Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00255 (825 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P62333|PRS10_HUMAN 26S protease regulatory subunit S10B ... 461 e-129 sp|O17071|PRS10_CAEEL Probable 26S protease regulatory subu... 433 e-121 sp|O74445|PRS10_SCHPO Probable 26S protease subunit rpt4 406 e-113 sp|P53549|PRS10_YEAST 26S protease subunit RPT4 (26S protea... 392 e-109 sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase (Pr... 248 1e-65 sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase (Pr... 246 4e-65 sp|Q8U4H3|PSMR_PYRFU Proteasome-activating nucleotidase (Pr... 244 2e-64 sp|O26824|PSMR_METTH Proteasome-activating nucleotidase (Pr... 239 9e-63 sp|O57940|PSMR_PYRHO Proteasome-activating nucleotidase (Pr... 238 1e-62 sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase (Pr... 238 1e-62
>sp|P62333|PRS10_HUMAN 26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6) sp|P62335|PRS10_SPETR 26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6) (Conserved ATPase domain protein 44) (CADp44) sp|P62334|PRS10_MOUSE 26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6) Length = 389 Score = 461 bits (1186), Expect = e-129 Identities = 227/266 (85%), Positives = 251/266 (94%) Frame = +1 Query: 28 REKIFNDHKRKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQL 207 R+K D+++KL+EH+EI+ +LKE RE+L++L+K+YEKSENDLKALQSVGQIVG+VLKQL Sbjct: 5 RDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQL 64 Query: 208 TDDHFIVKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSA 387 T++ FIVKA+NGPRYVVGCRR LDKSKLK GTRVALDMTTLTIMRYLpreVDPLVYNMS Sbjct: 65 TEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLpreVDPLVYNMSH 124 Query: 388 EDPGDVNYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLA 567 EDPG+V+Y+ IGGL+EQIRELREVIELPL NPELFQRVGI PPKGCLLYGPPGTGKTLLA Sbjct: 125 EDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLA 184 Query: 568 RAVASQLDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFS 747 RAVASQLD NFLKVVSS IVDKYIGESARLIREMF+YARDH+PC+IFMDEIDAIGGRRFS Sbjct: 185 RAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFS 244 Query: 748 EGTSADREIQRTLMELLNQMDGFDAL 825 EGTSADREIQRTLMELLNQMDGFD L Sbjct: 245 EGTSADREIQRTLMELLNQMDGFDTL 270
>sp|O17071|PRS10_CAEEL Probable 26S protease regulatory subunit S10B Length = 406 Score = 433 bits (1114), Expect = e-121 Identities = 208/269 (77%), Positives = 248/269 (92%) Frame = +1 Query: 19 DSAREKIFNDHKRKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVL 198 + R K N ++RKL E R+IE KLK+ R+K +++K+++KSEND+K+LQSVGQIVG+VL Sbjct: 19 EDERTKALNSYRRKLAECRDIEQKLKDLRKKESEMTKQFDKSENDIKSLQSVGQIVGEVL 78 Query: 199 KQLTDDHFIVKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYN 378 KQL+++ FIVKA+NGPRYVVGCRR+++K +LK GTRV+LDMTTLTIMR LpreVDPLVY Sbjct: 79 KQLSEEKFIVKATNGPRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLpreVDPLVYK 138 Query: 379 MSAEDPGDVNYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKT 558 MS EDPG+++Y+ +GGLAEQIRELREV+ELPL+NPELF+RVGITPPKGCLL+GPPGTGKT Sbjct: 139 MSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKT 198 Query: 559 LLARAVASQLDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGR 738 LLARAVASQLD NFLKVVSS IVDKYIGESAR+IREMF+YARDH+PC++FMDEIDAIGGR Sbjct: 199 LLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGR 258 Query: 739 RFSEGTSADREIQRTLMELLNQMDGFDAL 825 RFSEGTSADREIQRTLMELLNQ+DGFD+L Sbjct: 259 RFSEGTSADREIQRTLMELLNQLDGFDSL 287
