Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_03062
(473 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00750|P3C2B_HUMAN Phosphatidylinositol-4-phosphate 3-ki... 110 2e-24
sp|O75747|P3C2G_HUMAN Phosphatidylinositol-4-phosphate 3-ki... 108 6e-24
sp|Q61194|P3C2A_MOUSE Phosphatidylinositol-4-phosphate 3-ki... 108 6e-24
sp|Q5RAY1|P3C2A_PONPY Phosphatidylinositol-4-phosphate 3-ki... 107 1e-23
sp|O00443|P3C2A_HUMAN Phosphatidylinositol-4-phosphate 3-ki... 107 2e-23
sp|O70173|P3C2G_RAT Phosphatidylinositol-4-phosphate 3-kina... 102 4e-22
sp|O70167|P3C2G_MOUSE Phosphatidylinositol-4-phosphate 3-ki... 100 3e-21
sp|P54675|PI3K3_DICDI Phosphatidylinositol 3-kinase 3 (PI3-... 95 9e-20
sp|P48736|PK3CG_HUMAN Phosphatidylinositol-4,5-bisphosphate... 94 1e-19
sp|P42338|PK3CB_HUMAN Phosphatidylinositol-4,5-bisphosphate... 94 2e-19
>sp|O00750|P3C2B_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta
polypeptide (Phosphoinositide 3-Kinase-C2-beta)
(PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K)
Length = 1634
Score = 110 bits (274), Expect = 2e-24
Identities = 54/137 (39%), Positives = 83/137 (60%), Gaps = 2/137 (1%)
Frame = +1
Query: 67 SYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILV 240
S R+P P +L+ + +DCSYFNS +PL++ F+ +D ++FK GDDLRQD+L
Sbjct: 1035 SCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLT 1094
Query: 241 LQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNV 420
LQ+ ++M +W EGL++RMV +R STG G+VE++ + TLRKIQ G+ +
Sbjct: 1095 LQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKD- 1153
Query: 421 SGITEWLTCQNTTKAAY 471
+ +WL N + Y
Sbjct: 1154 RPLADWLQKHNPGEDEY 1170
>sp|O75747|P3C2G_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
(PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
Length = 1448
Score = 108 bits (270), Expect = 6e-24
Identities = 59/136 (43%), Positives = 85/136 (62%), Gaps = 4/136 (2%)
Frame = +1
Query: 76 VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLF----EIMFKSGDDLRQDILVL 243
+P +P + I ++ CSYF S LPL+I F I+ +L I+FK+GDDLRQD+LVL
Sbjct: 876 LPLNPALCIKGIDHDACSYFTSNALPLKITF--INANLMGKNISIIFKAGDDLRQDMLVL 933
Query: 244 QLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVS 423
QL ++MD++W EGL+++M+ YR +STG LV++V D TL KI G+ PL +
Sbjct: 934 QLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQRLVQMVPDAVTLAKIHRHSGLIGPLKE-N 992
Query: 424 GITEWLTCQNTTKAAY 471
I +W + N KA Y
Sbjct: 993 TIKKWFSQHNHLKADY 1008
>sp|Q61194|P3C2A_MOUSE Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170)
Length = 1686
Score = 108 bits (270), Expect = 6e-24
Identities = 58/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
Frame = +1
Query: 73 RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
R+P P ++ +L +K CS+F+S +PL++ D EI MFK G+DLRQD+L LQ
Sbjct: 1092 RLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQ 1151
Query: 247 LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
+ K+MD +W EGL+LRMV +R +STG G+VELV TLRKIQ G+ +
Sbjct: 1152 MIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1210
Query: 427 ITEWLTCQNTTKAAY 471
+ EWL N ++ Y
Sbjct: 1211 LAEWLRKYNPSEEEY 1225
>sp|Q5RAY1|P3C2A_PONPY Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha)
Length = 1685
Score = 107 bits (267), Expect = 1e-23
Identities = 57/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
Frame = +1
Query: 73 RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
R+P P ++ +L +K CS+F+S +PL++ D EI MFK G+DLRQD+L LQ
Sbjct: 1090 RLPLKPSLVAKELSIKSCSFFSSNAVPLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQ 1149
Query: 247 LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
+ K+MD +W EGL+LRMV ++ +STG G+VELV TLRKIQ G+ +
Sbjct: 1150 MIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1208
Query: 427 ITEWLTCQNTTKAAY 471
+ EWL N ++ Y
Sbjct: 1209 LAEWLRKYNPSEEEY 1223
>sp|O00443|P3C2A_HUMAN Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha
polypeptide (Phosphoinositide 3-Kinase-C2-alpha)
(PtdIns-3-kinase C2 alpha) (PI3K-C2alpha)
Length = 1686
Score = 107 bits (266), Expect = 2e-23
Identities = 57/135 (42%), Positives = 82/135 (60%), Gaps = 2/135 (1%)
Frame = +1
Query: 73 RVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFEI--MFKSGDDLRQDILVLQ 246
R+P P ++ +L +K CS+F+S +PL++ D EI MFK G+DLRQD+L LQ
Sbjct: 1092 RLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQ 1151
Query: 247 LFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSG 426
+ K+MD +W EGL+LRMV ++ +STG G+VELV TLRKIQ G+ +
