Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00337 (785 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9R0I6|BIRC4_RAT Baculoviral IAP repeat-containing prote... 59 2e-08 sp|P98170|BIRC4_HUMAN Baculoviral IAP repeat-containing pro... 55 2e-07 sp|Q60989|BIRC4_MOUSE Baculoviral IAP repeat-containing pro... 55 2e-07 sp|P41436|IAP_GVCP Apoptosis inhibitor IAP 55 3e-07 sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing pro... 52 1e-06 sp|Q9JIB3|BIR1G_MOUSE Baculoviral IAP repeat-containing pro... 52 1e-06 sp|Q9R016|BIRE_MOUSE Baculoviral IAP repeat-containing prot... 52 1e-06 sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of ap... 52 2e-06 sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing pro... 51 3e-06 sp|Q9QUK4|BIRB_MOUSE Baculoviral IAP repeat-containing prot... 50 7e-06
>sp|Q9R0I6|BIRC4_RAT Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (RIAP3) (RIAP-3) Length = 496 Score = 58.9 bits (141), Expect = 2e-08 Identities = 32/81 (39%), Positives = 44/81 (54%), Gaps = 2/81 (2%) Frame = +2 Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280 IY NP + + + R TF W A+L E+A+ G YYTG++D+ C CG LK W Sbjct: 153 IYPRNPAMCSEEARLKTFQNWPDYAHLSpreLASA-GLYYTGIDDQVQCFCCGGKLKNWE 211 Query: 281 RDDCPMALHAVHSPHCSFVMG 343 D + H H P+C FV+G Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 48.5 bits (114), Expect = 2e-05 Identities = 26/74 (35%), Positives = 34/74 (45%) Frame = +2 Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298 NP +A D R TF W N ++A GFY G D+ C CG GL W + P Sbjct: 258 NPAMAEYDARIVTFGTWLYSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 316 Query: 299 ALHAVHSPHCSFVM 340 HA P C +++ Sbjct: 317 EQHAKWYPGCKYLL 330
Score = 37.0 bits (84), Expect = 0.061 Identities = 16/45 (35%), Positives = 20/45 (44%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343 GF YTG D C C + W D + H SP+C F+ G Sbjct: 51 GFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFING 95
>sp|P98170|BIRC4_HUMAN Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP) Length = 497 Score = 55.5 bits (132), Expect = 2e-07 Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 2/81 (2%) Frame = +2 Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280 IY NP + + + R +F W A+L E+A+ G YYTG+ D+ C CG LK W Sbjct: 153 IYPRNPAMYSEEARLKSFQNWPDYAHLTpreLASA-GLYYTGIGDQVQCFCCGGKLKNWE 211 Query: 281 RDDCPMALHAVHSPHCSFVMG 343 D + H H P+C FV+G Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 46.6 bits (109), Expect = 8e-05 Identities = 25/74 (33%), Positives = 35/74 (47%) Frame = +2 Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298 NP +A+ + R TF W N ++A GFY G D+ C CG GL W + P Sbjct: 259 NPSMADYEARIFTFGTWIYSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 317 Query: 299 ALHAVHSPHCSFVM 340 HA P C +++ Sbjct: 318 EQHAKWYPGCKYLL 331
Score = 37.4 bits (85), Expect = 0.047 Identities = 16/45 (35%), Positives = 20/45 (44%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343 GF YTG D C C + W D + H SP+C F+ G Sbjct: 51 GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFING 95
>sp|Q60989|BIRC4_MOUSE Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3) Length = 496 Score = 55.1 bits (131), Expect = 2e-07 Identities = 30/81 (37%), Positives = 43/81 (53%), Gaps = 2/81 (2%) Frame = +2 Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280 IY NP + + + R +F W A+L E+A+ G YYTG +D+ C CG L+ W Sbjct: 153 IYPRNPAMCSEEARLKSFQNWPDYAHLTpreLASA-GLYYTGADDQVQCFCCGGKLENWE 211 Query: 281 RDDCPMALHAVHSPHCSFVMG 343 D + H H P+C FV+G Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 48.9 bits (115), Expect = 2e-05 Identities = 25/74 (33%), Positives = 34/74 (45%) Frame = +2 Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298 NP +A + R TF W N ++A GFY G D+ C CG GL W + P Sbjct: 258 NPAMAEYEARIVTFGTWTSSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 316 Query: 299 ALHAVHSPHCSFVM 340 HA P C +++ Sbjct: 317 EQHAKWYPGCKYLL 330
Score = 37.4 bits (85), Expect = 0.047 Identities = 16/45 (35%), Positives = 20/45 (44%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343 GF YTG D C C + W D + H SP+C F+ G Sbjct: 51 GFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFING 95
