Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_03071
(789 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13107|UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase ... 173 4e-43
sp|P35123|UBP4_MOUSE Ubiquitin carboxyl-terminal hydrolase ... 169 8e-42
sp|Q8R5H1|UBP15_MOUSE Ubiquitin carboxyl-terminal hydrolase... 152 1e-36
sp|Q9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase... 152 1e-36
sp|P51784|UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase... 150 4e-36
sp|P39538|UBP12_YEAST Ubiquitin carboxyl-terminal hydrolase... 144 4e-34
sp|Q01988|UBP11_CANFA Ubiquitin carboxyl-terminal hydrolase... 138 2e-32
sp|Q99K46|UBP11_MOUSE Ubiquitin carboxyl-terminal hydrolase... 137 3e-32
sp|O60079|UBP12_SCHPO Probable ubiquitin carboxyl-terminal ... 134 2e-31
sp|O22207|UBP5_ARATH Ubiquitin carboxyl-terminal hydrolase ... 133 6e-31
>sp|Q13107|UBP4_HUMAN Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4)
(Ubiquitin-specific processing protease 4)
(Deubiquitinating enzyme 4) (Ubiquitous nuclear protein
homolog)
Length = 963
Score = 173 bits (439), Expect = 4e-43
Identities = 97/258 (37%), Positives = 148/258 (57%), Gaps = 10/258 (3%)
Frame = +3
Query: 3 SNSSTDSSKIVNGNPF-KNIFSVILSETSSTSTNDHEINPLSRN-RSLKAEADQHIVVEW 176
++ S + K + G P K +F+ L + T+ +IN L+ + + LK + + ++W
Sbjct: 687 NDPSETTQKKIKGQPCPKRLFTFSLVNSYGTA----DINSLAADGKLLKLNSRSTLAMDW 742
Query: 177 SSEGMKNYQKNL------KRTSINCTQQIPKLTI--EDCLKQFLCEEYLGQKDLWFCPKC 332
E + Y K S+ Q+ K T+ DC++ F E LG+ D W+CP C
Sbjct: 743 DRETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNC 802
Query: 333 KKDEAASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEVIFPTKNLNLCQYVPKVENEN 512
KK + A+KK D+W LPK+LV+HLKRF Y+ DK++ V FP + LN+ ++V + +
Sbjct: 803 KKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNL-SAR 861
Query: 513 DFIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSNTSCVDENEIVTKSAYVLVYV 692
++YDL+AVSNH G + GHY A+AKN L +WY FDDSN S E++IVTK+AYVL Y
Sbjct: 862 PYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 921
Query: 693 ARSCNNEYNLPAMMNGHS 746
R + Y P++ + S
Sbjct: 922 RRD-DEFYKTPSLSSSGS 938
>sp|P35123|UBP4_MOUSE Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4)
(Ubiquitin-specific processing protease 4)
(Deubiquitinating enzyme 4) (Ubiquitous nuclear protein)
Length = 962
Score = 169 bits (428), Expect = 8e-42
Identities = 92/238 (38%), Positives = 142/238 (59%), Gaps = 10/238 (4%)
Frame = +3
Query: 15 TDSSKIVNGNP-FKNIFSVILSETSSTSTNDHEINPLSRN-RSLKAEADQHIVVEWSSEG 188
++S++ V G P K +F+ L + T+ +IN L+ + + LK + + ++W SE
Sbjct: 690 SESAQKVKGQPRHKRLFTFSLVNSCGTA----DINSLATDGKLLKLNSRSTLAIDWDSET 745
Query: 189 MKNY------QKNLKRTSINCTQQIPK--LTIEDCLKQFLCEEYLGQKDLWFCPKCKKDE 344
Y + K S++ Q+ K + + +C++ F E LG+ D W+CP CKK +
Sbjct: 746 RSLYFDEQESEACEKHLSMSQPQKKKKAAVALRECIELFTTMETLGEHDPWYCPTCKKHQ 805
Query: 345 AASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEVIFPTKNLNLCQYVPKVENENDFIY 524
