Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01017 (358 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 53 2e-07 sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 53 2e-07 sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 52 3e-07 sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 50 2e-06 sp|P81015|GRN3_CYPCA Granulin-3 49 5e-06 sp|P81014|GRN2_CYPCA Granulin-2 46 2e-05 sp|P81013|GRN1_CYPCA Granulin-1 45 7e-05 sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 43 3e-04 sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 42 4e-04 sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 42 6e-04
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Granulin 1; Granulin 2; Granulin 3; Granulin 4; Granulin 5; Granulin 6; Granulin 7] Length = 589 Score = 53.1 bits (126), Expect = 2e-07 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 4/52 (7%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 C ++CH + TCC CCP CC DG CC G++C A G C Sbjct: 517 CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKC 568
Score = 50.4 bits (119), Expect = 1e-06 Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 4/54 (7%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWC 268 D C C +++TCC CCP A CCSD + CC G+ C A G+C Sbjct: 361 DTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQGYC 414
Score = 42.7 bits (99), Expect = 3e-04 Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250 CPG+ + C S TCC CCP A+CC D CC +G C Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 41.6 bits (96), Expect = 6e-04 Identities = 18/48 (37%), Positives = 20/48 (41%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGKCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 CP Y C T CCP C DG CC G++C A G C Sbjct: 67 CPAGYSCLL--TVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSC 112
Score = 39.3 bits (90), Expect = 0.003 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250 D C + C TCC K CC +A CC D + CC GY C Sbjct: 439 DIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 486
Score = 38.5 bits (88), Expect = 0.005 Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQL 292 C C +TCC CCP A CC D CC G+ C C + + Q+ Sbjct: 282 CDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTCEMGILQV 340
Score = 37.7 bits (86), Expect = 0.008 Identities = 20/46 (43%), Positives = 20/46 (43%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CP-GNYYCHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250 CP C TCC GK CCP NA CCSD CC C Sbjct: 207 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 34.7 bits (78), Expect = 0.069 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%) Frame = +2 Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277 HT C G+ CCP+ + CC CC + +CC G+ C + Sbjct: 445 HTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNV 488
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Length = 593 Score = 53.1 bits (126), Expect = 2e-07 Identities = 26/53 (49%), Positives = 28/53 (52%), Gaps = 4/53 (7%) Frame = +2 Query: 128 CPGNYYCHSSHTCC--TPGK--CCPAQNANCCSDGEFCCRNGYYCCAYGWCCR 274 C C SS TCC T G+ CCP A CCSD + CC GY C A G C R Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQR 418
Score = 51.6 bits (122), Expect = 5e-07 Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 4/55 (7%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 D C ++CH + TCC + CCP + CC+D CC G+ C A G C Sbjct: 518 DVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
Score = 44.7 bits (104), Expect = 7e-05 Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 4/52 (7%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 C + +C + H+C CCP A C DG CC G++C A G C Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSC 112
Score = 40.4 bits (93), Expect = 0.001 Identities = 17/46 (36%), Positives = 22/46 (47%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250 CP + + C TCC CCP A+CC D CC +G +C Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 38.5 bits (88), Expect = 0.005 Identities = 18/39 (46%), Positives = 18/39 (46%), Gaps = 4/39 (10%) Frame = +2 Query: 146 CHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250 C TCC GK CCP NA CCSD CC C Sbjct: 215 CPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 38.5 bits (88), Expect = 0.005 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 4/67 (5%) Frame = +2 Query: 62 KVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFC 229 K A+ ++LTK + D C C +TCC CCP A CC D C Sbjct: 263 KENATTDLLTKLP-AHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC 321 Query: 230 CRNGYYC 250 C G+ C Sbjct: 322 CPAGFTC 328
Score = 37.7 bits (86), Expect = 0.008 Identities = 17/48 (35%), Positives = 20/48 (41%), Gaps = 4/48 (8%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYC 250 D C + C TCC CC +A CC D + CC GY C Sbjct: 441 DIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTC 488
Score = 34.7 bits (78), Expect = 0.069 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%) Frame = +2 Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277 HT C G+ CCP+ + CC CC + +CC G+ C + Sbjct: 447 HTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNV 490
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B) (Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Length = 588 Score = 52.4 bits (124), Expect = 3e-07 Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%) Frame = +2 Query: 98 SFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGW 265 +F S + C ++CH + +CC + CCP CC DG CC G++C A G Sbjct: 506 TFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGT 565 Query: 266 CC 271 C Sbjct: 566 KC 567