>sp|P41436|IAP_GVCP Apoptosis inhibitor IAP Length = 275 Score = 54.7 bits (130), Expect = 3e-07 Identities = 26/69 (37%), Positives = 33/69 (47%) Frame = +2 Query: 146 RKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPH 325 R TF KW E +NGFYY G DE C C + + W + P A H +P Sbjct: 10 RLNTFEKWPVSFLSPETMAKNGFYYLGRSDEVRCAFCKVEIMRWKEGEDPAADHKKWAPQ 69 Query: 326 CSFVMGIEI 352 C FV GI++ Sbjct: 70 CPFVKGIDV 78
Score = 42.4 bits (98), Expect = 0.001 Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%) Frame = +2 Query: 116 SNPFLANADNRKTTFNKWNKDANLI-EVANQNGFYYTGVEDETICVGCGLGLKAWARDDC 292 ++P A+ R +F+ W + E GF+YTG D T C C GLK W +D Sbjct: 101 AHPKYAHEAARVKSFHNWPRCMKQRPEQMADAGFFYTGYGDNTKCFYCDGGLKDWEPEDV 160 Query: 293 PMALHAVHSPHCSFV 337 P H C++V Sbjct: 161 PWEQHVRWFDRCAYV 175
>sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B) Length = 618 Score = 52.4 bits (124), Expect = 1e-06 Identities = 30/86 (34%), Positives = 37/86 (43%), Gaps = 7/86 (8%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV-- 382 GFYYTGV D+ C CGL L W D P+ H P CSF+ + L N Sbjct: 71 GFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSP 130 Query: 383 ----FKH-MKPTTSQIETISSSFKSI 445 F H + PT S S+ S+ Sbjct: 131 MRNSFAHSLSPTLEHSSLFSGSYSSL 156
Score = 43.5 bits (101), Expect = 7e-04 Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 4/75 (5%) Frame = +2 Query: 146 RKTTFNKWNKDANLI-EVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSP 322 R TF W + E GFYY G D+ C C GL+ W D P HA P Sbjct: 272 RMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFP 331 Query: 323 HCSFVM---GIEILD 358 C F++ G E +D Sbjct: 332 RCEFLIRMKGQEFVD 346
Score = 43.1 bits (100), Expect = 9e-04 Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 3/77 (3%) Frame = +2 Query: 116 SNPF---LANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286 +NP+ ++ + R T++ W + GFYY G D C CG L W Sbjct: 174 TNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPK 233 Query: 287 DCPMALHAVHSPHCSFV 337 D M+ H H P+C F+ Sbjct: 234 DDAMSEHRRHFPNCPFL 250
>sp|Q9JIB3|BIR1G_MOUSE Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7) Length = 1402 Score = 52.4 bits (124), Expect = 1e-06 Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%) Frame = +2 Query: 110 YSSNPFLANADNRKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286 Y ++ AN + R F W +++ + +E + GF+YTG +D C CG L+ WA Sbjct: 269 YCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEG 328 Query: 287 DCPMALHAVHSPHCSFVMGIE 349 D PM H P C F+ ++ Sbjct: 329 DDPMEDHIKFFPECVFLQTLK 349
Score = 38.1 bits (87), Expect = 0.028 Identities = 18/48 (37%), Positives = 21/48 (43%) Frame = +2 Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337 V + GF +TG D C CG L W D P HA P C F+ Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.5 bits (75), Expect = 0.68 Identities = 23/76 (30%), Positives = 34/76 (44%) Frame = +2 Query: 155 TFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSF 334 TF W E+A GFY+TGV+ C C L L + P+ H P C F Sbjct: 72 TFRSWTPQ----EMAAA-GFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEF 126 Query: 335 VMGIEILDLHKDRLNV 382 + G ++ ++ K + V Sbjct: 127 LQGKDVGNIGKYDIRV 142
>sp|Q9R016|BIRE_MOUSE Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5) Length = 1403 Score = 52.4 bits (124), Expect = 1e-06 Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%) Frame = +2 Query: 110 YSSNPFLANADNRKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286 Y ++ AN + R F W +++ + +E + GF+YTG +D C CG L+ WA Sbjct: 269 YCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEG 328 Query: 287 DCPMALHAVHSPHCSFVMGIE 349 D PM H P C F+ ++ Sbjct: 329 DDPMEDHIKFFPECVFLQTLK 349
Score = 38.1 bits (87), Expect = 0.028 Identities = 18/48 (37%), Positives = 21/48 (43%) Frame = +2 Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337 V + GF +TG D C CG L W D P HA P C F+ Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.5 bits (75), Expect = 0.68 Identities = 23/76 (30%), Positives = 34/76 (44%) Frame = +2 Query: 155 TFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSF 334 TF W E+A GFY+TGV+ C C L L + P+ H P C F Sbjct: 72 TFRSWTPQ----EMAAA-GFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEF 126 Query: 335 VMGIEILDLHKDRLNV 382 + G ++ ++ K + V Sbjct: 127 LQGKDVGNIGKYDIRV 142
>sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of apoptosis 2) (dIAP2) (DIAP) (IAP homolog A) (IAP-like protein) (DILP) Length = 498 Score = 51.6 bits (122), Expect = 2e-06 Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 1/74 (1%) Frame = +2 Query: 122 PFLANADNRKTTFNKWN-KDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298 P A D R TF W + Q G YY + D+ C C +GL++W ++D P Sbjct: 207 PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPW 266 Query: 299 ALHAVHSPHCSFVM 340 HA SP C FV+ Sbjct: 267 FEHAKWSPKCQFVL 280
Score = 35.8 bits (81), Expect = 0.14 Identities = 21/71 (29%), Positives = 26/71 (36%) Frame = +2 Query: 116 SNPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCP 295 S P L NR TF W + + GFYY D CV C + W ++D Sbjct: 106 SCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNA 165 Query: 296 MALHAVHSPHC 328 H P C Sbjct: 166 FEEHKRFFPQC 176
Score = 33.5 bits (75), Expect = 0.68 Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 1/66 (1%) Frame = +2 Query: 146 RKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSP 322 R TF +W +A + E NGF+ TG E C C + + W D H SP Sbjct: 12 RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSP 71 Query: 323 HCSFVM 340 CS V+ Sbjct: 72 ICSMVL 77
>sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2) Length = 612 Score = 51.2 bits (121), Expect = 3e-06 Identities = 27/70 (38%), Positives = 32/70 (45%), Gaps = 6/70 (8%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV-- 382 GFYYTGV D+ C CGL L W + D P+ H P CSFV + L N+ Sbjct: 71 GFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLSASLQSPSKNMSP 130 Query: 383 ----FKHMKP 400 F H P Sbjct: 131 VKSRFAHSSP 140
Score = 45.8 bits (107), Expect = 1e-04 Identities = 30/113 (26%), Positives = 44/113 (38%), Gaps = 11/113 (9%) Frame = +2 Query: 128 LANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALH 307 ++ + R T++ W + GFYY G D C CG L W D M+ H Sbjct: 174 MSTEEARFLTYSMWPLSFLSPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH 233 Query: 308 AVHSPHCSFVMGIE----------ILDLHKDRLNVFKHMKPTTS-QIETISSS 433 H PHC F+ + H RL F + P+ Q E ++S+ Sbjct: 234 RRHFPHCPFLENTSETQRFSISNLSMQTHSARLRTFLYWPPSVPVQPEQLASA 286
Score = 39.7 bits (91), Expect = 0.009 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 3/53 (5%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVM---GIEILD 358 GFYY D+ C C GL+ W D P HA P C F++ G E +D Sbjct: 287 GFYYVDRNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVD 339
>sp|Q9QUK4|BIRB_MOUSE Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2) Length = 1447 Score = 50.1 bits (118), Expect = 7e-06 Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 1/81 (1%) Frame = +2 Query: 110 YSSNPFLANADNRKTTFNKW-NKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286 Y ++ AN + R TF W ++ +E + G +YTG D C CG ++ WA Sbjct: 269 YCNDSVFANEELRMDTFKDWPHESPGAVEALVKAGLFYTGKRDIVQCFSCGGCMEKWAEG 328 Query: 287 DCPMALHAVHSPHCSFVMGIE 349 D P+ H P+C F+ ++ Sbjct: 329 DNPIEDHTKFFPNCVFLQTLK 349
Score = 37.0 bits (84), Expect = 0.061 Identities = 18/48 (37%), Positives = 21/48 (43%) Frame = +2 Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337 V + GF +TG D C CG L W D P HA P C F+ Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.9 bits (76), Expect = 0.52 Identities = 18/58 (31%), Positives = 29/58 (50%) Frame = +2 Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV 382 GFY+TGV+ C C L L + P+ H P C F++G ++ ++ K + V Sbjct: 85 GFYHTGVKLGVQCFCCSLILFSTRLRKLPIENHKKLRPECEFLLGKDVGNIGKYDIRV 142
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 90,784,014 Number of Sequences: 369166 Number of extensions: 1918158 Number of successful extensions: 4743 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 4543 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 4742 length of database: 68,354,980 effective HSP length: 108 effective length of database: 48,403,600 effective search space used: 7405750800 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)