DrC_00134
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00134 (1360 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) 137 6e-32 sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) 137 6e-32 sp|Q920Q6|MSI2H_MOUSE RNA-binding protein Musashi homolog 2... 66 3e-10 sp|Q96DH6|MSI2H_HUMAN RNA-binding protein Musashi homolog 2... 63 2e-09 sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotei... 60 2e-08 sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotei... 60 2e-08 sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotei... 59 2e-08 sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotei... 59 2e-08 sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoprotei... 59 3e-08 sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoprotei... 59 3e-08
>sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) Length = 414 Score = 137 bits (346), Expect = 6e-32 Identities = 64/130 (49%), Positives = 90/130 (69%) Frame = +1 Query: 19 ETSHSKGYAFIRFADYGAQVLCLAEKHLIDGRWCAVKVPFSKNEADKQEISKKIHVGYAS 198 +T HSKG+ F+RF +Y QV ++++H+IDGRWC K+P SK D+ S+K+ VG + Sbjct: 140 KTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCT 199 Query: 199 EDISMEDLRMAFEQYGYVTDIFIPKPFRNFAFVTFDSSDTAQSLIGQSINVNGHTLTIGS 378 ED++ E+L+ F QYG V D+FIPKPFR FAFVTF AQSL G+ + + G ++ I + Sbjct: 200 EDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISN 259 Query: 379 AVPKINSNRK 408 A PK NSNR+ Sbjct: 260 AEPKHNSNRQ 269
>sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) Length = 414 Score = 137 bits (346), Expect = 6e-32 Identities = 64/130 (49%), Positives = 90/130 (69%) Frame = +1 Query: 19 ETSHSKGYAFIRFADYGAQVLCLAEKHLIDGRWCAVKVPFSKNEADKQEISKKIHVGYAS 198 +T HSKG+ F+RF +Y QV ++++H+IDGRWC K+P SK D+ S+K+ VG + Sbjct: 140 KTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCT 199 Query: 199 EDISMEDLRMAFEQYGYVTDIFIPKPFRNFAFVTFDSSDTAQSLIGQSINVNGHTLTIGS 378 ED++ ++LR F QYG V D+FIPKPFR FAFVTF AQSL G+ + + G ++ I + Sbjct: 200 EDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISN 259 Query: 379 AVPKINSNRK 408 A PK NSNR+ Sbjct: 260 AEPKHNSNRQ 269
>sp|Q920Q6|MSI2H_MOUSE RNA-binding protein Musashi homolog 2 (Musashi-2) Length = 346 Score = 65.9 bits (159), Expect = 3e-10 Identities = 77/274 (28%), Positives = 111/274 (40%), Gaps = 34/274 (12%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCLAEKHL-IDGRWCAVKVPFSKNEADKQEI-SKKIHVGYA 195 T S+G+ F+ FAD + L + H +D + KV F + K +KKI VG Sbjct: 58 TKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGL 117 Query: 196 SEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-VNG 357 S + +ED++ FEQ+G V D + R F FVTF++ D + + + +N Sbjct: 118 SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINN 177 Query: 358 HTLTIGSAVPK-------INSNRKGMPGHYPMYSNDNSMQTQAYQT------RYAPGMIP 498 + A PK +G+P Y M + M Y R PG P Sbjct: 178 KMVECKKAQPKEVMFPPGTRGRARGLP--YTMDAFMLGMGMLGYPNFVATYGRGYPGFAP 235 Query: 499 TYGAAWP----PSYDMAAAQKVARV-NSNNNPYNAYPGLLTGQTYVMSNGSRAG--QEAL 657 +YG +P +Y AA VA S N Y+A P + SN +R G A Sbjct: 236 SYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGAN 295 Query: 658 QQG------GYANQDMMHQNYMNQYSANDPSQHG 741 G G A+QD NY++ S S G Sbjct: 296 SPGPVADLYGPASQDSGVGNYISAASPQPGSGFG 329
>sp|Q96DH6|MSI2H_HUMAN RNA-binding protein Musashi homolog 2 (Musashi-2) Length = 328 Score = 62.8 bits (151), Expect = 2e-09 Identities = 73/266 (27%), Positives = 107/266 (40%), Gaps = 26/266 (9%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCLAEKHL-IDGRWCAVKVPFSKNEADKQEI-SKKIHVGYA 195 T S+G+ F+ FAD + L + H +D + KV F + K +KKI VG Sbjct: 58 TKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGL 117 Query: 196 SEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-VNG 357 S + +ED++ FEQ+G V D + R F FVTF++ D + + + +N Sbjct: 118 SANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINN 177 Query: 358 HTLTIGSAVPK-------INSNRKGMPGHYPMYSNDNSMQTQAYQT------RYAPGMIP 498 + A PK +G+P Y M + M Y R PG P Sbjct: 178 KMVECKKAQPKEVMFPPGTRGRARGLP--YTMDAFMLGMGMLGYPNFVATYGRGYPGFAP 235 Query: 499 TYGAAWP----PSYDMAAAQKVARV-NSNNNPYNAYPGLLTGQTYVMSNGSRAGQEALQQ 663 +YG +P +Y AA VA S +NP A PG G+ + Sbjct: 236 SYGYQFPGFPAAAYGPVAAAAVAAARGSGSNP--ARPGGFP--------GANSPGPVADL 285 Query: 664 GGYANQDMMHQNYMNQYSANDPSQHG 741 G A+QD NY++ S S G Sbjct: 286 YGPASQDSGVGNYISAASPQPGSGFG 311
>sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) Length = 378 Score = 59.7 bits (143), Expect = 2e-08 Identities = 43/135 (31%), Positives = 66/135 (48%), Gaps = 11/135 (8%) Frame = +1 Query: 19 ETSHSKGYAFIRFA--DYGAQVLCLAEKHLIDGRWCAVKVPFSKNEADKQEIS---KKIH 183 +T S+G+ F+ ++ + +C A H +DGR K S+ ++ K KKI Sbjct: 71 QTKRSRGFGFVTYSCVEEVDAAMC-ARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIF 129 Query: 184 VGYASEDISMEDLRMAFEQYGYVTDIFIPKPF-----RNFAFVTFDSSDTAQSLIGQSIN 348 VG ED +LR FE+YG + I + + R FAFVTFD DT ++ Q + Sbjct: 130 VGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYH 189 Query: 349 -VNGHTLTIGSAVPK 390 +NGH + A+ K Sbjct: 190 TINGHNCEVKKALSK 204
Score = 31.6 bits (70), Expect = 5.6
Identities = 23/95 (24%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Frame = +1
Query: 145 NEADKQEISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDS 309
++ + E +K+ +G S + + + LR FE++G +TD + K R F FVT+
Sbjct: 26 HDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSC 85
Query: 310 -SDTAQSLIGQSINVNGHTLTIGSAVPKINSNRKG 411
+ ++ + V+G + AV + +S + G
Sbjct: 86 VEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPG 120
>sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) sp|Q6URK4|ROA3_RAT Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) Length = 379 Score = 59.7 bits (143), Expect = 2e-08 Identities = 43/135 (31%), Positives = 66/135 (48%), Gaps = 11/135 (8%) Frame = +1 Query: 19 ETSHSKGYAFIRFA--DYGAQVLCLAEKHLIDGRWCAVKVPFSKNEADKQEIS---KKIH 183 +T S+G+ F+ ++ + +C A H +DGR K S+ ++ K KKI Sbjct: 71 QTKRSRGFGFVTYSCVEEVDAAMC-ARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIF 129 Query: 184 VGYASEDISMEDLRMAFEQYGYVTDIFIPKPF-----RNFAFVTFDSSDTAQSLIGQSIN 348 VG ED +LR FE+YG + I + + R FAFVTFD DT ++ Q + Sbjct: 130 VGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYH 189 Query: 349 -VNGHTLTIGSAVPK 390 +NGH + A+ K Sbjct: 190 TINGHNCEVKKALSK 204
Score = 31.6 bits (70), Expect = 5.6
Identities = 23/95 (24%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Frame = +1
Query: 145 NEADKQEISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDS 309
++ + E +K+ +G S + + + LR FE++G +TD + K R F FVT+
Sbjct: 26 HDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSC 85
Query: 310 -SDTAQSLIGQSINVNGHTLTIGSAVPKINSNRKG 411
+ ++ + V+G + AV + +S + G
Sbjct: 86 VEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPG 120
>sp|P49312|ROA1_MOUSE Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) Length = 320 Score = 59.3 bits (142), Expect = 2e-08 Identities = 47/148 (31%), Positives = 68/148 (45%), Gaps = 15/148 (10%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCL-AEKHLIDGRWCAVKVPFSKNEADKQEIS---KKIHVG 189 T S+G+ F+ +A + A H +DGR K S+ ++ + KKI VG Sbjct: 51 TKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVG 110 Query: 190 YASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-V 351 ED LR FEQYG + I I R FAFVTFD D+ ++ Q + V Sbjct: 111 GIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTV 170 Query: 352 NGHTLTIGSAVPK-----INSNRKGMPG 420 NGH + A+ K +S+++G G Sbjct: 171 NGHNCEVRKALSKQEMASASSSQRGRSG 198
Score = 40.0 bits (92), Expect = 0.016
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 7/98 (7%)
Frame = +1
Query: 139 SKNEADKQ-EISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVT 300
SK+E+ K+ E +K+ +G S + + E LR FEQ+G +TD + K R F FVT
Sbjct: 2 SKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVT 61
Query: 301 FDSSDTAQSLI-GQSINVNGHTLTIGSAVPKINSNRKG 411
+ + + + + + V+G + AV + +S R G
Sbjct: 62 YATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPG 99
