL LI + D NILVDTVWALSYLTD GN+QIQMVI++ IV LVPLLSH +VKVQTAA
Sbjct: 245 PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAA 304
Query: 729 LRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
LRAVGNIVTGTDEQTQ VLN DALSHFP LL H KEKINKEAVW
Sbjct: 305 LRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVW 348
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Frame = +3
Query: 195 SHPN--IQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
+HP I EA W L+NI +G +Q AV+ A VP+ + LL ++A WA+ N+
Sbjct: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395
Query: 369 IGDGPTLR-DYAINLGVVAPLLKFL 440
G + Y I V+ P L
Sbjct: 396 TISGRKDQVAYLIQQNVIPPFCNLL 420
Score = 43.9 bits (102), Expect = 6e-04
Identities = 20/33 (60%), Positives = 26/33 (78%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ ++ K+ FLSNITAGNQ+QVQAVID L+P
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371
>sp|O00629|IMA4_HUMAN Importin alpha-4 subunit (Karyopherin alpha-4 subunit) (Qip1
protein)
Length = 521
Score = 421 bits (1082), Expect = e-117
Identities = 210/284 (73%), Positives = 239/284 (84%)
Frame = +3
Query: 9 DEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLD 188
D +Q ++L IV N+++ N I+L A+QAARKLLSSD+NPPID LI+SGI+PILV CL+
Sbjct: 65 DYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLE 124
Query: 189 NDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
D +P++QFEAAWALTNIASGTSEQT AVVQ+ AVPLFL+LL S H NVCEQAVWALGNI
Sbjct: 125 RDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Query: 369 IGDGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELL 548
IGDGP RDY I+LGVV PLL F++ +PITFLRNVTWV+VNLCR+KDPPP TI E+L
Sbjct: 185 IGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEIL 244
Query: 549 PALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAA 728
PAL LI + D NILVDTVWALSYLTD GN+QIQMVI++ IV LVPLLSH +VKVQTAA
Sbjct: 245 PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAA 304
Query: 729 LRAVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
LRAVGNIVTGTDEQTQ VLN DALSHFP LL H KEKINKEAVW
Sbjct: 305 LRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVW 348
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Frame = +3
Query: 195 SHPN--IQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNI 368
+HP I EA W L+NI +G +Q AV+ A VP+ + LL ++A WA+ N+
Sbjct: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395
Query: 369 IGDGPTLR-DYAINLGVVAPLLKFL 440
G + Y I V+ P L
Sbjct: 396 TISGRKDQVAYLIQQNVIPPFCNLL 420
Score = 43.9 bits (102), Expect = 6e-04
Identities = 20/33 (60%), Positives = 26/33 (78%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ ++ K+ FLSNITAGNQ+QVQAVID L+P
Sbjct: 339 KEKINKEAVWFLSNITAGNQQQVQAVIDANLVP 371
>sp|Q19969|IMA3_CAEEL Importin alpha-3 subunit (Karyopherin alpha-3 subunit)
Length = 514
Score = 380 bits (977), Expect = e-105
Identities = 191/282 (67%), Positives = 223/282 (79%)
Frame = +3
Query: 15 PIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDND 194
P + L V + + +P +L A+Q ARK+LS+D+NPPID LI SGI+P+LV+CL +
Sbjct: 61 PFDANLLRLTVAAAQSSDPAEQLTAVQQARKMLSTDRNPPIDDLIGSGILPVLVQCLSS- 119
