Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01321 (758 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruv... 349 5e-96 sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme 348 9e-96 sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytos... 347 2e-95 sp|P52480|KPYM_MOUSE Pyruvate kinase, isozyme M2 347 3e-95 sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruv... 344 1e-94 sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate ... 344 2e-94 sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvat... 343 3e-94 sp|O62619|KPYK_DROME Pyruvate kinase (PK) 317 3e-86 sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/... 304 2e-82 sp|P12928|KPYR_RAT Pyruvate kinase, isozymes R/L (L-PK) 291 2e-78
>sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme) Length = 531 Score = 349 bits (895), Expect = 5e-96 Identities = 177/254 (69%), Positives = 205/254 (80%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS P R++ IICTIGPA R+V TLK+MI SGMN+ARMNFSHG+H Sbjct: 22 MADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTH 81 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAETIK VR A E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 82 EYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLK 141 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D Y E C+E ILW+DYKNI K+++ G ++YVDDGLISL V++KGPDFL EVENGG Sbjct: 142 ITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVKQKGPDFLVTEVENGG 201 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR A V E+R ILGEK Sbjct: 202 FLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKILGEK 261 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 262 GKNIKIISKIENHE 275
>sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme Length = 530 Score = 348 bits (893), Expect = 9e-96 Identities = 172/254 (67%), Positives = 206/254 (81%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDSEP + R++ IICTIGPA R+V+ LK+MI SGMN+AR+NFSHG+H Sbjct: 21 MADTFLEHMCRLDIDSEPTIARNTGIICTIGPASRSVDKLKEMIKSGMNVARLNFSHGTH 80 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYH TIK VREA E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 81 EYHEGTIKNVREATESFASDPITYRPVAIALDTKGPEIRTGLIKGSGTAEVELKKGAALK 140 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D + E C+E +LWVDYKN++K+++ G +IYVDDGLISL+V+EKG DF+ EVENGG Sbjct: 141 VTLDNAFMENCDENVLWVDYKNLIKVIDVGSKIYVDDGLISLLVKEKGKDFVMTEVENGG 200 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR A V +R +LGEK Sbjct: 201 MLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQNVDMVFASFIRKAADVHAVRKVLGEK 260 Query: 716 GKHILIISKIENHE 757 GKHI IISKIENHE Sbjct: 261 GKHIKIISKIENHE 274
>sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytosolic thyroid hormone binding protein) (CTHBP) Length = 527 Score = 347 bits (890), Expect = 2e-95 Identities = 173/254 (68%), Positives = 205/254 (80%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDSEP V R++ IICTIGPA R+V LK+MI SGMNIAR+NFSHG+H Sbjct: 18 MADTFLEHMCRLDIDSEPIVARNTGIICTIGPASRSVEMLKEMIKSGMNIARLNFSHGTH 77 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHA TIK VREA E+ +YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG ++ Sbjct: 78 EYHAGTIKNVREATESLASNPIHYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATMR 137 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D+ + E C+E +LWVDYKN+ K++ PG +IYVDDGLISL+V+E GPDF E+ENGG Sbjct: 138 ITLDDAFQENCDENVLWVDYKNLTKVVKPGSKIYVDDGLISLLVKEIGPDFCVTEIENGG 197 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS KDI DL FGVEQ VDMVFASFIR A V E+R +LGEK Sbjct: 198 MLGSKKGVNLPGAAVDLPAVSSKDIQDLQFGVEQDVDMVFASFIRKAADVHEVREVLGEK 257 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 258 GKNIKIISKIENHE 271
>sp|P52480|KPYM_MOUSE Pyruvate kinase, isozyme M2 Length = 531 Score = 347 bits (889), Expect = 3e-95 Identities = 176/254 (69%), Positives = 203/254 (79%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS P R++ IICTIGPA R+V LK+MI SGMN+AR+NFSHG+H Sbjct: 22 MADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTH 81 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAETIK VREA E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 82 EYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLK 141 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D Y E C+E ILW+DYKNI K++ G +IYVDDGLISL V+EKG DFL EVENGG Sbjct: 142 ITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEVENGG 201 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR A V E+R +LGEK Sbjct: 202 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK 261 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 262 GKNIKIISKIENHE 275
>sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme) (Cytosolic thyroid hormone-binding protein) (CTHBP) (THBP1) Length = 531 Score = 344 bits (883), Expect = 1e-94 Identities = 174/254 (68%), Positives = 203/254 (79%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS P R++ IICTIGPA R+V TLK+MI SGMN+AR+NFSHG+H Sbjct: 22 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTH 81 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAETIK VR A E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 82 EYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLK 141 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D Y E C+E ILW+DYKNI K++ G +IYVDDGLISL V++KG DFL EVENGG Sbjct: 142 ITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGG 201 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR + V E+R +LGEK Sbjct: 202 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK 261 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 262 GKNIKIISKIENHE 275
>sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate kinase muscle isozyme) Length = 531 Score = 344 bits (882), Expect = 2e-94 Identities = 172/254 (67%), Positives = 203/254 (79%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS P R++ IICTIGPA R+V LK+MI SGMN+AR+NFSHG+H Sbjct: 22 MADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTH 81 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAETIK VR A E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 82 EYHAETIKNVRAATESFASDPIRYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLK 141 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D Y E C+E +LW+DYKNI K++ G ++YVDDGLISL+V+EKG DFL EVENGG Sbjct: 142 ITLDNAYMEKCDENVLWLDYKNICKVVEVGSKVYVDDGLISLLVKEKGADFLVTEVENGG 201 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR + V E+R +LGEK Sbjct: 202 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK 261 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 262 GKNIKIISKIENHE 275
>sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme) Length = 531 Score = 343 bits (880), Expect = 3e-94 Identities = 174/254 (68%), Positives = 202/254 (79%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS P R++ IICTIGPA R+V LK+MI SGMN+AR+NFSHG+H Sbjct: 22 MADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTH 81 Query: 185 EYHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAETIK VR A E+F YRPVA+ALDTKGPEIRTGLI GS TAE+ L KG +K Sbjct: 82 EYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLK 141 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D Y E C+E ILW+DYKNI K++ G +IYVDDGLISL V+EKG D+L EVENGG Sbjct: 142 ITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGG 201 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGSKKGVNLPGA VDLPAVS+KDI DL FGVEQ VDMVFASFIR A V E+R +LGEK Sbjct: 202 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEK 261 Query: 716 GKHILIISKIENHE 757 GK+I IISKIENHE Sbjct: 262 GKNIKIISKIENHE 275
>sp|O62619|KPYK_DROME Pyruvate kinase (PK) Length = 533 Score = 317 bits (811), Expect = 3e-86 Identities = 163/253 (64%), Positives = 198/253 (78%), Gaps = 3/253 (1%) Frame = +2 Query: 8 ARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSHE 187 A + LE++C L DS VR S I+CTIGPA +V L+KM+A+GMNIARMNFSHGSHE Sbjct: 26 ADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHE 85 Query: 188 YHAETIKLVREAVETFTP---YYRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIKM 358 YHA T+ VR+AV+ ++ Y PVA+ALDTKGPEIRTGLI GS TAEI L KG KIK+ Sbjct: 86 YHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKL 145 Query: 359 VIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGGK 538 ++++ E + EI++VDY+NIV ++ PG R++VDDGLISLIV+E G D L CEVENGG Sbjct: 146 TTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGS 205 Query: 539 LGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEKG 718 LGS+KGVNLPG VDLPAVS+KD SDL FGVEQ VDM+FASFIR AA+ EIR +LGEKG Sbjct: 206 LGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG 265 Query: 719 KHILIISKIENHE 757 K+I IISKIEN + Sbjct: 266 KNIKIISKIENQQ 278
>sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) Length = 574 Score = 304 bits (778), Expect = 2e-82 Identities = 152/254 (59%), Positives = 196/254 (77%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDSEP RS+SII TIGPA R+V LK+MI +GMNIAR+NFSHGSH Sbjct: 65 MADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSH 124 Query: 185 EYHAETIKLVREAVETFTPY---YRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAE+I VREAVE+F YRPVA+ALDTKGPEIRTG++ G +E+ L+KG+++ Sbjct: 125 EYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVL 184 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D + N +WVDY NIV+++ G RIY+DDGLISL+VQ+ GP+ L +VENGG Sbjct: 185 VTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGG 244 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGS+KGVNLPGA+VDLP +S++D+ DL FGVE GVD+VFASF+R + V +R+ LG + Sbjct: 245 VLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPE 304 Query: 716 GKHILIISKIENHE 757 G I IISKIENHE Sbjct: 305 GHGIKIISKIENHE 318
>sp|P12928|KPYR_RAT Pyruvate kinase, isozymes R/L (L-PK) Length = 574 Score = 291 bits (744), Expect = 2e-78 Identities = 142/254 (55%), Positives = 195/254 (76%), Gaps = 3/254 (1%) Frame = +2 Query: 5 IARSHLEYICNLDIDSEPDVVRSSSIICTIGPACRNVNTLKKMIASGMNIARMNFSHGSH 184 +A + LE++C LDIDS+P RS+SII TIGPA R+V+ LK+MI +GMNIAR+NFSHGSH Sbjct: 65 MADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSH 124 Query: 185 EYHAETIKLVREAVETFTPY---YRPVALALDTKGPEIRTGLINGSATAEISLIKGNKIK 355 EYHAE+I +REA E+F YRPVA+ALDTKGPEIRTG++ G +E+ ++KG+++ Sbjct: 125 EYHAESIANIREATESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVL 184 Query: 356 MVIDEKYAEACNEEILWVDYKNIVKILNPGCRIYVDDGLISLIVQEKGPDFLDCEVENGG 535 + +D K+ + + +WVDY NI +++ G RIY+DDGLISL+VQ+ GP+ L EVE+GG Sbjct: 185 VTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGG 244 Query: 536 KLGSKKGVNLPGAKVDLPAVSDKDISDLHFGVEQGVDMVFASFIRCGAAVDEIRSILGEK 715 LGS+KGVNLP +VDLP +S++D+ DL FGV+ VD++FASF+R + V +R LG + Sbjct: 245 ILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPE 304 Query: 716 GKHILIISKIENHE 757 G++I IISKIENHE Sbjct: 305 GQNIKIISKIENHE 318
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 82,711,858 Number of Sequences: 369166 Number of extensions: 1623620 Number of successful extensions: 5325 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4939 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5154 length of database: 68,354,980 effective HSP length: 108 effective length of database: 48,403,600 effective search space used: 6970118400 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)