Planaria EST Database


DrC_03062

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_03062
         (473 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|O00750|P3C2B_HUMAN  Phosphatidylinositol-4-phosphate 3-ki...   110   2e-24
sp|O75747|P3C2G_HUMAN  Phosphatidylinositol-4-phosphate 3-ki...   108   6e-24
sp|Q61194|P3C2A_MOUSE  Phosphatidylinositol-4-phosphate 3-ki...   108   6e-24
sp|Q5RAY1|P3C2A_PONPY  Phosphatidylinositol-4-phosphate 3-ki...   107   1e-23
sp|O00443|P3C2A_HUMAN  Phosphatidylinositol-4-phosphate 3-ki...   107   2e-23
sp|O70173|P3C2G_RAT  Phosphatidylinositol-4-phosphate 3-kina...   102   4e-22
sp|O70167|P3C2G_MOUSE  Phosphatidylinositol-4-phosphate 3-ki...   100   3e-21
sp|P54675|PI3K3_DICDI  Phosphatidylinositol 3-kinase 3 (PI3-...    95   9e-20
sp|P48736|PK3CG_HUMAN  Phosphatidylinositol-4,5-bisphosphate...    94   1e-19
sp|P42338|PK3CB_HUMAN  Phosphatidylinositol-4,5-bisphosphate...    94   2e-19
>sp|O00750|P3C2B_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta
            polypeptide (Phosphoinositide 3-Kinase-C2-beta)
            (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K)
          Length = 1634

 Score =  110 bits (274), Expect = 2e-24
 Identities = 54/137 (39%), Positives = 83/137 (60%), Gaps = 2/137 (1%)
 Frame = +1

Query: 67   SYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILV 240
            S R+P  P +L+  +  +DCSYFNS  +PL++ F+ +D       ++FK GDDLRQD+L 
Sbjct: 1035 SCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLT 1094

Query: 241  LQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNV 420
            LQ+ ++M  +W  EGL++RMV +R  STG   G+VE++ +  TLRKIQ   G+     + 
Sbjct: 1095 LQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKD- 1153

Query: 421  SGITEWLTCQNTTKAAY 471
              + +WL   N  +  Y
Sbjct: 1154 RPLADWLQKHNPGEDEY 1170
>sp|O75747|P3C2G_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
            polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
            (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
          Length = 1448

 Score =  108 bits (270), Expect = 6e-24
 Identities = 59/136 (43%), Positives = 85/136 (62%), Gaps = 4/136 (2%)
 Frame = +1

Query: 76   VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLF----EIMFKSGDDLRQDILVL 243
            +P +P + I  ++   CSYF S  LPL+I F  I+ +L      I+FK+GDDLRQD+LVL
Sbjct: 876  LPLNPALCIKGIDHDACSYFTSNALPLKITF--INANLMGKNISIIFKAGDDLRQDMLVL 933

Query: 244  QLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVS 423
            QL ++MD++W  EGL+++M+ YR +STG    LV++V D  TL KI    G+  PL   +
Sbjct: 934  QLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQRLVQMVPDAVTLAKIHRHSGLIGPLKE-N 992

Query: 424  GITEWLTCQNTTKAAY 471
             I +W +  N  KA Y
Sbjct: 993  TIKKWFSQHNHLKADY 1008
>sp|Q61194|P3C2A_MOUSE Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
            polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
            (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170)
          Length = 1686

 Score =  108 bits (270), Expect = 6e-24
 Identities = 58/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
 Frame = +1

Query: 73   RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
            R+P  P ++  +L +K CS+F+S  +PL++     D    EI  MFK G+DLRQD+L LQ
Sbjct: 1092 RLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQ 1151

Query: 247  LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
            + K+MD +W  EGL+LRMV +R +STG   G+VELV    TLRKIQ   G+     +   
Sbjct: 1152 MIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1210

Query: 427  ITEWLTCQNTTKAAY 471
            + EWL   N ++  Y
Sbjct: 1211 LAEWLRKYNPSEEEY 1225
>sp|Q5RAY1|P3C2A_PONPY Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
            polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
            (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha)
          Length = 1685

 Score =  107 bits (267), Expect = 1e-23
 Identities = 57/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
 Frame = +1

Query: 73   RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
            R+P  P ++  +L +K CS+F+S  +PL++     D    EI  MFK G+DLRQD+L LQ
Sbjct: 1090 RLPLKPSLVAKELSIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQ 1149

Query: 247  LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
            + K+MD +W  EGL+LRMV ++ +STG   G+VELV    TLRKIQ   G+     +   
Sbjct: 1150 MIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1208

Query: 427  ITEWLTCQNTTKAAY 471
            + EWL   N ++  Y
Sbjct: 1209 LAEWLRKYNPSEEEY 1223
>sp|O00443|P3C2A_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
            polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
            (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha)
          Length = 1686

 Score =  107 bits (266), Expect = 2e-23
 Identities = 57/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
 Frame = +1

Query: 73   RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
            R+P  P ++  +L +K CS+F+S  +PL++     D    EI  MFK G+DLRQD+L LQ
Sbjct: 1092 RLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQ 1151

