Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_P09
(783 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9R0I6|BIRC4_RAT Baculoviral IAP repeat-containing prote... 59 1e-08
sp|P98170|BIRC4_HUMAN Baculoviral IAP repeat-containing pro... 55 2e-07
sp|Q60989|BIRC4_MOUSE Baculoviral IAP repeat-containing pro... 55 2e-07
sp|P41436|IAP_GVCP Apoptosis inhibitor IAP 55 3e-07
sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing pro... 52 1e-06
sp|Q9JIB3|BIR1G_MOUSE Baculoviral IAP repeat-containing pro... 52 1e-06
sp|Q9R016|BIRE_MOUSE Baculoviral IAP repeat-containing prot... 52 1e-06
sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of ap... 52 2e-06
sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing pro... 51 3e-06
sp|Q9QUK4|BIRB_MOUSE Baculoviral IAP repeat-containing prot... 50 7e-06
>sp|Q9R0I6|BIRC4_RAT Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
protein 3) (X-linked inhibitor of apoptosis protein)
(X-linked IAP) (IAP homolog A) (RIAP3) (RIAP-3)
Length = 496
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/81 (39%), Positives = 44/81 (54%), Gaps = 2/81 (2%)
Frame = +2
Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280
IY NP + + + R TF W A+L E+A+ G YYTG++D+ C CG LK W
Sbjct: 153 IYPRNPAMCSEEARLKTFQNWPDYAHLSpreLASA-GLYYTGIDDQVQCFCCGGKLKNWE 211
Query: 281 RDDCPMALHAVHSPHCSFVMG 343
D + H H P+C FV+G
Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/74 (35%), Positives = 34/74 (45%)
Frame = +2
Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298
NP +A D R TF W N ++A GFY G D+ C CG GL W + P
Sbjct: 258 NPAMAEYDARIVTFGTWLYSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 316
Query: 299 ALHAVHSPHCSFVM 340
HA P C +++
Sbjct: 317 EQHAKWYPGCKYLL 330
Score = 37.0 bits (84), Expect = 0.061
Identities = 16/45 (35%), Positives = 20/45 (44%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343
GF YTG D C C + W D + H SP+C F+ G
Sbjct: 51 GFLYTGEGDTVQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFING 95
>sp|P98170|BIRC4_HUMAN Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
protein 3) (X-linked inhibitor of apoptosis protein)
(X-linked IAP) (IAP-like protein) (HILP)
Length = 497
Score = 55.5 bits (132), Expect = 2e-07
Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Frame = +2
Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280
IY NP + + + R +F W A+L E+A+ G YYTG+ D+ C CG LK W
Sbjct: 153 IYPRNPAMYSEEARLKSFQNWPDYAHLTpreLASA-GLYYTGIGDQVQCFCCGGKLKNWE 211
Query: 281 RDDCPMALHAVHSPHCSFVMG 343
D + H H P+C FV+G
Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 46.6 bits (109), Expect = 8e-05
Identities = 25/74 (33%), Positives = 35/74 (47%)
Frame = +2
Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298
NP +A+ + R TF W N ++A GFY G D+ C CG GL W + P
Sbjct: 259 NPSMADYEARIFTFGTWIYSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 317
Query: 299 ALHAVHSPHCSFVM 340
HA P C +++
Sbjct: 318 EQHAKWYPGCKYLL 331
Score = 37.4 bits (85), Expect = 0.047
Identities = 16/45 (35%), Positives = 20/45 (44%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343
GF YTG D C C + W D + H SP+C F+ G
Sbjct: 51 GFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFING 95
>sp|Q60989|BIRC4_MOUSE Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
protein 3) (X-linked inhibitor of apoptosis protein)
(X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3)
Length = 496
Score = 55.1 bits (131), Expect = 2e-07
Identities = 30/81 (37%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Frame = +2
Query: 107 IYSSNPFLANADNRKTTFNKWNKDANLI--EVANQNGFYYTGVEDETICVGCGLGLKAWA 280
IY NP + + + R +F W A+L E+A+ G YYTG +D+ C CG L+ W
Sbjct: 153 IYPRNPAMCSEEARLKSFQNWPDYAHLTpreLASA-GLYYTGADDQVQCFCCGGKLENWE 211
Query: 281 RDDCPMALHAVHSPHCSFVMG 343
D + H H P+C FV+G
Sbjct: 212 PCDRAWSEHRRHFPNCFFVLG 232
Score = 48.9 bits (115), Expect = 2e-05
Identities = 25/74 (33%), Positives = 34/74 (45%)
Frame = +2
Query: 119 NPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298
NP +A + R TF W N ++A GFY G D+ C CG GL W + P
Sbjct: 258 NPAMAEYEARIVTFGTWTSSVNKEQLARA-GFYALGEGDKVKCFHCGGGLTDWKPSEDPW 316
Query: 299 ALHAVHSPHCSFVM 340
HA P C +++
Sbjct: 317 EQHAKWYPGCKYLL 330
Score = 37.4 bits (85), Expect = 0.047
