Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_E24
(556 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P62333|PRS10_HUMAN 26S protease regulatory subunit S10B ... 334 1e-91
sp|O17071|PRS10_CAEEL Probable 26S protease regulatory subu... 321 7e-88
sp|O74445|PRS10_SCHPO Probable 26S protease subunit rpt4 304 1e-82
sp|P53549|PRS10_YEAST 26S protease subunit RPT4 (26S protea... 284 1e-76
sp|O26824|PSMR_METTH Proteasome-activating nucleotidase (Pr... 208 8e-54
sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase (Pr... 207 1e-53
sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase (Pr... 202 6e-52
sp|Q8U4H3|PSMR_PYRFU Proteasome-activating nucleotidase (Pr... 202 6e-52
sp|O57940|PSMR_PYRHO Proteasome-activating nucleotidase (Pr... 197 1e-50
sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase (Pr... 196 2e-50
>sp|P62333|PRS10_HUMAN 26S protease regulatory subunit S10B (Proteasome subunit p42)
(Proteasome 26S subunit ATPase 6)
sp|P62335|PRS10_SPETR 26S protease regulatory subunit S10B (Proteasome subunit p42)
(Proteasome 26S subunit ATPase 6) (Conserved ATPase
domain protein 44) (CADp44)
sp|P62334|PRS10_MOUSE 26S protease regulatory subunit S10B (Proteasome subunit p42)
(Proteasome 26S subunit ATPase 6)
Length = 389
Score = 334 bits (856), Expect = 1e-91
Identities = 165/181 (91%), Positives = 173/181 (95%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PRYVVGCRR LDKSKLK GTRVALDMTTLTIMRYLpreVDPLVYNMS EDPG+V+Y+ IG
Sbjct: 77 PRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLpreVDPLVYNMSHEDPGNVSYSEIG 136
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL+EQIRELREVIELPL NPELFQRVGI PPKGCLLYGPPGTGKTLLARAVASQLD NFL
Sbjct: 137 GLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFL 196
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
KVVSS IVDKYIGESARLIREMF+YARDH+PC+IFMD+IDAIGGRRFSEGTSADREIQRT
Sbjct: 197 KVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRT 256
Query: 553 L 555
L
Sbjct: 257 L 257
>sp|O17071|PRS10_CAEEL Probable 26S protease regulatory subunit S10B
Length = 406
Score = 321 bits (823), Expect = 7e-88
Identities = 153/181 (84%), Positives = 173/181 (95%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PRYVVGCRR+++K +LK GTRV+LDMTTLTIMR LpreVDPLVY MS EDPG+++Y+ +G
Sbjct: 94 PRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLpreVDPLVYKMSHEDPGNISYSDVG 153
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GLAEQIRELREV+ELPL+NPELF+RVGITPPKGCLL+GPPGTGKTLLARAVASQLD NFL
Sbjct: 154 GLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFL 213
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
KVVSS IVDKYIGESAR+IREMF+YARDH+PC++FMD+IDAIGGRRFSEGTSADREIQRT
Sbjct: 214 KVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREIQRT 273
Query: 553 L 555
L
Sbjct: 274 L 274
>sp|O74445|PRS10_SCHPO Probable 26S protease subunit rpt4
Length = 388
Score = 304 bits (778), Expect = 1e-82
Identities = 150/181 (82%), Positives = 162/181 (89%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PRYVVGCR N+D+S L G RV+LDMTTLTIMR LpreVDPLVYNMS EDPGD+++ +G
Sbjct: 76 PRYVVGCRNNVDQSHLVQGVRVSLDMTTLTIMRILpreVDPLVYNMSIEDPGDISFAGVG 135
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL EQIRELREVIELPL NPELF RVGI PPKG LLYGPPGTGKTLLARAVA+ L NFL