A+KK D+W LPK+LV+HLKRF Y+ DK++ V FP + LN+ ++V + ++Y
Sbjct: 806 QATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPVRALNMSEFVCD-RSARPYVY 864
Query: 525 DLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSNTSCVDENEIVTKSAYVLVYVAR 698
DL+AVSNH G + GHY A+AKN L +WY FDDS+ S E++IVTK+AYVL Y R
Sbjct: 865 DLIAVSNHYGAMGVGHYTAYAKNRLNGKWYYFDDSSVSLASEDQIVTKAAYVLFYQRR 922
>sp|Q8R5H1|UBP15_MOUSE Ubiquitin carboxyl-terminal hydrolase 15 (Ubiquitin thiolesterase 15)
(Ubiquitin-specific processing protease 15)
(Deubiquitinating enzyme 15)
Length = 981
Score = 152 bits (384), Expect = 1e-36
Identities = 75/194 (38%), Positives = 115/194 (59%), Gaps = 7/194 (3%)
Frame = +3
Query: 129 NRSLKAEADQHIVVEWSSEGMKNYQKNLKRTSINCTQQI-------PKLTIEDCLKQFLC 287
+R L+ + + ++W + K Y + + P + ++DC++ F
Sbjct: 738 DRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKRPFVKLKDCIELFTT 797
Query: 288 EEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEVIFPTK 467
+E LG +D W+CP CK+ + A+KKLD+W LP VLV+HLKRF + Y DK++ V FP
Sbjct: 798 KEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPIS 857
Query: 468 NLNLCQYVPKVENENDFIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSNTSCVD 647
+L++ +++ N Y+L+AVSNH G + GGHY AFAKN +WY FDDS+ S
Sbjct: 858 DLDMSEFLIN-PNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTAS 916
Query: 648 ENEIVTKSAYVLVY 689
E++IV+K+AYVL Y
Sbjct: 917 EDQIVSKAAYVLFY 930
>sp|Q9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Ubiquitin thiolesterase 15)
(Ubiquitin-specific processing protease 15)
(Deubiquitinating enzyme 15) (Unph-2) (Unph4)
Length = 981
Score = 152 bits (384), Expect = 1e-36
Identities = 75/194 (38%), Positives = 115/194 (59%), Gaps = 7/194 (3%)
Frame = +3
Query: 129 NRSLKAEADQHIVVEWSSEGMKNYQKNLKRTSINCTQQI-------PKLTIEDCLKQFLC 287
+R L+ + + ++W + K Y + + P + ++DC++ F
Sbjct: 738 DRQLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTT 797
Query: 288 EEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEVIFPTK 467
+E LG +D W+CP CK+ + A+KKLD+W LP VLV+HLKRF + Y DK++ V FP
Sbjct: 798 KEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPIN 857
Query: 468 NLNLCQYVPKVENENDFIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSNTSCVD 647
+L++ +++ N Y+L+AVSNH G + GGHY AFAKN +WY FDDS+ S
Sbjct: 858 DLDMSEFLIN-PNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTAS 916
Query: 648 ENEIVTKSAYVLVY 689
E++IV+K+AYVL Y
Sbjct: 917 EDQIVSKAAYVLFY 930
>sp|P51784|UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (Ubiquitin thiolesterase 11)
(Ubiquitin-specific processing protease 11)
(Deubiquitinating enzyme 11)
Length = 920
Score = 150 bits (379), Expect = 4e-36
Identities = 80/239 (33%), Positives = 137/239 (57%), Gaps = 9/239 (3%)
Frame = +3
Query: 51 KNIFSVILSETSSTSTNDHEINPLSRNRSLKAEADQHIVVEWSSEGMKNYQKNLKRTSI- 227
K +F+ L +S T+D +P + A +I ++W E K Y ++
Sbjct: 671 KQLFT--LQTVNSNGTSDRTTSPE------EVHAQPYIAIDWEPEMKKRYYDEVEAEGYV 722
