Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00791 (942 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q96QK1|VPS35_HUMAN Vacuolar protein sorting 35 (Vesicle ... 236 7e-62 sp|Q9EQH3|VPS35_MOUSE Vacuolar protein sorting 35 (Vesicle ... 234 3e-61 sp|O74552|VPS35_SCHPO Vacuolar protein sorting-associated p... 111 3e-24 sp|P34110|VPS35_YEAST Vacuolar protein sorting-associated p... 109 1e-23 sp|Q97WH0|RAD50_SULSO DNA double-strand break repair rad50 ... 33 1.2 sp|Q9ZD08|DNAB_RICPR Replicative DNA helicase 32 2.0 sp|P03752|VE47_LAMBD EA47 GENE PROTEIN 32 2.6 sp|P38170|CND2_YEAST Condensin complex subunit 2 (Barren ho... 32 3.4 sp|O75006|SEC15_SCHPO Exocyst complex component sec15 32 3.4 sp|Q9Z140|CPNE6_MOUSE Copine-6 (Copine VI) (Neuronal-copine... 30 9.9
>sp|Q96QK1|VPS35_HUMAN Vacuolar protein sorting 35 (Vesicle protein sorting 35) (hVPS35) (Maternal-embryonic 3) Length = 796 Score = 236 bits (602), Expect = 7e-62 Identities = 121/281 (43%), Positives = 179/281 (63%) Frame = +2 Query: 2 YKILIKMKKMLAPGGVKRLLRSYIPIVFQTLNLATRYHTQYDESEIWQRKLEKVFKLFHD 181 Y IL +K GG +R+ + P+VF LA RY + W++K +K+F H Sbjct: 507 YLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQ 566 Query: 182 CVSHFANNGAAELALRLFLQGALTIDRISKFEKRELLAYEFFAQAFSLFEEEIADSRAQI 361 +S AEL LRLFLQGAL I FE E +AYEF +QAFSL+E+EI+DS+AQ+ Sbjct: 567 TISALIKAELAELPLRLFLQGALAAGEIG-FENHETVAYEFMSQAFSLYEDEISDSKAQL 625 Query: 362 NAIMLITSTLERVSCLSEDNHCALRSQCAKAGALRLVKKMDQSRAVALAGHLFWSGKPIE 541 AI LI T ER+ C SE+NH LR+QCA A A +L+KK DQ RAV+ HLFWSG+ + Sbjct: 626 AAITLIIGTFERMKCFSEENHEPLRTQCALA-ASKLLKKPDQGRAVSTCAHLFWSGRNTD 684 Query: 542 EHGKELRDHKKLISCLDKSEKLANECLEVTMKAQLLIELLSRFLYFYNIDPENIPSLRIN 721 ++G+EL K+++ CL K+ K+AN+C++ +++ QL IE+L+R++YFY + + + +N Sbjct: 685 KNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLN 744 Query: 722 SLIRSIRKLLPDIQSGNDGESINNHFDNVISFIELKQRCAE 844 LI+ IR+ LP+++S + E IN HF N + + L++ E Sbjct: 745 QLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLRRESPE 785
>sp|Q9EQH3|VPS35_MOUSE Vacuolar protein sorting 35 (Vesicle protein sorting 35) (Maternal-embryonic 3) Length = 796 Score = 234 bits (597), Expect = 3e-61 Identities = 120/281 (42%), Positives = 178/281 (63%) Frame = +2 Query: 2 YKILIKMKKMLAPGGVKRLLRSYIPIVFQTLNLATRYHTQYDESEIWQRKLEKVFKLFHD 181 Y IL +K GG +R+ + P+VF LA RY + W++K +K+F H Sbjct: 507 YLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWEKKCQKIFSFAHQ 566 Query: 182 CVSHFANNGAAELALRLFLQGALTIDRISKFEKRELLAYEFFAQAFSLFEEEIADSRAQI 361 +S AEL LRLFLQGAL I FE E +AYEF +QAFSL+E+EI+DS+AQ+ Sbjct: 567 TISALIKAELAELPLRLFLQGALAAGEIG-FENHETVAYEFMSQAFSLYEDEISDSKAQL 625 Query: 362 NAIMLITSTLERVSCLSEDNHCALRSQCAKAGALRLVKKMDQSRAVALAGHLFWSGKPIE 541 AI LI T ER+ C SE+NH LR+QCA A A +L+KK DQ RAV+ HLFWSG+ + Sbjct: 626 AAITLIIGTFERMKCFSEENHEPLRTQCALA-ASKLLKKPDQGRAVSTCAHLFWSGRNTD 684 Query: 542 EHGKELRDHKKLISCLDKSEKLANECLEVTMKAQLLIELLSRFLYFYNIDPENIPSLRIN 721 ++G+EL K+++ CL K+ K+AN+C++ +++ QL IE+L+R++YFY + + + +N Sbjct: 685 KNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLN 744 Query: 722 SLIRSIRKLLPDIQSGNDGESINNHFDNVISFIELKQRCAE 844 LI+ IR+ LP+++S + E IN HF N + + ++ E Sbjct: 745 QLIQKIREDLPNLESSEETEQINKHFHNTLEHLRSRRESPE 785