>sp|P09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) Length = 372 Score = 59.3 bits (142), Expect = 2e-08 Identities = 47/148 (31%), Positives = 68/148 (45%), Gaps = 15/148 (10%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCL-AEKHLIDGRWCAVKVPFSKNEADKQEIS---KKIHVG 189 T S+G+ F+ +A + A H +DGR K S+ ++ + KKI VG Sbjct: 51 TKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVG 110 Query: 190 YASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-V 351 ED LR FEQYG + I I R FAFVTFD D+ ++ Q + V Sbjct: 111 GIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTV 170 Query: 352 NGHTLTIGSAVPK-----INSNRKGMPG 420 NGH + A+ K +S+++G G Sbjct: 171 NGHNCEVRKALSKQEMASASSSQRGRSG 198
Score = 40.0 bits (92), Expect = 0.016
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 7/98 (7%)
Frame = +1
Query: 139 SKNEADKQ-EISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVT 300
SK+E+ K+ E +K+ +G S + + E LR FEQ+G +TD + K R F FVT
Sbjct: 2 SKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVT 61
Query: 301 FDSSDTAQSLI-GQSINVNGHTLTIGSAVPKINSNRKG 411
+ + + + + + V+G + AV + +S R G
Sbjct: 62 YATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPG 99
>sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP B1) Length = 353 Score = 58.9 bits (141), Expect = 3e-08 Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 15/150 (10%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCLAEK-HLIDGRWCAVKVPFSKNEADKQEIS---KKIHVG 189 + S+G+ F+ F+ +A + H IDGR K ++ E+ K KK+ VG Sbjct: 58 SKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVG 117 Query: 190 YASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-V 351 ED LR FE+YG + I I R F FVTFD D ++ Q + + Sbjct: 118 GIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTI 177 Query: 352 NGHTLTIGSAVPK-----INSNRKGMPGHY 426 NGH + A+ + + S+R G G++ Sbjct: 178 NGHNAEVRKALSRQEMQEVQSSRSGRGGNF 207
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/100 (27%), Positives = 52/100 (52%), Gaps = 6/100 (6%)
Frame = +1
Query: 130 VPFSKNEADKQEISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAF 294
VP + + +K++ +K+ +G S + + E LR +EQ+G +TD + K R F F
Sbjct: 8 VPLERKKREKEQF-RKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGF 66
Query: 295 VTFDS-SDTAQSLIGQSINVNGHTLTIGSAVPKINSNRKG 411
VTF S ++ ++ + +++G + AV + S + G
Sbjct: 67 VTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPG 106
>sp|O88569|ROA2_MOUSE Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP B1) Length = 341 Score = 58.9 bits (141), Expect = 3e-08 Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 15/150 (10%) Frame = +1 Query: 22 TSHSKGYAFIRFADYGAQVLCLAEK-HLIDGRWCAVKVPFSKNEADKQEIS---KKIHVG 189 + S+G+ F+ F+ +A + H IDGR K ++ E+ K KK+ VG Sbjct: 46 SKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVG 105 Query: 190 YASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDSSDTAQSLIGQSIN-V 351 ED LR FE+YG + I I R F FVTFD D ++ Q + + Sbjct: 106 GIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTI 165 Query: 352 NGHTLTIGSAVPK-----INSNRKGMPGHY 426 NGH + A+ + + S+R G G++ Sbjct: 166 NGHNAEVRKALSRQEMQEVQSSRSGRGGNF 195
Score = 38.5 bits (88), Expect = 0.046
Identities = 26/94 (27%), Positives = 49/94 (52%), Gaps = 6/94 (6%)
Frame = +1
Query: 148 EADKQEISKKIHVGYASEDISMEDLRMAFEQYGYVTDIFI-----PKPFRNFAFVTFDS- 309
E +K++ +K+ +G S + + E LR +EQ+G +TD + K R F FVTF S
Sbjct: 2 EREKEQF-RKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSM 60
Query: 310 SDTAQSLIGQSINVNGHTLTIGSAVPKINSNRKG 411
++ ++ + +++G + AV + S + G
Sbjct: 61 AEVDAAMAARPHSIDGRVVEPKRAVAREESGKPG 94
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 150,059,570
Number of Sequences: 369166
Number of extensions: 3068936
Number of successful extensions: 8499
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7897
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8455
length of database: 68,354,980
effective HSP length: 114
effective length of database: 47,295,190
effective search space used: 15985774220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
