Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00137 (440 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 66 4e-11 sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 65 7e-11 sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 62 4e-10 sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 61 1e-09 sp|P81015|GRN3_CYPCA Granulin-3 54 1e-07 sp|P81014|GRN2_CYPCA Granulin-2 54 1e-07 sp|P81013|GRN1_CYPCA Granulin-1 54 2e-07 sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 52 7e-07 sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 51 1e-06 sp|P25776|ORYA_ORYSA Oryzain alpha chain precursor 46 3e-05
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Length = 593 Score = 65.9 bits (159), Expect = 4e-11 Identities = 24/49 (48%), Positives = 29/49 (59%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C + CP +CC L +G +GCCP P VCC D + CC QGY CV G Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG 414
Score = 60.8 bits (146), Expect = 1e-09 Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%) Frame = +1 Query: 193 RFGNKYV----CPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 R GN V CPD CP + +CC++++G +GCCP P CC DR CC G C Sbjct: 115 RSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 58.2 bits (139), Expect = 8e-09 Identities = 24/63 (38%), Positives = 30/63 (47%) Frame = +1 Query: 160 VEKIPISELLLRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQG 339 +EK+P L C CP Q+CC + G + CC P VCC DR+ CC G Sbjct: 426 LEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAG 485 Query: 340 YRC 348 Y C Sbjct: 486 YTC 488
Score = 56.6 bits (135), Expect = 2e-08 Identities = 22/47 (46%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Frame = +1 Query: 211 VCPDG-GHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 +CPD CP +CC L +G+YGCCP P CC D CC Q C Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 55.8 bits (133), Expect = 4e-08 Identities = 21/49 (42%), Positives = 27/49 (55%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C +G C Q+CC + CCP+ GVCC DR+ CC G+RC G Sbjct: 521 CGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
Score = 53.1 bits (126), Expect = 3e-07 Identities = 19/39 (48%), Positives = 23/39 (58%) Frame = +1 Query: 232 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 CP +CC L +G +GCCPF VCC D CC G+ C Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTC 328
Score = 51.2 bits (121), Expect = 1e-06 Identities = 20/51 (39%), Positives = 24/51 (47%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCS 366 C HC SC ++G CCPFP V C D CC +G+ C G S Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRS 111
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B) (Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Length = 588 Score = 65.1 bits (157), Expect = 7e-11 Identities = 24/53 (45%), Positives = 31/53 (58%) Frame = +1 Query: 202 NKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 N C D CP +CC L +G +GCCP P VCC D + CC QG++C+ G Sbjct: 359 NDVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEG 411
Score = 59.7 bits (143), Expect = 3e-09 Identities = 24/63 (38%), Positives = 32/63 (50%) Frame = +1 Query: 160 VEKIPISELLLRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQG 339 +EK+P+ + L C CP Q+CC + G + CC P VCC DR+ CC G Sbjct: 423 LEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAG 482 Query: 340 YRC 348 Y C Sbjct: 483 YTC 485
Score = 57.8 bits (138), Expect = 1e-08 Identities = 23/47 (48%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Frame = +1 Query: 211 VCPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 VCPD CP +CC L G+YGCCP P +CC D CC Q C Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 57.0 bits (136), Expect = 2e-08 Identities = 21/50 (42%), Positives = 29/50 (58%) Frame = +1 Query: 199 GNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 G+++ CPD +CC++I+G +GCCP P CC DR CC G C Sbjct: 127 GSQFECPDSA------TCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 54.7 bits (130), Expect = 9e-08 Identities = 23/56 (41%), Positives = 30/56 (53%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCST*KIN 381 C HCP SC L ++G CCPF GV C D + CC +G+ C G S +I+ Sbjct: 61 CQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQIS 116
Score = 54.3 bits (129), Expect = 1e-07 Identities = 21/49 (42%), Positives = 26/49 (53%) Frame = +1 Query: 202 NKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 N+ C CP +CC L G +GCCPF VCC D CC G++C Sbjct: 277 NEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQC 325
Score = 53.9 bits (128), Expect = 2e-07 Identities = 25/60 (41%), Positives = 30/60 (50%), Gaps = 3/60 (5%) Frame = +1 Query: 190 LRFGNKY---VCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 L FG+K C G C QSCC G + CCP+ GVCC D + CC G+ C G Sbjct: 505 LTFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKG 564
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Granulin 1; Granulin 2; Granulin 3; Granulin 4; Granulin 5; Granulin 6; Granulin 7] Length = 589 Score = 62.4 bits (150), Expect = 4e-10 Identities = 23/49 (46%), Positives = 29/49 (59%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C D CP +CC L +G +GCCP P VCC D + CC QG+ C+ G Sbjct: 364 CDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG 412
Score = 58.5 bits (140), Expect = 6e-09 Identities = 24/51 (47%), Positives = 27/51 (52%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCS 366 C GHCP SC L ++G CCPF GV C D CC QG+ C G S Sbjct: 61 CQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKS 111