Query: 247  LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
            + K+MD +W  EGL+LRMV ++ +STG   G+VELV    TLRKIQ   G+     +   
Sbjct: 1152 MIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1210

Query: 427  ITEWLTCQNTTKAAY 471
            + EWL   N ++  Y
Sbjct: 1211 LAEWLRKYNPSEEEY 1225
>sp|O70173|P3C2G_RAT Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
            polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
            (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
          Length = 1505

 Score =  102 bits (254), Expect = 4e-22
 Identities = 51/134 (38%), Positives = 80/134 (59%), Gaps = 2/134 (1%)
 Frame = +1

Query: 76   VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILVLQL 249
            +P +P + +  ++   CSYF S  LPL+I F   +       ++FK+GDDLRQD+LVLQ+
Sbjct: 936  LPLNPALCVKGIDRDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQI 995

Query: 250  FKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSGI 429
             ++MD++W  EGL+++M+ Y  ++TG   G +E+V D  TL KI    G+  PL   + I
Sbjct: 996  IQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKE-NTI 1054

Query: 430  TEWLTCQNTTKAAY 471
             +W +  N  K  Y
Sbjct: 1055 KKWFSQHNHLKEDY 1068
>sp|O70167|P3C2G_MOUSE Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
            polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
            (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
          Length = 1506

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 51/134 (38%), Positives = 77/134 (57%), Gaps = 2/134 (1%)
 Frame = +1

Query: 76   VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILVLQL 249
            +P +P + I  ++   CSYF S   PL+I F   +       ++FK+GDDLRQD+L LQ+
Sbjct: 937  LPLNPALCIKGIDRDACSYFTSNASPLKITFINANPMGKNISVIFKAGDDLRQDMLALQI 996

Query: 250  FKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSGI 429
             ++MD+ W  EGL+++M+ Y  +STG   G +E+V D  TL KI    G+  PL   + I
Sbjct: 997  IQVMDNAWLQEGLDMQMITYGCLSTGRAQGFIEMVPDAVTLAKIHLHSGLIGPLKE-NTI 1055

Query: 430  TEWLTCQNTTKAAY 471
             +W +  N  K  Y
Sbjct: 1056 KKWFSQHNHLKEDY 1069
>sp|P54675|PI3K3_DICDI Phosphatidylinositol 3-kinase 3 (PI3-kinase) (PtdIns-3-kinase) (PI3K)
          Length = 1585

 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 54/149 (36%), Positives = 82/149 (55%), Gaps = 2/149 (1%)
 Frame = +1

Query: 31   NFIEPELSHPLCSYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESL--FEIMF 204
            N +  E S P   + VP+ P + I  +  + C   +S  +PL + FK  D      +++ 
Sbjct: 1166 NNLREEQSFPTELF-VPFDPSIRILNIIPEKCKSMDSAKVPLWVTFKNADPFAPPLQMIA 1224

Query: 205  KSGDDLRQDILVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQ 384
            K+GDDLRQDIL LQL +LMD +W S+ L+L M  YR ++TG  +GL+E+V +  T  +IQ
Sbjct: 1225 KTGDDLRQDILTLQLLRLMDHMWKSQDLDLHMTIYRCIATGMGTGLIEVVPNSETAARIQ 1284

Query: 385  ESKGIAAPLTNVSGITEWLTCQNTTKAAY 471
               G  +     + I  WL   N T+ +Y
Sbjct: 1285 AGAGGVSGAFKQTPIANWLKNHNQTENSY 1313
>sp|P48736|PK3CG_HUMAN Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit,
            gamma isoform (PI3-kinase p110 subunit gamma)
            (PtdIns-3-kinase p110) (PI3K) (PI3Kgamma)
          Length = 1101

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 47/113 (41%), Positives = 72/113 (63%), Gaps = 5/113 (4%)
 Frame = +1

Query: 67   SYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFE-----IMFKSGDDLRQD 231
            S+RVPY PG+    L ++ C    S   PL + FK  D +        I+FK GDDLRQD
Sbjct: 781  SFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD 840

Query: 232  ILVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQES 390
            +L+LQ+ ++M+ +W +E L+L ++ Y  +STG + G++E+V D TT+ KIQ+S
Sbjct: 841  MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQS 893
>sp|P42338|PK3CB_HUMAN Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit,
            beta isoform (PI3-kinase p110 subunit beta)
            (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta)
          Length = 1070

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 53/136 (38%), Positives = 80/136 (58%), Gaps = 4/136 (2%)
 Frame = +1

Query: 61   LCSYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVF--KGIDESLFEIMFKSGDDLRQDI 234
            L   + P +P +++++L ++ C Y +S   PL +V+  K   E    ++FK+GDDLRQD+
Sbjct: 755  LSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDM 814

Query: 235  LVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQ--ESKGIAAP 408
            L LQ+ +LMD LW   GL+LRM+ Y  ++TG RSGL+E+V    T+  IQ   S   AA 
Sbjct: 815  LTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAA 874

Query: 409  LTNVSGITEWLTCQNT 456
              N   +  WL   N+
Sbjct: 875  AFNKDALLNWLKEYNS 890
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,378,304
Number of Sequences: 369166
Number of extensions: 983272
Number of successful extensions: 2680
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2596
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2663
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2783017720
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)