Sbjct: 1152 MIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKD-KP 1210
Query: 427 ITEWLTCQNTTKAAY 471
+ EWL N ++ Y
Sbjct: 1211 LAEWLRKYNPSEEEY 1225
>sp|O70173|P3C2G_RAT Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
(PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
Length = 1505
Score = 102 bits (254), Expect = 4e-22
Identities = 51/134 (38%), Positives = 80/134 (59%), Gaps = 2/134 (1%)
Frame = +1
Query: 76 VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILVLQL 249
+P +P + + ++ CSYF S LPL+I F + ++FK+GDDLRQD+LVLQ+
Sbjct: 936 LPLNPALCVKGIDRDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQI 995
Query: 250 FKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSGI 429
++MD++W EGL+++M+ Y ++TG G +E+V D TL KI G+ PL + I
Sbjct: 996 IQVMDNVWLQEGLDMQMIIYGCLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKE-NTI 1054
Query: 430 TEWLTCQNTTKAAY 471
+W + N K Y
Sbjct: 1055 KKWFSQHNHLKEDY 1068
>sp|O70167|P3C2G_MOUSE Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma
polypeptide (Phosphoinositide 3-Kinase-C2-gamma)
(PtdIns-3-kinase C2 gamma) (PI3K-C2gamma)
Length = 1506
Score = 99.8 bits (247), Expect = 3e-21
Identities = 51/134 (38%), Positives = 77/134 (57%), Gaps = 2/134 (1%)
Frame = +1
Query: 76 VPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDE--SLFEIMFKSGDDLRQDILVLQL 249
+P +P + I ++ CSYF S PL+I F + ++FK+GDDLRQD+L LQ+
Sbjct: 937 LPLNPALCIKGIDRDACSYFTSNASPLKITFINANPMGKNISVIFKAGDDLRQDMLALQI 996
Query: 250 FKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQESKGIAAPLTNVSGI 429
++MD+ W EGL+++M+ Y +STG G +E+V D TL KI G+ PL + I
Sbjct: 997 IQVMDNAWLQEGLDMQMITYGCLSTGRAQGFIEMVPDAVTLAKIHLHSGLIGPLKE-NTI 1055
Query: 430 TEWLTCQNTTKAAY 471
+W + N K Y
Sbjct: 1056 KKWFSQHNHLKEDY 1069
>sp|P54675|PI3K3_DICDI Phosphatidylinositol 3-kinase 3 (PI3-kinase) (PtdIns-3-kinase) (PI3K)
Length = 1585
Score = 94.7 bits (234), Expect = 9e-20
Identities = 54/149 (36%), Positives = 82/149 (55%), Gaps = 2/149 (1%)
Frame = +1
Query: 31 NFIEPELSHPLCSYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESL--FEIMF 204
N + E S P + VP+ P + I + + C +S +PL + FK D +++
Sbjct: 1166 NNLREEQSFPTELF-VPFDPSIRILNIIPEKCKSMDSAKVPLWVTFKNADPFAPPLQMIA 1224
Query: 205 KSGDDLRQDILVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQ 384
K+GDDLRQDIL LQL +LMD +W S+ L+L M YR ++TG +GL+E+V + T +IQ
Sbjct: 1225 KTGDDLRQDILTLQLLRLMDHMWKSQDLDLHMTIYRCIATGMGTGLIEVVPNSETAARIQ 1284
Query: 385 ESKGIAAPLTNVSGITEWLTCQNTTKAAY 471
G + + I WL N T+ +Y
Sbjct: 1285 AGAGGVSGAFKQTPIANWLKNHNQTENSY 1313
>sp|P48736|PK3CG_HUMAN Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit,
gamma isoform (PI3-kinase p110 subunit gamma)
(PtdIns-3-kinase p110) (PI3K) (PI3Kgamma)
Length = 1101
Score = 94.4 bits (233), Expect = 1e-19
Identities = 47/113 (41%), Positives = 72/113 (63%), Gaps = 5/113 (4%)
Frame = +1
Query: 67 SYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVFKGIDESLFE-----IMFKSGDDLRQD 231
S+RVPY PG+ L ++ C S PL + FK D + I+FK GDDLRQD
Sbjct: 781 SFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQD 840
Query: 232 ILVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQES 390
+L+LQ+ ++M+ +W +E L+L ++ Y +STG + G++E+V D TT+ KIQ+S
Sbjct: 841 MLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQS 893
>sp|P42338|PK3CB_HUMAN Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit,
beta isoform (PI3-kinase p110 subunit beta)
(PtdIns-3-kinase p110) (PI3K) (PI3Kbeta)
Length = 1070
Score = 94.0 bits (232), Expect = 2e-19
Identities = 53/136 (38%), Positives = 80/136 (58%), Gaps = 4/136 (2%)
Frame = +1
Query: 61 LCSYRVPYHPGMLITKLEMKDCSYFNSFTLPLRIVF--KGIDESLFEIMFKSGDDLRQDI 234
L + P +P +++++L ++ C Y +S PL +V+ K E ++FK+GDDLRQD+
Sbjct: 755 LSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDM 814
Query: 235 LVLQLFKLMDDLWTSEGLNLRMVHYRVMSTGFRSGLVELVDDCTTLRKIQ--ESKGIAAP 408
L LQ+ +LMD LW GL+LRM+ Y ++TG RSGL+E+V T+ IQ S AA
Sbjct: 815 LTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAA 874
Query: 409 LTNVSGITEWLTCQNT 456
N + WL N+
Sbjct: 875 AFNKDALLNWLKEYNS 890
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,378,304
Number of Sequences: 369166
Number of extensions: 983272
Number of successful extensions: 2680
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2596
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2663
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2783017720
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)