Query: 228 --NCTQQIPK---LTIEDCLKQFLCEEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLV 392
+C + K + +++C++ F E L +++ W+CP CK+ + A+KKLD+W LP++L+
Sbjct: 723 KHDCVGYVMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILI 782
Query: 393 LHLKRFKATSYFGDKINNEVIFPTKNLNLCQYVPKVENEND---FIYDLVAVSNHVGCLA 563
+HLKRF T + +K++ V FP ++L+ ++V + +NE++ + YDL+AVSNH G +
Sbjct: 783 IHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMR 842
Query: 564 GGHYFAFAKNYLYNRWYKFDDSNTSCVDENEIVTKSAYVLVYVARSCNNEYNLPAMMNG 740
GHY FA N +W+ FDD++ S V+EN+I +K+AYVL Y + PA +G
Sbjct: 843 DGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSG 901
>sp|P39538|UBP12_YEAST Ubiquitin carboxyl-terminal hydrolase 12 (Ubiquitin thiolesterase 12)
(Ubiquitin-specific processing protease 12)
(Deubiquitinating enzyme 12)
Length = 1254
Score = 144 bits (362), Expect = 4e-34
Identities = 65/149 (43%), Positives = 93/149 (62%)
Frame = +3
Query: 252 LTIEDCLKQFLCEEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFG 431
+T++DCL+ F E LG D W+CP CK+ A+K++ +W P +L++HLKRF++ F
Sbjct: 962 ITLDDCLQLFSKPEILGLTDSWYCPTCKEHRQATKQIQLWNTPDILLIHLKRFESQRSFS 1021
Query: 432 DKINNEVIFPTKNLNLCQYVPKVENENDFIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRW 611
DKI+ V FP +L+L +YV ++ IYDL AV NH G L GGHY A+ KN+ N+W
Sbjct: 1022 DKIDATVNFPITDLDLSRYVVYKDDPRGLIYDLYAVDNHYGGLGGGHYTAYVKNFADNKW 1081
Query: 612 YKFDDSNTSCVDENEIVTKSAYVLVYVAR 698
Y FDDS + + SAY+L Y+ R
Sbjct: 1082 YYFDDSRVTETAPENSIAGSAYLLFYIRR 1110
>sp|Q01988|UBP11_CANFA Ubiquitin carboxyl-terminal hydrolase 11 (Ubiquitin thiolesterase
11) (Ubiquitin-specific processing protease 11)
(Deubiquitinating enzyme 11)
Length = 445
Score = 138 bits (348), Expect = 2e-32
Identities = 72/189 (38%), Positives = 114/189 (60%), Gaps = 9/189 (4%)
Frame = +3
Query: 150 ADQHIVVEWSSEGMKNYQKNLKRTSI---NCTQQIPK---LTIEDCLKQFLCEEYLGQKD 311
A +I ++W E K Y ++ +C + K + +++C++ F E L +++
Sbjct: 221 AQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVLKKAPVRLQECIELFTTVETLEKEN 280
Query: 312 LWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEVIFPTKNLNLCQYV 491
WFCP CK+ + A+KKLD+W LP+ L++HLKRF T + +K++ V FP ++L+ ++V
Sbjct: 281 PWFCPTCKQHQLATKKLDLWMLPETLIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFV 340
Query: 492 PKVENEND---FIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSNTSCVDENEIV 662
K +NE+ + YDL+AVSNH G L GHY FA N + FDD++ S V EN+I
Sbjct: 341 IKPQNESAPELYKYDLIAVSNHYGGLRDGHYTTFACNKDSGQSDYFDDNSVSPVTENQIE 400
Query: 663 TKSAYVLVY 689
+K+AYVL Y
Sbjct: 401 SKAAYVLFY 409
>sp|Q99K46|UBP11_MOUSE Ubiquitin carboxyl-terminal hydrolase 11 (Ubiquitin thiolesterase 11)
(Ubiquitin-specific processing protease 11)
(Deubiquitinating enzyme 11)
Length = 797
Score = 137 bits (346), Expect = 3e-32
Identities = 74/222 (33%), Positives = 128/222 (57%), Gaps = 9/222 (4%)
Frame = +3
Query: 51 KNIFSVILSETSSTSTNDHEINPLSRNRSLKAEADQHIVVEWSSEGMKNYQKNLKRTSI- 227
