Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_03066
(478 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8TEY7|UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase... 113 2e-25
sp|Q9Y2K6|UBP20_HUMAN Ubiquitin carboxyl-terminal hydrolase... 106 2e-23
sp|P51784|UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase... 67 2e-11
sp|O75604|UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase ... 66 5e-11
sp|Q01988|UBP11_CANFA Ubiquitin carboxyl-terminal hydrolase... 64 1e-10
sp|Q9UPT9|UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase... 64 2e-10
sp|O57429|UBP2_CHICK Ubiquitin carboxyl-terminal hydrolase ... 64 2e-10
sp|Q5DU02|UBP22_MOUSE Ubiquitin carboxyl-terminal hydrolase... 63 3e-10
sp|P40818|UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase ... 63 3e-10
sp|Q80U87|UBP8_MOUSE Ubiquitin carboxyl-terminal hydrolase ... 63 3e-10
>sp|Q8TEY7|UBP33_HUMAN Ubiquitin carboxyl-terminal hydrolase 33 (Ubiquitin thiolesterase
33) (Ubiquitin-specific processing protease 33)
(Deubiquitinating enzyme 33) (VHL-interacting
deubiquitinating enzyme 1)
Length = 942
Score = 113 bits (283), Expect = 2e-25
Identities = 60/129 (46%), Positives = 77/129 (59%), Gaps = 9/129 (6%)
Frame = +1
Query: 109 SHPLPPTSNTAISLLYYQLSWILTFLIWIK--------NWFINRVVTLEQCLELFFSQDE 264
SHP + Y WI F+ ++K +WF VVTL+ CL FF++DE
Sbjct: 522 SHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDE 581
Query: 265 LKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHDFGCS-KITTAVRFPVEGLD 441
LKGDN YSC+KC+ +N V K+ PEILC HLKRFRH+ S KI+T V FP+EGLD
Sbjct: 582 LKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLD 641
Query: 442 MSPFLHPDN 468
+ PFL D+
Sbjct: 642 LQPFLAKDS 650
>sp|Q9Y2K6|UBP20_HUMAN Ubiquitin carboxyl-terminal hydrolase 20 (Ubiquitin thiolesterase
20) (Ubiquitin-specific processing protease 20)
(Deubiquitinating enzyme 20)
Length = 913
Score = 106 bits (265), Expect = 2e-23
Identities = 56/111 (50%), Positives = 73/111 (65%), Gaps = 2/111 (1%)
Frame = +1
Query: 130 SNTAISLLYYQLSWILTFLI-WIKNWFINRVVTLEQCLELFFSQDELKGDNKYSCDKCQG 306
S A L + + +I F++ +WF VVTLE CL FF+ DELKGDN YSC++C+
Sbjct: 505 SYAAQGWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKK 564
Query: 307 HQNAVMQSKLLKSPEILCFHLKRFRHDFGCS-KITTAVRFPVEGLDMSPFL 456
+N V K+L+ PEILC HLKRFRH+ S KI + V FP+EGLD+ PFL
Sbjct: 565 LRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFL 615
>sp|P51784|UBP11_HUMAN Ubiquitin carboxyl-terminal hydrolase 11 (Ubiquitin thiolesterase
11) (Ubiquitin-specific processing protease 11)
(Deubiquitinating enzyme 11)
Length = 920
Score = 67.0 bits (162), Expect = 2e-11
Identities = 35/87 (40%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Frame = +1
Query: 220 VTLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRH-DFGC 396
V L++C+ELF + + L+ +N + C C+ HQ A + L PEIL HLKRF + F
Sbjct: 736 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 795
Query: 397 SKITTAVRFPVEGLDMSPF-LHPDNKN 474
K+ T V FP+ LD S F + P N++
Sbjct: 796 EKLDTLVEFPIRDLDFSEFVIQPQNES 822
>sp|O75604|UBP2_HUMAN Ubiquitin carboxyl-terminal hydrolase 2 (Ubiquitin thiolesterase 2)
(Ubiquitin-specific processing protease 2)
(Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific
protease)
Length = 605
Score = 65.9 bits (159), Expect = 5e-11
Identities = 32/79 (40%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Frame = +1
Query: 220 VTLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHD-FGC 396
VTL C+ LF +D L GD K +C +C+G + + + + + P+IL HLKRF
Sbjct: 453 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 512
Query: 397 SKITTAVRFPVEGLDMSPF 453
SK+TT V FP+ LD+ F
Sbjct: 513 SKLTTFVNFPLRDLDLREF 531
>sp|Q01988|UBP11_CANFA Ubiquitin carboxyl-terminal hydrolase 11 (Ubiquitin thiolesterase
11) (Ubiquitin-specific processing protease 11)
(Deubiquitinating enzyme 11)
Length = 445