Sbjct: 136 GLNEQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVAASLGVNFL 195
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
KVVSS IVDKYIGESAR+IREMF YA++HEPCVIFMD+IDAIGGRRFSEGTSADREIQRT
Sbjct: 196 KVVSSAIVDKYIGESARIIREMFGYAKEHEPCVIFMDEIDAIGGRRFSEGTSADREIQRT 255
Query: 553 L 555
L
Sbjct: 256 L 256
>sp|P53549|PRS10_YEAST 26S protease subunit RPT4 (26S protease subunit SUG2) (Proteasomal
cap subunit)
Length = 437
Score = 284 bits (726), Expect = 1e-76
Identities = 136/181 (75%), Positives = 160/181 (88%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PRY+VG R ++D+SKLK G RV LD+TTLTIMR Lpre DPLVYNM++ + G++ + IG
Sbjct: 125 PRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILpreTDPLVYNMTSFEQGEITFDGIG 184
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL EQIRELREVIELPL NPE+FQRVGI PPKG LLYGPPGTGKTLLA+AVA+ + ANF+
Sbjct: 185 GLTEQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFI 244
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
+SGIVDKYIGESAR+IREMF+YA++HEPC+IFMD++DAIGGRRFSEGTSADREIQRT
Sbjct: 245 FSPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSADREIQRT 304
Query: 553 L 555
L
Sbjct: 305 L 305
>sp|O26824|PSMR_METTH Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 410
Score = 208 bits (529), Expect = 8e-54
Identities = 98/183 (53%), Positives = 133/183 (72%)
Frame = +1
Query: 7 TRPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTS 186
T P +V+ R +D+ +L+ G RVAL+ T +I+ LP E DP+V M E+ DV+Y
Sbjct: 93 TGPHFVINYSRFIDRKQLEPGARVALNQQTFSIVDVLPSEKDPVVTGMEVEEKPDVSYEQ 152
Query: 187 IGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDAN 366
IGGL EQ+RE++E +ELPL PELF+++GI PPKG LLYGPPGTGKTLLA+AVA + +A
Sbjct: 153 IGGLEEQVREVKETVELPLKKPELFEKIGIEPPKGVLLYGPPGTGKTLLAKAVAHETNAT 212
Query: 367 FLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQ 546
F+K+V+S V KYIGE ARL+R +F A++ P +IF+D+IDA+ +R TS DRE+Q
Sbjct: 213 FIKIVASEFVRKYIGEGARLVRGVFELAKEKSPSIIFIDEIDAVAAKRLKSSTSGDREVQ 272
Query: 547 RTL 555
RTL
Sbjct: 273 RTL 275
>sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 398
Score = 207 bits (528), Expect = 1e-53
Identities = 101/183 (55%), Positives = 131/183 (71%)
Frame = +1
Query: 7 TRPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTS 186
T P++VV + +++ +LK G RVAL+ TL I+ LP DP+VY E+ +V+Y
Sbjct: 83 TGPKFVVNTSQYINEEELKPGARVALNQQTLAIVNVLPTSKDPMVYGFEVEEKPEVSYED 142
Query: 187 IGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDAN 366
IGGL QI E+RE +ELPLL PELF VGI PPKG LLYGPPGTGKTLLA+AVA+Q A
Sbjct: 143 IGGLDVQIEEIREAVELPLLKPELFAEVGIEPPKGVLLYGPPGTGKTLLAKAVANQTRAT 202
Query: 367 FLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQ 546
F++VV S V KYIGE ARL+RE+F A++ P +IF+D++DAI RR + TS DRE+Q
Sbjct: 203 FIRVVGSEFVQKYIGEGARLVREVFQLAKEKAPSIIFIDELDAIAARRTNSDTSGDREVQ 262
Query: 547 RTL 555
RT+
Sbjct: 263 RTM 265
>sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 436
Score = 202 bits (513), Expect = 6e-52
Identities = 96/183 (52%), Positives = 132/183 (72%)
Frame = +1
Query: 7 TRPRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTS 186
T P++V +D+++L+ G VAL+ ++ ++ LP E D V M ++ DV+Y
Sbjct: 121 TGPKFVSNVSPTVDRNELEPGANVALNQQSMAVVDVLPSEKDSRVLAMEVDESPDVSYDD 180
Query: 187 IGGLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDAN 366