>sp|O74445|PRS10_SCHPO Probable 26S protease subunit rpt4 Length = 388 Score = 406 bits (1044), Expect = e-113 Identities = 203/268 (75%), Positives = 231/268 (86%) Frame = +1 Query: 22 SAREKIFNDHKRKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLK 201 S R+ +K L++HRE ++KLK+ R RDL K+Y+K+E+D+K+LQSVGQI+G+VLK Sbjct: 2 SERDTALEKYKSYLLQHREWDSKLKDLRFGNRDLVKKYDKTEDDIKSLQSVGQIIGEVLK 61 Query: 202 QLTDDHFIVKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNM 381 QL + FIVKAS+GPRYVVGCR N+D+S L G RV+LDMTTLTIMR LpreVDPLVYNM Sbjct: 62 QLDSERFIVKASSGPRYVVGCRNNVDQSHLVQGVRVSLDMTTLTIMRILpreVDPLVYNM 121 Query: 382 SAEDPGDVNYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTL 561 S EDPGD+++ +GGL EQIRELREVIELPL NPELF RVGI PPKG LLYGPPGTGKTL Sbjct: 122 SIEDPGDISFAGVGGLNEQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTL 181 Query: 562 LARAVASQLDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRR 741 LARAVA+ L NFLKVVSS IVDKYIGESAR+IREMF YA++HEPCVIFMDEIDAIGGRR Sbjct: 182 LARAVAASLGVNFLKVVSSAIVDKYIGESARIIREMFGYAKEHEPCVIFMDEIDAIGGRR 241 Query: 742 FSEGTSADREIQRTLMELLNQMDGFDAL 825 FSEGTSADREIQRTLMELLNQMDGFD L Sbjct: 242 FSEGTSADREIQRTLMELLNQMDGFDYL 269
>sp|P53549|PRS10_YEAST 26S protease subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit) Length = 437 Score = 392 bits (1007), Expect = e-109 Identities = 187/267 (70%), Positives = 230/267 (86%) Frame = +1 Query: 25 AREKIFNDHKRKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQ 204 A K N KRKL+EHR + +LK+ R+ +RDL K Y+K+END+KALQS+GQ++G+V+K+ Sbjct: 52 AHNKALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKALQSIGQLIGEVMKE 111 Query: 205 LTDDHFIVKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMS 384 L+++ +IVKAS+GPRY+VG R ++D+SKLK G RV LD+TTLTIMR Lpre DPLVYNM+ Sbjct: 112 LSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILpreTDPLVYNMT 171 Query: 385 AEDPGDVNYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLL 564 + + G++ + IGGL EQIRELREVIELPL NPE+FQRVGI PPKG LLYGPPGTGKTLL Sbjct: 172 SFEQGEITFDGIGGLTEQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLL 231 Query: 565 ARAVASQLDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRF 744 A+AVA+ + ANF+ +SGIVDKYIGESAR+IREMF+YA++HEPC+IFMDE+DAIGGRRF Sbjct: 232 AKAVAATIGANFIFSPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRF 291 Query: 745 SEGTSADREIQRTLMELLNQMDGFDAL 825 SEGTSADREIQRTLMELL QMDGFD L Sbjct: 292 SEGTSADREIQRTLMELLTQMDGFDNL 318
>sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 436 Score = 248 bits (634), Expect = 1e-65 Identities = 129/268 (48%), Positives = 180/268 (67%), Gaps = 3/268 (1%) Frame = +1 Query: 31 EKIFNDHKRKLIEHREIETKLKEA---REKLRDLSKEYEKSENDLKALQSVGQIVGDVLK 201 EK+ + +R+ +E+E + E RE+LR EK +DL+ ++ IVG V + Sbjct: 49 EKLRIEARRRKTLEKELEMERDEKAELREELRRKEVMIEKLRSDLQRMKKPPLIVGTVEE 108 Query: 202 QLTDDHFIVKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNM 381 L D IVK+S GP++V +D+++L+ G VAL+ ++ ++ LP E D V M Sbjct: 109 ILDDGRVIVKSSTGPKFVSNVSPTVDRNELEPGANVALNQQSMAVVDVLPSEKDSRVLAM 168 Query: 382 SAEDPGDVNYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTL 