Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_M19
(656 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O88952|LIN7C_MOUSE LIN-7 homolog C (LIN-7C) (mLin7C) (Ma... 276 4e-74
sp|Q9Z252|LIN7B_RAT LIN-7 homolog B (LIN-7B) (Mammalian LIN... 275 6e-74
sp|O88951|LIN7B_MOUSE LIN-7 homolog B (LIN-7B) (Mammalian L... 275 6e-74
sp|Q9HAP6|LIN7B_HUMAN LIN-7 homolog B (LIN-7B) (hLin7B) (Ma... 272 6e-73
sp|O14910|LIN7A_HUMAN LIN-7 homolog A (LIN-7A) (hLin-7) (Ma... 254 1e-67
sp|Q8JZS0|LIN7A_MOUSE LIN-7 homolog A (LIN-7A) (mLin-7) (Ma... 254 1e-67
sp|Q9Z250|LIN7A_RAT LIN-7 homolog A (LIN-7A) (Mammalian LIN... 254 1e-67
sp|P31007|DLG1_DROME Discs large-1 tumor suppressor protein 87 4e-17
sp|P31016|DLG4_RAT Postsynaptic density protein 95 (PSD-95)... 81 2e-15
sp|Q62108|DLG4_MOUSE Postsynaptic density protein 95 (PSD-9... 81 2e-15
>sp|O88952|LIN7C_MOUSE LIN-7 homolog C (LIN-7C) (mLin7C) (Mammalian LIN-seven protein 3)
(MALS-3) (Vertebrate LIN 7 homolog 3) (Veli-3 protein)
sp|Q792I0|LIN7C_RAT LIN-7 homolog C (LIN-7C) (Mammalian LIN-seven protein 3) (MALS-3)
(Vertebrate LIN 7 homolog 3) (Veli-3 protein)
sp|Q9NUP9|LIN7C_HUMAN LIN-7 homolog C (LIN-7C) (Mammalian LIN-seven protein 3) (MALS-3)
(Vertebrate LIN 7 homolog 3) (Veli-3 protein)
Length = 197
Score = 276 bits (705), Expect = 4e-74
Identities = 133/188 (70%), Positives = 157/188 (83%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
EP+ L+RDI RA+ELLE LQ+ ++ P+KL LQ++LQS+FCN VREVYEH+YETVDI
Sbjct: 6 EPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISS 65
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
S EVR EGH+HPRVVE+PKTEEGLGFN+MGGKEQNSPIYISRIIPG
Sbjct: 66 SPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPG 125
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
G+ADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG VKLVVRYTPKVL+EME+RF
Sbjct: 126 GIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRF 185
Query: 544 DKQKARRR 567
+K ++ +R
Sbjct: 186 EKMRSAKR 193
>sp|Q9Z252|LIN7B_RAT LIN-7 homolog B (LIN-7B) (Mammalian LIN-seven protein 2) (MALS-2)
(Vertebrate LIN 7 homolog 2) (Veli-2 protein)
Length = 207
Score = 275 bits (704), Expect = 6e-74
Identities = 134/188 (71%), Positives = 159/188 (84%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI G
Sbjct: 6 EPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITG 65
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
SAEVR EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+IPG
Sbjct: 66 SAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPG 125
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG+VKLVVRYTP+VL+EMEARF
Sbjct: 126 GVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARF 185
Query: 544 DKQKARRR 567
+K ++ RR
Sbjct: 186 EKMRSARR 193
>sp|O88951|LIN7B_MOUSE LIN-7 homolog B (LIN-7B) (Mammalian LIN-seven protein 2) (MALS-2)
(Vertebrate LIN 7 homolog 2) (Veli-2 protein)
Length = 207
Score = 275 bits (704), Expect = 6e-74
Identities = 134/188 (71%), Positives = 159/188 (84%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI G
Sbjct: 6 EPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITG 65
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
SAEVR EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+IPG
Sbjct: 66 SAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPG 125
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVADR+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAAQG+VKLVVRYTP+VL+EMEARF
Sbjct: 126 GVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARF 185
Query: 544 DKQKARRR 567
+K ++ RR
Sbjct: 186 EKMRSARR 193
>sp|Q9HAP6|LIN7B_HUMAN LIN-7 homolog B (LIN-7B) (hLin7B) (Mammalian LIN-seven protein 2)
(MALS-2) (Vertebrate LIN 7 homolog 2) (Veli-2 protein)
(hVeli2)
Length = 207
Score = 272 bits (695), Expect = 6e-73
Identities = 132/188 (70%), Positives = 158/188 (84%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