IGGL EQIRE+REV+E PL PELF++VG+ PPKG LLYGPPGTGKTLLA+AVA+ DA
Sbjct: 181 IGGLDEQIREIREVVEKPLKEPELFEKVGVEPPKGVLLYGPPGTGKTLLAKAVANHADAT 240
Query: 367 FLKVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQ 546
F+++ + +V K+IGE ARL+RE+F AR+ P +IF+D+IDAIG RR + TS DRE+Q
Sbjct: 241 FIRLAAPELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIGARRMRDATSGDREVQ 300
Query: 547 RTL 555
RTL
Sbjct: 301 RTL 303
>sp|Q8U4H3|PSMR_PYRFU Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 396
Score = 202 bits (513), Expect = 6e-52
Identities = 98/181 (54%), Positives = 129/181 (71%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PR+VV +DKSKL+ GTRVALD T+ I+ LP DP V + +V Y IG
Sbjct: 81 PRFVVRIAPWIDKSKLRPGTRVALDQRTMAIIEILPASKDPAVLGFEVVERPNVTYNDIG 140
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL +Q++ELRE IELPL +PELF+ VGI PPKG LLYGPPG GKTL+A+A+A +++A F+
Sbjct: 141 GLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKAIAHEVNATFI 200
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
+VV S +V KYIGE ARL+ E+F A++ P +IF+D+IDAIG +R E T +RE+ RT
Sbjct: 201 RVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRLDETTGGEREVNRT 260
Query: 553 L 555
L
Sbjct: 261 L 261
>sp|O57940|PSMR_PYRHO Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 399
Score = 197 bits (502), Expect = 1e-50
Identities = 95/181 (52%), Positives = 128/181 (70%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
PR+VV +D+ KL+ GTRVALD T+ ++ LP DP V + +V Y IG
Sbjct: 84 PRFVVRIAPWIDRKKLRPGTRVALDQRTMAVVEILPTSKDPTVLGFEVIERPNVTYNDIG 143
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL +Q++ELRE IELPL +PELF+ VGI PPKG LLYGPPG GKTL+A+A+A +++A F+
Sbjct: 144 GLKKQLQELREAIELPLKHPELFEEVGIDPPKGVLLYGPPGCGKTLMAKALAHEVNATFI 203
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
+VV S +V KYIGE ARL+ E+F A++ P +IF+D+IDAIG +R E T +RE+ RT
Sbjct: 204 RVVGSELVRKYIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRMDETTGGEREVNRT 263
Query: 553 L 555
L
Sbjct: 264 L 264
>sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase (Proteasome regulatory subunit)
Length = 393
Score = 196 bits (499), Expect = 2e-50
Identities = 95/181 (52%), Positives = 130/181 (71%)
Frame = +1
Query: 13 PRYVVGCRRNLDKSKLKAGTRVALDMTTLTIMRYLpreVDPLVYNMSAEDPGDVNYTSIG 192
P VV ++D+ +K G VAL+ TI+ LP++ DP+V M + +V Y+ IG
Sbjct: 78 PNLVVNIASHIDQKLIKPGISVALNQRGSTILEVLPQKEDPIVKTMEIIERPNVTYSEIG 137
Query: 193 GLAEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFL 372
GL EQIRELREV+ELPL NPE+F+ +G+ PPKG LLYGPPGTGKT+LA+AVA++ +A F+
Sbjct: 138 GLEEQIRELREVVELPLKNPEIFREIGVEPPKGVLLYGPPGTGKTMLAKAVATESNAVFI 197
Query: 373 KVVSSGIVDKYIGESARLIREMFSYARDHEPCVIFMDDIDAIGGRRFSEGTSADREIQRT 552
VV+S K++GE AR++RE+F A+ P +IF+D+IDAIG +R GTS +REIQRT
Sbjct: 198 HVVASEFAQKFVGEGARIVRELFEMAKRKAPSIIFIDEIDAIGAKRIDIGTSGEREIQRT 257
Query: 553 L 555
L
Sbjct: 258 L 258
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,636,771
Number of Sequences: 369166
Number of extensions: 1178374
Number of successful extensions: 6445
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5890
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6378
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3931403200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)