Query: 195 SHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIG 374
+ PN+QFEAAWALTNIASGTSEQT AVV AGAVPLFL+LL + NVCEQ+VWALGNIIG
Sbjct: 120 TDPNLQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNIIG 179
Query: 375 DGPTLRDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPA 554
DGP RDY + LG++ PLL+F+N ++PI FLRNVTWVIVNLCR KDP PSP + +LPA
Sbjct: 180 DGPHFRDYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPA 239
Query: 555 LRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALR 734
L LI + DTNIL+DTVWALSYLTDGGN+ IQMVIEA +V LVPLL H DVKVQTAALR
Sbjct: 240 LSLLIHHQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALR 299
Query: 735 AVGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
AVGNIVTGTDEQTQ VL+ L P LL H KEKINKEAVW
Sbjct: 300 AVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVW 341
Score = 62.0 bits (149), Expect = 2e-09
Identities = 54/239 (22%), Positives = 95/239 (39%), Gaps = 4/239 (1%)
Frame = +3
Query: 138 DSLIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLG 317
D ++ GI+ L++ ++ + W + N+ + V +P L+
Sbjct: 186 DYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIH 245
Query: 318 SAHSNVCEQAVWALGNIIGDGPTLRDYAINLGVVA---PLLKFLNTDVPITFLRNVTWVI 488
+N+ VWAL + G I VV PLL ++ V LR V
Sbjct: 246 HQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVG--- 302
Query: 489 VNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEAD 668
N+ D S +L + L+ + I + VW +S +T G Q+Q V +A
Sbjct: 303 -NIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQDVFDAG 361
Query: 669 IVRFLVPLLSHNDVKVQTAALRAVGNI-VTGTDEQTQYVLNYDALSHFPQLLQHSKEKI 842
I+ ++ LL D Q A A+ N+ ++G Q + ++ L F +L + +I
Sbjct: 362 IMPMIIHLLDRGDFPTQKEAAWAISNVTISGRPNQVEQMVKLGVLRPFCAMLSCTDSQI 420
Score = 38.1 bits (87), Expect = 0.036
Identities = 16/33 (48%), Positives = 24/33 (72%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ ++ K+ F+SNITAGNQ+QVQ V D ++P
Sbjct: 332 KEKINKEAVWFVSNITAGNQQQVQDVFDAGIMP 364
>sp|P52170|IMA1_XENLA Importin alpha-1 subunit (Karyopherin alpha-1 subunit)
Length = 522
Score = 291 bits (744), Expect = 2e-78
Identities = 140/277 (50%), Positives = 192/277 (69%)
Frame = +3
Query: 30 NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
+L EIV + +P L QAARK+LS ++NPP++ +I++G++P LVE L + +
Sbjct: 74 SLEEIVQGMNSGDPENELRCTQAARKMLSRERNPPLNDIIEAGLIPKLVEFLSRHDNSTL 133
Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
QFEAAWALTNIASGTS+QT +VV GA+P F+ L+ S H ++ EQAVWALGNI GDGP
Sbjct: 134 QFEAAWALTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY 193
Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
RD IN V+ PLL +N P+ +LRN+TW++ NLCRNK+P P + + ++LP L L+
Sbjct: 194 RDALINCNVIPPLLALVNPQTPLGYLRNITWMLSNLCRNKNPYPPMSAVLQILPVLTQLM 253
Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
+ D +IL DT WA+SYLTDG ND+I +V++ IV L+ L+ ++ + T +LR VGNI
Sbjct: 254 HHDDKDILSDTCWAMSYLTDGSNDRIDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNI 313
Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
VTGTD+QTQ ++ LS PQLL+H K I KEA W
Sbjct: 314 VTGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAW 350
Score = 56.2 bits (134), Expect = 1e-07
