DrC_00423
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00423 (669 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O88952|LIN7C_MOUSE LIN-7 homolog C (LIN-7C) (mLin7C) (Ma... 276 3e-74 sp|Q9Z252|LIN7B_RAT LIN-7 homolog B (LIN-7B) (Mammalian LIN... 276 4e-74 sp|O88951|LIN7B_MOUSE LIN-7 homolog B (LIN-7B) (Mammalian L... 276 4e-74 sp|Q9HAP6|LIN7B_HUMAN LIN-7 homolog B (LIN-7B) (hLin7B) (Ma... 273 4e-73 sp|O14910|LIN7A_HUMAN LIN-7 homolog A (LIN-7A) (hLin-7) (Ma... 256 4e-68 sp|Q8JZS0|LIN7A_MOUSE LIN-7 homolog A (LIN-7A) (mLin-7) (Ma... 256 4e-68 sp|Q9Z250|LIN7A_RAT LIN-7 homolog A (LIN-7A) (Mammalian LIN... 256 4e-68 sp|P31007|DLG1_DROME Discs large-1 tumor suppressor protein 87 4e-17 sp|P31016|DLG4_RAT Postsynaptic density protein 95 (PSD-95)... 81 2e-15 sp|Q62108|DLG4_MOUSE Postsynaptic density protein 95 (PSD-9... 81 2e-15
>sp|O88952|LIN7C_MOUSE LIN-7 homolog C (LIN-7C) (mLin7C) (Mammalian LIN-seven protein 3) (MALS-3) (Vertebrate LIN 7 homolog 3) (Veli-3 protein) sp|Q792I0|LIN7C_RAT LIN-7 homolog C (LIN-7C) (Mammalian LIN-seven protein 3) (MALS-3) (Vertebrate LIN 7 homolog 3) (Veli-3 protein) sp|Q9NUP9|LIN7C_HUMAN LIN-7 homolog C (LIN-7C) (Mammalian LIN-seven protein 3) (MALS-3) (Vertebrate LIN 7 homolog 3) (Veli-3 protein) Length = 197 Score = 276 bits (707), Expect = 3e-74 Identities = 133/190 (70%), Positives = 158/190 (83%) Frame = +2 Query: 11 MAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDI 190 + EP+ L+RDI RA+ELLE LQ+ ++ P+KL LQ++LQS+FCN VREVYEH+YETVDI Sbjct: 4 LGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDI 63 Query: 191 EGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRII 370 S EVR EGH+HPRVVE+PKTEEGLGFN+MGGKEQNSPIYISRII Sbjct: 64 SSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRII 123 Query: 371 PGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEA 550 PGG+ADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG VKLVVRYTPKVL+EME+ Sbjct: 124 PGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMES 183 Query: 551 RFDKQKARRR 580 RF+K ++ +R Sbjct: 184 RFEKMRSAKR 193
>sp|Q9Z252|LIN7B_RAT LIN-7 homolog B (LIN-7B) (Mammalian LIN-seven protein 2) (MALS-2) (Vertebrate LIN 7 homolog 2) (Veli-2 protein) Length = 207 Score = 276 bits (706), Expect = 4e-74 Identities = 134/190 (70%), Positives = 160/190 (84%) Frame = +2 Query: 11 MAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDI 190 + EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI Sbjct: 4 LVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDI 63 Query: 191 EGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRII 370 GSAEVR EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+I Sbjct: 64 TGSAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVI 123 Query: 371 PGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEA 550 PGGVADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG+VKLVVRYTP+VL+EMEA Sbjct: 124 PGGVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEA 183 Query: 551 RFDKQKARRR 580 RF+K ++ RR Sbjct: 184 RFEKMRSARR 193
>sp|O88951|LIN7B_MOUSE LIN-7 homolog B (LIN-7B) (Mammalian LIN-seven protein 2) (MALS-2) (Vertebrate LIN 7 homolog 2) (Veli-2 protein) Length = 207 Score = 276 bits (706), Expect = 4e-74 Identities = 134/190 (70%), Positives = 160/190 (84%) Frame = +2 Query: 11 MAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDI 190 + EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI Sbjct: 4 LVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDI 63 Query: 191 EGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRII 370 GSAEVR EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+I Sbjct: 64 TGSAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVI 123 Query: 371 PGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEA 550 PGGVADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG+VKLVVRYTP+VL+EMEA Sbjct: 124 PGGVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEA 183 Query: 551 RFDKQKARRR 580 RF+K ++ RR Sbjct: 184 RFEKMRSARR 193
