Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_A22
(429 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 66 3e-11
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 65 6e-11
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 62 4e-10
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 61 1e-09
sp|P81015|GRN3_CYPCA Granulin-3 54 1e-07
sp|P81014|GRN2_CYPCA Granulin-2 54 1e-07
sp|P81013|GRN1_CYPCA Granulin-1 54 1e-07
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 52 7e-07
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 51 9e-07
sp|P25776|ORYA_ORYSA Oryzain alpha chain precursor 46 3e-05
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 65.9 bits (159), Expect = 3e-11
Identities = 24/49 (48%), Positives = 29/49 (59%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C + CP +CC L +G +GCCP P VCC D + CC QGY CV G
Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG 414
Score = 60.8 bits (146), Expect = 1e-09
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 5/57 (8%)
Frame = +3
Query: 189 RFGNKYV----CPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
R GN V CPD CP + +CC++++G +GCCP P CC DR CC G C
Sbjct: 115 RSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 58.2 bits (139), Expect = 7e-09
Identities = 24/63 (38%), Positives = 30/63 (47%)
Frame = +3
Query: 156 VEKIPISELLLRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQG 335
+EK+P L C CP Q+CC + G + CC P VCC DR+ CC G
Sbjct: 426 LEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAG 485
Query: 336 YRC 344
Y C
Sbjct: 486 YTC 488
Score = 56.6 bits (135), Expect = 2e-08
Identities = 22/47 (46%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 207 VCPDG-GHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
+CPD CP +CC L +G+YGCCP P CC D CC Q C
Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 55.8 bits (133), Expect = 4e-08
Identities = 21/49 (42%), Positives = 27/49 (55%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C +G C Q+CC + CCP+ GVCC DR+ CC G+RC G
Sbjct: 521 CGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
Score = 53.1 bits (126), Expect = 2e-07
Identities = 19/39 (48%), Positives = 23/39 (58%)
Frame = +3
Query: 228 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
CP +CC L +G +GCCPF VCC D CC G+ C
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTC 328
Score = 51.2 bits (121), Expect = 9e-07
Identities = 20/51 (39%), Positives = 24/51 (47%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCS 362
C HC SC ++G CCPFP V C D CC +G+ C G S
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRS 111
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 65.1 bits (157), Expect = 6e-11
Identities = 24/53 (45%), Positives = 31/53 (58%)
Frame = +3
Query: 198 NKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
N C D CP +CC L +G +GCCP P VCC D + CC QG++C+ G
Sbjct: 359 NDVPCDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEG 411
Score = 59.7 bits (143), Expect = 2e-09
Identities = 24/63 (38%), Positives = 32/63 (50%)
Frame = +3
Query: 156 VEKIPISELLLRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQG 335
+EK+P+ + L C CP Q+CC + G + CC P VCC DR+ CC G
Sbjct: 423 LEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAG 482
Query: 336 YRC 344
Y C
Sbjct: 483 YTC 485
Score = 57.8 bits (138), Expect = 9e-09
Identities = 23/47 (48%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 207 VCPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
VCPD CP +CC L G+YGCCP P +CC D CC Q C
Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 57.0 bits (136), Expect = 2e-08
Identities = 21/50 (42%), Positives = 29/50 (58%)
Frame = +3
Query: 195 GNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
G+++ CPD +CC++I+G +GCCP P CC DR CC G C
Sbjct: 127 GSQFECPDSA------TCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 54.7 bits (130), Expect = 8e-08
Identities = 23/56 (41%), Positives = 30/56 (53%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCST*KIN 377
C HCP SC L ++G CCPF GV C D + CC +G+ C G S +I+
Sbjct: 61 CQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQIS 116
Score = 54.3 bits (129), Expect = 1e-07
Identities = 21/49 (42%), Positives = 26/49 (53%)
Frame = +3
Query: 198 NKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
N+ C CP +CC L G +GCCPF VCC D CC G++C
Sbjct: 277 NEVKCDLEVSCPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQC 325
Score = 53.9 bits (128), Expect = 1e-07
Identities = 25/60 (41%), Positives = 30/60 (50%), Gaps = 3/60 (5%)
Frame = +3
Query: 186 LRFGNKY---VCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
L FG+K C G C QSCC G + CCP+ GVCC D + CC G+ C G
Sbjct: 505 LTFGSKVGNVECGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKG 564
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 62.4 bits (150), Expect = 4e-10
Identities = 23/49 (46%), Positives = 29/49 (59%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C D CP +CC L +G +GCCP P VCC D + CC QG+ C+ G
Sbjct: 364 CDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG 412
Score = 58.5 bits (140), Expect = 6e-09
Identities = 24/51 (47%), Positives = 27/51 (52%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGGCS 362
C GHCP SC L ++G CCPF GV C D CC QG+ C G S
Sbjct: 61 CQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKS 111
Score = 57.8 bits (138), Expect = 9e-09