Identities = 38/147 (25%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Frame = +3
Query: 6 IDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLS-SDKNPPIDSLIQSGIMPILVEC 182
ID ++ + ++ +P +I +++ +++ +DK + I +G++ +L +
Sbjct: 279 IDVVVKTGIVDRLIQLMYSPELSIVTPSLRTVGNIVTGTDKQT--QAAIDAGVLSVLPQL 336
Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
L + P+IQ EAAWA++NIA+G + Q ++ G + + LL ++AVWA+
Sbjct: 337 LRHQK-PSIQKEAAWAISNIAAGPAPQIQQMITCGLLSPLVDLLNKGDFKAQKEAVWAVT 395
Query: 363 NIIGDGPTLR-DYAINLGVVAPLLKFL 440
N G + + GV+ PLL L
Sbjct: 396 NYTSGGTVEQVVQLVQCGVLEPLLNLL 422
>sp|P52171|IMA2_XENLA Importin alpha-2 subunit (Karyopherin alpha-2 subunit)
Length = 523
Score = 285 bits (729), Expect = 1e-76
Identities = 137/277 (49%), Positives = 192/277 (69%)
Frame = +3
Query: 30 NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
+L EIV + + L + QAARK+LS ++NPP++ +I++G++P LVE L ++ +
Sbjct: 74 SLEEIVQGMNSGDNENELRSTQAARKMLSKERNPPLNDIIEAGLIPKLVEFLSYHNNSTL 133
Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
QFEAAWALTNIASGTS+QT +VV GA+P F+ L+ S H ++ EQAVWALGNI GDGP
Sbjct: 134 QFEAAWALTNIASGTSDQTKSVVDGGAIPAFISLISSPHLHISEQAVWALGNIAGDGPLY 193
Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
RD I+ V+ PLL +N P+ +LRN+TW + NLCRNK+P P + + ++LP L L+
Sbjct: 194 RDALISCNVIPPLLTLVNPQTPLGYLRNITWTLSNLCRNKNPYPPMSAVLQILPVLTQLM 253
Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
+ D +IL DT WA+SYLTDG ND+I +V++ +V L+ L+ ++ + T +LR VGNI
Sbjct: 254 LHEDKDILSDTCWAMSYLTDGSNDRIDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNI 313
Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
VTGTD+QTQ ++ LS PQLL+H K I KEA W
Sbjct: 314 VTGTDKQTQAAIDAGVLSVLPQLLRHQKPSIQKEAAW 350
Score = 56.6 bits (135), Expect = 1e-07
Identities = 39/147 (26%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Frame = +3
Query: 6 IDEPIQMSNLSEIVTNSTNPNPTIRLEAIQAARKLLS-SDKNPPIDSLIQSGIMPILVEC 182
ID ++ + ++ +P +I +++ +++ +DK + I +G++ +L +
Sbjct: 279 IDVVVKTGLVERLIQLMYSPELSILTPSLRTVGNIVTGTDKQT--QAAIDAGVLSVLPQL 336
Query: 183 LDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALG 362
L + P+IQ EAAWAL+NIA+G + Q ++ G + + LL ++AVWA+
Sbjct: 337 LRHQK-PSIQKEAAWALSNIAAGPAPQIQQMITCGLLSPLVDLLKKGDFKAQKEAVWAVT 395
Query: 363 NIIGDGPTLR-DYAINLGVVAPLLKFL 440
N G + + GV+ PLL L
Sbjct: 396 NYTSGGTVEQVVQLVQCGVLEPLLNLL 422
>sp|P52292|IMA2_HUMAN Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha)
(RAG cohort protein 1)
Length = 529
Score = 278 bits (710), Expect = 2e-74
Identities = 143/281 (50%), Positives = 189/281 (67%), Gaps = 4/281 (1%)
Frame = +3
Query: 30 NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
++ +IV + N +L+A QAARKLLS +K PPID++I++G++P V L I
Sbjct: 77 SVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPI 136
Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
QFE+AWALTNIASGTSEQT AVV GA+P F+ LL S H+++ EQAVWALGNI GDG
Sbjct: 137 QFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVF 196
Query: 390 RDYAINLGVVAPLLKFL----NTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPAL 557
RD I G V PLL L + + +LRN+TW + NLCRNK+P P + ++LP L