561 ++ DV+Y IGGL EQIRE+REV+E PL PELF++VG+ PPKG LLYGPPGTGKTL Sbjct: 169 EVDESPDVSYDDIGGLDEQIREIREVVEKPLKEPELFEKVGVEPPKGVLLYGPPGTGKTL 228 Query: 562 LARAVASQLDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRR 741 LA+AVA+ DA F+++ + +V K+IGE ARL+RE+F AR+ P +IF+DEIDAIG RR Sbjct: 229 LAKAVANHADATFIRLAAPELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIGARR 288 Query: 742 FSEGTSADREIQRTLMELLNQMDGFDAL 825 + TS DRE+QRTL +LL +MDGFD L Sbjct: 289 MRDATSGDREVQRTLTQLLAEMDGFDPL 316
>sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 398 Score = 246 bits (629), Expect = 4e-65 Identities = 128/255 (50%), Positives = 174/255 (68%) Frame = +1 Query: 55 RKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQLTDDHFIVKA 234 R+L E E K E+ E++R +E + ++++ L+S +VG V L D +VK+ Sbjct: 24 RELYRRLEDEKKFIES-ERIR-YEREVRRLRSEVERLRSPPLLVGVVSDILEDGRVVVKS 81 Query: 235 SNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYT 414 S GP++VV + +++ +LK G RVAL+ TL I+ LP DP+VY E+ +V+Y Sbjct: 82 STGPKFVVNTSQYINEEELKPGARVALNQQTLAIVNVLPTSKDPMVYGFEVEEKPEVSYE 141 Query: 415 SIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDA 594 IGGL QI E+RE +ELPLL PELF VGI PPKG LLYGPPGTGKTLLA+AVA+Q A Sbjct: 142 DIGGLDVQIEEIREAVELPLLKPELFAEVGIEPPKGVLLYGPPGTGKTLLAKAVANQTRA 201 Query: 595 NFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFSEGTSADREI 774 F++VV S V KYIGE ARL+RE+F A++ P +IF+DE+DAI RR + TS DRE+ Sbjct: 202 TFIRVVGSEFVQKYIGEGARLVREVFQLAKEKAPSIIFIDELDAIAARRTNSDTSGDREV 261 Query: 775 QRTLMELLNQMDGFD 819 QRT+M+LL ++DGFD Sbjct: 262 QRTMMQLLAELDGFD 276
>sp|Q8U4H3|PSMR_PYRFU Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 396 Score = 244 bits (624), Expect = 2e-64 Identities = 123/255 (48%), Positives = 172/255 (67%) Frame = +1 Query: 55 RKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQLTDDHFIVKA 234 ++ I E++ ++ EA ++ L +E + +++ L+ G V++ L DD IV+ Sbjct: 20 KRRIRQLELQVRMLEADKER--LERELSRLRSEMSRLRQPPAFAGSVIEVLDDDRAIVQN 77 Query: 235 SNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYT 414 NGPR+VV +DKSKL+ GTRVALD T+ I+ LP DP V + +V Y Sbjct: 78 YNGPRFVVRIAPWIDKSKLRPGTRVALDQRTMAIIEILPASKDPAVLGFEVVERPNVTYN 137 Query: 415 SIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDA 594 IGGL +Q++ELRE IELPL +PELF+ VGI PPKG LLYGPPG GKTL+A+A+A +++A Sbjct: 138 DIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKAIAHEVNA 197 Query: 595 NFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFSEGTSADREI 774 F++VV S +V KYIGE ARL+ E+F A++ P +IF+DEIDAIG +R E T +RE+ Sbjct: 198 TFIRVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRLDETTGGEREV 257 Query: 775 QRTLMELLNQMDGFD 819 RTLM+LL +MDGFD Sbjct: 258 NRTLMQLLAEMDGFD 272
>sp|O26824|PSMR_METTH Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 410 Score = 239 bits (609), Expect = 9e-63 Identities = 121/259 (46%), Positives = 177/259 (68%), Gaps = 2/259 (0%) Frame = +1 Query: 52 KRKLI-EHREIET-KLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQLTDDHFI 225 KR L+ + R++E KL E+ R L +E + +++ ++ ++ V + L D Sbjct: 30 KRNLMWKIRKLEKDKLLIENERTR-LDREVKSLRGEIERFRTPPLVIATVTEVLDDHRVA 88 Query: 226 VKASNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDV 405 VK++ GP +V+ R +D+ +L+ G RVAL+ T +I+ LP E DP+V M E+ DV Sbjct: 89 