>sp|Q9HAP6|LIN7B_HUMAN LIN-7 homolog B (LIN-7B) (hLin7B) (Mammalian LIN-seven protein 2) (MALS-2) (Vertebrate LIN 7 homolog 2) (Veli-2 protein) (hVeli2) Length = 207 Score = 273 bits (697), Expect = 4e-73 Identities = 132/190 (69%), Positives = 159/190 (83%) Frame = +2 Query: 11 MAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDI 190 + EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI Sbjct: 4 LVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDI 63 Query: 191 EGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRII 370 GSAE+R EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+I Sbjct: 64 TGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVI 123 Query: 371 PGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEA 550 PGGVADR+GGLKRGDQLLSVNG+SVE E HEKAV+LLKAAQG+VKLVVRYTP+VL+EMEA Sbjct: 124 PGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEA 183 Query: 551 RFDKQKARRR 580 RF+K ++ RR Sbjct: 184 RFEKMRSARR 193
>sp|O14910|LIN7A_HUMAN LIN-7 homolog A (LIN-7A) (hLin-7) (Mammalian LIN-seven protein 1) (MALS-1) (Vertebrate LIN 7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33) Length = 233 Score = 256 bits (654), Expect = 4e-68 Identities = 124/192 (64%), Positives = 154/192 (80%) Frame = +2 Query: 5 LLMAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETV 184 L + +PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ Sbjct: 17 LTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETI 76 Query: 185 DIEGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISR 364 + G E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISR Sbjct: 77 TVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISR 136 Query: 365 IIPGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEM 544 IIPGGVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EM Sbjct: 137 IIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEM 196 Query: 545 EARFDKQKARRR 580 EARF+K + RR Sbjct: 197 EARFEKLRTARR 208
>sp|Q8JZS0|LIN7A_MOUSE LIN-7 homolog A (LIN-7A) (mLin-7) (Mammalian LIN-seven protein 1) (MALS-1) (Vertebrate LIN 7 homolog 1) (Veli-1 protein) Length = 233 Score = 256 bits (654), Expect = 4e-68 Identities = 124/192 (64%), Positives = 154/192 (80%) Frame = +2 Query: 5 LLMAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETV 184 L + +PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ Sbjct: 17 LTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETI 76 Query: 185 DIEGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISR 364 + G E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISR Sbjct: 77 TVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISR 136 Query: 365 IIPGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEM 544 IIPGGVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EM Sbjct: 137 IIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEM 196 Query: 545 EARFDKQKARRR 580 EARF+K + RR Sbjct: 197 EARFEKLRTARR 208
>sp|Q9Z250|LIN7A_RAT LIN-7 homolog A (LIN-7A) (Mammalian LIN-seven protein 1) (MALS-1) (Vertebrate LIN 7 homolog 1) (Veli-1 protein) Length = 232 Score = 256 bits (654), Expect = 4e-68 Identities = 124/192 (64%), Positives = 154/192 (80%) Frame = +2 Query: 5 LLMAEPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETV 184 L + +PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ Sbjct: 17 LTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETI 76 Query: 185 DIEGSAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISR 364 + G E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISR Sbjct: 77 TVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISR 136 Query: 365 IIPGGVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEM 544 IIPGGVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EM Sbjct: 137 IIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEM 196 Query: 545 EARFDKQKARRR 580 EARF+K + RR Sbjct: 197 EARFEKLRTARR 208
>sp|P31007|DLG1_DROME Discs large-1 tumor suppressor protein Length = 970 Score = 87.0 bits (214), Expect = 4e-17 Identities = 45/99 (45%), Positives = 62/99 (62%) Frame = +2 Query: 272 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 451 PR + I K +GLGFN++GG E IY+S I+ GG AD LKRGDQLLSVN +++ + Sbjct: 504 PRTITIQKGPQGLGFNIVGG-EDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTH 562 Query: 452 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARFDKQK 568 HE+A LK + G V L+ +Y P+ + EAR + K Sbjct: 563 ATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELK 601