Identities = 16/45 (35%), Positives = 20/45 (44%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMG 343
GF YTG D C C + W D + H SP+C F+ G
Sbjct: 51 GFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFING 95
>sp|P41436|IAP_GVCP Apoptosis inhibitor IAP
Length = 275
Score = 54.7 bits (130), Expect = 3e-07
Identities = 26/69 (37%), Positives = 33/69 (47%)
Frame = +2
Query: 146 RKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPH 325
R TF KW E +NGFYY G DE C C + + W + P A H +P
Sbjct: 10 RLNTFEKWPVSFLSPETMAKNGFYYLGRSDEVRCAFCKVEIMRWKEGEDPAADHKKWAPQ 69
Query: 326 CSFVMGIEI 352
C FV GI++
Sbjct: 70 CPFVKGIDV 78
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Frame = +2
Query: 116 SNPFLANADNRKTTFNKWNKDANLI-EVANQNGFYYTGVEDETICVGCGLGLKAWARDDC 292
++P A+ R +F+ W + E GF+YTG D T C C GLK W +D
Sbjct: 101 AHPKYAHEAARVKSFHNWPRCMKQRPEQMADAGFFYTGYGDNTKCFYCDGGLKDWEPEDV 160
Query: 293 PMALHAVHSPHCSFV 337
P H C++V
Sbjct: 161 PWEQHVRWFDRCAYV 175
>sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis
protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF
signaling complex protein 2) (IAP homolog B)
Length = 618
Score = 52.4 bits (124), Expect = 1e-06
Identities = 30/86 (34%), Positives = 37/86 (43%), Gaps = 7/86 (8%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV-- 382
GFYYTGV D+ C CGL L W D P+ H P CSF+ + L N
Sbjct: 71 GFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSP 130
Query: 383 ----FKH-MKPTTSQIETISSSFKSI 445
F H + PT S S+ S+
Sbjct: 131 MRNSFAHSLSPTLEHSSLFSGSYSSL 156
Score = 43.5 bits (101), Expect = 7e-04
Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 4/75 (5%)
Frame = +2
Query: 146 RKTTFNKWNKDANLI-EVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSP 322
R TF W + E GFYY G D+ C C GL+ W D P HA P
Sbjct: 272 RMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFP 331
Query: 323 HCSFVM---GIEILD 358
C F++ G E +D
Sbjct: 332 RCEFLIRMKGQEFVD 346
Score = 43.1 bits (100), Expect = 9e-04
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Frame = +2
Query: 116 SNPF---LANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286
+NP+ ++ + R T++ W + GFYY G D C CG L W
Sbjct: 174 TNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPK 233
Query: 287 DCPMALHAVHSPHCSFV 337
D M+ H H P+C F+
Sbjct: 234 DDAMSEHRRHFPNCPFL 250
>sp|Q9JIB3|BIR1G_MOUSE Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis
inhibitory protein 7)
Length = 1402
Score = 52.4 bits (124), Expect = 1e-06
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Frame = +2
Query: 110 YSSNPFLANADNRKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286
Y ++ AN + R F W +++ + +E + GF+YTG +D C CG L+ WA
Sbjct: 269 YCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEG 328
Query: 287 DCPMALHAVHSPHCSFVMGIE 349
D PM H P C F+ ++
Sbjct: 329 DDPMEDHIKFFPECVFLQTLK 349
Score = 38.1 bits (87), Expect = 0.027
Identities = 18/48 (37%), Positives = 21/48 (43%)
Frame = +2
Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337
V + GF +TG D C CG L W D P HA P C F+
Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.5 bits (75), Expect = 0.67
Identities = 23/76 (30%), Positives = 34/76 (44%)
Frame = +2
Query: 155 TFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSF 334
TF W E+A GFY+TGV+ C C L L + P+ H P C F
Sbjct: 72 TFRSWTPQ----EMAAA-GFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEF 126
Query: 335 VMGIEILDLHKDRLNV 382
+ G ++ ++ K + V
Sbjct: 127 LQGKDVGNIGKYDIRV 142
>sp|Q9R016|BIRE_MOUSE Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis
inhibitory protein 5)
Length = 1403
Score = 52.4 bits (124), Expect = 1e-06
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Frame = +2
Query: 110 YSSNPFLANADNRKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286
Y ++ AN + R F W +++ + +E + GF+YTG +D C CG L+ WA
Sbjct: 269 YCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEG 328
Query: 287 DCPMALHAVHSPHCSFVMGIE 349
D PM H P C F+ ++
Sbjct: 329 DDPMEDHIKFFPECVFLQTLK 349
Score = 38.1 bits (87), Expect = 0.027
Identities = 18/48 (37%), Positives = 21/48 (43%)
Frame = +2
Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337
V + GF +TG D C CG L W D P HA P C F+
Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.5 bits (75), Expect = 0.67