VKSTTGPHFVINYSRFIDRKQLEPGARVALNQQTFSIVDVLPSEKDPVVTGMEVEEKPDV 148 Query: 406 NYTSIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQ 585 +Y IGGL EQ+RE++E +ELPL PELF+++GI PPKG LLYGPPGTGKTLLA+AVA + Sbjct: 149 SYEQIGGLEEQVREVKETVELPLKKPELFEKIGIEPPKGVLLYGPPGTGKTLLAKAVAHE 208 Query: 586 LDANFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFSEGTSAD 765 +A F+K+V+S V KYIGE ARL+R +F A++ P +IF+DEIDA+ +R TS D Sbjct: 209 TNATFIKIVASEFVRKYIGEGARLVRGVFELAKEKSPSIIFIDEIDAVAAKRLKSSTSGD 268 Query: 766 REIQRTLMELLNQMDGFDA 822 RE+QRTLM+LL ++DGF++ Sbjct: 269 REVQRTLMQLLAELDGFES 287
>sp|O57940|PSMR_PYRHO Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 399 Score = 238 bits (608), Expect = 1e-62 Identities = 119/255 (46%), Positives = 171/255 (67%) Frame = +1 Query: 55 RKLIEHREIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQLTDDHFIVKA 234 ++ I E++ ++ EA ++ L +E + +++ L+ G V++ L +D IV+ Sbjct: 23 KRRIRQLELQVRMLEADKER--LERELSRLRSEMSRLRQPPAFAGTVIEVLDEDRAIVQN 80 Query: 235 SNGPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYT 414 NGPR+VV +D+ KL+ GTRVALD T+ ++ LP DP V + +V Y Sbjct: 81 YNGPRFVVRIAPWIDRKKLRPGTRVALDQRTMAVVEILPTSKDPTVLGFEVIERPNVTYN 140 Query: 415 SIGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDA 594 IGGL +Q++ELRE IELPL +PELF+ VGI PPKG LLYGPPG GKTL+A+A+A +++A Sbjct: 141 DIGGLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKALAHEVNA 200 Query: 595 NFLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFSEGTSADREI 774 F++VV S +V KYIGE ARL+ E+F A++ P +IF+DEIDAIG +R E T +RE+ Sbjct: 201 TFIRVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRMDETTGGEREV 260 Query: 775 QRTLMELLNQMDGFD 819 RTLM+LL +MDGFD Sbjct: 261 NRTLMQLLAEMDGFD 275
>sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase (Proteasome regulatory subunit) Length = 393 Score = 238 bits (607), Expect = 1e-62 Identities = 120/251 (47%), Positives = 172/251 (68%) Frame = +1 Query: 73 REIETKLKEAREKLRDLSKEYEKSENDLKALQSVGQIVGDVLKQLTDDHFIVKASNGPRY 252 R +E K+K + ++ +L KE + +++ + S I VL L D +V++S+GP Sbjct: 21 RLLEEKIKSLQIEIENLRKELNYYKAEMEKMLSPPLIEAVVLDVLPDGRVLVRSSSGPNL 80 Query: 253 VVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIGGLA 432 VV ++D+ +K G VAL+ TI+ LP++ DP+V M + +V Y+ IGGL Sbjct: 81 VVNIASHIDQKLIKPGISVALNQRGSTILEVLPQKEDPIVKTMEIIERPNVTYSEIGGLE 140 Query: 433 EQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFLKVV 612 EQIRELREV+ELPL NPE+F+ +G+ PPKG LLYGPPGTGKT+LA+AVA++ +A F+ VV Sbjct: 141 EQIRELREVVELPLKNPEIFREIGVEPPKGVLLYGPPGTGKTMLAKAVATESNAVFIHVV 200 Query: 613 SSGIVDKYIGESARLIREMFSYARDHEPCVIFMDEIDAIGGRRFSEGTSADREIQRTLME 792 +S K++GE AR++RE+F A+ P +IF+DEIDAIG +R GTS +REIQRTLM+ Sbjct: 201 ASEFAQKFVGEGARIVRELFEMAKRKAPSIIFIDEIDAIGAKRIDIGTSGEREIQRTLMQ 260 Query: 793 LLNQMDGFDAL 825 LL ++DGFD L Sbjct: 261 LLAELDGFDPL 271
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 86,517,363 Number of Sequences: 369166 Number of extensions: 1655904 Number of successful extensions: 9606 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 8610 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 9488 length of database: 68,354,980 effective HSP length: 109 effective length of database: 48,218,865 effective search space used: 7956112725 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)