K +F+ L +S T+D +P + + +I ++W + + Y ++
Sbjct: 549 KQLFT--LQTVNSNGTSDRTTSPE------EMQTQPYIAMDWEPDMKRRYYDEVEAEGYV 600
Query: 228 --NCTQQIPK---LTIEDCLKQFLCEEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLV 392
+C + K + +++C+K F E L +++ W+C CK+ + A+KKLD+W LP+VL+
Sbjct: 601 KHDCVGYMLKKSPVQLKECIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLI 660
Query: 393 LHLKRFKATSYFGDKINNEVIFPTKNLNLCQYVPKVENEND---FIYDLVAVSNHVGCLA 563
+HLKRF + +K++ V FP ++L+ ++V K +NE+ + YDL+AVSNH G +
Sbjct: 661 IHLKRFSFSKISREKLDTLVQFPIRDLDFSEFVIKPKNESSPDLYKYDLIAVSNHYGGMR 720
Query: 564 GGHYFAFAKNYLYNRWYKFDDSNTSCVDENEIVTKSAYVLVY 689
GHY FA N +W+ DD++ S V+EN+I +K+AYVL Y
Sbjct: 721 DGHYTTFACNKDSGQWHYLDDNSVSPVNENQIESKAAYVLFY 762
>sp|O60079|UBP12_SCHPO Probable ubiquitin carboxyl-terminal hydrolase 12 (Ubiquitin
thiolesterase 12) (Ubiquitin-specific processing protease
12) (Deubiquitinating enzyme 12)
Length = 979
Score = 134 bits (338), Expect = 2e-31
Identities = 69/150 (46%), Positives = 94/150 (62%), Gaps = 4/150 (2%)
Frame = +3
Query: 252 LTIEDCLKQFLCEEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFG 431
+T+ DCL +F E LG++D W+CP CK+ ASK+++IW+ P++L+ HLKRF + F
Sbjct: 825 ITLNDCLDEFEKTEQLGEEDPWYCPTCKEFRQASKQMEIWRCPEILIFHLKRFSSERRFR 884
Query: 432 DKINNEVIFPTKNLNLCQYVPKV---ENEN-DFIYDLVAVSNHVGCLAGGHYFAFAKNYL 599
DKI++ V FP NL++ E EN IY+L AV NH G L GGHY AFAKN
Sbjct: 885 DKIDDLVEFPIDNLDMSMRTGSYKLSEKENPKLIYELYAVDNHYGGLGGGHYTAFAKNPD 944
Query: 600 YNRWYKFDDSNTSCVDENEIVTKSAYVLVY 689
++Y FDDS + V E VT +AY+L Y
Sbjct: 945 NGQFYCFDDSRVTPVCPEETVTSAAYLLFY 974
>sp|O22207|UBP5_ARATH Ubiquitin carboxyl-terminal hydrolase 5 (Ubiquitin thiolesterase 5)
(Ubiquitin-specific processing protease 5)
(Deubiquitinating enzyme 5) (AtUBP5)
Length = 924
Score = 133 bits (334), Expect = 6e-31
Identities = 73/203 (35%), Positives = 111/203 (54%), Gaps = 15/203 (7%)
Frame = +3
Query: 138 LKAEADQHIVVEWSSEGMKNYQKNLKRTSINCTQQIPK---------------LTIEDCL 272
L + A I ++W+ E Y I C + +P+ L++ CL
Sbjct: 722 LPSSATVTIYLDWTPELSGMYD-------ITCLESLPEVLKYGPTTKKARSEPLSLYACL 774
Query: 273 KQFLCEEYLGQKDLWFCPKCKKDEAASKKLDIWKLPKVLVLHLKRFKATSYFGDKINNEV 452
+ FL EE L ++WFCP+C + ASKKLD+W+LP+VLV+HLKRF + K+ V
Sbjct: 775 EAFLREEPLVPDEMWFCPQCNERRQASKKLDLWRLPEVLVIHLKRFSYSRSMKHKLETFV 834
Query: 453 IFPTKNLNLCQYVPKVENENDFIYDLVAVSNHVGCLAGGHYFAFAKNYLYNRWYKFDDSN 632
FP +L+L +YV +Y+L A++NH G + GHY A K +RWY FDDS+
Sbjct: 835 NFPIHDLDLTKYVANKNLSQPQLYELYALTNHYGGMGSGHYTAHIKLLDDSRWYNFDDSH 894
Query: 633 TSCVDENEIVTKSAYVLVYVARS 701
S ++E+++ + +AYVL Y +S
Sbjct: 895 ISHINEDDVKSGAAYVLFYRRKS 917
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,449,825
Number of Sequences: 369166
Number of extensions: 1913121
Number of successful extensions: 5310
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5047
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5236
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)