>sp|O74552|VPS35_SCHPO Vacuolar protein sorting-associated protein vps35 Length = 785 Score = 111 bits (278), Expect = 3e-24 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 1/198 (0%) Frame = +2 Query: 140 WQRKLEKVFKLFHDCVSHFANNG-AAELALRLFLQGALTIDRISKFEKRELLAYEFFAQA 316 W K+ +++ + C++ NG + EL L L+L A D+ E AYEFF QA Sbjct: 527 WAEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQ----ENYPDFAYEFFTQA 582 Query: 317 FSLFEEEIADSRAQINAIMLITSTLERVSCLSEDNHCALRSQCAKAGALRLVKKMDQSRA 496 FS++EE + DS Q +++I L++ S D++ L ++C A +L+KK DQ Sbjct: 583 FSIYEESVLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLY-ASKLLKKPDQCCG 641 Query: 497 VALAGHLFWSGKPIEEHGKELRDHKKLISCLDKSEKLANECLEVTMKAQLLIELLSRFLY 676 + LA HL+W E+ + +D K+++ CL KS K+A+ C++ +L I +L R+ Y Sbjct: 642 IYLASHLWWQVASGED-SRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINILERYFY 700 Query: 677 FYNIDPENIPSLRINSLI 730 +Y+ E+I + I+ LI Sbjct: 701 YYDQHCESIIAKHISGLI 718
>sp|P34110|VPS35_YEAST Vacuolar protein sorting-associated protein VPS35 Length = 944 Score = 109 bits (272), Expect = 1e-23 Identities = 73/234 (31%), Positives = 130/234 (55%), Gaps = 15/234 (6%) Frame = +2 Query: 152 LEKVFKLFHDCVSHF---ANNGAAELALRLFLQGALTIDRISKFEKRELLAYEFFAQAFS 322 L+++FK C++ NN +L L+L LQ A+ D++ E ++Y+FF+QAF+ Sbjct: 623 LKQMFKFVSRCINDIFNSCNNSCTDLILKLNLQCAILADQLQLNE----ISYDFFSQAFT 678 Query: 323 LFEEEIADSRAQINAIMLITSTLERV-SCLSEDNHCALRSQCAKAGALRLVKKMDQSRAV 499 +FEE ++DS+ Q+ A++ I +L++ S E + +L +C G+ +L+KK DQ RAV Sbjct: 679 IFEESLSDSKTQLQALIYIAQSLQKTRSLYKEAYYDSLIVRCTLHGS-KLLKKQDQCRAV 737 Query: 500 ALAGHLFWSGKPIEEHGKE-------LRDHKKLISCLDKSEKLANECLEVTMKAQLLIEL 658 L HL+W+ + I G+E RD K+++ CL +S ++A+ ++ +L++E+ Sbjct: 738 YLCSHLWWATE-ISNIGEEEGITDNFYRDGKRVLECLQRSLRVADSIMDNEQSCELMVEI 796 Query: 659 LSRFLYFYNIDPE---NIPSLRINSLIRSIRKLLPDIQ-SGNDGESINNHFDNV 808 L+R LY++ E +I IN LI I+ L ++ N I N ++ Sbjct: 797 LNRCLYYFIHGDESETHISIKYINGLIELIKTNLKSLKLEDNSASMITNSISDL 850
>sp|Q97WH0|RAD50_SULSO DNA double-strand break repair rad50 ATPase Length = 864 Score = 33.1 bits (74), Expect = 1.2 Identities = 38/168 (22%), Positives = 77/168 (45%), Gaps = 19/168 (11%) Frame = +2 Query: 260 RISKFEKRELLAYEFFAQAFSLFEEEIADSRAQINAIMLITSTLERVSCLSEDNHCALRS 439 ++ + +K++ + ++ Q L +EE+ + R ++N I E+ + L++ Sbjct: 595 KLDEMKKKKGILEDYIRQV-KLLQEEVKNLREEVNIIQF-----------DENRYNELKT 642 Query: 440 QCAKAGALRLVKKMDQSRAVALAGHLFWSGKPIEE-------HGKELRDHKKLISCLDKS 598 A L K ++R + G L K IEE + +L+D +K+I+ ++K Sbjct: 643 SL---DAYNLSLKEKENRKSRIEGELESLEKDIEEISNRIANYELQLKDREKIINAINKL 699 Query: 599 EKLANECLE------VTMKAQLLIE-----LLSRF-LYFYNIDPENIP 706 EK+ + E + M + LIE ++S+F L N++ E +P Sbjct: 700 EKIRSALGERKLQSYIIMTTKQLIENNLNDIISKFDLSIKNVEMEIMP 747