Score = 45.8 bits (107), Expect = 3e-05 Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 4/73 (5%) Frame = +2 Query: 62 KVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFC 229 KV AS ++ K+ D C C S++TCC CCP A CC D + C Sbjct: 344 KVTASLSLPDPQILKN---DVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHC 400 Query: 230 CRNGYYCCAYGWC 268 C G+ C G+C Sbjct: 401 CPQGFKCMDEGYC 413
Score = 44.3 bits (103), Expect = 9e-05 Identities = 21/57 (36%), Positives = 24/57 (42%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGKCCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQLLG 298 CP Y C T CCP C DG+ CC G++C A G C LLG Sbjct: 67 CPDGYSCLL--TVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLLG 121
Score = 42.7 bits (99), Expect = 3e-04 Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250 CPG+ + C S TCC CCP A+CC D CC +G C Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 39.3 bits (90), Expect = 0.003 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250 D C + C TCC K CC +A CC D + CC GY C Sbjct: 438 DIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 485
Score = 38.1 bits (87), Expect = 0.006 Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQL 292 C C +TCC CCP A CC D CC G+ C C + + Q+ Sbjct: 281 CDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTCELGVLQV 339
Score = 37.7 bits (86), Expect = 0.008 Identities = 20/46 (43%), Positives = 20/46 (43%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CP-GNYYCHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250 CP C TCC GK CCP NA CCSD CC C Sbjct: 206 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 34.7 bits (78), Expect = 0.069 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%) Frame = +2 Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277 HT C G+ CCP+ + CC CC + +CC G+ C + Sbjct: 444 HTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNV 487
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7] Length = 591 Score = 50.1 bits (118), Expect = 2e-06 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 D C ++CH TCC + CCP CC D CC G++C + G C Sbjct: 515 DVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRC 569
Score = 42.0 bits (97), Expect = 4e-04 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250 CPG + C S TCC CCP A+CC D CC +G C Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 41.2 bits (95), Expect = 7e-04 Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%) Frame = +2 Query: 107 SSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 S + + C C H+C CCP A C DG CC G++C G C Sbjct: 40 SGYLGRPCQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTC 98
Score = 40.8 bits (94), Expect = 0.001 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYC 250 D C + C TCC CC +A CC DG+ CC GY C Sbjct: 438 DVGCDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 38.9 bits (89), Expect = 0.004 Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Frame = +2 Query: 47 RTKVVKVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCT--PGK--CCPAQNANCCS 214 +++ + +K +LTK + +D C C TCC GK CCP A CC Sbjct: 257 QSRCLSQNKAKTLLTKLP-SWTVWDVECDQEVSCPEGQTCCRLQSGKWGCCPFPKAVCCE 315 Query: 215 DGEFCCRNGYYC 250 D CC + C Sbjct: 316 DHVHCCPERFRC 327
Score = 36.6 bits (83), Expect = 0.018 Identities = 18/46 (39%), Positives = 19/46 (41%), Gaps = 5/46 (10%) Frame = +2 Query: 128 CPGNY-YCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250 CP + C TCC CCP NA CCSD CC C Sbjct: 208 CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
>sp|P81015|GRN3_CYPCA Granulin-3 Length = 57 Score = 48.5 bits (114), Expect = 5e-06 Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 4/53 (7%) Frame = +2 Query: 125 WCPGNYYCHSSHTCCTPG----KCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 +C C S TCC CCP CC DG CCR+GY+C + C Sbjct: 3 FCDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLC 55
>sp|P81014|GRN2_CYPCA Granulin-2 Length = 57 Score = 46.2 bits (108), Expect = 2e-05 Identities = 20/53 (37%), Positives = 23/53 (43%), Gaps = 4/53 (7%) Frame = +2 Query: 125 WCPGNYYCHSSHTCCTPG----KCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271 +C C S TCC CCP CC DG CCR+GY C + C Sbjct: 3 YCNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLC 55
>sp|P81013|GRN1_CYPCA Granulin-1 Length = 57 Score = 44.7 bits (104), Expect = 7e-05 Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 4/45 (8%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250 C C TCC CCP CC DG CCR+GY+C Sbjct: 4 CDAATICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 Length = 46 Score = 42.7 bits (99), Expect = 3e-04 Identities = 16/46 (34%), Positives = 21/46 (45%), Gaps = 4/46 (8%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGY 244 D C ++CH TCC + CCP CC+D CC G+ Sbjct: 1 DVQCGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21) Length = 462 Score = 42.0 bits (97), Expect = 4e-04 Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 9/51 (17%) Frame = +2 Query: 128 CPGNYYCHSSHTCCTP---GK------CCPAQNANCCSDGEFCCRNGYYCC 253 C Y C S+TCC GK CCP + A CC D CC + Y C Sbjct: 375 CDSYYTCPESNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVC 425
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor Length = 471 Score = 41.6 bits (96), Expect = 6e-04 Identities = 18/54 (33%), Positives = 21/54 (38%), Gaps = 9/54 (16%) Frame = +2 Query: 119 DQWCPGNYYCHSSHTCCTP---------GKCCPAQNANCCSDGEFCCRNGYYCC 253 D C N+ C + TCC CCP + A CC D CC Y C Sbjct: 382 DHVCDDNFSCPAGSTCCCAFGFRNLCLVWGCCPVEGATCCKDHASCCPPDYPVC 435
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,912,189 Number of Sequences: 369166 Number of extensions: 656321 Number of successful extensions: 3513 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 2855 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3334 length of database: 68,354,980 effective HSP length: 86 effective length of database: 52,467,770 effective search space used: 1678968640 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)