Sbjct: 197 RDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTL 256
Query: 558 RFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRA 737
L+ + D +L DT WA+SYLTDG N++I MV++ +V LV LL +++ + T ALRA
Sbjct: 257 VRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRA 316
Query: 738 VGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
+GNIVTGTDEQTQ V++ AL+ FP LL + K I KEA W
Sbjct: 317 IGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATW 357
Score = 59.3 bits (142), Expect = 1e-08
Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Frame = +3
Query: 144 LIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSA 323
+I +G + + L N NIQ EA W ++NI +G +Q VV G VP + +L A
Sbjct: 331 VIDAGALAVFPSLLTNPK-TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKA 389
Query: 324 HSNVCEQAVWALGNIIGDGPTLR-DYAINLGVVAPLLKFL 440
++AVWA+ N G + Y ++ G++ PL+ L
Sbjct: 390 DFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLL 429
Score = 33.5 bits (75), Expect = 0.88
Identities = 13/33 (39%), Positives = 23/33 (69%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ + K+ +SNITAG Q+Q+Q V+++ L+P
Sbjct: 348 KTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
>sp|P52293|IMA2_MOUSE Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha)
(RAG cohort protein 1) (Pendulin) (Pore targeting
complex 58 kDa subunit) (PTAC58) (Importin alpha P1)
Length = 529
Score = 275 bits (702), Expect = 2e-73
Identities = 141/281 (50%), Positives = 189/281 (67%), Gaps = 4/281 (1%)
Frame = +3
Query: 30 NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
++ +IV + N +L+A QAARKLLS +K PPID++I++G++P V L I
Sbjct: 77 SVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPI 136
Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
QFE+AWALTNIASGTSEQT AVV GA+P F+ LL S H+++ EQAVWALGNI GDG
Sbjct: 137 QFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAF 196
Query: 390 RDYAINLGVVAPLLKFLN----TDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPAL 557
RD I G + PLL L + + +LRN+TW + NLCRNK+P P + ++LP L
Sbjct: 197 RDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTL 256
Query: 558 RFLIQNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRA 737
L+ + D +L D+ WA+SYLTDG N++I+MV++ +V LV LL ++ + T ALRA
Sbjct: 257 VRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRA 316
Query: 738 VGNIVTGTDEQTQYVLNYDALSHFPQLLQHSKEKINKEAVW 860
+GNIVTGTDEQTQ V++ AL+ FP LL + K I KEA W
Sbjct: 317 IGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATW 357
Score = 57.8 bits (138), Expect = 4e-08
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 1/101 (0%)
Frame = +3
Query: 144 LIQSGIMPILVECLDNDSHPNIQFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSA 323
+I +G + + L N NIQ EA W ++NI +G +Q VV G VP + +L A
Sbjct: 331 VIDAGALAVFPSLLTNPK-TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKA 389
Query: 324 HSNVCEQAVWALGNIIGDGPTLR-DYAINLGVVAPLLKFLN 443
++A WA+ N G + Y ++ G++ PL+ L+
Sbjct: 390 DFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLS 430
Score = 33.5 bits (75), Expect = 0.88
Identities = 13/33 (39%), Positives = 23/33 (69%)