EPL L+RD+SRAVELLE LQ+ +L P+KL LQ++LQS FC+ +REVYE +Y+T+DI G
Sbjct: 6 EPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITG 65
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
SAE+R EGHAHPRVVE+PKT+EGLGFN+MGGKEQNSPIYISR+IPG
Sbjct: 66 SAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPG 125
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVADR+GGLKRGDQLLSVNG+SVE E HEKAV+LLKAAQG+VKLVVRYTP+VL+EMEARF
Sbjct: 126 GVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARF 185
Query: 544 DKQKARRR 567
+K ++ RR
Sbjct: 186 EKMRSARR 193
>sp|O14910|LIN7A_HUMAN LIN-7 homolog A (LIN-7A) (hLin-7) (Mammalian LIN-seven protein 1)
(MALS-1) (Vertebrate LIN 7 homolog 1) (Veli-1 protein)
(Tax interaction protein 33) (TIP-33)
Length = 233
Score = 254 bits (650), Expect = 1e-67
Identities = 123/188 (65%), Positives = 152/188 (80%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
+PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ + G
Sbjct: 21 QPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNG 80
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISRIIPG
Sbjct: 81 CPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPG 140
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EMEARF
Sbjct: 141 GVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARF 200
Query: 544 DKQKARRR 567
+K + RR
Sbjct: 201 EKLRTARR 208
>sp|Q8JZS0|LIN7A_MOUSE LIN-7 homolog A (LIN-7A) (mLin-7) (Mammalian LIN-seven protein 1)
(MALS-1) (Vertebrate LIN 7 homolog 1) (Veli-1 protein)
Length = 233
Score = 254 bits (650), Expect = 1e-67
Identities = 123/188 (65%), Positives = 152/188 (80%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
+PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ + G
Sbjct: 21 QPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNG 80
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISRIIPG
Sbjct: 81 CPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPG 140
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EMEARF
Sbjct: 141 GVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARF 200
Query: 544 DKQKARRR 567
+K + RR
Sbjct: 201 EKLRTARR 208
>sp|Q9Z250|LIN7A_RAT LIN-7 homolog A (LIN-7A) (Mammalian LIN-seven protein 1) (MALS-1)
(Vertebrate LIN 7 homolog 1) (Veli-1 protein)
Length = 232
Score = 254 bits (650), Expect = 1e-67
Identities = 123/188 (65%), Positives = 152/188 (80%)
Frame = +1
Query: 4 EPLTLQRDISRAVELLESLQKCPDLKPEKLIGLQKILQSDFCNMVREVYEHIYETVDIEG 183
+PLTL RD++RA+ELLE LQ+ ++ KL L+K+LQS+FC +REVY++++ET+ + G
Sbjct: 21 QPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNG 80
Query: 184 SAEVRXXXXXXXXXXXXXXXEGHAHPRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPG 363
E R EGH+HPRVVE+PKT+EGLGFNVMGGKEQNSPIYISRIIPG
Sbjct: 81 CPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPG 140
Query: 364 GVADRYGGLKRGDQLLSVNGISVENEHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARF 543
GVA+R+GGLKRGDQLLSVNG+SVE EHHEKAV+LLKAA+ +VKLVVRYTPKVL+EMEARF
Sbjct: 141 GVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARF 200
Query: 544 DKQKARRR 567
+K + RR
Sbjct: 201 EKLRTARR 208
>sp|P31007|DLG1_DROME Discs large-1 tumor suppressor protein
Length = 970
Score = 87.0 bits (214), Expect = 4e-17
Identities = 45/99 (45%), Positives = 62/99 (62%)
Frame = +1
Query: 259 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 438
PR + I K +GLGFN++GG E IY+S I+ GG AD LKRGDQLLSVN +++ +
Sbjct: 504 PRTITIQKGPQGLGFNIVGG-EDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTH 562
Query: 439 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEARFDKQK 555
HE+A LK + G V L+ +Y P+ + EAR + K
Sbjct: 563 ATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELK 601
Score = 57.8 bits (138), Expect = 2e-08
Identities = 32/84 (38%), Positives = 49/84 (58%), Gaps = 5/84 (5%)
Frame = +1
Query: 268 VEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISV 432
+++ + GLGF++ GG + ++ IYI+++I GG A G L D ++SVN +SV