Score = 57.8 bits (138), Expect = 1e-08 Identities = 23/47 (48%), Positives = 26/47 (55%), Gaps = 1/47 (2%) Frame = +1 Query: 211 VCPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 VCPD CP +CC L G+YGCCP P +CC D CC Q C Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 56.6 bits (135), Expect = 2e-08 Identities = 20/50 (40%), Positives = 29/50 (58%) Frame = +1 Query: 199 GNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 G+++ CPD +CC++++G +GCCP P CC DR CC G C Sbjct: 127 GSQFECPDSA------TCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 56.2 bits (134), Expect = 3e-08 Identities = 26/64 (40%), Positives = 34/64 (53%), Gaps = 1/64 (1%) Frame = +1 Query: 160 VEKIPISELL-LRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQ 336 +EKIP + L+ G+ C CP Q+CC + G + CC P VCC DR+ CC Sbjct: 424 LEKIPARQTTPLQIGD-IGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPA 482 Query: 337 GYRC 348 GY C Sbjct: 483 GYTC 486
Score = 53.1 bits (126), Expect = 3e-07 Identities = 19/39 (48%), Positives = 23/39 (58%) Frame = +1 Query: 232 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 CP +CC L G +GCCPF VCC D CC G++C Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQC 326
Score = 51.6 bits (122), Expect = 7e-07 Identities = 20/49 (40%), Positives = 26/49 (53%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C +G C Q+CC G + CCP+ GVCC D + CC G+ C G Sbjct: 517 CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARG 565
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7] Length = 591 Score = 60.8 bits (146), Expect = 1e-09 Identities = 23/47 (48%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Frame = +1 Query: 211 VCPDG-GHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 +CPD CP +CCLL +G YGCCP P +CC D CC Q C Sbjct: 207 ICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 60.8 bits (146), Expect = 1e-09 Identities = 22/45 (48%), Positives = 28/45 (62%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 C CP Q+CC L +G++GCCPFP VCC D CC + +RC Sbjct: 283 CDQEVSCPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRC 327
Score = 56.6 bits (135), Expect = 2e-08 Identities = 21/46 (45%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Frame = +1 Query: 214 CPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 CP G CP +CC +++G +GCCP P CC DR CC G C Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 54.7 bits (130), Expect = 9e-08 Identities = 21/49 (42%), Positives = 26/49 (53%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C D C Q+CC G + CCPF GVCC D++ CC G+ C G Sbjct: 518 CGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQG 566
Score = 52.8 bits (125), Expect = 3e-07 Identities = 19/45 (42%), Positives = 23/45 (51%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 C CP Q+CC + G + CC P VCC D + CC GY C Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 44.7 bits (104), Expect = 9e-05 Identities = 18/49 (36%), Positives = 21/49 (42%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 360 C +CP SC L G CCPF + C D CC G+ C G Sbjct: 47 CQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
Score = 32.7 bits (73), Expect = 0.36 Identities = 16/47 (34%), Positives = 21/47 (44%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVP 354 C + C CC L +G +GCCP G C + C+ G R P Sbjct: 378 CDEVVSCRPGNICCRLASGEWGCCPSSEGYLCMAGER-CQVGDRLAP 423
>sp|P81015|GRN3_CYPCA Granulin-3 Length = 57 Score = 54.3 bits (129), Expect = 1e-07 Identities = 21/45 (46%), Positives = 25/45 (55%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 C G CP +CC G + CCPF +G CC D + CCR GY C Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
>sp|P81014|GRN2_CYPCA Granulin-2 Length = 57 Score = 54.3 bits (129), Expect = 1e-07 Identities = 20/39 (51%), Positives = 24/39 (61%) Frame = +1 Query: 232 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 CP +CC G + CCPF +G CC D + CCR GYRC Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P81013|GRN1_CYPCA Granulin-1 Length = 57 Score = 53.9 bits (128), Expect = 2e-07 Identities = 22/46 (47%), Positives = 26/46 (56%) Frame = +1 Query: 211 VCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 +CPDG +CCL G + CCPF +G CC D CCR GY C Sbjct: 9 ICPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 Length = 46 Score = 51.6 bits (122), Expect = 7e-07 Identities = 18/43 (41%), Positives = 24/43 (55%) Frame = +1 Query: 214 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGY 342 C +G C Q+CC G CCP+ GVCC D++ CC G+ Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1) Length = 54 Score = 51.2 bits (121), Expect = 1e-06 Identities = 19/39 (48%), Positives = 22/39 (56%) Frame = +1 Query: 232 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 348 CPG ++CC G GCCP+ GVCC D CC G C Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P25776|ORYA_ORYSA Oryzain alpha chain precursor Length = 458 Score = 46.2 bits (108), Expect = 3e-05 Identities = 21/51 (41%), Positives = 23/51 (45%), Gaps = 4/51 (7%) Frame = +1 Query: 202 NKYVCPDGGHCPGYQSCCLLINGRY----GCCPFPLGVCCPDRKSCCRQGY 342 N Y CPD C CC+ G+Y GCCP CC D SCC Y Sbjct: 369 NYYTCPDSTTC-----CCIYEYGKYCYAWGCCPLEGATCCDDHYSCCPHEY 414
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 49,415,046 Number of Sequences: 369166 Number of extensions: 1089698 Number of successful extensions: 3219 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 2958 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3182 length of database: 68,354,980 effective HSP length: 100 effective length of database: 49,881,480 effective search space used: 2294548080 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)