Identities = 23/76 (30%), Positives = 34/76 (44%)
Frame = +2
Query: 155 TFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSF 334
TF W E+A GFY+TGV+ C C L L + P+ H P C F
Sbjct: 72 TFRSWTPQ----EMAAA-GFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEF 126
Query: 335 VMGIEILDLHKDRLNV 382
+ G ++ ++ K + V
Sbjct: 127 LQGKDVGNIGKYDIRV 142
>sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of apoptosis 2) (dIAP2) (DIAP)
(IAP homolog A) (IAP-like protein) (DILP)
Length = 498
Score = 51.6 bits (122), Expect = 2e-06
Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Frame = +2
Query: 122 PFLANADNRKTTFNKWN-KDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPM 298
P A D R TF W + Q G YY + D+ C C +GL++W ++D P
Sbjct: 207 PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPW 266
Query: 299 ALHAVHSPHCSFVM 340
HA SP C FV+
Sbjct: 267 FEHAKWSPKCQFVL 280
Score = 35.8 bits (81), Expect = 0.14
Identities = 21/71 (29%), Positives = 26/71 (36%)
Frame = +2
Query: 116 SNPFLANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCP 295
S P L NR TF W + + GFYY D CV C + W ++D
Sbjct: 106 SCPDLLLEANRLVTFKDWPNPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNA 165
Query: 296 MALHAVHSPHC 328
H P C
Sbjct: 166 FEEHKRFFPQC 176
Score = 33.5 bits (75), Expect = 0.67
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 1/66 (1%)
Frame = +2
Query: 146 RKTTFNKWNKDANL-IEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSP 322
R TF +W +A + E NGF+ TG E C C + + W D H SP
Sbjct: 12 RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSP 71
Query: 323 HCSFVM 340
CS V+
Sbjct: 72 ICSMVL 77
>sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis
protein 2) (MIAP2) (MIAP-2)
Length = 612
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/70 (38%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV-- 382
GFYYTGV D+ C CGL L W + D P+ H P CSFV + L N+
Sbjct: 71 GFYYTGVNDKVKCFCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLSASLQSPSKNMSP 130
Query: 383 ----FKHMKP 400
F H P
Sbjct: 131 VKSRFAHSSP 140
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/113 (26%), Positives = 44/113 (38%), Gaps = 11/113 (9%)
Frame = +2
Query: 128 LANADNRKTTFNKWNKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALH 307
++ + R T++ W + GFYY G D C CG L W D M+ H
Sbjct: 174 MSTEEARFLTYSMWPLSFLSPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH 233
Query: 308 AVHSPHCSFVMGIE----------ILDLHKDRLNVFKHMKPTTS-QIETISSS 433
H PHC F+ + H RL F + P+ Q E ++S+
Sbjct: 234 RRHFPHCPFLENTSETQRFSISNLSMQTHSARLRTFLYWPPSVPVQPEQLASA 286
Score = 39.7 bits (91), Expect = 0.009
Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVM---GIEILD 358
GFYY D+ C C GL+ W D P HA P C F++ G E +D
Sbjct: 287 GFYYVDRNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVD 339
>sp|Q9QUK4|BIRB_MOUSE Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis
inhibitory protein 2)
Length = 1447
Score = 50.1 bits (118), Expect = 7e-06
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Frame = +2
Query: 110 YSSNPFLANADNRKTTFNKW-NKDANLIEVANQNGFYYTGVEDETICVGCGLGLKAWARD 286
Y ++ AN + R TF W ++ +E + G +YTG D C CG ++ WA
Sbjct: 269 YCNDSVFANEELRMDTFKDWPHESPGAVEALVKAGLFYTGKRDIVQCFSCGGCMEKWAEG 328
Query: 287 DCPMALHAVHSPHCSFVMGIE 349
D P+ H P+C F+ ++
Sbjct: 329 DNPIEDHTKFFPNCVFLQTLK 349
Score = 37.0 bits (84), Expect = 0.061
Identities = 18/48 (37%), Positives = 21/48 (43%)
Frame = +2
Query: 194 VANQNGFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFV 337
V + GF +TG D C CG L W D P HA P C F+
Sbjct: 180 VLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFL 227
Score = 33.9 bits (76), Expect = 0.52
Identities = 18/58 (31%), Positives = 29/58 (50%)
Frame = +2
Query: 209 GFYYTGVEDETICVGCGLGLKAWARDDCPMALHAVHSPHCSFVMGIEILDLHKDRLNV 382
GFY+TGV+ C C L L + P+ H P C F++G ++ ++ K + V
Sbjct: 85 GFYHTGVKLGVQCFCCSLILFSTRLRKLPIENHKKLRPECEFLLGKDVGNIGKYDIRV 142
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,357,068
Number of Sequences: 369166
Number of extensions: 1949290
Number of successful extensions: 4839
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4637
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4838
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)