Score = 64.3 bits (155), Expect = 1e-10
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Frame = +1
Query: 220 VTLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRH-DFGC 396
V L++C+ELF + + L+ +N + C C+ HQ A + L PE L HLKRF + F
Sbjct: 261 VRLQECIELFTTVETLEKENPWFCPTCKQHQLATKKLDLWMLPETLIIHLKRFSYTKFSR 320
Query: 397 SKITTAVRFPVEGLDMSPF-LHPDNKN 474
K+ T V FP+ LD S F + P N++
Sbjct: 321 EKLDTLVEFPIRDLDFSEFVIKPQNES 347
>sp|Q9UPT9|UBP22_HUMAN Ubiquitin carboxyl-terminal hydrolase 22 (Ubiquitin thiolesterase
22) (Ubiquitin-specific processing protease 22)
(Deubiquitinating enzyme 22)
Length = 525
Score = 63.9 bits (154), Expect = 2e-10
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Frame = +1
Query: 208 INRVVTLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHD 387
++ TL CL F + L K C C +Q + Q + K P + CFHLKRF H
Sbjct: 356 VSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHS 415
Query: 388 FGC-SKITTAVRFPVEGLDMSPFL 456
KITT V FP+E LDM+PF+
Sbjct: 416 AKLRRKITTYVSFPLE-LDMTPFM 438
>sp|O57429|UBP2_CHICK Ubiquitin carboxyl-terminal hydrolase 2 (Ubiquitin thiolesterase 2)
(Ubiquitin-specific processing protease 2)
(Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific
protease)
Length = 357
Score = 63.5 bits (153), Expect = 2e-10
Identities = 33/79 (41%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Frame = +1
Query: 220 VTLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRH-DFGC 396
VTL CL LF +D L GD K +C +C+ + + K P+IL HLKRF
Sbjct: 205 VTLMDCLRLFTKEDVLDGDEKPTCCRCKARTRCTKKFSIQKFPKILVLHLKRFSEARIRA 264
Query: 397 SKITTAVRFPVEGLDMSPF 453
SK+TT V FP++ LD+ F
Sbjct: 265 SKLTTFVNFPLKDLDLREF 283
>sp|Q5DU02|UBP22_MOUSE Ubiquitin carboxyl-terminal hydrolase 22 (Ubiquitin thiolesterase
22) (Ubiquitin-specific processing protease 22)
(Deubiquitinating enzyme 22)
Length = 525
Score = 63.2 bits (152), Expect = 3e-10
Identities = 34/79 (43%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Frame = +1
Query: 223 TLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHDFGC-S 399
TL CL F + L K C C +Q + Q + K P + CFHLKRF H
Sbjct: 361 TLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRR 420
Query: 400 KITTAVRFPVEGLDMSPFL 456
KITT V FP+E LDM+PF+
Sbjct: 421 KITTYVSFPLE-LDMTPFM 438
>sp|P40818|UBP8_HUMAN Ubiquitin carboxyl-terminal hydrolase 8 (Ubiquitin thiolesterase 8)
(Ubiquitin-specific processing protease 8)
(Deubiquitinating enzyme 8) (hUBPy)
Length = 1118
Score = 63.2 bits (152), Expect = 3e-10
Identities = 28/79 (35%), Positives = 51/79 (64%), Gaps = 1/79 (1%)
Frame = +1
Query: 223 TLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHDFGCS- 399
TL+ CL LF +++L +N++ C C+ ++++ + ++ K P +L HLKRF +D
Sbjct: 963 TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQ 1022
Query: 400 KITTAVRFPVEGLDMSPFL 456
K+ T+V FP+E LD+S ++
Sbjct: 1023 KLQTSVDFPLENLDLSQYV 1041
>sp|Q80U87|UBP8_MOUSE Ubiquitin carboxyl-terminal hydrolase 8 (Ubiquitin thiolesterase 8)
(Ubiquitin-specific processing protease 8)
(Deubiquitinating enzyme 8) (mUBPy)
Length = 1080
Score = 63.2 bits (152), Expect = 3e-10
Identities = 28/79 (35%), Positives = 51/79 (64%), Gaps = 1/79 (1%)
Frame = +1
Query: 223 TLEQCLELFFSQDELKGDNKYSCDKCQGHQNAVMQSKLLKSPEILCFHLKRFRHDFGCS- 399
TL+ CL LF +++L +N++ C C+ ++++ + ++ K P +L HLKRF +D
Sbjct: 925 TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQ 984
Query: 400 KITTAVRFPVEGLDMSPFL 456
K+ T+V FP+E LD+S ++
Sbjct: 985 KLQTSVDFPLENLDLSQYV 1003
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,596,794
Number of Sequences: 369166
Number of extensions: 949663
Number of successful extensions: 2516
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2446
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2502
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2832714465
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)