>sp|Q9ZD08|DNAB_RICPR Replicative DNA helicase Length = 486 Score = 32.3 bits (72), Expect = 2.0 Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 2/123 (1%) Frame = +2 Query: 377 ITSTLERVSCLSEDNHCALRSQCAKAGALRLVKKMDQSRAVALAGHLFWSGKPIEEH--G 550 I ST R LSED + LR + L+ +D + A++++ + + +H G Sbjct: 279 IDSTALRTGMLSEDKYNRLRKEANTLSELQFF--IDDTPALSISAIRTRARRMKRKHNLG 336 Query: 551 KELRDHKKLISCLDKSEKLANECLEVTMKAQLLIELLSRFLYFYNIDPENIPSLRINSLI 730 D+ +LI + KSE NE E+T + + + L NIP + ++ L Sbjct: 337 ILFIDYLQLIRGVSKSENRVNEISEITQGLKAIAKEL------------NIPVIALSQLS 384 Query: 731 RSI 739 R++ Sbjct: 385 RAV 387
>sp|P03752|VE47_LAMBD EA47 GENE PROTEIN Length = 410 Score = 32.0 bits (71), Expect = 2.6 Identities = 15/56 (26%), Positives = 29/56 (51%) Frame = +2 Query: 140 WQRKLEKVFKLFHDCVSHFANNGAAELALRLFLQGALTIDRISKFEKRELLAYEFF 307 W+R+L+ + L C+ + + L L FLQ A T+ I + K +++ Y+ + Sbjct: 6 WERRLKDLSHLLKCCIDTYFDPELFRLNLNQFLQTARTVTFIIQKNKNQIIGYDIW 61
>sp|P38170|CND2_YEAST Condensin complex subunit 2 (Barren homolog) (CAPH homolog) Length = 728 Score = 31.6 bits (70), Expect = 3.4 Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 1/67 (1%) Frame = +2 Query: 653 ELLSRFLYFYNIDPENIPSLRINSLIRSIRKLLPDIQSGNDG-ESINNHFDNVISFIELK 829 E+LS + F D I I+ I +R ++ DI D E++NN FDN ++ EL Sbjct: 253 EILSLGMDFIKFD--QIAVCEISGSIEQLRNVVEDINQAKDFIENVNNRFDNFLTEEEL- 309 Query: 830 QRCAEDN 850 Q DN Sbjct: 310 QAAVPDN 316
>sp|O75006|SEC15_SCHPO Exocyst complex component sec15 Length = 785 Score = 31.6 bits (70), Expect = 3.4 Identities = 34/143 (23%), Positives = 58/143 (40%) Frame = +2 Query: 311 QAFSLFEEEIADSRAQINAIMLITSTLERVSCLSEDNHCALRSQCAKAGALRLVKKMDQS 490 Q SL E+ +++ L + + RV LS +N+ + +R + QS Sbjct: 27 QLISLACEKGQETQVYERLNELASKSAIRVEQLSAENNQDFSKSVNQLSVVRSELRSLQS 86 Query: 491 RAVALAGHLFWSGKPIEEHGKELRDHKKLISCLDKSEKLANECLEVTMKAQLLIELLSRF 670 L + SG+ ++ ++L L K L C++V + Q ELLS+ Sbjct: 87 LMADLNTDIQASGRDLQNMKQQLNSLSTSERFLTKYHNLVRSCMQVLHQVQYSQELLSKK 146 Query: 671 LYFYNIDPENIPSLRINSLIRSI 739 Y +P+LRI S I + Sbjct: 147 QY--------LPTLRICSEISEV 161
>sp|Q9Z140|CPNE6_MOUSE Copine-6 (Copine VI) (Neuronal-copine) (N-copine) Length = 557 Score = 30.0 bits (66), Expect = 9.9 Identities = 22/66 (33%), Positives = 29/66 (43%) Frame = +2 Query: 683 NIDPENIPSLRINSLIRSIRKLLPDIQSGNDGESINNHFDNVISFIELKQRCAEDNNATK 862 N DPEN I+ +I S R+ LP IQ N + E QR ATK Sbjct: 379 NFDPENPECEEISGVIASYRRCLPQIQLYGP----TNVAPIINRVAEPAQREQSTGQATK 434 Query: 863 FSQLMI 880 +S L++ Sbjct: 435 YSVLLV 440
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 98,201,881 Number of Sequences: 369166 Number of extensions: 1849551 Number of successful extensions: 4755 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4618 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4747 length of database: 68,354,980 effective HSP length: 110 effective length of database: 48,034,130 effective search space used: 9750928390 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)