Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_K06
(358 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 53 2e-07
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 53 2e-07
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 52 3e-07
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 50 2e-06
sp|P81015|GRN3_CYPCA Granulin-3 49 5e-06
sp|P81014|GRN2_CYPCA Granulin-2 46 2e-05
sp|P81013|GRN1_CYPCA Granulin-1 45 7e-05
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 43 3e-04
sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 42 4e-04
sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 42 6e-04
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 53.1 bits (126), Expect = 2e-07
Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 4/52 (7%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
C ++CH + TCC CCP CC DG CC G++C A G C
Sbjct: 517 CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKC 568
Score = 50.4 bits (119), Expect = 1e-06
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWC 268
D C C +++TCC CCP A CCSD + CC G+ C A G+C
Sbjct: 361 DTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQGYC 414
Score = 42.7 bits (99), Expect = 3e-04
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250
CPG+ + C S TCC CCP A+CC D CC +G C
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 41.6 bits (96), Expect = 6e-04
Identities = 18/48 (37%), Positives = 20/48 (41%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGKCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
CP Y C T CCP C DG CC G++C A G C
Sbjct: 67 CPAGYSCLL--TVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSC 112
Score = 39.3 bits (90), Expect = 0.003
Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250
D C + C TCC K CC +A CC D + CC GY C
Sbjct: 439 DIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 486
Score = 38.5 bits (88), Expect = 0.005
Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQL 292
C C +TCC CCP A CC D CC G+ C C + + Q+
Sbjct: 282 CDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTCEMGILQV 340
Score = 37.7 bits (86), Expect = 0.008
Identities = 20/46 (43%), Positives = 20/46 (43%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CP-GNYYCHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250
CP C TCC GK CCP NA CCSD CC C
Sbjct: 207 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 34.7 bits (78), Expect = 0.069
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%)
Frame = +2
Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277
HT C G+ CCP+ + CC CC + +CC G+ C +
Sbjct: 445 HTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNV 488
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 53.1 bits (126), Expect = 2e-07
Identities = 26/53 (49%), Positives = 28/53 (52%), Gaps = 4/53 (7%)
Frame = +2
Query: 128 CPGNYYCHSSHTCC--TPGK--CCPAQNANCCSDGEFCCRNGYYCCAYGWCCR 274
C C SS TCC T G+ CCP A CCSD + CC GY C A G C R
Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQR 418
Score = 51.6 bits (122), Expect = 5e-07
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 4/55 (7%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
D C ++CH + TCC + CCP + CC+D CC G+ C A G C
Sbjct: 518 DVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
Score = 44.7 bits (104), Expect = 7e-05
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 4/52 (7%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
C + +C + H+C CCP A C DG CC G++C A G C
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSC 112
Score = 40.4 bits (93), Expect = 0.001
Identities = 17/46 (36%), Positives = 22/46 (47%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250
CP + + C TCC CCP A+CC D CC +G +C
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 38.5 bits (88), Expect = 0.005
Identities = 18/39 (46%), Positives = 18/39 (46%), Gaps = 4/39 (10%)
Frame = +2
Query: 146 CHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250
C TCC GK CCP NA CCSD CC C
Sbjct: 215 CPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 38.5 bits (88), Expect = 0.005
Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 4/67 (5%)
Frame = +2
Query: 62 KVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFC 229
K A+ ++LTK + D C C +TCC CCP A CC D C
Sbjct: 263 KENATTDLLTKLP-AHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC 321
Query: 230 CRNGYYC 250
C G+ C
Sbjct: 322 CPAGFTC 328
Score = 37.7 bits (86), Expect = 0.008
Identities = 17/48 (35%), Positives = 20/48 (41%), Gaps = 4/48 (8%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYC 250
D C + C TCC CC +A CC D + CC GY C
Sbjct: 441 DIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTC 488
Score = 34.7 bits (78), Expect = 0.069
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%)
Frame = +2
Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277
HT C G+ CCP+ + CC CC + +CC G+ C +
Sbjct: 447 HTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNV 490
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 52.4 bits (124), Expect = 3e-07
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Frame = +2
Query: 98 SFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGW 265
+F S + C ++CH + +CC + CCP CC DG CC G++C A G
Sbjct: 506 TFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGT 565
Query: 266 CC 271
C
Sbjct: 566 KC 567
Score = 45.8 bits (107), Expect = 3e-05
Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Frame = +2
Query: 62 KVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFC 229
KV AS ++ K+ D C C S++TCC CCP A CC D + C
Sbjct: 344 KVTASLSLPDPQILKN---DVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHC 400