Frame = +1
Query: 832 RRRLTKKQFGFLSNITAGNQEQVQAVIDYALIP 930
+ + K+ +SNITAG Q+Q+Q V+++ L+P
Sbjct: 348 KTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
>sp|O04294|IMA2_ARATH Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (KAP alpha)
Length = 531
Score = 267 bits (683), Expect = 3e-71
Identities = 137/278 (49%), Positives = 183/278 (65%), Gaps = 1/278 (0%)
Frame = +3
Query: 30 NLSEIVTNSTNPNPTIRLEAIQAARKLLSSDKNPPIDSLIQSGIMPILVECLDNDSHPNI 209
NL +V + + +LEA RKLLS ++NPPI+ ++QSG++P +V+ L D P +
Sbjct: 76 NLPAMVAGIWSEDSNSQLEATNLLRKLLSIEQNPPINEVVQSGVVPRVVKFLSRDDFPKL 135
Query: 210 QFEAAWALTNIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTL 389
QFEAAWALTNIASGTSE TN ++++GAVP+F++LL SA +V EQAVWALGN+ GD P
Sbjct: 136 QFEAAWALTNIASGTSENTNVIIESGAVPIFIQLLSSASEDVREQAVWALGNVAGDSPKC 195
Query: 390 RDYAINLGVVAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLI 569
RD ++ G + PLL N + ++ LRN TW + N CR K PPP+ LP L L+
Sbjct: 196 RDLVLSYGAMTPLLSQFNENTKLSMLRNATWTLSNFCRGK-PPPAFEQTQPALPVLERLV 254
Query: 570 QNVDTNILVDTVWALSYLTDGGNDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNI 749
Q++D +L D WALSYL+D ND+IQ VIEA +V L+ LL H+ V ALR +GNI
Sbjct: 255 QSMDEEVLTDACWALSYLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNI 314
Query: 750 VTGTDEQTQYVLNYDALSHFPQLLQHS-KEKINKEAVW 860
VTG D QTQ VL+ AL LL+++ K+ I KEA W
Sbjct: 315 VTGDDLQTQMVLDQQALPCLLNLLKNNYKKSIKKEACW 352
Score = 85.9 bits (211), Expect = 1e-16
Identities = 68/280 (24%), Positives = 124/280 (44%), Gaps = 16/280 (5%)
Frame = +3
Query: 66 NPTIRLEAIQAARKLLSS---DKNPPIDSLIQSGIMPILVECLDNDSHPNIQFEAAWALT 236
N +L ++ A LS+ K PP Q + P+L E L + +A WAL+
Sbjct: 213 NENTKLSMLRNATWTLSNFCRGKPPPAFEQTQPAL-PVL-ERLVQSMDEEVLTDACWALS 270
Query: 237 NIASGTSEQTNAVVQAGAVPLFLKLLGSAHSNVCEQAVWALGNIIGDGPTLRDYAINLGV 416
++ ++++ AV++AG VP ++LLG + +V A+ +GNI+ ++
Sbjct: 271 YLSDNSNDKIQAVIEAGVVPRLIQLLGHSSPSVLIPALRTIGNIVTGDDLQTQMVLDQQA 330
Query: 417 VAPLLKFLNTDVPITFLRNVTWVIVNLCRNKDPPPSPTTISELLPALRFLIQNVDTNILV 596
+ LL L + + + W I N+ + ++ +L +++Q+ + +
Sbjct: 331 LPCLLNLLKNNYKKSIKKEACWTISNITAGNADQIQAVIDAGIIQSLVWVLQSAEFEVKK 390
Query: 597 DTVWALSYLTDGG-NDQIQMVIEADIVRFLVPLLSHNDVKVQTAALRAVGNIV------- 752
+ W +S T GG +DQI+ ++ ++ L LL+ D+KV T L A+ NI+
Sbjct: 391 EAAWGISNATSGGTHDQIKFMVSQGCIKPLCDLLTCPDLKVVTVCLEALENILVVGEAEK 450
Query: 753 ----TGTDE-QTQYVLNYDALSHFPQLLQHSKEKINKEAV 857
TG D Q + + L L H I +AV
Sbjct: 451 NLGHTGEDNLYAQMIDEAEGLEKIENLQSHDNNDIYDKAV 490
Score = 36.6 bits (83), Expect = 0.10
Identities = 19/43 (44%), Positives = 29/43 (67%)
Frame = +1
Query: 799 CLISLSYYNIQRRRLTKKQFGFLSNITAGNQEQVQAVIDYALI 927
CL++L N ++ + K+ +SNITAGN +Q+QAVID +I
Sbjct: 333 CLLNLLKNNY-KKSIKKEACWTISNITAGNADQIQAVIDAGII 374
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,447,240
Number of Sequences: 369166
Number of extensions: 2270267
Number of successful extensions: 5782
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5258
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5560
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9558791870
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)