Score = 57.8 bits (138), Expect = 3e-08
Identities = 32/84 (38%), Positives = 49/84 (58%), Gaps = 5/84 (5%)
Frame = +2
Query: 281 VEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISV 445
+++ + GLGF++ GG + ++ IYI+++I GG A G L D ++SVN +SV
Sbjct: 217 IQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSV 276
Query: 446 ENEHHEKAVDLLKAAQGTVKLVVR 517
+ H AVD LK A VKL V+
Sbjct: 277 VDVPHASAVDALKKAGNVVKLHVK 300
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/95 (38%), Positives = 56/95 (58%), Gaps = 11/95 (11%)
Frame = +2
Query: 272 PRVVEIP--KTEEGLGFNVMGG-KEQNSP----IYISRIIPGGVADRYGGLKRGDQLLSV 430
P+V+EI K +GLGF++ GG Q+ P IY+++++ GG A G L GD+L++V
Sbjct: 326 PKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAV 385
Query: 431 --NGI--SVENEHHEKAVDLLKAAQGTVKLVVRYT 523
NG ++EN HE AV LK+ V L++ T
Sbjct: 386 RTNGSEKNLENVTHELAVATLKSITDKVTLIIGKT 420
>sp|P31016|DLG4_RAT Postsynaptic density protein 95 (PSD-95) (Synapse-associated protein 90) (SAP90) (Discs large homolog 4) Length = 724 Score = 81.3 bits (199), Expect = 2e-15 Identities = 42/94 (44%), Positives = 59/94 (62%) Frame = +2 Query: 272 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 451 PR + I + GLGFN++GG E I+IS I+ GG AD G L++GDQ+LSVNG+ + N Sbjct: 311 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 369 Query: 452 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEAR 553 HE+A LK A TV ++ +Y P+ EA+ Sbjct: 370 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 403
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/108 (34%), Positives = 55/108 (50%), Gaps = 6/108 (5%)
Frame = +2
Query: 257 EGHAHPRVVEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQL 421
EG + + + GLGF++ GG + + I+I++IIPGG A + G L+ D +
Sbjct: 58 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 117
Query: 422 LSVNGISVENEHHEKAVDLLKAAQGTVKL-VVRYTPKVLDEMEARFDK 562
L VN + V H AV+ LK A V+L V+R P ME + K
Sbjct: 118 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 165
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/83 (39%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Frame = +2
Query: 281 VEIPKTEEGLGFNVMGGK-EQNSP----IYISRIIPGGVADRYGGLKRGDQLLSVNGISV 445
+++ K +GLGF++ GG Q+ P IY+++II GG A + G L+ GD++L+VN + +
Sbjct: 161 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 220
Query: 446 ENEHHEKAVDLLKAAQGTVKLVV 514
E+ HE AV LK V L V
Sbjct: 221 EDVMHEDAVAALKNTYDVVYLKV 243
>sp|Q62108|DLG4_MOUSE Postsynaptic density protein 95 (PSD-95) (Synapse-associated protein 90) (SAP90) (Discs large homolog 4) Length = 724 Score = 81.3 bits (199), Expect = 2e-15 Identities = 42/94 (44%), Positives = 59/94 (62%) Frame = +2 Query: 272 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 451 PR + I + GLGFN++GG E I+IS I+ GG AD G L++GDQ+LSVNG+ + N Sbjct: 311 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 369 Query: 452 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEAR 553 HE+A LK A TV ++ +Y P+ EA+ Sbjct: 370 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 403
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 5/91 (5%)
Frame = +2
Query: 257 EGHAHPRVVEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQL 421
EG + + + GLGF++ GG + + I+I++IIPGG A + G L+ D +
Sbjct: 58 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 117
Query: 422 LSVNGISVENEHHEKAVDLLKAAQGTVKLVV 514
L VN + V H AV+ LK A V+L V
Sbjct: 118 LFVNEVDVREVTHSAAVEALKEAGSIVRLYV 148
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/83 (39%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Frame = +2
Query: 281 VEIPKTEEGLGFNVMGGK-EQNSP----IYISRIIPGGVADRYGGLKRGDQLLSVNGISV 445
+++ K +GLGF++ GG Q+ P IY+++II GG A + G L+ GD++L+VN + +
Sbjct: 161 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 220
Query: 446 ENEHHEKAVDLLKAAQGTVKLVV 514
E+ HE AV LK V L V
Sbjct: 221 EDVMHEDAVAALKNTYDVVYLKV 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,545,062
Number of Sequences: 369166
Number of extensions: 1446608
Number of successful extensions: 4701
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4250
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4610
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5657676120
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