Query: 230 CRNGYYCCAYGWC 268
C G+ C G+C
Sbjct: 401 CPQGFKCMDEGYC 413
Score = 44.3 bits (103), Expect = 9e-05
Identities = 21/57 (36%), Positives = 24/57 (42%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGKCCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQLLG 298
CP Y C T CCP C DG+ CC G++C A G C LLG
Sbjct: 67 CPDGYSCLL--TVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLLG 121
Score = 42.7 bits (99), Expect = 3e-04
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250
CPG+ + C S TCC CCP A+CC D CC +G C
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 39.3 bits (90), Expect = 0.003
Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250
D C + C TCC K CC +A CC D + CC GY C
Sbjct: 438 DIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 485
Score = 38.1 bits (87), Expect = 0.006
Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCCRI*LSQL 292
C C +TCC CCP A CC D CC G+ C C + + Q+
Sbjct: 281 CDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTCELGVLQV 339
Score = 37.7 bits (86), Expect = 0.008
Identities = 20/46 (43%), Positives = 20/46 (43%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CP-GNYYCHSSHTCCT--PGK--CCPAQNANCCSDGEFCCRNGYYC 250
CP C TCC GK CCP NA CCSD CC C
Sbjct: 206 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 34.7 bits (78), Expect = 0.069
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 4/44 (9%)
Frame = +2
Query: 158 HTCCTPGK-CCPAQNAN--CCS-DGEFCCRNGYYCCAYGWCCRI 277
HT C G+ CCP+ + CC CC + +CC G+ C +
Sbjct: 444 HTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNV 487
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 50.1 bits (118), Expect = 2e-06
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
D C ++CH TCC + CCP CC D CC G++C + G C
Sbjct: 515 DVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRC 569
Score = 42.0 bits (97), Expect = 4e-04
Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CPGNYY-CHSSHTCCT----PGKCCPAQNANCCSDGEFCCRNGYYC 250
CPG + C S TCC CCP A+CC D CC +G C
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 41.2 bits (95), Expect = 7e-04
Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 4/59 (6%)
Frame = +2
Query: 107 SSFYDQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
S + + C C H+C CCP A C DG CC G++C G C
Sbjct: 40 SGYLGRPCQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTC 98
Score = 40.8 bits (94), Expect = 0.001
Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTP----GKCCPAQNANCCSDGEFCCRNGYYC 250
D C + C TCC CC +A CC DG+ CC GY C
Sbjct: 438 DVGCDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 38.9 bits (89), Expect = 0.004
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%)
Frame = +2
Query: 47 RTKVVKVKASKNVLTKSSFKSSFYDQWCPGNYYCHSSHTCCT--PGK--CCPAQNANCCS 214
+++ + +K +LTK + +D C C TCC GK CCP A CC
Sbjct: 257 QSRCLSQNKAKTLLTKLP-SWTVWDVECDQEVSCPEGQTCCRLQSGKWGCCPFPKAVCCE 315
Query: 215 DGEFCCRNGYYC 250
D CC + C
Sbjct: 316 DHVHCCPERFRC 327
Score = 36.6 bits (83), Expect = 0.018
Identities = 18/46 (39%), Positives = 19/46 (41%), Gaps = 5/46 (10%)
Frame = +2
Query: 128 CPGNY-YCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250
CP + C TCC CCP NA CCSD CC C
Sbjct: 208 CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 48.5 bits (114), Expect = 5e-06
Identities = 20/53 (37%), Positives = 24/53 (45%), Gaps = 4/53 (7%)
Frame = +2
Query: 125 WCPGNYYCHSSHTCCTPG----KCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
+C C S TCC CCP CC DG CCR+GY+C + C
Sbjct: 3 FCDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLC 55
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 46.2 bits (108), Expect = 2e-05
Identities = 20/53 (37%), Positives = 23/53 (43%), Gaps = 4/53 (7%)
Frame = +2
Query: 125 WCPGNYYCHSSHTCCTPG----KCCPAQNANCCSDGEFCCRNGYYCCAYGWCC 271
+C C S TCC CCP CC DG CCR+GY C + C
Sbjct: 3 YCNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLC 55
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 44.7 bits (104), Expect = 7e-05
Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 4/45 (8%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGYYC 250
C C TCC CCP CC DG CCR+GY+C
Sbjct: 4 CDAATICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 42.7 bits (99), Expect = 3e-04
Identities = 16/46 (34%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTPGK----CCPAQNANCCSDGEFCCRNGY 244
D C ++CH TCC + CCP CC+D CC G+
Sbjct: 1 DVQCGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21)
Length = 462
Score = 42.0 bits (97), Expect = 4e-04
Identities = 20/51 (39%), Positives = 23/51 (45%), Gaps = 9/51 (17%)
Frame = +2
Query: 128 CPGNYYCHSSHTCCTP---GK------CCPAQNANCCSDGEFCCRNGYYCC 253
C Y C S+TCC GK CCP + A CC D CC + Y C
Sbjct: 375 CDSYYTCPESNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVC 425
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor
Length = 471
Score = 41.6 bits (96), Expect = 6e-04
Identities = 18/54 (33%), Positives = 21/54 (38%), Gaps = 9/54 (16%)
Frame = +2
Query: 119 DQWCPGNYYCHSSHTCCTP---------GKCCPAQNANCCSDGEFCCRNGYYCC 253
D C N+ C + TCC CCP + A CC D CC Y C
Sbjct: 382 DHVCDDNFSCPAGSTCCCAFGFRNLCLVWGCCPVEGATCCKDHASCCPPDYPVC 435
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,912,189
Number of Sequences: 369166
Number of extensions: 656321
Number of successful extensions: 3513
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2855
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3334
length of database: 68,354,980
effective HSP length: 86
effective length of database: 52,467,770
effective search space used: 1678968640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)