Identities = 23/47 (48%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +3
Query: 207 VCPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
VCPD CP +CC L G+YGCCP P +CC D CC Q C
Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 56.6 bits (135), Expect = 2e-08
Identities = 20/50 (40%), Positives = 29/50 (58%)
Frame = +3
Query: 195 GNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
G+++ CPD +CC++++G +GCCP P CC DR CC G C
Sbjct: 127 GSQFECPDSA------TCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 56.2 bits (134), Expect = 3e-08
Identities = 26/64 (40%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Frame = +3
Query: 156 VEKIPISELL-LRFGNKYVCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQ 332
+EKIP + L+ G+ C CP Q+CC + G + CC P VCC DR+ CC
Sbjct: 424 LEKIPARQTTPLQIGD-IGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPA 482
Query: 333 GYRC 344
GY C
Sbjct: 483 GYTC 486
Score = 53.1 bits (126), Expect = 2e-07
Identities = 19/39 (48%), Positives = 23/39 (58%)
Frame = +3
Query: 228 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
CP +CC L G +GCCPF VCC D CC G++C
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQC 326
Score = 51.6 bits (122), Expect = 7e-07
Identities = 20/49 (40%), Positives = 26/49 (53%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C +G C Q+CC G + CCP+ GVCC D + CC G+ C G
Sbjct: 517 CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARG 565
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 60.8 bits (146), Expect = 1e-09
Identities = 23/47 (48%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Frame = +3
Query: 207 VCPDG-GHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
+CPD CP +CCLL +G YGCCP P +CC D CC Q C
Sbjct: 207 ICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 60.8 bits (146), Expect = 1e-09
Identities = 22/45 (48%), Positives = 28/45 (62%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
C CP Q+CC L +G++GCCPFP VCC D CC + +RC
Sbjct: 283 CDQEVSCPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRC 327
Score = 56.6 bits (135), Expect = 2e-08
Identities = 21/46 (45%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Frame = +3
Query: 210 CPDGG-HCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
CP G CP +CC +++G +GCCP P CC DR CC G C
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 54.7 bits (130), Expect = 8e-08
Identities = 21/49 (42%), Positives = 26/49 (53%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C D C Q+CC G + CCPF GVCC D++ CC G+ C G
Sbjct: 518 CGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQG 566
Score = 52.8 bits (125), Expect = 3e-07
Identities = 19/45 (42%), Positives = 23/45 (51%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
C CP Q+CC + G + CC P VCC D + CC GY C
Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 44.7 bits (104), Expect = 8e-05
Identities = 18/49 (36%), Positives = 21/49 (42%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVPGG 356
C +CP SC L G CCPF + C D CC G+ C G
Sbjct: 47 CQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
Score = 32.7 bits (73), Expect = 0.33
Identities = 16/47 (34%), Positives = 21/47 (44%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRCVP 350
C + C CC L +G +GCCP G C + C+ G R P
Sbjct: 378 CDEVVSCRPGNICCRLASGEWGCCPSSEGYLCMAGER-CQVGDRLAP 423
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 54.3 bits (129), Expect = 1e-07
Identities = 21/45 (46%), Positives = 25/45 (55%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
C G CP +CC G + CCPF +G CC D + CCR GY C
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 54.3 bits (129), Expect = 1e-07
Identities = 20/39 (51%), Positives = 24/39 (61%)
Frame = +3
Query: 228 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
CP +CC G + CCPF +G CC D + CCR GYRC
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 53.9 bits (128), Expect = 1e-07
Identities = 22/46 (47%), Positives = 26/46 (56%)
Frame = +3
Query: 207 VCPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
+CPDG +CCL G + CCPF +G CC D CCR GY C
Sbjct: 9 ICPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 51.6 bits (122), Expect = 7e-07
Identities = 18/43 (41%), Positives = 24/43 (55%)
Frame = +3
Query: 210 CPDGGHCPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGY 338
C +G C Q+CC G CCP+ GVCC D++ CC G+
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 51.2 bits (121), Expect = 9e-07
Identities = 19/39 (48%), Positives = 22/39 (56%)
Frame = +3
Query: 228 CPGYQSCCLLINGRYGCCPFPLGVCCPDRKSCCRQGYRC 344
CPG ++CC G GCCP+ GVCC D CC G C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P25776|ORYA_ORYSA Oryzain alpha chain precursor
Length = 458
Score = 46.2 bits (108), Expect = 3e-05
Identities = 21/51 (41%), Positives = 23/51 (45%), Gaps = 4/51 (7%)
Frame = +3
Query: 198 NKYVCPDGGHCPGYQSCCLLINGRY----GCCPFPLGVCCPDRKSCCRQGY 338
N Y CPD C CC+ G+Y GCCP CC D SCC Y
Sbjct: 369 NYYTCPDSTTC-----CCIYEYGKYCYAWGCCPLEGATCCDDHYSCCPHEY 414
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,747,406
Number of Sequences: 369166
Number of extensions: 1079151
Number of successful extensions: 3102
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2844
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3065
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2095022160
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)