Sbjct: 217 IQLERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSV 276
Query: 433 ENEHHEKAVDLLKAAQGTVKLVVR 504
+ H AVD LK A VKL V+
Sbjct: 277 VDVPHASAVDALKKAGNVVKLHVK 300
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/95 (38%), Positives = 56/95 (58%), Gaps = 11/95 (11%)
Frame = +1
Query: 259 PRVVEIP--KTEEGLGFNVMGG-KEQNSP----IYISRIIPGGVADRYGGLKRGDQLLSV 417
P+V+EI K +GLGF++ GG Q+ P IY+++++ GG A G L GD+L++V
Sbjct: 326 PKVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAV 385
Query: 418 --NGI--SVENEHHEKAVDLLKAAQGTVKLVVRYT 510
NG ++EN HE AV LK+ V L++ T
Sbjct: 386 RTNGSEKNLENVTHELAVATLKSITDKVTLIIGKT 420
>sp|P31016|DLG4_RAT Postsynaptic density protein 95 (PSD-95) (Synapse-associated
protein 90) (SAP90) (Discs large homolog 4)
Length = 724
Score = 81.3 bits (199), Expect = 2e-15
Identities = 42/94 (44%), Positives = 59/94 (62%)
Frame = +1
Query: 259 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 438
PR + I + GLGFN++GG E I+IS I+ GG AD G L++GDQ+LSVNG+ + N
Sbjct: 311 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 369
Query: 439 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEAR 540
HE+A LK A TV ++ +Y P+ EA+
Sbjct: 370 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 403
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/108 (34%), Positives = 55/108 (50%), Gaps = 6/108 (5%)
Frame = +1
Query: 244 EGHAHPRVVEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQL 408
EG + + + GLGF++ GG + + I+I++IIPGG A + G L+ D +
Sbjct: 58 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 117
Query: 409 LSVNGISVENEHHEKAVDLLKAAQGTVKL-VVRYTPKVLDEMEARFDK 549
L VN + V H AV+ LK A V+L V+R P ME + K
Sbjct: 118 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 165
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/83 (39%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Frame = +1
Query: 268 VEIPKTEEGLGFNVMGGK-EQNSP----IYISRIIPGGVADRYGGLKRGDQLLSVNGISV 432
+++ K +GLGF++ GG Q+ P IY+++II GG A + G L+ GD++L+VN + +
Sbjct: 161 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 220
Query: 433 ENEHHEKAVDLLKAAQGTVKLVV 501
E+ HE AV LK V L V
Sbjct: 221 EDVMHEDAVAALKNTYDVVYLKV 243
>sp|Q62108|DLG4_MOUSE Postsynaptic density protein 95 (PSD-95) (Synapse-associated
protein 90) (SAP90) (Discs large homolog 4)
Length = 724
Score = 81.3 bits (199), Expect = 2e-15
Identities = 42/94 (44%), Positives = 59/94 (62%)
Frame = +1
Query: 259 PRVVEIPKTEEGLGFNVMGGKEQNSPIYISRIIPGGVADRYGGLKRGDQLLSVNGISVEN 438
PR + I + GLGFN++GG E I+IS I+ GG AD G L++GDQ+LSVNG+ + N
Sbjct: 311 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 369
Query: 439 EHHEKAVDLLKAAQGTVKLVVRYTPKVLDEMEAR 540
HE+A LK A TV ++ +Y P+ EA+
Sbjct: 370 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAK 403
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 5/91 (5%)
Frame = +1
Query: 244 EGHAHPRVVEIPKTEEGLGFNVMGGKEQ-----NSPIYISRIIPGGVADRYGGLKRGDQL 408
EG + + + GLGF++ GG + + I+I++IIPGG A + G L+ D +
Sbjct: 58 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 117
Query: 409 LSVNGISVENEHHEKAVDLLKAAQGTVKLVV 501
L VN + V H AV+ LK A V+L V
Sbjct: 118 LFVNEVDVREVTHSAAVEALKEAGSIVRLYV 148
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/83 (39%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Frame = +1
Query: 268 VEIPKTEEGLGFNVMGGK-EQNSP----IYISRIIPGGVADRYGGLKRGDQLLSVNGISV 432
+++ K +GLGF++ GG Q+ P IY+++II GG A + G L+ GD++L+VN + +
Sbjct: 161 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 220
Query: 433 ENEHHEKAVDLLKAAQGTVKLVV 501
E+ HE AV LK V L V
Sbjct: 221 EDVMHEDAVAALKNTYDVVYLKV 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,262,659
Number of Sequences: 369166
Number of extensions: 1418707
Number of successful extensions: 4603
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4156
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4512
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5462583840
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)